IUPS 2013 programme by PhySoc

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Contents Key to Themes CR

Cardiac & Respiratory Physiology

Metabolism & Endocrinology

Neuroscience

Vascular & Smooth Muscle Physiology

Epithelia & Membrane Transport

Education & Teaching

Human & Exercise Physiology

General Interest

Page

Welcome Letters IUPS SPS ESM AND EVBO About IUPS and Partners Congress Organisation

Thursday 25 July 2 2 3 4 7

8-9 10-11 13-14 17 14 15 16 17 18

Sunday 21 July At a glance Opening Ceremony Welcome Reception

23 23 23

Monday 22 July At a glance Symposia Poster Comms Other Activities

25 26 34 55

Tuesday 23 July At a glance Symposia Poster Comms Other Activities

61 62 70 93

Wednesday 24 July At a glance Symposia Poster Comms Other Activities

At a glance Symposia Poster Comms Other Activities

133 134 142 167

Friday 26 July

Scientific Programme Overview Scientific Overview 8.30 - 11.30 Overview 11.45 - 16.15 Overview 16.30 - 19.30 Plan of Hall 3 Venue Maps Venue Information Venue Level Plans Hall 3 Trade Exhibition and Poster Plan Prize Lectures and Keynote Lectures

Page

97 98 106 131

At a glance Symposia Late Breaking Posters Other Activities

169 170 174 181

Venue Information General Information Registration Storage Internet Access In Case Of Emergency Mobile Phones Video/Audio Recording Arriving Late To Sessions Smoking Food And Drink Certificate Of Attendance Feedback Changes To Abstracts Twitter Prayer Room Accessibility Information

182

Social Programme Closing Ceremony General Interest and Industry Sessions Woman in science

184 184 186 188

Other Meetings By Day By Society Awards Hall 3 Trade Exhibition and Poster Plan List Of Exhibitors Numerical Alphabetical Exhibitors Catalogue

190 192 194 198 199 199 200

All photos courtesy of Prem Kumar Design: Oracle Creative | www.oraclecreative.co.uk

Welcome Welcome to IUPS

Welcome from SPS

Welcome to the 37th International Congress of Physiological Sciences. Here in Birmingham you will find a state of the art scientific programme with speakers carefully selected from all over the world. There will also be enjoyable entertainment to relax those evenings away after the debates and arguments of the day. In those debates you will experience a great celebration of the vibrancy of our work as physiologists. Your organisers here in the UK and from IUPS have arranged a programme that demonstrates the now obvious fact that interpretation of function at all biological levels is essential to understanding the vast amount of data that has emerged from sequencing genomes, cataloguing proteins and their actions, unravelling biochemical networks and discovering the often unexpected facts about life on earth. Understanding function, which requires unravelling the logic of life – the meaning of ‘physiology’ – is precisely our mission. This is the way in which we can give meaning to all those DNA sequences and to all the growing multitude of RNAs, through revealing the mechanisms of control. Organisation and control are what characterise living systems. Defining the nature of our subject in this way can be traced back to Claude Bernard in the nineteenth century and to Walter B Cannon in the twentieth century. But even they would be astonished at the challenge that twentyfirst century biology has created since sequencing the whole human genome at the turn of the millennium. This is an exciting time to be working in the physiological sciences, as this Congress will show.

The Scandinavian Physiological Society (SPS) was founded in 1925 and is a society for researchers in physiology and related sciences in the Nordic countries; Denmark, Finland, Iceland, Norway and Sweden. We are a non-profit organization and our objectives are to promote research, education and interest in physiological sciences in our member countries. We now have more than 900 members.

The first international Congress was held 124 years ago in Basel. It brought together around 130 scientists, mostly from Europe. IUPS Congress numbers are now counted in thousands and come from more than 50 nations. A strong theme that runs through the history of the Congresses is the opportunities they created for renewing and making friendships and collaborations. We hope that you will find that is also true of Birmingham 2013.

Bridget Lumb, Chair of organising committee

Denis Noble President of IUPS

David Eisner, Chair of scientific programme committee

Walter Boron Secretary-General of IUPS

Our society supports meetings in the physiological sciences in the Scandinavian countries and arranges annual meetings. Our members can apply for travel grants to these meetings. We also support international symposia exchange and Nordic research networks. The funds for this are partially provided by our journal Acta Physiologica. Members also get free online access to this journal. Acta Physiologica Scandinavica was founded in 1889 as Skandinavisches Archiv für Physiologie and is one of the oldest physiological journals. In January 2006 it changed its name to Acta Physiologica. It is also the official journal of The Federation of European Physiological Societies (FEPS). In 2012, SPS and Acta Physiologica established the Carl Ludwig Award - for an outstanding publication by a young scientist. We would like to invite you to our next annual meeting in Stockholm, 22-24 August 2014. For more information, visit the SPS website: www.scandphys.org Best wishes, Anders Arner President, SPS

Joint Meeting

At IUPS 21-26 July 2013 Birmingham, UK

27th EUROPEAN SOCIETY for MICROCIRCULATION hosted by the AND 7th EUROPEAN VASCULAR BIOLOGY ORGANISATION

On behalf of the European Society for Microcirculation and European Vascular Biology Organisation, we welcome you to the 37th International Congress of Physiological Sciences (IUPS) in Birmingham, 21-26 July 2013. The joint meeting of our two societies under the auspices of IUPS features 18 research symposia, a plenary lecture by Prof Peter Carmeliet (Belgium), keynote lectures by Prof Elisabetta Dejana (Italy) and Prof Takayuki Asahara (Japan), and a Malpighi Award lecture by Prof Steven Segal (USA). The Physiological Society is coordinating the IUPS Congress in Birmingham and, in addition to our joint meeting, you will be able to attend state-of-the-art scientific lectures and symposia with international speakers carefully selected from around the world. We are particularly pleased to have secured designated ESM-EVBO poster sessions for over 250 posters on Wednesday and Thursday, 24th and 25th July. We encourage you to attend these poster sessions as they provide a unique opportunity to discuss and debate new scientific research in a friendly atmosphere, very similar to the vibrant sessions at Experimental Biology. Early career investigators will have had the opportunity for their poster(s) to be evaluated by an international scientific committee comprised of members of the British Microcirculation Society, Italian Microcirculation Society, Japanese Microcirculation Society, Microcirculatory Society Inc., Dutch Microcirculation Society, European Society for Microcirculation and European Vascular Biology Organisation. To further celebrate our joint meeting, we are hosting a Malpighi Reception on Wednesday evening from 20:00â&#x20AC;&#x201C;21:30. The European Society for Microcirculation and the British Microcirculation Society are co-hosting this reception to which all our delegates are invited. We will be awarding up to 20 prizes for the best Poster Abstracts at the Malpighi Reception. In addition, the European Society for Microcirculation will be awarding 4 Young Investigator Travel Awards. The Birmingham International Conference Centre is located in the centre of the city and in close proximity to numerous excellent restaurants and pubs. A lovely canal system surrounds the conference site and will enable you to relax in the evenings. We hope that you will enjoy the science and social events during our joint meeting at IUPS in Birmingham. We look forward to welcoming you and should you have any further queries, please do not hesitate to contact either of us. Giovanni E Mann ESM President 2013

Jeremy D Pearson EVBO Council

About IUPS

Congress Hosts

The IUPS is an organization which brings together physiologists from throughout the world. The unifying objective for physiologists is to increase mankind’s understanding of the functions of cells, tissues, organs and organ systems of animals and humans.

The Physiological Society

The objectives of the IUPS are: to encourage the advancement of the physiological sciences; to facilitate the dissemination of knowledge in the field of physiological sciences; to promote the International Congresses of Physiological Sciences: to promote such other meetings as may be useful for the advancement of the physiological sciences; and to promote such other measures as will contribute to the development of physiological sciences in developing countries. The IUPS publishes a journal, Physiology in cooperation with the American Physiological Society. The articles are short, up-to-date reviews of modern physiology, directed to scientists and teachers throughout the world in order to help them maintain a current knowledge of all fields of physiology. The IUPS has eight active Scientific Commissions and seven Committees. Member societies to IUPS include 51 National Members, 14 Associate Members, 4 Regional Members and 2 Affiliated Members. It is an adhering member of the International Council for Science (ICSU), the Council for International Organizations of Medical Sciences (CIOMS) and International Council of Laboratory Animal Science (ICLAS). Adhering bodies to IUPS include 51 National Members, 9 Associate Members, 2 Affiliated Members, 3 Regional Members and 15 Special Members.

The Physiological Society brings together over 3000 scientists from over 60 countries. Since its foundation in 1876, its Members have made significant contributions to our knowledge of biological systems and the treatment of disease. We promote physiology and support those working in the field by organising world-class scientific meetings, offering grants for research, collaboration and international travel, and by publishing the latest developments in its two leading scientific journals, The Journal of Physiology and Experimental Physiology. Recently, The Physiological Society and The American Physiological Society (APS) announced their partnership to publish a new open-access peer-reviewed journal – Physiological Reports. The Society also runs events for the general public on how physiology relates to everyday life, and for students who may be considering physiology as a career. Membership is available for all career stages, from undergraduate level to senior level scientists.

Congress Partners Federation of European Physiological Societies The Federation of European Physiological Societies (FEPS) was founded during the Regional Meeting of IUPS in Prague (Czech Republic) on July 2, 1991. It now comprises 27 Constituent Societies. The aims of FEPS can be summarized as follows:

• to promote and foster the exchange and diffusion of concepts

Previous Congresses XXXVI XXXV XXXIV XXXIII XXXII XXXI XXX XXIX XXVIII XXVII XXVI XXV XXIV XXIII XXII XXI XX XIX XVIII XVII XVI XV XIV XIII XII XI X IX VIII VII VI V IV III II I

2009 Kyoto 2005 San Diego 2001 Christchurch 1997 St. Petersburg 1993 Glasgow 1989 Helsinki 1986 Vancouver 1983 Sydney 1980 Budapest 1977 Paris 1974 New Delhi 1971 Munich 1968 Washington, D.C. 1965 Tokyo 1962 Leiden 1959 Buenos Aires 1956 Brussels 1953 Montréal 1950 Copenhagen 1947 Oxford 1938 Zurich 1935 Leningrad-Moscow 1932 Rome 1929 Boston 1926 Stockholm 1923 Edinburgh 1920 Paris 1913 Groningen 1910 Vienna 1907 Heidelberg 1904 Brussels 1901 Turin 1898 Cambridge 1895 Bern 1892 Liege 1889 Basel

• • •

•

and information between physiologists and the societies of physiology in the European region to facilitate the dissemination of information concerning the activities of the member societies to encourage joint meetings of two or more member societies to facilitate the exchange of invitations between member societies to national or regional meetings to advance knowledge in the scientific disciplines relating to physiology by supporting and providing suitable mechanisms for training programs in physiology to advance the exchange of graduate students and scientists within Europe and on an international scale to stimulate international scientific research projects in Europe.

The Scandinavian Physiological Society The Scandinavian Physiological Society was founded in 1925 and is a society for researchers in physiology and related sciences in the Nordic countries; Denmark, Finland, Iceland, Norway and Sweden. The Society is a non-profit organization whose objectives are to promote research, education and interest in physiological sciences in its member countries. The Society is registered in Sweden, with its administration moving between different Nordic countries. The present administration is situated in Uppsala and Stockholm, Sweden. The executive board is elected for a period of 4 years, and includes a President, Secretary General, Chief editor, Meeting secretary and two councillors from each of the Nordic countries. In earlier years, the Society arranged Nordic Congresses every 3rd or 4th year; the last one took place in Copenhagen 1992. Since then, annual or bi-annual meetings, which were introduced in 1968, have become the only type of regular meeting activity. Typically, these meetings last from Friday to Sunday – longer with larger meetings and congresses – and consist of several symposia, oral and poster presentations, invited lecturers, and sometimes laboratory demonstrations. The English language is used throughout to accommodate the many foreign visitors. The abstracts are printed

in Acta Physiologica, which is one of the oldest physiological journals in the world (founded in 1889). The journal is healthy and is the main source of active income for the Society, which gives the money back to the members in the form of support to meetings, travel grants and many other activities. From the very beginning, the Society has supported the congresses and ordinary meetings with fairly generous travel grants, thanks to means supplied by its journal, the Acta Physiologica. In addition to these ordinary member meetings, the Society also runs its own series of specialist symposia – Acta Physiologica International Symposia – and from time to time supports specialist meetings arranged by others in one of the Nordic countries.

The British Microcirculation Society The British Microcirculation Society was founded in July 1963 “to advance the study of circulation of the blood and other tissue fluids especially, though not exclusively, in the small vessels and of matters relating thereto”. The membership of more than 250 is drawn largely from the medical sciences - anatomy, biophysics, pathology, pharmacology, physiology and clinical medicine and surgery - but the pharmaceutical industry and the veterinary and physical sciences and mathematics are also represented.

European Society for Microcirculation The European Society for Microcirculation was founded in Hamburg in 1960 following a first meeting of interested scientists in Lund, Sweden in 1959, and now has 500-600 regular members. The aims of the Society are to advance understanding of the microcirculation by bringing together clinicians and scientists from a wide range of specialists, but including physiology, vascular biology, genetics and biophysics. It is now widely recognized that involvement of the small blood vessels is fundamental to numerous disease processes including the spread of cancer, delayed healing, circulatory shock and the complications of diabetes. Such conditions affect people of all ages and result in considerable disability and premature death. New preventative measures and treatments are likely to rely on a more thorough understanding of how the small blood vessels fail in such conditions. By combining the efforts of both basic and clinical scientists, the Society is well poised to make significant contributions towards achieving such goals. The Society has members in over 25 countries and 8 European countries are represented on the Executive Board. Specific goals of the Society are to encourage and help young scientists to join this exciting and important field through Travel Awards to attend its meetings, as well as Career Development Awards to allow them to visit other institutions and learn new techniques. In addition, the Society encourages the development of microvascular science in other European countries and in particular the former Eastern bloc. Since 1980, the Society has its own journal, the Journal of Vascular Research, an international publication of growing impact, through which the world wide scientific community is informed of the Society’s endeavours.

European Vascular Biology Organisation EVBO was launched in 2006, after discussion between European vascular biologists who recognised that there is a need for a democratic society to provide a united focus and forum for vascular biologists in Europe, primarily by organising conferences but also by maintaining and enhancing an interactive network of researchers; evolving from the experience of the previous European Vascular Biology Association and building on the achievements of the FP6 European Vascular Genomics Network (EVGN). Membership is open to all European non-clinical and clinical scientists with an interest in vascular biology. The founding membership (around 200) was augmented to 450 by recruitment at the 4th European Meeting on Vascular Biology and Medicine (EMVBM) in Bristol in 2007 and more recently at the 5th

EMVBM to 500 members. At present there is no directly charged fee for new members: anyone who wishes to join should email the secretary (S.J.George@bristol.ac.uk). EVBO is directed by a Council elected by the membership. Several new members have recently been elected to council with the retirement of eight members who are now listed as ex-officio.

American Physiological Society The American Physiological Society (APS) is a non-profit devoted to fostering education, scientific research, and dissemination of information in the physiological sciences. The Society was founded in 1887 with 28 members. APS now has over 10,500 members. Most members have doctoral degrees in physiology and/or medicine (or other health professions). APS is governed by an elected Council consisting of a President, President-Elect, Past President, and nine Councillors. The National headquarters of the Society is based in Bethesda, Maryland, on the campus of the Federation of American Societies for Experimental Biology (FASEB). APS is a member of FASEB, a coalition of 22 independent societies that plays an active role in lobbying for the interests of biomedical scientists.

The Brazilian Physiological Society The Brazilian Society of Physiology or “Sociedade Brasileira de Fisiologia (SBFis)” was founded in 1957 and during these past 55 years it has played an essential role for the development of Physiology in Brazil. Each year SBFis organizes a national congress of physiology, which is a very important activity for Brazilian Physiologists’. Today SBFis is proud to host the first, and for the immediate future, unique Brazilian National Multicenter Program for Graduation in Physiology with accreditation by CAPES, the federal agency for graduated programs in Brazil. This innovative Network Program for Graduation in Physiology developed by SBFis, integrates several traditional universities with new and developing universities all over Brazil, providing opportunities for young faculties and graduated students from these new institutions, mostly in the interior of the country, to be linked with the most advanced centers for research in Physiology in Brazil. With this Program, SBFis is contributing to the training of a new generation of Physiologists’ and improving the quality of research in Brazil. In the recent past SBFis organized succesful Joint Meetings with the Latin-American Society of Physiology (2003) and also with The Physiological Society (2006). More recently SBFis is taking a leading role on developing and hosting important international congresses such as the 1st Pan-American Congress of Physiological Sciences (Physiology without borders) in Iguassu Falls in 2014, and also the 38th International Congress of IUPS (Rhythms of Life) in Rio de Janeiro in 2017. With these very important projects, SBFis and the Brazilian Physiologists’ are actively contributing to the development of Physiology at national and international levels.

The Canadian Physiological Society The Canadian Physiological Society is a non-profit society that serves as a forum for the dissemination and discussion of scientific information of interest to researchers in Physiology and related Biological Sciences. The major aims of the Society are to encourage research in the Physiological Sciences and to foster communication between members of the Canadian scientific community. The Society has one major meeting each year in January.

Congress Partners The Chinese Association of Physiological Sciences Physiological Society (Chinese Association for Physiological Sciences, abbreviated as CAPS) Chinese physiological scientists voluntary national academic and science of corporate social groups, is part of the China Association for Science and Technology, whose purpose is to promote our scientific and technological progress, economic revitalization and social development, so this will become important social force in promoting our country the physiological scientific talent to grow and improve, and promote the development and popularization of Physiological Sciences in China, promote physiological science and technology and economic integration, and to strengthen international academic exchanges and cooperation. This will carry forward the “respect knowledge, respect talent, fashion, and advocate the spirit of” dedication, innovation, pragmatism, collaboration “unite physiological scientists to carry out continuing education and popularization of physiological science and technology for the prosperity and development of China’s science and technology career knowledge, to promote the achievements contribute to talent and international exchanges.

The Physiological Society of Japan The Physiological Society of Japan (PSJ) was founded in 1922 when the first meeting was organized with contributions of 37 papers. Since then, the Society’s scientific meeting has been held annually except in 1944 and 1945 when all social activities suffered from tremendous difficulties resulting from the World War II. The activities of PSJ were quickly revived after the end of the war, and the Society now has about 3,000 members. Its aim is to promote research in the physiological sciences by providing free communications to members and by actively committing itself to the national and international scientific communities. Besides an Annual Meeting, the Society has frequent regional meetings in 8 major regions. 2012 marked our 90th Anniversary of our founding.

Congress Organisation Honorary Presidents Colin Blakemore (Oxford, UK) Alan North (Manchester, UK) Ole Petersen (Cardiff, UK) Clive Orchard (Bristol, UK) K Michael Spyer (London, UK)

Organising Committee Chair Bridget Lumb (Bristol, UK) Permanent members David Eisner (Manchester, UK) Ian McGrath (Glasgow, UK) Prem Kumar (Birmingham, UK) Members from The Physiological Society President Deputy President Treasurer Meetings Secretary Chair, Education & Outreach Committee Chair, Policy Committee Chair, Publications Committee

Tobias Wang (Aarhus, Denmark) Xian Wang (Beijing, China) Susan Wray (Liverpool, UK) David Wyllie (Edinburgh, UK)

Sponsorship Committee Chair Ian McGrath (Glasgow, UK) Invited members Dave Bates (Bristol, UK) Maynard Case (Manchester, UK) Mike Collis (London, UK) Giovanni Mann (London, UK)

Staff from The Physiological Society Nick Boross-Toby Christine Carr Sarah Bundock Ruth King

Director, Events & Marketing Events & Marketing Manager Events & Marketing Manager Events & Marketing Administrator

Invited Members Ulrich Pohl (Munich, Germany)

Scientific Programme Committee Chair David Eisner (Manchester, UK) Co-Chair Walter Boron (Ohio, USA) Members RenĂŠ Bindels (Nijmegen, Netherlands) Bryndis Birnir (Uppsala, Sweden) Yang-Sook Chun (Seoul, Korea) Graham Collingridge (Bristol, UK) Annette Dolphin (London, UK) Malcolm Gordon (Los Angeles, USA) Lucy Green (Southampton, UK) Penny Hansen (St Johnâ&#x20AC;&#x2122;s, Canada) Hans Hoppeler (Bern, Switzerland) Peter Hunter (Auckland, New Zealand) Ryuji Inoue (Fukuoka, Japan) Anne King (Leeds, UK) Bridget Lumb (Bristol, UK) Benedito H Machado (Brazil, IUPS 2017) Giovanni Mann (London, UK) Patrick Maxwell (London, UK) Andrew McCulloch (California, USA) Paul McLoughlin (Dublin, RoI) Caroline McMillen (Newcastle, Australia) Denis Noble (Oxford, UK) Anant Parekh (Oxford, UK) Julian Paton (Bristol, UK) Jeremy Pearson (London, UK) Quentin Pittman (Calgary, Canada) Ulrich Pohl (Munich, Germany) Jens Rettig (Homburg, Germany) Frank Sengpiel (Cardiff, UK) John R Speakman (Aberdeen, UK) Mike Spyer (London, UK) David Thwaites (Newcastle, UK) Andrew Trafford (Manchester, UK)

Scientific Programme Overview 8.30 - 11.30 Sunday

Monday

Tuesday

8.30 - 9.15

KEYNOTES

8.30 - 9.15

KEYNOTES

Hall 1

Pathological development of brain microvasculature

Hall 1

Calcium signal mechanisms in secretory cells: physiology and pathology

Elisabetta Dejana,

Ole H Petersen, Cardiff University, United Kingdom

University of Milan, Italy

Hall 4

3R’s: Reproductive Regulation Revised

Hall 4

Iain Clarke,

Stem cell biology for vascular medicine Takayuki Asahara,

Monash University, Australia

Tokai University, Japan

Hall 8

Local protein synthesis Erin Schuman, Max Planck Institute for Brain Research, Germany

9.15 - 9.30

CHANGE OVER PERIOD

9.15 - 9.30

CHANGE OVER PERIOD

9.30 - 11.30

RESEARCH SYMPOSIA

9.30 - 11.30

RESEARCH SYMPOSIA

Hall 1

Neuronal inhibition dynamically regulates neuronal excitability

Hall 1

Physiology of fasting and starvation

Hall 4

Hypoxia shows double faces -- Effects and mechanisms

Hall 4

Stem and progenitor cells in vascular remodelling and repair

Hall 5

Signalling mechanisms that regulate microvascular permeability

Hall 5

Dysfunctional chemoreceptors: Cause or consequence of the symptoms of cardiorespiratory disease?

Hall 6

Epigenetic and post-translational modification of the diseased heart

Hall 6

The Good, the Bad and the Ugly: New mechanisms of neuronal and glial signalling in the injured spinal cord

Hall 7

Contributions of skeletal muscle myopathy to heart failure: Novel mechanisms and therapies

Hall 7

The role of toxic Ca signals in initiating pancreatitis and promoting pancreatic cancer

Hall 8

Physiomics of TRP ion channels

Hall 8

Perivascular fat: Role in metabolic and cardiovascular disease

Hall 9

What’s hot in brown adipose tissue biology? Hall 9

Hall 10

Physiology and Evolution: Has physiology become relevant again to evolutionary biology?

Hall 10

Historical perspectives on early physiology, 18701960

Hall 11

Cellular senescence in cardiovascular disease

Hall 11

Transverse tubules in the heart: Normal physiology and involvement in disease

Symphony Ballroom (Hyatt Regency Hotel)

CFTR – Linking physiology, regulation and structure

Symphony Ballroom (Hyatt Regency Hotel)

Mammalian nutrient sensing

Sonata Room (Hyatt Regency Hotel)

Using technology to improve millennial students’ learning

Sonata Room (Hyatt Regency Hotel)

Bicarbonate transport in normal and cancerous tissues

Kingston Theatre (Austin Court)

Stem cells and tissue homeostasis

Kingston Theatre (Austin Court)

An integrated approach to the physiology of organic cation transporters

11.30 - 11.45

CHANGE OVER PERIOD

11.30 - 11.45 CHANGE OVER PERIOD

From perceiving to acting: Neurophysiological mechanisms of conscious visual perception

Wednesday

Thursday

Friday

8.30 - 9.15

KEYNOTES

8.30 - 9.15

KEYNOTES

8.30 - 9.15

Hall 1

Mitochondrial superoxide flashes

Hall 1

The renin-angiotensin system: new concepts and perspectives

Late breaking abstracts 8.00 - 11.30 Hall 3 (The ICC)

Heping (Peace) Cheng, Peking University, China

Robson A Santos, Federal University of Minas Gerais, Brazil Hall 4

Hall 8

T-type calcium channels, thalamic Hall 4 firing modes, and control of consciousness and cognition

TRPV1 channels: from molecules to physiology

Hall 4

Tamara Rosenbaum,

Hee-Sup Shin, Institute for Basic

Science, Daejeon, South Korea

Universidad Nacional Autónoma de México, Mexico

Role of ATP - regulated potassium Hall 8 channels in pancreatic alpha- and beta-cells

Purinergic signalling: the discovery and current developments

Patrik Rorsman, University of Oxford,

Geoffrey Burnstock,

UCL School of Pharmacy, United Kingdom

Hall 5

CHANGE OVER PERIOD

9.15 - 9.30

9.30 - 11.30

RESEARCH SYMPOSIA

Hall 1

CHANGE OVER PERIOD

Respiratory and neural consequences for fish of a warmer and more carbonated future Göran Nilsson, University of Oslo, Norway

EP Early Author Prize

9.15 - 9.30

Cortical HCN channels: function, trafficking and plasticity Mala Shah,

Autonomic Neuroscience Centre, United Kingdom

United Kingdom

KEYNOTES

9.15 - 9.30

CHANGE OVER PERIOD

9.30 - 11.30 RESEARCH SYMPOSIA

9.30 - 11.30

RESEARCH SYMPOSIA

Mechanical stress and vascular remodelling

Hall 1

Physiology and mechanisms of the circadian control

Hall 1

Ageing, exercise training, gender, inactivity and nutrition: Implications to skeletal muscle mass and metabolic function in humans

Hall 4

Role of TRP channels in the cardiovascular system

Hall 4

Recent advances in ReninAngiotensin System and implications in health and disease

Hall 4

Cardiac ß-adrenergic signalling in health and disease

Hall 5

Insight into the physiological roles of membrane transporters from drug transport studies

Hall 5

Microvascular networks: causes and consequences

Hall 5

Dendritic ion channel function and plasticity

Hall 6

Peptide modulation of hedonic food intake

Hall 6

Myometrial physiology time to translate?

Hall 6

Understanding microcirculatory blood flow using quantitative approaches

Hall 7

Neurons, synapses and circuits in the auditory system: Physiology, pathophysiology and potential therapeutics for hearing disorders

Hall 7

Solute and ion cotransporters and exchangers at atomic resolution

Hall 7

Shedding light in the neurophysiological black box

Hall 8

Generation of respiratory and sympathetic activities in health and diseases

Hall 8

Hall 8 Epigenetics: A new regulator of gene expression and cardiovascular diseases

Hall 9

Molecular basis of cardiac conduction system in disease

Hall 9

Intracellular signalling microdomains in heart

Hall 9

Publishing for beginners

Hall 10

The glutamatergic synapse: A neurodegenerative and psychiatric disease target

Hall 10

Brain imaging – an ethical time bomb?

Hall 10

Developmental programming of cardiovascular and renal disease in adulthood

Hall 11

Voltage-gated calcium channels: Novel roles

Hall 11

Membrane potential investigated with voltage sensitive dyes

Hall 11

Neurotransmitter transporters: Impact on nerve cell excitability and function

Symphony Ballroom (Hyatt Regency Hotel)

New advances in the physiome and systems biology

Symphony Ballroom (Hyatt Regency Hotel)

Interplay between neurones, astrocytes and blood vessels

Symphony Ballroom (Hyatt Regency Hotel)

Current advances in structure and regulation of epithelial tight junctions

Kingston Theatre (Austin Court)

Network oscillations: Binding brain Kingston High resolution microscopy Theatre (Austin (nanoscopy) and correlative areas to functional structures Court) light and electron microscopy

Kingston Theatre (Austin Court)

Hypometabolism, hypothermia and hibernation

11.30 -11.45

CHANGE OVER PERIOD

11.30 - 11.45 CHANGE OVER PERIOD

Intercellular communications in the vasculature: From physiology to pathophysiology

Scientific Programme Overview 11.45 - 16.15 Sunday

Monday

Tuesday

11.45 - 12.45

PLENARY

11.45 - 12.45 PLENARY

Hall 1

Health-promoting effects of exercise in diabetes and obesity: from molecular mechanisms to clinical action

Hall 1

Vascular metabolism: principles and strategies Peter Carmeliet, VIB Vesalius Research Center, KU Leuven, Belgium

Juleen R. Zierath, Karolinska Institutet, Sweden

12.45 - 13.00

CHANGE OVER PERIOD

12.45 - 13.00 CHANGE OVER PERIOD

13.00 - 14.15

POSTERS, GENERAL SESSIONS

13.00 - 14.15 POSTERS, GENERAL SESSIONS

Hall 9

Industry Session: Telemetry in neuroscience research: Exploring experimental models of sleep and epilepsy

Hall 9

Industry Session: TR(i)P to Automated Patch Clamp sponsored by Nanion Technologies

Hall 10

General Session: Women in Science Why mentoring and sponsorship works sponsored by The Biochemical Society

sponsored by Data Sciences International Sonata Room (Hyatt Regency Hotel)

General Session: Effective presentation skills

Sonata Room (Hyatt Regency Hotel)

General Session: Effective presentation skills

Hall 8

General Session: Statistics: The Emperor’s clothes

14.15 - 16.15

RESEARCH SYMPOSIA

14.15 - 16.15 RESEARCH SYMPOSIA

Hall 1

Ageing – epigenetic mechanisms underlying lifelong health and wellbeing

Hall 1

Local Ca2+ signals: Mechanism and function

Hall 4

Epithelial Na channels – linking physiology, regulation and structure

Hall 4

Potassium channel complexes: Dynamic aspects of the assembly and regulation towards their physiological roles

Hall 5

Hypoxic pulmonary hypertension: Mechanisms of pulmonary vascular change and their effect on the right ventricle

Hall 5

Understanding the brain mechanisms of chronic pain

Hall 6

Evolution of the vertebrate fourchambered heart

Hall 6

Multidisciplinary approaches to understanding synaptopathies

Hall 7

Competency-based education in physiology: A global perspective

Hall 7

New insights into the acid-base microclimate as an integral regulator of epithelial function in health and disease

Hall 8

Obesity: Intergenerational programming and consequences

Hall 8

Angiogenesis: Growth points

Hall 9

Essential role of the vagus nerve for cardiac health

Hall 9

Mother, placenta, fetus and life long health

Hall 10

Hydrogen sulphide in the vascular system: Diverse roles and mechanisms

Hall 10

Using narratives and stories to enhance learning

Hall 11

Central versus peripheral neural control mechanisms in man: Inputs and outputs

Hall 11

Leukocyte recruitment in inflammation

Symphony Ballroom (Hyatt Regency Hotel)

Inhibitory synapses: Ionic shift plasticity

Symphony Ballroom (Hyatt Regency Hotel)

The activation of skeletal muscles - implications for fatigue

Sonata Room (Hyatt Regency Hotel)

Physiological solutions in symbiotic systems

Sonata Room (Hyatt Regency Hotel)

Ethical issues in physiology - synthetic biology: Scientific progress or ethical dilemma?

Kingston Theatre (Austin Court)

Macrophage phenotype modulation in atherosclerosis

Kingston Theatre (Austin Court)

Development and functional organisation of neural circuits controlling breathing

Wednesday

Thursday

Friday

11.45 - 12.45 PLENARY

11.45 - 12.45

PLENARY

Hall 1

Hall 4

Optical deconstruction of fully-assembled biological systems

Sifting circuits for motor control Thomas M. Jessell,

Columbia University, United States

The molecular mechanisms of signaling at chemical synapses Eric Gouaux, Oregon Health &

Sponsored by:

ESM & EVBO programme

ME 27

Research Symposia - Monday 22 July CFTR – Linking physiology, regulation and structure

Physiology and Evolution: Has physiology become relevant again to evolutionary biology?

Stem cells and tissue homeostasis

Hall 10 (The ICC)

Kingston Theatre (Austin Court)

Organised by David Sheppard University of Bristol, UK Jeng-Haur Chen University of Hong Kong, China

Organised by Denis Noble University of Oxford, UK

Organised by Bettina Wilm University of Liverpool, UK Silvia Fre Institut Curie, France

09.30

Deciphering the physiological role of CFTR using pig models of cystic fibrosis Michael Welsh University of Iowa, USA

Relating genotypes to phenotypes Stig Omholt Norwegian University of Science and

Generating and regenerating blood and the cardiovascular system Roger Patient University of Oxford, UK

10.00

Symphony Ballroom (Hyatt Regency Hotel)

SA28

SA32

Technology, Norway

SA33

09.30

SA37

SA38

CFTR activation by specific regions of the R domain Jeng-Haur Chen University of Hong Kong, China

Cross-species cloning: influence of cytoplasmic factors on development Yonghua Sun Institute of Hydrobiology, China

The fate of mesothelial cells and their role in tissue homeostasis Tarek Benameur University of Liverpool, UK

10.15

SA29

3D structural models of CFTR Isabelle Callebaut Université Pierre et Marie Curie,

The Read-Write (RW) genome James Shapiro University of Chicago, USA

10.45

France

SA30

SA34

SA39

HIFs, metabolism, and tumor progression M Celeste Simon University of Pennsylvania, USA

SA35

10.45

SA40

CFTR’s degenerate nucleotide binding site 1 probably moves during channel gating Paola Vergani University College London, UK

Computational biology as a tool for reverse engineering genotype-phenotype relations Chae Young Cha

Notch signals and intestinal stem cells: from crypt homeostasis to colon cancer Silvia Fre Institut Curie, France

11.00

SA31

Seoul National University, South Korea University of Oxford, UK

Employing chemical biology to define the molecular defects caused by the major Cystic Fibrosis mutant, F508del-CFTR Christine Bear The Hospital for Sick Children, Canada

The modern synthesis: extension or replacement? Gerd Müller University of Vienna, Austria

Sponsored by:

EM 28

09.30 – 11.30

SA36

SA41

CD133+ progenitors and regeneration of the renal tissue: from cells to vesicles Benedetta Bussolati University of Torino, Italy

EM ME

Contributions of skeletal muscle myopathy to heart failure: Novel mechanisms and therapies

Epigenetic and posttranslational modification of the diseased heart

Using technology to improve millennial students’ learning

Hall 7 (The ICC)

Hall 6 (The ICC)

Sonata Room (Hyatt Regency Hotel)

Organised by Mark Chapleau University of Iowa, USA Elizabeth McNally University of Chicago, USA

Organised by Loren Wold The Research Inst. at Nationwide Children’s

09.30

SA42

Hospital/The Ohio State University, USA

Lea Delbridge University of Melbourne, Australia

SA47

Organised by Xian Wang Peking University, China Jonathan Kibble University of Central Florida, USA

09.30

SA52

Pathophysiology of human heart failure: importance of skeletal muscle myopathy and reflexes Antonio Crisafulli University of Cagliari, Italy

Extracellular matrix remodeling in the postmyocardial infarction diabetic heart Merry Lindsey University of Mississippi Medical

Interactive pedagogies in physiology education Jonathan Kibble University of Central Florida, USA

10.00

SA43

Center, USA

SA48

SA53

Skeletal muscle dysfunction in heart failure and its reversal by exercise training Patricia Brum University of São Paulo, Brazil

Lysyl oxidase, collagen cross-linking, and cardiac dysfunction Jason Gardner LSU Health Sciences Center, USA

Use of the moodle platform to create an effective online learning site Beatriz Ramirez University of Santiago, Chile

10.15

SA44

Modifiers of heart and muscle function: where genetics meets physiology Elizabeth McNally University of Chicago, USA

SA49

10.45

SA45

SA54

G-protein coupled receptor signaling in the diseased heart Ulrike Mende Rhode Island Hospital & Brown

Strategic directions and collaborations for teaching physiology in the new millennium Philip Poronnik The University of Sydney, Australia

10.45

University, USA

SA50

SA55

Autonomic, locomotor and cardiac abnormalities in a mouse model of muscular dystrophy: targeting the renin angiotensin system Rasna Sabharwal University of Iowa, USA

Genetic modulation of heart failure progression Farah Sheikh University of California, San Diego, USA

Experiences in using online courses Achini Vidanapathirana University of Colombo,

11.00

SA46

Maintaining skeletal muscle mass: lessons learned from hibernation Ronald Cohn The Hospital for Sick Children and University of Toronto, Canada

SA51

Early epigenetic modulation of the diseased heart Lea Delbridge University of Melbourne, Australia

M O N D A Y

Sri Lanka

SA56

Development and evaluation of online courses and resources David Dewhurst University of Edinburgh, UK

Sponsored by: American Physiological Society

ET 29

Research Symposia - Monday 22 July

14.15 – 16.15

Ageing – epigenetic mechanisms underlying lifelong health and wellbeing

Epithelial Na channels – linking physiology, regulation and structure

Obesity: Intergenerational programming and consequences

Hall 1 (The ICC)

Hall 4 (The ICC)

Hall 8 (The ICC)

Organised by Susan Ozanne University of Cambridge, UK Wolf Reik The Babraham Institute, UK

Organised by David Cook The University of Sydney, Australia Daniela Rotin The Hospital for Sick Children, Canada

Organised by Lucy Green University of Southampton, UK Robert Hester University of Mississippi Medical

14.15

SA57

SA62

Center, USA

14.15

Aging and DNA methylation: A role in fetal origins of adult disease? Carmen Sapienza Temple University, USA

Regulation of ENaC by external clues Thomas Kleyman University of Pittsburg, USA

Human and small animal studies of maternal obesity and weight gain Lucilla Poston King’s College London, UK

14.45

SA58

The ageing brain; effects on DNA repair and DNA methylation in mice Sabine Langie Flemish Institute of Technological Research (VITO), Belgium

SA63

Activation of the epithelial sodium channel by plasmin and cathepsin-S Silke Haerteis Friedrich-Alexander-Universität

Erlangen-Nürnberg, Germany

SA67

SA68

Offspring of mothers on a high fat diet show altered circadian biology and fatty liver Kimberley Bruce The Scripps Research Institute, USA

15.00

SA59

Genome-wide epigenetic changes during ageing Mario Fraga Universidad de Oviedo, Spain

15.00

SA64

Regulation of the epithelial Na+ channel (ENaC) by kinases Anuwat Dinudom The University of Sydney, Australia

15.00

SA69

Programming metabolic and psychological diseases: effects of maternal obesity and diet Kevin Grove Oregon Health & Science University,

USA

15.30

SA60

15.30

SA65

15.30

SA70

Epigenetic regulation of retrotransposable elements by TET enzymes Miguel Branco The Babraham Institute, UK

Multiple COMMD proteins alter the trafficking of the epithelial sodium channel, ENaC Fiona McDonald University of Otago, New Zealand

Periconceptional overnutrition and maternal weight loss effects on offspring obesity and metabolism in sheep Lisa Nicholas University of South Australia, Australia

15.45

SA61

Epigenetic regulation of fetal growth and healthy aging Rosalind John Cardiff University, UK

SA66

In vivo regulation of ENaC by the ubiquitin ligase Nedd4L in lung and intestinal epithelia Daniela Rotin The Hospital for Sick Children, Canada

SA71

Pre-gestational versus gestational exposure to maternal obesity differentially programs the offspring Rebecca Simmons University of Pennsylvania, USA

Sponsored by:

Australia

SA75

SA76

Pattern control of human locomotion Yuri Ivanenko Fondazione Santa Lucia, Italy

Lung Research, Germany

M O N D A Y

The evolving role of vagal activity and its potential in clinical management Maria Teresa La Rovere Istituto Scientifico di

Montescano, Italy

SA82

SA83

CR 31

Research Symposia - Monday 22 July Inhibitory synapses: Ionic shift plasticity Symphony Ballroom (Hyatt Regency Hotel) Organised by Melanie Woodin University of Toronto, Canada Peter Blaesse University of Münster, Germany

14.15 – 16.15

Hydrogen sulphide in the vascular system: Diverse roles and mechanisms (ESM and EVBO)

Macrophage phenotype modulation in atherosclerosis (ESM and EVBO)

Hall 10 (The ICC)

Kingston Theatre (Austin Court)

Organised by Ákos Koller University of Pécs, Hungary Philip Aaronson King’s College London, UK

Organised by Klaus Ley La Jolla Institute for Allergy & Immunology,

USA

Sussan Nourshargh William Harvey Research

Institute, UK

14.15

SA84

14.15

SA89

14.15

Inhibitory synaptic plasticity of GABAergic synapses in the hippocampus Melanie Woodin University of Toronto, Canada

Hydrogen sulfide in the vascular system: an overview of its roles and mechanisms Rui Wang Lakehead University, Canada

JAM’S in inflammation and vascular disease Beat Imhof University of Geneva, Switzerland

14.45

New tools for exploring ionic plasticity in the nervous system Colin Akerman University of Oxford, UK

Role of H2S balancing oxidative stress and antioxidant pathways and modulating vascular tone Daniel Henrion INSERM – CNRS, France

Monocyte influx supports the proliferation of angiogenic microvessels under ischemic and inflammatory conditions Abigail Woodfin Queen Mary, University of London,

15.00

SA86

GABAergic synaptic plasticity in the developing spinal cord Peter Wenner Emory University, USA

15.30

SA87

SA90

SA91

15.30

SA92

15.45

SA93

Mitochondria-targeted slow release hydrogen sulfide donors: a novel link to an old ‘tail’? Matthew Whiteman University of Exeter Medical School, UK

USA

15.45

SA98

Recruitment of Ly6Chigh monocytes is required for the enhancement of antiinflammatory (M2) macrophage phenotype in vivo in atherosclerosis regression in mice Edward Fisher NYU Langone Medical Center and

Sponsored by:

Canadian Physiological Society

ESM & EVBO programme

SA97

Role of adaptive immunity in foam cell inflammatory phenotype Klaus Ley La Jolla Institute for Allergy & Immunology,

School of Medicine, USA

SA96

15.30

15.45

Ionic plasticity of GABAergic synapses by rapid regulation of the K-Cl cotransporter KCC2 Peter Blaesse University of Münster, Germany

Role of cholesterol in determining macrophage phenotype Theo Van Berkel Leiden University, The Netherlands

Transient receptor potential ankyrin 1 receptors mediate hydrogen-sulphideinduced calcitonin-gene-related-peptide release and cutaneous vasodilatation Zsófia Hajna University of Pécs, Hungary

SA88

SA95

Homocysteine to hydrogen sulfide: in vitro, ex vivo and in vivo Suresh Tyagi University of Louisville, USA

Alterations in KCC2 compromise GABAergic control of the HPA axis Jamie Maguire Tufts University School of Medicine,

USA

SA94

Competency-based education in physiology: A global perspective

Evolution of the vertebrate four-chambered heart

Physiological solutions in symbiotic systems

Hall 7 (The ICC)

Hall 6 (The ICC)

Sonata Room (Hyatt Regency Hotel)

Organised by William Galey Howard Hughes Medical Institute, USA Dee U. Silverthorn University of Texas, USA

Organised by James Hicks University of California, Irvine, USA Antoon Moorman University of Amsterdam, The Netherlands

Organised by Mónica Medina University of California,

Merced, USA

Michele Weber University of California,

Merced, USA

14.15

SA99

What do we mean by competency-based education and how does it apply to professional curricula? William Galey Howard Hughes Medical Institute, USA

14.15

SA104

The evolution of the vertebrate heart: functional and phylogenetic insights James Hicks University of California, Irvine, USA

14.15

SA110

M O N D A Y

Genomic evidence for the evolution of physiological robustness in coral-algal symbiosis Michele Weber University of California, Merced, USA

14.45

SA100

Competency-based education: a European perspective Christina Karatzaferi University of Thessaly, Greece

14.45

SA105

SA101

Aligning competencies in undergraduate and professional programs Dee Silverthorn University of Texas, USA

SA111

Transcription factors regulate cardiac septum formation in the vertebrate evolution Kazuko Koshiba-Takeuchi The University of

Role of light and multiple scattering on the establishment of mutualistic relationship with photosynthetic organisms Susana Enríquez Universidad Nacional Autónoma de México, Mexico

15.00

15.15

Tokyo, Japan

15.00

14.45

SA106

Development of the cardiac building plan Antoon Moorman University of Amsterdam,

The Netherlands

SA112

Individuality and temporal stability of the human gut microbiome Shinichi Sunagawa European Molecular Biology

Organization, Germany

15.30

SA102

15.30

SA107

The development of competency-based curriculum and quality assurance in Indonesian medical education Muhammad Irfannuddin Misbach University of

Evolution of the building plan of the heart Bjarke Jensen University of Amsterdam and Aarhus

15.45

University, The Netherlands

15.45

SA113

Endophytic bacteria in plant meristems: a new type of mutualistic symbiosis Anna Maria Pirttilä University of Oulu, Finland

Sriwijaya, Indonesia

SA103

Is competency-based education the way forward in the Middle East? Feisal Subhan Arabian Gulf University, Bahrain

SA108

The evolving role of the cardiac sarcoplasmic reticulum Holly Shiels University of Manchester, UK

GI 33

Poster Communications - Monday 22 July Xanthohumol reduces PCA001 transcription of pro-inflammatory markers TNF-α, IL-1β, NFκB2, and CR HO1 in the lung of senescenceaccelerated prone mice (SAMP8) Sergio D. Paredes*, Adrián Carrasco, Lisa Rancan, Roman Kireev, Elena Vara, Jesús A. F. Tresguerres

Melatonin decreases the expression of inflammation and apoptosis markers in the lung of a senescence-accelerated mice model

PCA002

The effects of velocity and temperature on swimming performance in rainbow trout (Oncorhynchus mykiss)

PCA007

Adam Keen*, Emma John, Holly Shiels, Robert Nudds

Anemia in medical students and its relationship with heart rate variability

Aldehyde dehydrogenase-2 PCA003 activation ameliorates agingrelated vulnerability to myocardial ischemia reperfusion CR injury

PCA004

Yawer Saeed*, Zoltan Borbas, Ian Temple, Andrew Atkinson, Jospeh Yanni, Mark Boyett, Clifford Garratt, Halina Dobrzynski

PCA008

Kopila Agrawal*, Bishnu Paudel, Rita Khadka, Namrata Upadhyay, Santosh Dev, S. Majhi

Stimulation of M2cholinoreceptors increases the outward current of sodiumcalcium exchanger in fish atrial myocytes

Salma Ibrahim, Omer Musa*

Effects of transient receptor potential melastatin 2 on secondary myocardial injury induced by mechanical trauma

Denis Abramochkin*, Svetlana Tapilina, Matti Vornanen

Oral contraceptive-induced PCA010 impaired glucose tolerance is associated with elevated plasma CR uric acid, triglyceride/highdensity lipoprotein-cholesterol ratio but not with high C-reactive protein levels in female rats

PCA005

The effects of blood components PCA011 modulation on load-dependent cardiac function during an acute CR hemodilution

Cardiac-targeted deletion of Cα subunit of PP2A in mice caused dilated cardiomyopathy with electrical remodeling

PCA015

Dachuan Dong, Jinxu Liu, Zhonghua Zhu, Wen Chen, Pengyu Gu, Xiang Gao, Zhao Zhang*

Effects of hydrogen sulfide on PCA016 inflammatory factors in acute myocardial ischemia injury in rats CR Jianxin Zhang*, Fang Liu, Lanfang Li

The role of fibre orientation in cardioversion of chronic atrial fibrillation: a simulation study

PCA017

Sanjay Kharche*, Tomas Stary, Irina Biktasheva, Henggui Zhang, Vadim Biktashev

Surapong Chatpun*, Pedro Cabrales

Simulating cell apoptosis induced PCA018 sinus node dysfunction PCA006

Effects of class III anti-arrhythmic PCA012 agents with hERG channel block and facilitation on cardiac action CR potential: a simulation study Kazuharu Furutani*, Kunichika Tsumoto, I-Shan Chen, Yoshihisa Kurachi

Sanjay Kharche*, Tomas Stary, Irina Biktasheva, Henggui Zhang, Vadim Biktashev

Effects of diabetes mellitus and PCA019 exercise training on expression of mRNA, contraction and calcium CR transport in the adult GotoKakizaki rat heart Frank Howarth*, Khawla Salem, Muhammad Qureshi, Vadym Sydorenko, Khatija Parekh, Petrilla Jayaprakash, Tahreem Iqbal, Jai Singh, Murat Oz, Thomas Adrian

PCA014

PCA009

Lawrence Olatunji*, Sikiru Biliaminu, Abass Safiriyu, Oluwaseun Adeyanju, Temitope Abiodun, Ayodele Soladoye

Lih Cheah*, Kerry Rostron, Jenny Wilkinson, Matthew Lancaster

Effects of the aging process on pulmonary functions and respiratory muscle power

Kunichika Tsumoto*, Takashi Ashihara, Ryo Haraguchi, Kazuo Nakazawa, Yoshihisa Kurachi

Lu Yu, Yuan Xing, Li Jiang, Yue Yin, Heng Ma*

Ageing has heterogeneous effects within the left ventricle and between genders on mRNA expression for key calciumregulatory proteins

PCA013

Shuzhuang Li*, Liang Zhu, Kai Yu, Xinpei Sun, Chong Chen, Xiaolong Chen, Deqin Yu

Angela Puig*, Lisa Rancan, Sergio D. Paredes, Guillermo Yoldi, Roman Kireev, Elena Vara, Jesús A. F. Tresguerres

Ageing is associated with changes in structure and ion channel expression within the atrioventricular conduction axis

Ischemia-induced subcellular remodeling of sodium channels as a mechanism of ventricular proarrhythmia by class-I antiarrhythmic drug

Hall 3, ICC

*Denotes presenting author

AT1 receptor blockade by irbesartan attenuates hyposmostic-induced increase of IKs current and prevents shortening of APD in guinea-pig atrial myocytes

PCA020

Jie Wu*, Wei-Guang Ding, Jian-Wei Dou, Hiroshi Matsuura, Minoru Horie

Implication of myocardial connexin-43 and PKC signaling in cardio-protective effects of melatonin in spontaneously hypertensive rats

PCA021

An extra-mitochondrial domain PCA026 rich in carbonic anhydrase activity improves myocardial energetics CR

Arterial hypertension promotes PCA032 atrial remodelling and fibrillation in pigs CR

Marie Schroeder, Mohammad Ali, Alzbeta Hulikova, Claudiu Supuran, Kieran Clarke, Richard Vaughan-Jones, Damian Tyler, Pawel Swietach*

Gudrun Antoons*, Michael Schwarzl, Ge Jin, David Zweiker, Stefan Huber, Jochen Verderber, Allesio Alogna, Patrick Schoenleitner, Paulina Wakula, Andreas Lueger, Frank Heinzel, Burkert Pieske, Heiner Post

A new experimental approach PCA027 reveals a high Ca2+ sensitivity of TRPM4 channel and its significant CR implications in arrhythmogenicity Ryuji Inoue*, Yaopeng Hu, Yubin Duan, Rin Kurahara-Hai, Jun Ichikawa

Rob Wüst*, Michiel Helmes, Ger Stienen

Narcisa Tribulova*, Tamara Benova, Csilla Viczenczova, Jana Radosinska, Barbara Bacova, Vladimir Knezl, Victor Dosenko, Michal Zeman

Left ventricle structural PCA022 remodelling in the streptozotocininduced type 1 diabetic rat CR Jaipaul Singh*, Alicia D’Souza-, Tahreem Iqbal, Ernest Adeghate, Frank Howarth, Keshore Bidasee

Fibrosis and downregulation of Ca2+-handling proteins as an underlying cause of cardiac repolarisation alternans and sudden cardiac death in the human

PCA023

PCA028

Taka-aki Matsuyama*, Hideo Tanaka, Tetsuya Adachi, Yan Jiang, Hatsue IshibashiUeda, Tetsuro Takamatsu

Altered thyroid status affects PCA029 myocardial connexin-43 and PKC expression in male and female CR Wistar rats: effect of antioxidantrich red palm oil intake Barbara Bacova, Csilla Viczenczova, Jana Radosinska, Jitka Zurmanova, Stanislav Pavelka, Tomas Soukup, Jacques van Royen, Narcisa Tribulova*

Joseph Yanni*, Pier Lambiase, Michele Orini, Ben Hanson, Halina Dobrzynski, Xiao Jie, Mark Boyett, Martin Hayward, Peter Taggart

Cardioprotection of Hydrogen PCA024 sulfide post-conditioning against CR ischemia reperfusion injury involved in ATF6 activated endoplasmic reticulum stress -induced apoptosis

Spermine reduced no-reflow size PCA030 induced by ischemia-reperfusion through regulating autophagy CR Han Liping*, Yuan Linbo, Shentu Yangping, Shao Jundan

Generation of reentrant PCA031 arrhythmias by spatially nonuniform gap-junction connection CR with myofibroblasts in rat cultured myocyte monolayers

Xiao-Hong Yan*, Jing Deng, Tao-Xiang Chen, Yuan Wang, Ze-Fen Wang, Ya-Lan Ding

Protective effect of ghrelin against tilmicosin-induced acute cardiotoxicity in rats

Intrinsic left atrial histoanatomy as the basis for reentrant excitation causing atrial fibrillation/flutter in rats

PCA025

Tetsuya Adachi, Yan Jiang, Hideo Tanaka*, Emi Hashimoto, Tetsuro Takamatsu

NADH and FAD kinetics reveal PCA033 altered mitochondrial function in right ventricular heart failure CR

Conduction of excitation in the rabbit and rat pulmonary veins myocardium under normal conditions and parasympathetic stimulation

M O N D A Y

PCA034

Vladislav Kuzmin*, Yury Egorov, Leonid Rosenshtraukh

Chaotic excitation spread during tachycardia-like excitation in the rat isolated atrium revealed by optical mapping studies

PCA035

Tetsuro Sakai*, Kohtaro Kamino

Early growth response 1 acts as an early signal to induce Cav3.2 T-type calcium channels during cardiac hypertrophy in mice

PCA036

Shao-Chun Hsu, Chien-Chang Chen*

Modulation of Ca2+ uptake by PCA037 changing of SERCA activity in mouse myocardium did not alter CR Ca2+ leak from sarcoplasmic reticulum in physiological condition Satoshi Morimoto*, Kenichi Hongo, Makoto Kawai, Jin O-Uchi, Yoichiro Kusakari, Kimiaki Komukai, Michihiro Yoshimura, Satoshi Kurihara

Nazmi Çetin*, Ebru Çetin

Poster Communications - Monday 22 July The Langendorff perfused heart and cardiac tissue slices, a comparison study

PCA038

Ken Wang, Peter Lee, David Gavaghan, Peter Kohl, Christian Bollensdorff*

Pharmacological and pH PCA045 modulation of sodium-dependent background current in rabbit CR atrioventricular node cells Hongwei Cheng*, Mark Boyett, Clive Orchard, Hancox Jules

Low Na increases ventricular PCA039 gap junction resistivity and phosphorylation levels of connexion43-serine 368: Possible CR synergistic interaction between calcineurin and protein kinase C

Investigation of the influence of hERG 1b on hERG channel pharmacology

PCA046

Aziza EL Harchi*, Dario Melgari, Henggui Zhang, Jules Hancox

Cristiane Matsuura, Carla Peres, Eduardo Carvalho, Vinicius Rocha, Jorge Carvalho, Antonio Claudio Mendes-Ribeiro, Tatiana Brunini*

PCA040

Detecting diffusion barriers PCA047 in rat cardiomyocytes with extended raster image correlation CR spectroscopy Paivo Simson*, Natalja Jepihhina, Pearu Peterson, Marko Vendelin

Assay of the perfused rat heart during cardiac ischemia with Rb Electron Probe Microanalysis

PCA042

Valentina Pogorelova*, Alexandr Pogorelov

Regulation of ICa by basal protein kinase A activity and its facilitation by caveolin-3 are altered in heart failure in rat ventricular myocytes

PCA054

PCA044

PCA050

Mark Richards*, Graeme Kirkwood, Jessica Clarke, Katharine Dibb

Membrane nanotubes as a novel long distance intercellular connectivity between Cardiomyocytes and Cardiofibroblasts

Yi Zhang*, Fang Yuan, Li Zhang, Sheng Wang

Loss of myocardial nNOS in atrial PCA055 fibrillation (AF) affects action potential duration: Implications CR for AF-induced electrical remodelling Xing Liu*, Svetlana Reilly, Alfonso BuenoOrovio, Ricardo Carnicer, Alice Recalde, Raja Jayaram, Blanca Rodriguez, Barbara Casadei

Zijian Li*

Effects of detubulation on spatiotemporal properties of Ca transients in sheep atrial myocytes

Opioid receptors involved in PCA043 cardioprotection of chronic intermittent hypobaric hypoxia in rats through a PKC/ERS signaling CR pathway

HIP-55 inhibits isoproterenolPCA049 induced cardiac remodeling through negatively regulating p38 CR MAPK

Suhn Hee Kim*, Shan Gao, Byung Mun Park, Seung Ah Cha, Jong Hun Kim

Yue Cai, Yuhong Wang, Xu Zuo, Yanfang Xu*

PCA053

PCA048

Yu-ling Ma*, Penelope Noble, Soojin Lee, Robert Wilkins, Clive Ellory, Denis Noble

Post-transcriptional regulation of human ether-a-go-go-related gene potassium channel protein by AT1 receptor stimulation

Simultaneous measurement of cytoplasmic and SR calcium during modulation of ryanodine receptor open probability in canine ventricular myocytes.

Simon Bryant*, Cherrie Kong, M.Saadeh Suleiman, Andrew James, Clive Orchard

The effect of Mudanpi and PCA041 its main active component on cardiac ischemia and ion channels

Augmentation of CGP 42112A-induced ANP secretion via PI3K/NO/sGC/PKG/ pathway in hypertensive rats

Krzysztof Wypijewski*, Jacqueline Howie, Louise Reilly, Lijun Tian, Michael Shipston, Michael Ashford, William Fuller

PCA052

David Greensmith*, Gina Galli, Michael Morton, Christopher Pollard, Andrew Trafford, David Eisner

Abdul Waheed*, Samatha Salvage, Alejandro Orlowski, Christopher Fry, Rita Jabr

Exercise training in doxorubicin induced cardiomyopathy

Palmitoylation of the Na pump catalytic subunit

Youyi Zhang*

PCA051

A molecular modeling approach for understanding mechanism of disease causing mutations in domain C1 of cardiac myosin binding protein C

PCA056

Navaneethakrishnan Krishnamoorthy*, Poornima Gajendra Rao, Heba Kassem, Sarah Moharem-Elgamal, Franco Cecchi, Iacopo Olivotto, Magdi Yacoub

Properties of pro-arrhythmic Ca2+ PCA057 waves in rat ventricular myocytes are altered globally and locally by CR changes in intracellular pH Kerrie Ford*, Emma Moorhouse, Mario Bortolozzi, Richard Vaughan-Jones

Hall 3, ICC

*Denotes presenting author

The effects of repaglinide on cardiac action potential and ion channels

PCA058

Hyang-Ae Lee*, Sung-Gurl Park, Ki-Suk Kim

Structural characteristics of the PCA059 sinus node and surrounding atrial tissue in the goat heart Zoltan Borbas*, Jane Caldwell, Akbar Vohra, Andreas Hoschtitzky, Mark Boyett, Clifford Garratt, Halina Dobrzynski

PCA061

Phospholamban ablation reduces PCA067 the propensity for triggered activity in CPVT transgenic heart CR cells despite increased SR Ca2+ load Konstantin Gusev*, Stephan Lehnart

PCA071

Simvastatin’s effects on muscle PCA072 are temporally defined and tissue specific

David MacDougall*, Sara Pugh, Amelia Schorah, Wendy Rennie, Sarah Calaghan

Localization of atrial natriuretic peptide and impact of acute stressors on its expression in rat heart PCA068

Julia Walker, Emma Johnston, Jacqueline Howie, Helen Parry, Andrew Cassidy, Michael Shattock, Colin Palmer, William Fuller*

M O N D A Y

PCA073

Jana Slavikova*, Magdalena Chottova Dvorakova, Sixtus Hynie, Pavel Sida, Eliska Mistrova, Vera Klenerova

Ischemia modified albumin: a PCA074 sensitive and reliable marker of cardioprotection during on-pump CR cardiac operations

CR Popdc genes and cardiac PCA069 pacemaking: The molecular basis of genetic redundancy

Jayanti Pant*, Pratibha Ranjan, Mahendra Pant, Shripad Deshpande

Principles of Membrane and Protein Network Organization in Health and Disease Tobias Kohl, Eva Wagner, Soeren Brandenbúrg, Ulrich Parlitz, Jon Lederer, Stephan Lehnart*

Svetlana Kotlyarova*, Merle Mandel, Niina Sokolova, Dunja Aksentijevic, Craig Lygate, Stefan Neubauer, Marko Vendelin, Rikke Birkedal

Biochemical phenotype of a human phospholemman mutation

Hyoung Kyu Kim, Jae Boum Youm, Sung Ryul Lee, Kyung Soo Ko, Byoung Doo Rhee, Nari Kim, Jin Han*

Isik Solak Gormus*, Aysel Kiyici, Mehmet Kayrak, Niyazi Gormus, Neyhan Ergene

Myofilament basis analyses of PCA062 afterload dependent increasing in crossbridge formation in ejecting CR rat heart Yamato Tamura*, Kengo Horiuchi, Takehiro Miyasaka, Juichiro Shimizu

Stimulation of ICa by protein kinase A in the t-tubules of rat cardiac ventricular myocytes is facilitated by caveolin-3

PCA066

Angiotensin II receptor blocker PCA060 and PPAR-gamma agonist, telmisartan, delayed inactivation CR of cardiac Nav1.5: A novel drug mechanism

Bisphenol A decreases in vitro atrial contractility and also attenuates Phenylbiguanide evoked reflexes after chronic exposure in anaesthetized rats

Cardiomyocytes from creatine deficient AGAT mice show no changes in mitochondrial organization and cellular compartmentation

Subreena Simrick*, Roland Schindler, Roman Kreutzer, Marcus Krüger, Thomas Braun, Cesare Terracciano, Larissa Fabritz, Thomas Brand

Potential antiarrhythmic effects of paeoniflorin and paeonol extracted from the paeoniaceae family PCA064

Simon Bryant*, Tomomi Kimura-Wozniak, Clive Orchard, Andrew James

Soojin Lee*, Penelope Noble, Yu-ling Ma, Yung E Earm, Denis Noble

Mapping of repolarisation gradients in the canine left ventricular free wall using myocardial slices PCA070

PCA075

Patrizia Camelliti*, Samha Al-Ayoubi, James Cartledge, Priyanthi Dias, Magdi Yacoub, Arun Sridhar, Cesare Terracciano

CR Histological and immunohistochemical study of the myocardial sleeves of the extensive pulmonary vein network of the rat

PCA076

Yaqiong Xiao*, Xue Cai, Andrew Atkinson, Sunil Jit Logantha, George Hart, Mark Boyett, Zhigang Shui, Halina Dobrzynski

Inhibition Of SK2 channel by verapamil in myocardium cells from human chronic atrial fibrillation

PCA065

Li Tao*, Mao Liang, Huang Wen Jun, Zhou Rui, Li Miao Ling, Yang Yan, Zeng Xiao Rong

Poster Communications - Monday 22 July Steep APD restitution in rat failing PCA077 right ventricular myocytes. Matthew Hardy*, Olivier Bernus, Ed White

Functional characterization of stem cell-derived cardiomyocytes: a comparative study.

PCA078

PCA079

Gestational intermittent hypoxia PCA090 induces sex-differential DNA methylation of corticotropinCR releasing hormone receptor 1 associated with anxiety-like behavior in rat offspring Xi Wang*, Fan-Sen Meng, Zong-Yun Liu, Jun-Ming Fan, Ke Hao, Xue-Qun Chen, Ji Zeng Du

PCA084

Codon 104 variation of p53 gene is necessary for enhancing cellular survival strategy in mammals of the Tibet plateau

Yang Zhao*, Ming-Yang Wang, Xue-Qun Chen, Ji Zeng Du

Dragan Djuric*, Vladimir Jakovljevic, Vladimir Zivkovic

Unambiguous rapid sarcomere length measurements using remote focussing microscopy

PCA085

Rebecca-Ann Burton, Alexander Corbett, Edward Botcherby, Christopher Smith, Christian Bollensdorff, Tony Wilson, Martin Booth, Gil Bub*

Cellular Localisation and PCA092 Functions of the ACE2 Metabolite of (Pyr1)apelin-13 CR Peiran Yang*, Rhoda Kuc, Janet Maguire, Aimee Brame, Nicholas Morrell, Anthony Davenport

PCA080

Individual microvascular units are PCA086 critical to cardiac performance Stuart Egginton*, David Hauton, James Winter, Abdullah Al Shammari, Eamonn Gaffney, Rhys Evans

PCA081

Fahima Syeda*, Dana Kucerova, Ilaria Piccini, Lisa Fortmueller, Genna Riley, Michael Schaefers, Michael Kuhlman, Paulus Kirchhof, Larissa Fabritz

Life with “arrhythmia”: peculiarity PCA082 of pacemakering in ascidia’s heart myoepithelial cells.

Effects of cannabinoid-1 receptor blockade in diabetic cardiomyopathy

Delivery of Oct4 and SirT1 genes into aged retinal pigment epithelium by cationinc PEIpolyurethanes

PCA093

Jong yuh Cherng*

PCA087

Sandor Batkai*, Mohanraj Rajesh, Partha Mukhopadhyay, Bela Horvath, Resat Cinar, Lucas Liaudet, Ken Mackie, György Hasko, Pal Pacher

Curcumin protects nigral PCA094 dopaminergic neurons by iron-chelation in the 6-hydroxydopamine rat model of N Parkinson’s disease Huamin Xu*

A new index for evaluating the PCA088 strength of left ventricular vortex: in silico study

Eun Bo Shim*, Chae Hun Leem, Yung E Earm

Vladimir Golovko*, Mikhail Gonotkov

A novel antibody against Aβ sequence 31-35 efficiently neutralizes Aβ1-42-induced impairments in spatial memory and synaptic plasticity in rats

PCA095

Li Cheng, Xinyi Li, Yanfang Pan, Xiaorong Chen, Jinshun Qi*

Effects of edaravone on prolonged survival and brain apoptosis in a rat model of cardiac arrest and cardiopulmonary resuscitation Meng-Hua Chen*, Ling-Yan Lei, Lei-Lei Sun, Lu Xie

PCA089

Apolipoprotein E4 disrupts the PCA096 induction, not the maintenance of hippocampal late-phase longN term potentiation in rats Feng Qiao, Xiuping Gao, Jinshun Qi*

PCA091

Patrick Schoenleitner*, Gudrun Antoons, Shelina Khan, Gregor Unterer, Paulina Wakula, Stefan Engelhardt, Burkert Pieske, Frank Heinzel

Conduction defects and fibrosis in aged hearts with long QT syndrome 3

Vladimir Jakovljevic*, Nevena Barduzic, Drenka Turjacanin-Pantelic, Vladimir Zivkovic, Dragica Selakovic, Ivan Srejovic, Jovana Joksimovic, Dragan Djuric

Cardiotoxic effects of DLhomocysteine thiolactone in isolated rat heart: gasotransmitters and oxidative stress in focus

Hayley Bennett*, Bernard Davenport, Andrew Trafford, Christian Pinali, Ashraf Kitmitto

Increased cytosolic [Na] despite increased sodium potassium pump activity during early development of heart failure in beta1 adrenergic receptor overexpressing mice.

PCA083

Irene Marcu, Pernilla Heuking, Marisa Jaconi, Nina Ullrich*

An investigation into the effects of single point mutations found in patients with hypertrophic cardiomyopathy upon Junctophilin-2 structure and stability.

The effects of cyclooxygenase and nitric oxide synthase inhibition on oxidative stress in isolated rat heart

Hall 3, ICC

*Denotes presenting author

Neuroprotective effects of Lycium PCA097 barbarum L on senescenceaccelerated mouse N Zhenhua Miao*, Yin Wang

14-3-3 regulates hippocampal long-term petentiation in mice Haifa Qiao*, Molly Foote, Yuying Wu, Yi Zhou

Aging and peri-infarct depolarizations during and after ischemia in rat

PCA098

Potential ameliorative role of PCA104 honey supplementation against the adverse effects of exposure N to gasoline on red cell indices and bone marrow megakaryocytes in Sprague-Dawley male rats Murtala Abubakar*, Wan Abdullah, Siti Sulaiman, Ang Suen

N Detailing peripheral nerve PCA105 activities by oligofiber recordings: a resolution of sympathetic nerve N discharge PCA099

Chun-Kuei Su*, Chia-Hsun Chiang, Yu-Pei Fan, Chiu-Ming Ho

Adam Institoris, Darren Clark, Gábor Kozák, Eszter Farkas, Ferenc Bari*

Altered neurophysiological reactivity to hypocapnia and oxidative stress in elderly healthy carriers of the common Alzheimer’s risk genetic variants

Deregulation of adrenomedullin system in cerebellar vermis of hypertensive rats PCA100

Melatonin treatment could PCA101 regulate the levels of pro/antiinflammatory cytokines in brain N of senescence accelerated mouse Guillermo Yoldi*, Roman Kireev, Elena Vara, Jesús Tresguerres

Estrogen and melatonin PCA102 treatments improved neuroinflammation processes in N dentate gyrus of ovariectomized female rats Roman Kireev, Guillermo Yoldi*, Elena Vara, Jesús Tresguerres

Haematological, biochemical and PCA103 physical changes during blood storage in three different blood N bags

Orexin-neuromodulated PCA108 cerebellar folium-p-parabrachial microcomplex adaptively controls N redistribution of arterial blood flow for defense behavior Naoko Nisimaru*, Akiko Arata, Tutomu Hashikawa, Soichi Nagao, Masao Ito

Contribution of spinal μ-opioid receptors to inhibition of heatinduced heart rate response by touch in anesthetized rats

PCA109

Nobuhiro Watanabe*, Piché Mathieu, Harumi Hotta

Provocative motion elicits PCA110 hypothermia and tail vasodilation in rats and shrews: A new index N of nausea in pre-clinical studies? Sukonthar Ngampramuan*, Matteo Cerri, Flavia Vecchio, Amornrat Kamphee, John Rudd, Eugene Nalivaiko

Bruce Lindsey*, Lauren Segers, Sarah Nuding, Mackenzie Ott, Jay Dean, Donald Bolser, Russell O’Connor, Kendall Morris

The Basic Rest-Activity Cycle PCA112 (BRAC) is present in transgenic rats with ataxin3-mediated N destruction of orexin neurons, but amplitudes of the BRACassociated brown adipose tissue and body temperature change are reduced.

M O N D A Y

Bill Blessing*, Mazher Mohammed, Youichirou Ootsuka, Masashi Yanagisawa

Anita Stern Israel*, Leticia Figueira

Natalya Ponomareva*, Tatiana Andreeva, Maria Protasova, Lef Shagam, Daria Malina, Andrey Goltsov, Evgeny Rogaev

Robert Nneli*, John Chukwu, Mudie Okhiai

PCA106

The drive to breathe is tuned PCA111 via multi-path modulation of inhibitory tonic expiratory N neurons in the ventral respiratory column (VRC) network

Sudden access to live cochroaches increases brown adipose tissue (BAT) thermogenesis in conscious unrestrained rats

PCA113

Bill Blessing*, Mazher Mohammed, Youichirou Ootsuka

Withdrawal of oestrogen elicits PCA114 changes in the expression of GABA receptors and markers of GABA transmission in the nucleus N of the solitary tract Emma Spary*, Mark Drinkhill, Simon Crossland, Azhar Maqbool, Trevor Batten

Intrinsic pacemaker activity of PCA115 pre-sympathetic neurons of adult rats is not altered by chronic N intermittent hypoxia (CIH) Carlos E Almado*, Ricardo M Leão, Benedito Machado

Voluntary wheel-running PCA116 improves neuro-cardiovascular regulation and prevents N hyperalgesia in a mouse model of chronic widespread pain Rasna Sabharwal*, Lynn Rasmussen, Kathleen Sluka, Mark Chapleau

Poster Communications - Monday 22 July Sustained hypoxia increases PCA117 excitatory transmission in the nucleus tractus solitarius neurons N of juvenile rats Daniela Accorsi-MendonĂ§a*, Carlos E Almado, Benedito Machado

Transgenic Sprague Dawley rats with ataxin3-mediated destruction of orexin neurons display reduced tail artery Sympathetic Cutaneous Vasomotor Alerting Responses (SCVARs)

PCA123

Neuroprotective anti-oxidant effect of a Nitric Oxide synthase inhibitor in cerebral injury induced by transient focal ischemia/reperfusion in rats

PCA130

Amal Saeed*, Hiba Awooda, Gehan Sharara

Mazher Mohammed*, Youichirou Ootsuka, Masashi Yanagisawa, Bill Blessing

Catecholamines in the medial prefrontal cortex and nucleus accumbens alter cardiorespiratory and metabolic functions

PCA118

Ann Goodchild*, Sarah Hassan, Jennifer Cornish

Co-localisation of the neurotransmitter synthesising enzymes GAD67 and choline acetyltransferase in the mouse nucleus tractus solitarius.

PCA124

Neuroprotective effects of Lycium PCA131 barbarum polysaccharides in lipopolysaccharide-induced BV2 N microglia cells Yin Wang*, Yunhong Li, Peng Teng, Xiaolin Hou, Le Wang, Qi Qi, Liang Zhou, Ying Shen, Yumei Zhang, Zhenhua Miao

Jittima Gotts*, Ian Edwards, Susan Deuchars, Jim Deuchars

The inflammatory response in the spontaneously hypertensive rat: Effects of anti-hypertensive interventions

PCA119

Paul Marvar*, Fiona McBryde, Julian Paton

The role of glucocorticoid PCA120 receptors within the Basolateral Amygdala on the alteration in N morphine-induced conditioned place preference following swim stress

The properties and synaptic inputs of cholinergic interneurones

PCA125

Inhibition of G9a stimulates the PCA132 selfrenew of glioma cancer stem cells Qikuan Hu*, Haiying Li, Hong Tao, Danni Feng

Varinder Lall*, Ian Edwards, Jim Deuchars, Sue Deuchars

Redox-sensitive endoplasmic PCA126 reticulum stress and autophagy at rostral ventrolateral medulla N contribute to hypertension in SHR

Peptide hormone ghrelin PCA133 enhances neuronal excitability by inhibition of Kv7/KCNQ channels

Limin Shi, Xiling Bian, Zhiqiang Qu, Zegang Ma, Yu Zhou, KeWei Wang, Hong Jiang*, Junxia Xie

Yung-Mei Chao*, Julie Y.H. Chan

Ghassem Attarzadeh Yazdi*, Saeid YazdiRavandi, Sara Karimi, Abbas Haghparast

ATP-mediated signalling in the PCA121 pre-sympathetic area of the brainstem is critical for the N development of hypertension in spontaneously hypertensive rats

Low extracellular pH leads to free radical formation and mitochondria depolarization in rat brain synaptosomes

PCA127

Sergei Fedorovich*, Tatyana Pekun, Valeriya Lemeshchenko, Tatyana Waseem

Neurorescue effect of rosmarinic PCA134 acid on 6-hydroxydopaminelesioned nigral dopamine N neurons in rat model of Parkinsonâ&#x20AC;&#x2122;s disease Jieyu Wang, Huamin Xu, Hong Jiang, Xixun Du, Peng Sun, Junxia Xie*

Richard Ang*, Nephtali Marina, Sergey Kasparov, Alexander Gourine

Evaluation of hypothalamic PCA122 neuropeptides and inflammatory factors correlated to blood pressure changes in high fat diet- N induced obesity in mice Laiali Chaar*, Izabela Ribeiro, Natalia Silva, William Festuccia, Vagner Antunes

Electrophysiological PCA128 characteristics of newborn cells in the adult mouse midbrain

Anupa Dey*, Tim Aumann

6-Hydroxydopamine upregulates PCA135 iron regulatory protein 1 by activating certain protein kinase N C isoforms in the dopaminergic MES23.5 cell line Wenjie Wang, Ning Song, Haoyun Zhang, Junxia Xie*, Jun Wang

Fructose increases ATP-and PCA129 ROS-dependent neurotransmitter release Kay Wu*, Samuel Chan, Julie Chan

HO-1 participates differentially in astroglia and neurons vulnerability Xiaojun Yu, Ning Song*, Hong Jiang, Junxia Xie

PCA136

Hall 3, ICC

*Denotes presenting author

The function of Gene X isoforms in neural development and its possible role in pathogenesis of schizophrenia

PCA137

Developmental changes of TRPV1 PCA144 expression in C57BL/6 mice brain Wenxian Huang, Fang Yu, Xiaohua He, Biwen Peng*

Yiliang Xu*, Yuhui Sun, Haihong Ye, Chunyan Zhu, Li Zhu, Jianghong Liu, Jane Wu, Qi Xu

Presynaptic glutamine transport sustains glutamatergic transmission at a mammalian central synapse

PCA139

PCA140

Igor Filippov*, Artem Krebs, Konstantin Pugachev

Characterization of hypoxia inducible factor pathway in neuroprotection and neurorestoration following cerebral ischaemia

Long-term potentiation of PCA146 excitatory synaptic transmission from primary afferents or N descending inputs to neonatal rat spinal cord motoneurons in vitro Meng-Ya Wang*, Yan-Yan Su, Xiao Jiang, Jian-Hui Jin, Huan Zhang, Hao Luo, Yan Zhang

PCA141

Igor Putrenko*, Stephan Schwarz

Serotonin-induced presynaptic PCA152 inhibition of GABAergic transmission onto cholinergic N neurons in the rat basal forebrain Toshihiko Momiyama*, Takuma Nishijo

M O N D A Y

A role for whirlin in proprioceptor PCA153 mechanotransduction

Clathrin and its role in fast PCA154 endocytosis in retinal bipolar cells and hippocampal neurons N Mathias Pasche*, Ilaria Pelassa, CongJian Zhao, Benjamin Odermatt, Leon Lagnado

Aiyu Yao*, Wenhua Li, Hui Zhi, Yongqing Zhang, Kuldeep Kaur

N A TRPV channel controls presynaptic Ca2+ concentration to regulate presynaptic growth and synaptic vesicle release probability PCA142

PCA149

Ching-On Wong*, Yong Qi Lin, Kuchuan Chen, Geoffrey Broadhead, Lita Duraine, Anutosh Ganguly, Fernando Cabral, Hugo Bellen, Kartik Venkatachalam

Du Sik Kim, Jeong Mi An, Jeong Wan Kang, Jeong Taeg Seo*

Lidocaine unmasks L-type Ca2+ current-mediated action potentials in rat thalamocortical neurons

Xian-Guo Liu*, Wen-Jie Ren, Yong Liu, Jun Wang, Li-Jun Zhou

Joriene de Nooij, Anna Simon, Staceyann Doobar, Karen Steel, Thomas Jessell, Robert Banks, Guy Bewick*

The Angelman syndrome PCA147 protein Ube3a regulates synapse development by ubiquitinating N Tkv in Drosophila

Ruoli Chen*, Simon Nagel, Michalis Papadakis, Chris Schofield, Peter Ratcliffe, Chris Pugh, Alastair Buchan

Role of Rac1/NADPH oxidase in staurosporine-induced neurite outgrowth in PC12 cells

Sergiy Korol*, Zhe Jin, Bryndis Birnir

Brian Billups*, Mari-Carmen Marx, Daniela Billups

Infraslow (<0.5 Hz) brain potentials reflect different neurophysiologic mechanisms of sensory information neuroprocessing in the human brain

Glucagon-like peptide-1 and PCA145 exendin-4 change neuronal excitability by modulating N currents through GABAA channels

The over-expression of TNF-Îą PCA151 differentially modulates the synaptic connection in N hippocampus and in spinal dorsal horn following peripheral nerve injury

PCA143

Abnormal hyperphosphorylation PCA150 of tau in rat hippocampus following transient focal cerebral N ischemia

Effects of neurotensin and/or PCA155 morphine on gene expression of the opioid receptors

Haiqing Liu, Bo Bai*

A novel technique that combines PCA156 single cell electroporation with extracellular recordings in vitro N and in vivo Bowen Dempsey, Lama Bou Farah, Anita Turner, Simon McMullan*

Wang Ze-Fen*, Chen Juan, Lei Rui-Xue

Neuregulin-2 regulates synaptogenesis in hippocampal newborn granule cells

PCA157

Kyu-Hee Lee*, Hyunsu Lee, Che Ho Yang, Chang-Hwan Park, Won-Kyung Ho, Suk-Ho Lee

Poster Communications - Monday 22 July The Cu/Zn superoxide dismutase PCA158 inhibitor diethyldithiocarbamate inhibits axonal transport in N cultured mouse dorsal root ganglion neurons Risa Isonaka*, Tatsumi Kusakabe, Takashi Katakura, Toshifumi Takenaka, Tadashi Kawakami

Enhanced inhibitory synaptic PCA159 transmission underlies the inputspecific suppression of long-term N depression by serotonin in the rat visual cortex Hyun-Jong Jang*, Yang-Hyeok Jo, Duck-Joo Rhie

Enhancing feedback provision and use through in situ audio commenting

Does practical demonstration class help medical students to develop their skill domain?

Dave Lewis*

Namrata Upadhayay*, Bishnu Paudel, Agrawal Kopila, Nirmal Baral

Phenomenological appreciative inquiry into the Experiential Learning process

PCA162

Latha Rajendra Kumar*

New challenge of Physiological Society of Japan – Reform of annual meeting and establishment of Physiology Educator

PCA163

Self-tests with certainty-based- PCA168 marking in early years of medical course ET

Engaging the gen Y students with PCA169 STD - Speed Triage Dating Lisa Tee*

Maria José Rocha*, Mauro Ferreira, Dorival Gaspar, Wilson Mestriner-Júnior

Quality of essay plans in finals papers correlates with the mark awarded to the essay by independent examiners

PCA175

More than semantics: Moving PCA170 physiology instruction to learner competencies from learning ET objectives Robert Carroll*

Evidence based medicine. Changing the paradigm of medical education

Peter Lillie, Alice Reid, Judy Harris*

South East Asian medical PCA176 students perceive and accept PBL as useful learning process: report ET from an upcoming medical school in Malaysia . Sarmishtha Ghosh*

PCA171

Perception of basic medical PCA177 science teachers and medical students on objective structured ET practical examination (OSPE) and viva in a medical institute Namrata Upadhayay*, Bishnu Paudel, Nirmal Baral, Kopila Agrawal

Doctors’ perception about PCA178 clinical relevance of physiology to practice in the houseman ship ET in Sudan. Comparison between graduates from Problem based learning and conventional curricula Lamis A. Kaddam*; Hiba Awooda; Mustafa Elnimeiri; Amal Saeed; Rehab Badi

Merits and demerits of ‘Frequent PCA179 Discussion Embedded Interactive Lecture (FDEIL)’ in learning ET physiology: a students’ opinion Md Khan*

PCA174

Undergraduate-led practical PCA172 physiology activities can enhance learning for both university ET students and A-level school pupils

Performance 2012: Engaging the PCA164 public with the physiology and pharmacology of sporting success

A practical class to teach masticatory efficiency for dental students

Phil Langton*, Richard Helyer, Frankie MacMillan

Mohammad Hossain*, Anwar Siddiqui

Noriyuki Koibuchi*, Akira Nakashima, Masaru Ishimatsu, Satoshi Okumura, Tetsu Okumura, Yasuaki Kawai, Miyuki Kuno, Amane Koizumi, Michio Shiibashi, Atsuko Suzuki, Tetsuya Matsuda, Hironobu Morita, Toshikazu Yamashita, Akihiro Yamanaka

Dave Lewis*, Charlotte Haigh

PCA167

Nancy Curtin*, A. Gardner-Medwin

PCA161

Developing students’ advanced PCA173 scientific thinking skills through effective inquiry-based physiology ET practical classes Kirsten Zimbardi*, Kay Colthorpe, Judit Kibedi, Phil Long

Development of a wiki of PCA166 education and training resources in in-vivo sciences

A. Gardner-Medwin*

Reem Abraham*, Murray Fisher, Asha Kamath, T Aizan Izzati, Saidatul Nabila, Nik Nur Atikah

Kay Colthorpe*, Kirsten Zimbardi, Andrew Dekker, Peter Hay, Craig Engstrom, Andrea Bugarcic, Phil Long, Lesley Lluka, Prasad Chunduri, Peter Worthy, Justin Marrington

Optimisation of certainty-based assessment scores

Exploring undergraduate medical PCA160 students’ self-directed learning readiness ET

PCA165

Hall 3, ICC

*Denotes presenting author

Cooperative learning, a tool to teach physiology in nursing education

PCA180

Muhammad Kanpurwala*, Sana Saleem, Asima Faisal

A comparison of teaching styles of physiology faculty based in Pakistan and the middle east institutes

PCA181

Muhammad Kanpurwala*, Feisal Subhan

Natsudaidain isolated from PCA188 Citrus plants inhibits activation of mast cells in the late phase of EM immediate allergy

When platelets start to function – PCA195 insight into primary hemostasis in developing murine fetuses using EM a new in vivo microscopy model

Takuya Matsui*, Hiroyuki Shiono, Chihiro Ito, Masataka Itoigawa, Tadashi Okada

Andreas Margraf*, Claudia Nussbaum, Sarah Schmidt, Steffen Dietzel, Elizabeth Quackenbush, Ulrich von Andrian, Markus Sperandio

Mer receptor tyrosine kinase promotes resolution of acute sterile inflammation through upregulation of liver X receptor expression and activation

PCA189

Mohammed Salim*

Teaching acid-base physiology to medical students: A comparison of group work and peer instruction for interpreting arterial blood gases

PCA183

Heterogeneity of commercially available human serum albumin products: thiol oxidation and protein carbonylation

PCA190

Marie Petersen*, Linea Toksvang, Ronni Plovsing, Ronan M. Berg

PCA191

Linea Natalie Toksvang*, Ronan Berg

The effect on anticoagulation by siRNA-mediated tissue factor knockdown in pig aortic endothelial cells in vitro

PCA192

Ming Ji*, Shou Yi

The contribution of Adolf Beck to PCA185 Physiology (to 150-anniversary from his birth)

Oksana Zayachkivska*, Mechyslav Gzhegotsky, Antonina Coenen

In vitro reversal of human sickled PCA193 erythrocytes by high K+ -isotonic solutions EM

Effect of extract from peanut shell in kidney of in senile rats Min Wang, Xinmei Zhou*, Chuanlong Ye, Yu Zheng, Chao Yuan, Ying Liu

PCA187

MicroRNA let-7i can control PCA198 TLR4 expression and affect IFN-γ secretion in T cells from patients EM with ankylosing spondylitis

ANGII-AT1 receptor antagonizes bone resorption through TLR-4 signaling in an animal model of LPS-induced periodontitis in rat

PCA199

The effect of asthma related allergens in human gingival epithelial cells

PCA200

Aran Son*, Sung Jun Lee, Syng-Ill Lee, Wonse Park, Dong Min Shin

PCA186

Etienne Roux*

PCA197

Maria del Rosario Garrido*, Maria Gabriela Matos, Anita Israel, Lourdes Perdomo, Marco Alvarez

Olutayo Ajayi*, Abimbola Sekumade, Patrick Ogbechie

Claude Bernard and the “evolution of organisms and species”

Lethal and adaptive macroautophagy as typical cellular responses to hypoxia/ reoxygenation

Hui Chun Yu*, Wei Ting Liu, Ning Sheng Lai, Hua Chien Chen, Chia Li Yu, Ming Chi Lu, Hsien Bin Huang

Mariko Nakamura*, Masanori Sunagawa, Tadayoshi Kosugi

Using a classic paper by Robin PCA184 Fåhraeus and Torsten Lindqvist to teach basic hemorheology

M O N D A Y

Alexander Kabakov*, Vera Mosina, Karina Budagova

Seiichi Era*, Tomoyoshi Terada, Takeshi Minami, Teppei Takahashi, Hajime Arikawa

A fragment of recombinant habutobin inhibited collageninduced platelet aggregation

PCA196

Hande Yapislar*, Eylem Taskin

Ji-Yeon Choi*, Young-So Yoon, Jeong Seo, Jihee Kang

First-year Bayero University PCA182 medical students prefer multiple learning styles

How carnosine affects cardiovascular parameters in remnant kidney model

The roles of Macrophage MHC receptor (MMR)1 in allorecognition: Isolation of a cDNA encoding a novel MHC receptor for HLA-B44, human MMR1 Junko Yamaji*, Tetsunosuke Shimizu, Ryotaro Yoshida, Takahiro Kubota

PCA194

Hypo-osmotic stress regulates PCA201 RANKL mRNA expression through TRPM3 and TRPV4 in primary EM cultured human PDL cells Gayun Son*, Sung Jun Lee, Yu-Mi Yang, Syng-Ill Lee, Dong Min Shin

Poster Communications - Monday 22 July Decreased calcium mobility and the lack of secretion in equine sweat gland cells

PCA202

Jennifer Robertson*, Douglas Bovell

Transient receptor potential vanilloid 4-dependent calcium influx and ATP release in mouse esophageal keratinocytes

PCA209

Ammar Boudaka*, Hiroshi Mihara, Toshiro Sugiyama, Yoshinori Moriyama, Makoto Tominaga

A protein arginine methyltransferase isoform controls the HIF-1-mediated adaptation to hypoxia by reducing de novo synthesis of HIF-1α protein.

Ahmed Qasem*, Christopher Fry, Rita Jabr

PCA203

Uk il Ju*, Hyoung Sook Park, Jong Wan Park, Yang Sook Chun

Development of new molecular PCA211 tools to monitor various inositol compounds in stimulated human EM HEK-293 fibroblasts

Xiuling Zhi, Meng Xiang, Xiaobo Li, Lianhua Yin, Ping Zhou*

Cholinergic pathways in human chronic myeloid leukemia cell proliferation

PCA212

Juan Feng*, Yanxiang Gao, Yi Zhu, Qingbo Xu, Xian Wang

Differential beta-arrestin2 PCA213 requirements for constitutive and agonist-induced internalization of EM CB1 cannabinoid receptor Pal Gyombolai*, Eszter Boros, Laszlo Hunyady, Gabor Turu

Diabetes alters Ca2+ release from PCA206 the endoplasmic reticulum in submandibular acinar cells

Nataliya Fedirko*, Olga Kopach, Nana Voitenko

The role of store operated calcium entry in endocytic vacuole formation in pancreatic acinar cells

PCA214

David Collier*, Robert Sutton, Alexei Tepikin, Svetlana Voronina

Marlen Kolb*, Susanne Trettner, Susanne Büttner, Kathrin M. Y. Engel, Thomas Seiboth, Klaus Huse, Gerd Birkenmeier

Effects of hormon-induced phosphatidylinositol 4,5-bisphosphate depletion on G protein-coupled receptor endocytosis

PCA219

Dániel Tóth*, József Tóth, Bernadett Tallósy, László Hunyady, Péter Várnai

Effect of the nicotinic acid PCA220 adenine dinucleotide phosphate antagonist Ned-19 on pancreatic EM acinar cell calcium signalling Martyn Charlesworth*, Ole Petersen, Julia Gerasimenko, Oleg Gerasimenko

PCA207

Yukari Takeda*, Akinori Noma

Liangzhi Xu*, Tingting Li, Wenjuan Li, Meng Cheng

A truncated splice variant of LRP1 PCA218

Banu Aydin*, M. Zafer Goren, Hulya Cabadak

8,9-epoxyeicosatrienoic acid PCA205 inhibits antibody production of B lymphocytes in mice

Initial investigation of the signaling pathway of leptin receptor in rat osteoblasts

Measurement of inositol-1,4,5- PCA217 trisphosphate in living cells using newly developed resonance EM energy transfer-based biosensors Gergö Gulyás*, József Tóth, Dániel Tóth, László Hunyady, Tamás Balla, Péter Várnai

József Tóth*, Gergö Gulyás, Dániel Tóth, László Hunyady, Péter Várnai

CD73 suppression induces PCA204 apoptosis and cell-cycle arrest in human breast cancer cells EM

A simulation study of the effects of GLP-1 on membrane excitability in pancreatic β-cells

Assessment of gap junction PCA216 communication between human umbilical endothelial cells and EM monocytes in response to tumour necrosis factor (TNF-α)

PCA208

BRET titration experiments to PCA215 study G protein coupled receptor dimerization: New insights into EM an old tool Bence Szalai*, Péter Hoffmann, Péter Várnai, László Hunyady

Modulation of calcium entry and PCA221 extrusion mechanisms in relation to the development of acute EM pancreatitis Eloise Stapleton*, Julia Gerasimenko, Ole Petersen, Oleg Gerasimenko

Caveolin-1 knockdown decreased PCA222 the expression of Cavin-1 in human mammary epithelial cells

Dan Shi, Yan Liu, Xin Lian, Wei Zou*

Hall 3, ICC

*Denotes presenting author

Could developing an infection during pregnancy indirectly increase the risk of the foetus developing schizophrenia in adulthood?

PCA223

Antioxidant enzymes in prostate cancer Nihal Salmayenli*, Canan Kucukgergin, Tzevat Tefik, Oner Sanli, Sule Seckin

PCA229

PCA235

Bonnie Blazer-Yost*, Stephanie Flaig, Alex Carr, Vincent Gattone

William Ind*, Fay Maguire

Cytological remodeling of the PCA224 periodontal ligament tissues due to mechanical stress

SIRT1 expression enhanced PCA230 antitumor effect of Cisplatin decreased by chronic hypoxia in EM human non-small cell lung cancer Donghoon Shin*

Assessment of blood perfusion PCA225 as possible tool in differentiating between human benign skin naevi and malignant melanomas EM Marco Rossi*, Aneta Stefanovska, Gian Marco Vezzoni, Margherita Pesce, Barbara Loggini, Fabrizio Ghiara, Giuseppe Rossi, Francesco Pingitore, Paolo Barachini

The effect of SDF1- 3’A and PCA226 CXCR4 gene polymorphisms on the susceptibility and EM clinicopathological characteristics of prostate cancer Sule Seckin*, Canan Kucukgergin, Ferruh Isman, Dasdemir Selcuk, Çakmakoglu Bedia, Oner Sanli

The role of MCP-1 A2518G and PCA227 CCR2A V64I gene polymorphisms on the susceptibility and clinicopathological characteristics EM of bladder cancer

Jia-Wey Shiau-Uau San (JWSYS) PCA231 is the most common Chinese medicine prescribed in Taiwan EM for disorders of menstruation in female and for sleep disturbances in males Jung-Sheng Yu*, Chung-Han Ho, Ching-Ping Chang

Semiconductor quantum dots for innovative approaches in photodynamic diagnosis and therapy

PCA232

PCA233

Shigenobu Yano*, Masami Naemura, Akio Toshimitsu, Motofusa Akiyama, Atsushi Ikeda, Jyunichi Kikuchi, Atsushi Narumi, Kei Ohkubo, Shunichi Fukuzumi, Michael Gottschaldt, Ulrich Schubert

Canan Kucukgergin*, Ferruh Isman, Selcuk Dasdemir, Bedia Cakmakoglu, Oner Sanli, Sule Seckin

Manganese superoxide dismutase PCA228 ILE-58THR, catalase C-262T and myeloperoxidase G-463A gene EM polymorphisms in prostate cancer patients: Relation to advanced and metastatic disease

Hyperbaric oxygen treatment ameliorates the course of DSS-induced colitis in BALB/c mice and reduces the Foxp3+ regulatory T cell expansion Martina Mihalj*, Dorde Pojatic, Emese Ugor, Zoltan Kellermayer, Sanja Novak, Marinko Zulj, Aleksandar Vcev, Timea Berki, Ines Drenjancevic

PCA236

Plasmin in urine - a new biomarker and target for renal protection in diabetes

M O N D A Y

PCA237

Henrik Andersen*, Ulla G. Friis, Pernille B. L. Hansen, Jan Erik Henriksen, Boye L. Jensen

Recruitment mechanisms and PCA238 anti-inflammatory effects of haematopoietic stem cells in the EM injured kidney Rebecca White*, Gerard Nash, Dean Kavanagh, Caroline Savage, Neena Kalia

Eugeny Ermilov, Weronika Kuzyniak, Edward Sekhosana, Christian Litwinski, Björn Hoffmann, Axel Radlach Pries, Michael Hoepfner*

Photocytotoxicity and excited-state properties of glycoconjugated C60 derivatives

The difference of serum RNA profile: RNA extraction method and detection method Satoko Takizawa, Hideo Akiyama*, Satoshi Kondo, Nobuyoshi Kosaka, Takahiro Ochiya

Toshiyuki Kawakami*, Mihoko Tomida, Rina Muraoka, Takami Nakamura, Keisuke Nakano

Canan Kucukgergin*, Tzevat Tefik, Oner Sanli, Tayfun Oktar, Cavit Ozsoy, Sule Seckin

Treatment of polycystic kidney disease with PPARγ agonists: Effects of sub-pharmacological doses in rodent models.

PCA234

The rat’s dry skin model is useful PCA239 to identify the cutaneous effects of oral supplementation with EM fish oil Raquel Barcelos, Cristina Sampayo, Hecson Segat, Caren Antoniazzi, Henrique Silva, M. Burger, Luis Rodrigues*, Beatriz Lima

Simulation of the anti-arrhythmic PCA240 properties of herbal remedies Penelope Noble*, Kazuyo Maria Tasaki, David Gavaghan, Gary Mirams, Denis Noble

Multi-targeted therapy of chemotherapy-induced oral mucositis by hangeshashinto, a traditional Japanese herbal medicine

PCA241

Toru Kono*, Atsushi Kaneko, Reo Nozaki, Chinami Matsumoto, Chika Miyagi, Katsuya Ohbuchi, Yuji Omiya, Yasuharu Mizuhara, Kanako Miyano, Yasuhito Uezono

Poster Communications - Monday 22 July Multitargeted treatment of experimental colitis by daikenchuto, a traditional Japanese herbal medicine

PCA242

PCA249

Bianca Zietsman*, Peter McCarthy

Nobuhiro Ueno*, Mark W Musch, Takumu Hasebe, Toru Kono, Yunwei Wang, Atsushi Kaneko, Yuji Omiya, Masahiro Yamamoto, Mikihiro Fujiya, Yasuhito Uezono, Yutaka Kohgo, Eugene B Chang

Multiple actions via systems biology â&#x20AC;&#x201C; ten principles of systems biology and biological relativity

Position played affects cervical spine range of motion of elite female rugby union players.

Chester Ray*, Charity Sauder

Physics-based soft-tissue modelling and simulation Mark Warburton*, Steve Maddock

PCA250

PCA243

EM Pointing at and tracking falling PCA251 targets: Directional aspects of an internal model of gravity

Denis Noble*, Toshiaki Tasaki, Yasuhide Mohri, Pengpeng Liu, Yasong Yang, Kazuyo Maria Tasaki

The reactions of peripheral blood PCA257 volumes to tilt-test in athletes after aerobic exercise HE Andrei Melnikov*, Sergei Popov, Dmitriy Nikolaev, Aleksander Vikulov

Jonathan Flavell*, Ian Loram, Dilwyn Marple-Horvat

A reassessment of the linear relationship between VO2max and peak power with age

Stimulation of the otolith organs PCA256 by ultrasonic bone stimulation of the mastoid increases muscle HE sympathetic nerve activity in humans

Evidence for beat-to-beat myogenic responses in the regulation of resting limb blood flow in man

PCA244

Ross Pollock*, Norman Lazarus, Stephen D.R. Harridge

Effects of diabetic peripheral neuropathy on muscular activations during stair descent

PCA252

Adam Williams*, Julia Smith, David Allaway, Pat Harris, Susan Liddell, Ali Mobasheri

Paul Fadel*, Seth Fairfax, Makoto Takahashi, Michael Davis, Jaume Padilla

Joseph Handsaker*, Andrew Boulton, Frank Bowling, Steve Brown, Glen Cooper, Costantinos Maganaris, Neil Reeves

Selective depletion of high PCA245 abundance extracellular matrix proteins from the secretome HE of articular cartilage explant cultures does not facilitate identification of lower abundance proteins

PCA258

Influence of diabetes and diabetic PCA253 peripheral neuropathy on lower limb joint moment distribution HE during stair negotiation

Cardiovascular response to PCA259 aerobic exercise training is attenuated in middle-aged adults HE with polymorphism of eNOS gene at position intron 4 a/b: A double-blind study Angelina Zanesco*, Carlos Sponton, Rodrigo Esposti, Cynara Rodovalho, Maycon Ferreira, Aline Jarrete, Chadi Anaruma, Mauricio Bacci

Steven Brown*, Andrew Boulton, Constantinos Maganaris, Frank Bowling, Joseph Handsaker, Neil Reeves

Ageing differentially affects the PCA246 short and medium latency motor responses evoked by stochastic HE vestibular stimulation Callum Osler*, Matthew Bancroft, Helen Southall, Raymond Reynolds

Low-dose L- arginine PCA254 supplementation improved total antioxidant activity and HE erythrocyte integrity in sickle cell anaemia subjects

Young adult asian males have a PCA260 lower baro-reflex gain compared to matched caucasians, as measured by heart rate variability HE analysis David Saint*, Laura Casey, Adrian Elliott

Stephen Ogungbemi*, Chikodi Anigbogu, Micheal Kehinde, Smith Jaja

The impact of age on upper PCA247 airway morphology: a risk factor for obstructive sleep apnoea? Elliott Carthy*, Tom Carlisle, Martin Glasser, Peter Drivas, Alison McMillan, Neil Ward, Anita Simonds, Mary Morrell

Evidence for refractoriness in a PCA248 whole-body human balance task. Cornelis van de Kamp, Peter Gawthrop, Henrik Gollee, Ian Loram*

The change in diastolic blood pressure during autonomic blockade is associated with T50 and error signal in young and older women Ana Peinado*, Emma Hart, Nisha Charkoudian, Michael Joyner, Jill Barnes

PCA255

Change of functioning of PCA261 cardiorespiratory sisem at impact noise

Olga Indeykina, Dmitriy Dimitriev*, Olesia Sofronova

Hall 3, ICC

*Denotes presenting author

Capsaicin-based analgesic balm attenuates the skeletal muscle metaboreflex in humans

PCA262

Implications of enhanced kynurenic acid and extracellular tryptophan during fatigue

PCA269

Takanobu Yamamoto*

Lauro Vianna*, Igor Fernandes, Thales Barbosa, Antonio N贸brega

Enhanced cardiovascular PCA263 responses is associated with increased orthostatic tolerance in young men following oral glucose HE and Vitamin C ingestion

PKC-dependent regulation of mTOR activity is mediated through TSC2/Rheb signaling in C2C12 myoblasts

Yan Lei Xiong, Lei Lin, Hui Gong, Xiang Mei Chen, Nan Chen, Cheng Li Xu*

PCA270

Mitsunori Miyazaki*

Taofeek Usman*, Victoria Olatunji, Aaron Adah, Lawrence Olatunji

Yogic practices can increase PCA264 estrogen and progesterone levels and heart rate variability in periHE menopausal women Rita Khadka*, B. Paudel, S. Majhi, N. Shrestha, M. Regmi, S. Chhetri, A. Das, D. Sharma, V. Gautam, P. Karki

Cerebrovascular reactivity is associated with central pulse wave characteristics in healthy adults

PCA265

Elliott Carthy*, Leigh White, Fraser Russell, Mark Holmes, Anthony Leicht, Peter Brooks, Deborah Hitchen-Holmes, Christopher Askew

Zia Rahman, Khushi Saquib*, Saeed Ahmad, Farheen Asad

M O N D A Y

Exercise stimulates lactate PCA279 disposal and monocarboxylate transporter expression in rainbow HE trout Teye Omlin*, Lo茂c Teulier, Jean-Michel Weber

Timur Mirzoev*, Olga Turtikova, Evgenia Kachaeva, Boris Shenkman

Maternal diet influences circadian PCA280 cardiovascular function in the offspring

Evaluation of serum and salivary PCA274 immunoglobulin classes A, G and M in patients with orofacial HE squamous cell carcinoma Taye Lasisi*, Olawale Lasisi, Bamidele Kolude, Effiom Akang

Ethnic differences in heat adaptation and autonomic tone during intensive exercise in elite athletes

Clint Gray, Sheila Gardiner, David Gardner*

Novel protein and mRNA PCA281 expression of voltage-dependent potassium channels in first HE trimester human placentae

Yulia Lomonosova*, Alexey Krasnuy, Evgeniy Lysenko, Boris Shenkman

PCA267

Effect of simulated microgravity PCA278 on the body and organs weight and serum biochemistry profiles HE of rats during different season

Activity of anabolic and catabolic PCA272 signaling pathways in rat soleus during recovery following HE gravitational unloading

Responses of elongation factor 2 PCA273 and its kinase to short- and longterm hindlimb unloading in rat HE skeletal muscle

Heart rate variability: the impact PCA266 of hypoxia and gender

Cardiovascular responsiveness to sympathoexcitatory stress in mild-hypertensive and normotensive participants

Yulia Lomonosova*, Boris Shenkman, Tatyana Nemirovskaya

PCA271

Jill Barnes*, Jenn Taylor, Michael Joyner

Danielle Hodson*, Christopher Marley, Lewis Fall, Kevin Evans, Dean Whitcombe, Julien Brugniaux, Karl New, Damian Bailey

Skeletal muscle damage from eccentric exercise: protective effect of nitric oxide II

The changes of the cardiovascular PCA277 function and its hormones regulation of the 28th chinese HE inland expeditioners at antarctic dome-A environment of hypoxia and extreme cold

PCA275

Hiten Mistry*, Lesia Kurlak, Guy Whitley, Judith Cartwright, Fiona Broughton Pipkin, Rachel Tribe

Evaluation of physical fitness of subjects with sickle cell trait: effects of ad libitum fluid intake on thermoregulatory responses in heat environments

PCA281a

Abdoulaye Samb*, Mor Diaw, Abdou Khadir Sow, Fatou Bintou Sar, Gora Seck, Abdoulaye Ba, Mbayang Ndiaye Niang

Jonathan Dalzell, Avijit Datta*

A novel integrated tilt table-lower PCA268 body negative pressure box to investigate differential arterial HE baroreflex responses with tilt in humans Mike Tymko*, Nathan Ingram-Cotton, Mike Howatt, Rachel Skow, Trevor Day

Exercise training activates behavioral thermoregulation in mice Kei Nagashima*, Chen-Hsien Lin

PCA276

Changes of AMPK and SirT1 PCA282 activity in the trophocytes and fat cells of young and old worker ME honeybees (Apis mellifera) Chin-Yuan Hsu*, Yu-Lung Chuang

Poster Communications - Monday 22 July Long-lived and obesity resistant mice exhibit 24 h locomotor circadian rhythms at young and old age

PCA283

Roee Gutman*, Oren Froy

Oxidant-antioxidant balance and PCA284 homocysteine in postmenopausal women: the role of hormone ME replacement therapy

Studying molecular physiology of PCA290 DNA cruciforms with a coarsegrained computational model

Reference haemoglobin value PCA297 in apparently healthy Sudanese children in Khartoum state, Sudan

Christian Matek*, Thomas Ouldridge, Jonathan Doye, Ard Louis

Iman Hamad*, Omer Musa

Plasma viscosity pattern during menstruation

PCA292

Stephen Anjorin*, Arthur Omorogiuwa

Yanning Cai*, Lan Zhang, Qingling Lin, Lin Li

Steroids hormone and nitrite/ nitrate levels are unchanged in normotensive and hypertensive postmenopausal women after aerobic exercise training

PCA285

William Kyle Mitchell*, John Williams, Bethan Phillips, Debbie Rankin, Jonathan Lund, Kenneth Smith, Philip Atherton

The effects of bolus versus pulse PCA288 feeding strategies on muscle anabolism in older men

William Kyle Mitchell*, John Williams, Bethan Phillips, Debbie Rankin, Jonathan Lund, Kenneth Smith, Philip Atherton

Pattern of immunogenicity in a representative group of canines following anti-rabies immunization

PCA293

Dose dependent effects of fish oil PCA299 on oxidative stress Marcela Martins*, Monique Moss, Iara Mendes, Carolina Chamma, Wanda Mury, Márcia Águila, Tatiana Brunini, Antônio Cláudio Mendes-Ribeiro

Mangala Gunatilake*, Ruvini Pimburage, Omala Wimalaratne, Aindralal Balasuriya, Devika Perera

Gabexate mesilate mitigates coagulopathy and organ dysfunction in rats with endotoxemia

PCA294

PCA289

Erythrocyte osmotic fragility and PCA295 lipid peroxidation in experimental hyperthyroidism

Nuran Dariyerli*, Rifat Yucel, Semra Ozdemir, Selmin Toplan, Mehmet Can Akyolcu, Gunnur Yigit

The effects of experimental PCA296 hypothyroidism on hemorheology and plasma fibrinogen ME concentration Selmin Toplan*, Nuran Dariyerli, Semra Ozdemir, Mehmet Can Akyolcu, Husrev Hatemi, Gunnur Yigit

Beneficial effect of Cinnamomum PCA300 burmannii in streptozotocininduced type 1 diabetic rats

Maria Silva*, Paula Pereira, Alexandra Bernardo, Margarida Moncada, Jaipaul Singh, Fernanda Mesquita

Cheng-Ming Tsao*, Hsin-Jung Tsai, WenJinn Liaw, Chin-Chen Wu

Adding arginine to an essential PCA287 amino acid (EAA) feed reverses age-related impairments in ME vascular responsiveness but does not offset age-related anabolic blunting

Seol Kim, Awraris Assefa, Se Won Park*

PCA298

PCA286

Iane Novais*, Guilherme Puga, Hygor Araújo, Rodrigo Esposti, Aline Jarrete, Carlos Sponton, Maria Andreia Delbin, Angelina Zanesco

Optimization and extraction of antioxidants from Aloe verai using response surface methodology

Determination of hematological and biochemical blood parameters in kitten and adult Angora cats Sevket Arikan, Miyase Cinar, Ozkan Simsek*

Cahide Gokkusu*, Sule Seckin, Sule Tamer

Tissue specific modification of clock methylation in aging mice

Hypertrophic cardiomyopathy PCA301 and impairment mitochondrial function in insulin-resistant obese ME mice. Aline Santos, Carlos Alberto Costa, Aluana Santana, Erika Cortez, Viviam Soares, Erica Garcia-Souza, Anibal Moura, Celly Cristina Nascimento-Saba*

Effects of 100 kV/m nuclear PCA302 electromagnetic pulse on dogs’ECG, blood pressure and the ME concentration of AII,ANF in dogs Yu Rong Li*, Jie Zhang, Tao Zhao, Lihua Zeng

Hypothalamic AMP-activated PCA303 protein kinase is implicated in leptin-induced sympathetic nerve ME activation Mamoru Tanida*, Toshishige Shibamoto, Kamal Rahmouni

Hall 3, ICC

*Denotes presenting author

Biochemical and hemodynamic alterations induced for high fat diet in perinatal period

PCA304

Robervan Santos, Vitor Melo, Fabricio Macedo, José Brito Alves, Marcio Viana dos Santos, Larissa Oliveira, Michael Santana, Luciana Brito, Elizabeth Nascimento, João Henrique Silva, Valter Santana-Filho*

Improvement of structural and functional microvascular abnormalities after central sympathetic nervous system modulation in a rat model of metabolic syndrome.

Recurrent low glucose exposure PCA311 attenuates α1AMPK activity and reduces basal metabolism in GT1ME 7 neurons

Hae Jin Yoon*, Jong-Wan Park

Elizabeth Haythorne*, D.Lee Hamilton, Craig Beall, John Findlay, Michael Ashford, Rory McCrimmon

PCA305

Alessandro Nascimento*, Marcos Adriano Lessa, Marcus Vinicius Machado, Bárbara Antunes, Isabela Bonomo, Pascal Bousquet, Eduardo Tibiriçá

A novel role for IL-6 in the suppression of hypothalamic glucose sensing

PCA312

Geoffrey Denwood*, Kenneth Watterson, Ann Gardiner, Kirsty Ward, Elizabeth Haythorne, Lee Hamilton, Kathryn Wright, Fiona Ashford, Michael Ashford, Rory McCrimmon

Resveratrol induces central PCA306 hypotensive effect via AMPKmediated signaling to eliminate ME fructose induces NADPH oxidase overexpression Pei-Wen Cheng*, Ching-Jiunn Tseng, LuoPing Ger

Koji Ohba, Kiriko Kaneko, Hiroshi Nishiyama, Takuo Hirose, Kazuhito Totsune, Kazuhiro Takahashi*

A central role of E3 ubiquitin PCA314 ligase MG53 in insulin resistance and metabolic disorders

Neuronal nitric oxide synthase PCA307 activation is involved in midkinemediated cardiovascular effect in ME the nucleus tractus solitarii

Yan Zhang*, Ruisheng Song, Wei Peng, Fengxiang Lv, Chun-Mei Cao, Rui-Ping Xiao

Hsin-Hung Chen*, Ching-Jiunn Tseng

Connexin 36 signalling during intercellular communication within pancreatic islets PCA308

Green tea (GMB4 clone) PCA319 catechins influences the retinoidrelated orphan receptor α ME (ROR-α) and CCAAT/enhancer binding protein-α (C/EBP-α) expression in primary cultured of preadipocyte Retty Ratnawati*, Faridha Hasniy, Diana Lyrawati, Ciptati Ciptati

Role of (Pro)renin receptor in cell PCA313 proliferation

Cross-talk between Wnt and insulin signaling in central blood pressure regulation

SIRT1 differentially regulates PCA318 HIF-1a and HIF-2a activities under hypoxia

PCA315

Daniella Penko, Heshan Peiris, P. Toby Coates, Claudine Bonder, Claire Jessup*

M O N D A Y

The use of bioinformatics to PCA320 prioritise palmitoylation enzyme isoforms as novel research ME targets Bernadette Adeyileka*, Louise Davies, Avril Dempsey, Samuel Falconer, Niall Donohoe

The metabolic profile of pregnant PCA321 mice fed a diet high in sugar and fat Barbara Musial*, Susanne Ozanne, Abigail Fowden, Amanda Sferruzzi-Perri

Asymmetric dimethylarginine causes adipocyte hypertrophy through NO-independent upregulation of the mTOR lipid biosynthesis pathway

PCA322

Laura Dowsett*, Olga Boruc, James Leiper

Wen-Han Cheng*, Ching-Jiunn Tseng

Neuroprotective effects of acetyl- PCA309 L-carnitine against ischemiareperfusion injury: a spin ME resonance study

Estrogenic effects of ginsenoside PCA316 Rg1 in endometrial Ishikawa cells and neuroblastoma SK-NME SH cells were not observed in preosteoblast MC3T3-E1 cells Wen-Fang Chen*, Quan-Gui Gao

Osamu Tokumaru*, Masaki Shimada, Yuki Mizutani, Kazue Ogata, Takaaki Kitano, Isao Yokoi

BACE1 overexpression shifts PCA310 glucose metabolism toward aerobic glycolysis in SH-SY5Y cells ME

Effect of secretory products PCA317 of colon cancer cells on the cancer-associated fibroblasts: The ME reverse Warburg effect Young-Im Kim*, Hyun-Woo Shin, Yang-Sook Chun, Chung-Hyun Cho, Jong-Wan Park

Interleukin-induced calcium channel current modulation in osteoblasts

PCA323

Hiroshi Kobayashi*, Takayuki Endoh, Masakazu Tazaki, Kenji Sueishi

Birth weight is a strong PCA324 independent determinant of white-to-white corneal diameter ME of newborns Victoria Olatunji*, Dupe Ademola-Popoola, Grace Adepoju, Lawrence Olatunji

John Findlay*, D. Lee Hamilton, Paul Meakin, Mike Ashford

Poster Communications - Monday 22 July Alterations in intrauterine electrical impedance in mice measured by four-electrode methods

PCA325

Effects of exposure to Bisphenol A on Expression of obesity-related genes in zebrafish

PCA332

Tatiana Kostrominova*

Megumi Yamamoto*, Takayoshi Hosono, Chihiro Igi, Mayu Arakawa, Miki Nakamoto, Keisuke Akasaka, Hitomi Nakamura, Tadashi Kimura

Zhichao Zhou, Vincent de Beer, Shawn Bender, Harold Laughlin, Daphne Merkus, Dirk Duncker*

An increase in intellectual PCA326 activity during menstruation by abdominal warming using a heatME and steam-generating sheet

Oxidative stress during a cold growth arrest of the teleost Sparus aurata is related with dietary lipids

PCA333

Rodrigo Roco*, Teresa Carbonell, Norma Alva, Josefina Blasco, Jaume FernàndezBorràs, Ramon Fontanillas, Antoni Ibarz

Phenolic compounds content, PCA327 antioxidant and antibacterial activities of green / black tea ME decoction as affected by cooking treatment Karima Dhaouadi, Hela Jlassi, Sami Fattouch, Mohamed Hamdaoui*

PCA328

Fatma El-Demerdash*, Hoda Nasr, Ali Jebur

Protective effect of vitamins C and E on abamectin-induced oxidative stress in rats Hoda Nasr*, Fatma El-Demerdash

The role of adrenergic receptors in nicotine-induced hyperglycemia in the common african toad (Bufo regularis)

Changes in hsp mRNA dynamics are involved in HSP72 level regulation during one month of heat acclimation decline

Frank Mojiminiyi*

PCA334

Atallah Abbas*, Michal Horowitz

High-performance thermogenesis PCA335 of brown adipose tissue under hypothermic condition during ME hibernation in Syrian hamsters Masaaki Hashimoto*, Hiroshi Ohinata, Naoya Kitao

Xin Sun*, Dan Tian, Fanglin Man, Ming Zhu

ME Endothelial SHIP2 confers agePCA337 dependent contrasting affects on whole body glucose homeostasis VS and vascular function PCA330

Grace Isehunwa*, Grace Adewunmi, Abdul Rasaq Alada

Endothelial relaxation mechanisms dysfunction are reversed by atorvastatin or metformin in animals with estrogen deficiency state

Matthew Gage*, Stephen Wheatcroft, Afroze Abbas, Helen Imrie, Hema Viswambharan, Stacey Galloway, Piruthivi Sukumar, Richard Cubbon, Jessica Smith, Stephane Schurmans, Monique Jacoby, Eleonore Dubois, Mark Kearney

Kv7 channels are major determinants of basal coronary flow and active response to ischemia

Ojashwi Nepal*, Bhola Pokhrel

The impact of advanced maternal PCA338 age on the initiation and progress of parturition in a pregnant VS mouse model Rima Patel*

PCA342

Saereh Khanamiri*, Ewa Soltysinska, Thomas Jepps, Bo Bentzen, Preet Chadha, Nicole Schmitt, Iain Greenwood, SørenPeter Olesen

Cardioprotection from cold stress and subsequent fatty diet is mediated by Epac-1 in the isolated mouse heart

PCA343

Fridtjov Edland*

Enhanced phenylephrine contractions in rabbit carotid arteries following exposure to erythrocytes from subjects with sickle cell trait Anthony Ebeigbe*, Ifedayo Ajayi

Thyroid hormones in high altitude PCA331 natives

PCA341

Izabela Caliman*, Phablo Oliveira, Aline Lamas, Suely Figueiredo, Polyana Dalpiaz, Glauciene Sousa, Nazaré Bissoli

Pak5 inhibit the apoptosis of PCA336 cultured vascular smooth muscle cells VS PCA329

A toxicity profile of the aqueous PCA340 calyx extract of Hibiscus sabdariffa in Sprague Dawley rats

Chihiro Igi*, Takayoshi Hosono, Megumi Yamamoto, Miki Nakamoto, Mayu Arakawa, Keisuke Akasaka

Oxidative Stress and antioxidant response in rats exposed to permethrin, a pyrethroid insecticide, and ameliorating effect of vitamin C

Phosphodiesterase-5 activity PCA339 exerts a coronary vasoconstrictor influence in awake swine that is VS partly mediated via an increase in endothelin production

PCA344

Hall 3, ICC

*Denotes presenting author

Flow-mediated outward remodeling and NO-dependent dilation of resistance arteries are both determined by sex and age with a key role of timing in estradiol replacement therapy

PCA345

The role of Na+/H+ exchanger-1 during ischemia-induced cerebrovascular dysfunction

Yi-Sook Jung*

Assessment of arterial distensibility in patients with sarcoidosis

Optimal ROS level is essential PCA346 for induced pluripotent stem cell adhesion, transendothelial VS migration, and trafficking in mice Dan Meng*, Yi Wu, Rong Wang, Ning Li, Wenjun Yuan, Sifeng Chen

PCA352

Huriye Balci, Sevtap Sipahi Demirkok, Mustafa Yildiz, Gokhan Metin, Munire Hacibekiroglu, Gonul Simsek*

Increased permeability of pulmonary arterioles after cardiopulmonary bypass.

VS Peripheral circulatory changes during Valsalva maneuver using DC component of Photoplethysmographic signal

Improvement of blood-retinal PCA348 barrier breakdown in type 2 diabetic rats by alpha-mangostin

PCA354

Yinghua Gao, Dan Meng, Ning Sun, Zhu Zhu, Ran Zhao, Xiaobo Li, Chao Lu, Sifeng Chen, Ruizhe Qian*

Ian Evans*, William Pickworth, Gregory Schey, Paul Frankel, Ian Zachary

PCA355

Cintia Helena Santuzzi*, Renata Tiraddentes, Vinicius Mengal, Helder Mauad, Paulo Henrique Matos, Sonia Gouvea, Marcia Cunha, Glaucia Abreu

João Guilherme Dini*, Danize Rizzetti, Franck Maciel Peçanha, Dalton Valentim Vassalo, Giulia Alessandra Wiggers

Sulforaphane pre-treatment reduces Nrf2 content in core and peri-infarct brain regions in rats subjected to ischaemiareperfusion injury

Claire Stevenson*, Craig Daly, Elspeth McLachlan, Ian (J.C.) McGrath

PCA357

PCA362

Salil Srivastava*, Alessio Alfieri, Richard Siow, Paul Fraser, Giovanni Mann

Interaction of Sequestosome1/ p62 with voltage-activated potassium channels in arterial smooth muscle cells in injuryinduced arterial remodeling

VS Mathematical modelling of capillary O2 supply capacity in cardiac and skeletal muscle

Natchaya Wongeakin*, Parvapan Bhattarakosol, Suthiluk Patumraj

Pharmacological analysis of PCA356 sympathetically-mediated constriction in wild type and VS α1-AR knock out mouse tail artery PCA350

Curcumin could ameliorate PCA360 diabetic vascular inflammation by decreasing ROS overproduction, VS leukocyte-endothelium interaction, and NOX2 expression

Apocynin prevents vascular PCA361 effects caused by chronic exposition to low concentrations VS of mercury

Dinu Chandran*, Ajoe Kattoor, Ashok Jaryal, Kishore Deepak

Aliskiren associate with L-Arginine improves vascular reactivity of renovascular hypertension rats

Clock upregulates intercellular PCA349 adhesion molecule-1 expression and promotes mononuclear cells VS adhesion to endothelial cells

Chonticha Areebambud*, Chantana Mekseepralard, Amporn Jariyapongskul

PCA359

M O N D A Y

PCA353

PCA347

Ziva Melik*, Polona Zaletel, Tina Virtic, Ksenija Cankar

Tissue- and agonist-specific isolated murine arterial responses to ageing. Chris Nicholson*, Michèle Sweeney, Stephen Robson, Michael Taggart

Timea Beleznai*, Laura Walker, Raimondo Ascione, Kim Dora

Neuropilin-1 regulates endothelial focal adhesion turnover via p130Cas phosphorylation.

The effects of Insulin-like Growth PCA358 Factor Binding Protein-1 on endothelial repair in the insulin VS resistant setting Amir Aziz*, Nadira Yuldasheva, Jessica Smith, Natalie Haywood, Paul Cordell, Richard Cubbon, Karen Porter, Mark Kearney, Stephen Wheatcroft

Kahena Tarhouni, Anne-Laure Guihot, Linda Grimaud, Bertrand Toutain, Laurent Loufrani, Françoise Lenfant, Jean-François Arnal, Daniel Henrion*

The effect of l-arginine on microvascular reactivity in normotensive subjects with family history of hypertension

PCA351

PCA363

Tetsuro Ishii*, Eiji Warabi, Richard Siow, Giovanni Mann

Abdullah Al-Shammari*, Eamonn Gaffney, Stuart Egginton

Poster Communications - Monday 22 July Inhibitory Effects of Sprouty4 PCA364 on proliferation and migration of vascular smooth muscle cells VS involving in suppression of MAPK and Akt double signal pathways Hongfang Li*, Xuehui Yang, Ruth Liaw, Ying Shi, Shuyi Ma, Bob Friesel

TRPV1 and autocrine serotonin PCA365 signalling elicit Ca2+ release from the acidic organelles of ADPVS stimulated human platelets. Stewart Sage, Alan Harper*

Exchange protein activated by cAMP (Epac) induces vascular relaxation by activating Ca2+sensitive K+ channels in rat mesenteric artery

PCA366

Is platelet mediated leukocyte recruitment a potential therapeutic target in atherosclerosis?

PCA370

Matthew Harrison*, Gerard Nash, Steve Watson, Ed Rainger

The role of Na+/Ca2+ exchange and ER Ca2+ buffering in the regulation of oxytocin-induced [Ca2+]i oscillations.

Sankanika Roy*, Ashok Jaryal, Achal Srivastava, Kishore Deepak

PCA371

Benjamin Hamilton*, Yulia Timofeeva, Anatoly Shmygol

Role of Nitric Oxide in the PCA367 control of the SR Ca2+ release in myocytes of arteriolar networks VS in situ

Restoring Akt1 activity in PCA372 endothelial progenitors from insulin resistant humans rescues VS vascular reparative capacity

Lyudmyla Borysova*, Susan Wray, David Eisner, Theodor Burdyga

The effect of IL-6 -174 G/C polymorphism on adiponectin and IL-6 Levels in peripheral vascular disease

The contributions of muscarinic PCA377 receptors and changes in plasma aldosterone levels to the antiVS hypertensive effect of Tulbaghia violacea Ismaila Raji*, Pierre Mugabo, Kenechukwu Obikeze

Pericytes derived from the human foetal kidney are progenitors for renin-producing cells

PCA378

Anna Stefanska*, John Mullins, Bruno Péault

Richard Cubbon*, Nadira Yuldasheva, Hema Viswambharan, Ben Mercer, Vivek Baliga, Sam Stephen, Jonathan Askham, Piruthivi Sukumar, Anna Skromna, Romana Mughal, Helen Imrie, Matthew Gage, Mark Rakobowchuk, Jing Li, Karen Porter, Sreenivasan Ponnambalam, Stephen Wheatcroft, David Beech, Mark Kearney

Owain Ll Roberts*, Tomoko Kamishima, Richard Barrett-Jolley, John Quayle, Caroline Dart

Sympathetic Vascular reactivity PCA376 to cold pressor test in Parkinson’s disease and Parkinsonian variant VS of Multiple System Atrophy with orthostatic hypotension

Intravital investigations of lymphocyte and platelet recruitment to murine liver following ischemia-reperfusion injury PCA373

PCA379

Joseph Robinson*, David Adams, Neena Kalia

Nihal Salmayenli*, Elif Özkök, Yilmaz Basar

Asthmatic cytokines IL-13 and PCA368 TGFβ alter TRPC6 expression and calcium handling via SMAD2/3 in VS human airway smooth muscle Yasin Shaifta*, David Wright, Vladimir Snetkov, Jeremy Ward

PCA374

Renal transplantation improves PCA375 baroreflex sensitivity and arterial stiffness in end stage renal VS disease patients Manpreet Kaur*, Dinu Chandran, Charanjit Lal, Dipankar Bhowmik, Ashok Jaryal, Kishore Deepak, Sanjay Agarwal

Ksenija Cankar*, Tina Virtic, Polona Zaletel, Ziva Melik

Molecular and functional changes PCA381 of Cav1.2 channels in vascular smooth muscles after hypoxia

Ping Liao*

Bilobalide enhances coronary artery endothelial potassium currents Wattana Watanapa*, Teerasak Wongsatan, Katesirin Ruamyod

PCA380

Shinsuke Nakayama*, Satoshi Atsuta, Masao Kondo, Tsuyoshi Uchiyama

Mechanisms regulating localized PCA369 and global calcium responses in vascular cells Nikolaos Tsoukias*, Adam Kapela, Jaimit Parikh

Applications of pulse-driven magnetoimpedance sensors to biological magnetic fields

The effect of L-arginine on the function of the microvascular endothelium in healthy trained and sedentary subjects

PCA382

Hall 3, ICC

*Denotes presenting author

Bronchoconstrictor signal transduction involves protein kinase C-mediated phosphorylation of Kv7.5 potassium channels in human airway smooth muscle cells

PCA383

Jennifer Haick*, Lioubov Brueggemann, Jeffrey Prochot, Devjit Randhawa, Christopher Wigfield, Kenneth Byron

Study on mRNA and protein expression levels of small conductance calcium-activated potassium channel in human mesenteric artery from patients with hypertension

PCA388

Changes in the expression, the composition and the function of vascular L-type Ca2+ channels in a mouse model of essential hypertension

Sarka Tumova*, Bing Hou, Mohamed Amer, Lynn McKeown, Nicholas Moss, Yahya Bahnasi, Jing Li, Karen Porter, Asipu Sivaprasadarao, David Beech

José Lopez-Lopez*, Sendoa Tajada, Pilar Cidad, Olaia Colinas, Esperanza Alonso, Rodrigo de Pedro, Luis Santana, Teresa Perez-Garcia

PCA389

Identification of functional P2X receptors in rat middle cerebral arteries.

Rikuo Ochi*, Sukrutha Chettimada, Sachin Gupte

Myristoylated alanine-rich C kinase substrate (MARCKS) mediates activation of canonical transient receptor potential 1 (TRPC1) channels in vascular myocytes

Lynn McKeown*, Nicholas Moss, Paul Turner, Jing Li, Nikki Heath, Dermot Burke, O’Regan David, Mark Gilthorpe, Porter Karen, David Beech

Kv1.3 channel modulates human PCA387 vascular smooth muscle cells proliferation acting on ERK1/2 VS signaling pathway. Teresa Perez-Garcia, Pilar Cidad*, Eduardo Miguel-Velado, Christian Ruiz-McDavitt, Esperanza Alonso, Javier Lopez, Mirella Fernández, Yngrid Marroquín, José LópezLópez

GoSlo-SR-5-69: a novel, potent, efficacious BK channel activator Subhrangsu Roy*, Timothy Webb, Adebola Akande, Arvind Kshatri, Roddy Large, Keith Thornbury, Noel McHale, Gerard Sergeant, Mark Hollywood

Using BK channel chimaeras to identify the molecular site of action of the BK channel opener GoSlo-SR-5-6.

PCA395

M O N D A Y

Hydrogen sulfide inhibits PCA396 recombinant T-type Ca2+ channels

PCA390

VS Deletion of the ion channel TRPV4 increases detrusor contractility in the mouse

Jian Shi*, Lutz Birnbaumer, William Large, Anthony Albert

PDGF maintains stored calcium PCA386 through a non-clustering Orai1 mechanism but evokes clustering VS if the ER is stressed by store depletion

Oleksandr Povstyan*, Claire Nichols, Maksym Harhun

Jacobo Elies*, Mark Dallas, Jason Scragg, John Boyle, Chris Peers

Overload of cholesterol inhibits PCA385 L-type Ca2+ channel current and augments its voltage-dependent VS inactivation in A7r5 cells

PCA394

Regis Azizieh*, Akinori Ohno, Susumu Ohya, Yoshiaki Suzuki, Hisao Yamamura, Yuji Imaizumi

Liang Mao, Tao Li, Huan Lan, Wen-jun Huang, Rui Zhou, Chang Li, Peng-yun Li, Yan Yang, Xiao-rong Zeng*

Heteromultimerization with PCA384 TRPC1 affects TRPC5 channel function by regulating its plasma VS membrane residence and cholesterol-triggered retraction.

There gulatory mechanis munderlying the enhanced expression of large conductance Ca2+ activated K+ channel by testosterone

PCA397

Antonio Ramos-Filho, Florence Johnson, Edson Antunes, Andrew Grant*

PCA391

Rapid androgen effects on PCA398 potassium channels in human coronary artery endothelial cells

Katesirin Ruamyod*, Wattana Watanapa, Chairat Shayakul

PCA392

Timothy Webb*, Roddy Large, Arvind Kshatri, Subhrangsu Roy, Adebola Akande, Gerard Sergeant, Noel McHale, Keith Thornbury, Mark Hollywood

Endogenously-generated lipid peroxidation products dilate rat cerebral arteries by activating transient receptor potential channel ankyrin 1 in the endothelium

PCA399

Michelle Sullivan*, Allison Bruhl, Scott Earley

A mathematical model of PCA393 pacemaking activity in interstitial cells of Cajal VS Jae Boum Youm*, Hyoung Kyu Kim, Hye-Jin Heo, Nari Kim, Byung Joo Kim, Chae Hun Leem, Jin Han

Poster Communications - Monday 22 July NO stimulates BKCa channels in smooth muscle cells of human mesenteric artery

PCA400

Yan Yang*, Jun Cheng, Jing Wen, Peng-yun Li, Chang Li, Zhi-fei Liu, Xiao-rong Zeng**

Segregated calcium stores are important for stretch-induced calcium signaling in smooth muscle cells: implication in pulmonary hypertension

PCA406

Gilbert Guillaume*, Thomas Ducret, Roger Marthan, Jean-Pierre Savineau, JeanFrancois Quignard

Voltage dependent potassium channels remodeled in hypertrophic intestinal smooth muscle cells induced by partial obstruction in murine

Molecular identification of P2X receptors in human arteries Claire Nichols*, Oleksandr Povstyan, Omar Khan, Georgios Vasilikostas, Teck Khong, Andrew Wan, Marcus Reddy, Maksym Harhun

PCA402

Nada Abuarab*, Melanie Ludlow, Javeriah Ayub, Lin-Hua Jiang, Asipu Sivaprasadarao

Mutation of R317 in the BK PCA403 channel splice variant Slo1_9a partially restores the effect of the VS GoSlo-SR-5-6. Arvind Kshatri*, Timothy Webb, Roddy Large, Subhrangsu Roy, Gerard Sergeant, Noel McHale, Keith Thornbury, Mark Hollywood

PCA407

Different regulatory effects of H2S and NO on gastric motility in mice

Dominika Bijos, Marcus Drake, Bahareh Vahabi*

Effect of ethanol exposure on slow wave activity and smooth muscle contraction in the small intestine

Electrical propagation in the guinea pig urinary bladder Wim Lammers*, John Morrison, Loay Lubbad, Betty Stephen, Fayez Hammad

Caveolins in the gastrocnemius muscle of STZ and diet induced diabetic rats Qin Huang*

PCA414

Quantification of urinary exosomes by nanoparticle tracking analysis

PCA415

Wilna Oosthuyzen*, Emma Turtle, Jonathan Street, John Pound, David Webb, Christopher Gregory, Matthew Bailey, James Dear

PCA409

Comparison of the phasic activity PCA416 of upper, middle and lower segments of pig ureter

Motaz ElMahdy*, Marcus Drake, Bahareh Vahabi

PCA410

Wim Lammers*, Sandeep Subramanya, Betty Stephen, Herbert Schäfer

PCA405

Gender differences in the response to salt stress in uninephrectomised SpragueDawley rats Ahmed Oloyo*, Oluwashola Oyeniyi, Yewande Oduneye, Oluwatorinmo Salau, Olusoga Sofola

Methanol extract of Poncirus PCA408 fructus modulates pacemaker activity in interstitial cells of Cajal VS from the murine small intestine

Xu Huang*, Xiang-Min Meng, Dong-Hai Liu, Yi-Song Wu, Xin Guo, Hong-LI Lu, Wen-Xie Xu

Identification and PCA404 characterization of the functional role of calcium-activated chloride VS channel anoctamin-1 (ANO1) in rat urinary bladder

Harry A. Pritchard*, Anthony Albert, Iain Greenwood

Kaushik Sarkar*, Panchali Tarafder, Mouri Ghosh, Amit Ghati, Goutam Paul

Byung Joo Kim*, Hyung Woo Kim, Seok Choi, Jae Yeoul Jun, Insuk So, Seon Jeong Kim

Cholesterol depletion reveals an inhibitory role of PIP2 on Ca2+activated Cl- Channel activity in rat pulmonary arteries.

PCA413

PCA401

Dong-Hai Liu*, Xu Huang, Xin Guo, XiangMIn Meng, Yi-Song Wu, Hong-Li Lu, ChunMei Zhang, Wen-Xie Xu

TRPM2 mediated zinc redistribution mediates H2O2 induced endothelial cell death

Inhibition of duodenal movement in vitro of rat by Bisphenol A through nitric oxide mediated guanylyl cyclase and α-adrenergic pathways

The effects of cannabinoid PCA417 receptor 1 on capsaicin/ bradykinin-induced activity of VS afferent nerve in an ex vivo rat ectopic endometrium preparation Guohua Zhang*, Biying Sun, Weifang Rong

PCA411

PCA412

Combined endothelial progenitor PCA418 cells (EPCs) and mesenchymal stem cells (MSCs) can enhance VS wound healing in diabetic mice model associated with increased VEGF and decrκeased neutrophil infiltration. S. Sukpat*, N. Israsena, S. Patumraj

Other Activities Monday 22 July 10.30 – 12.30

Faraday Room (Austin Court)

Associate Editors Meeting, Physiological Reports

12.00 – 14.00

Executive Room 9 (The ICC)

Benevolent Fund Trustees Meeting and Annual General Meeting, The Physiological Society

13.00 – 14.00

Hall 9 (The ICC)

Telemetry in Neuroscience Research: Exploring Experimental Models of Sleep and Epilepsy sponsored by Data Sciences International

13.00 – 14.00

M O N D A Y

Faraday Room (Austin Court)

Committee Meeting, British Microcirculation Society

13.00 – 14.00

Lodges Room (Austin Court)

Editorial Board, Physiological Reports

13.00 – 14.00

Sonata Room (Hyatt Regency Hotel)

Effective presentation skills

16.00 – 17.00

Faraday Room (Austin Court)

Council Meeting, European Vascular Biology Organisation

16.00 – 18.00

Executive Room 9 (The ICC)

International Liaison Committee for Microcirculation

17.30 – 18.30

Hall 7 (The ICC)

Annual General Meeting, European Vascular Biology Organisation

17.30 – 19.00

Hall 3 (The ICC)

European Launch, Physiological Reports

17.30 – 19.00

Executive Room 8 (The ICC)

Joint Acta FEPS Committee Meeting

Free public event Annual Public Lecture of The Physiological Society

The Rhythms of Life What your body clock means to you from eye disease to jet lag Russell Foster, University of Oxford, UK 7.30pm - 8.30pm, Monday 22 July Hall 1, The ICC Birmingham, UK Find out more at www.iups2013.org 56

Better Data. Better Science.

Integrated Physiologic Monitoring Solutions for Life Science Research DSI exhibiting at IUPS Booth #32 Lunch-time Industry Session

When: 22, July 2013 from 13:00-14:00 Where: Hall 9, ICC

Telemetry in Neuroscience Research: Exploring Experimental Models of Sleep and Epilepsy Data Sciences International (DSI) will host a one-hour luncheon featuring the following scientific presentations: 1. “Differential effects of day versus night-time dosing with diazepam on sleep-wake patterns in telemetered, freely moving rats.” Haifeng Weia, Fei-Yue Zhaoa, Ross Jeggoa and David Spanswicka,b a Neurosolutions Ltd, bUniversity of Warwick, Coventry, UK 2. “Radiotelemetry in epilepsy models.” Professor John Jefferys, University of Birmingham, Birmingham, UK Please join us to learn more about the unique research applications being explored by each of these presenters. Lunch and refreshments will be served. www.datasci.com 57

Free public event Are you the strongest person in Birmingham? What does the inside of your body look like? How much air fits in your lungs? What happens to you when you exercise?

Meet real scientists in their ‘Lab in a Lorry’ with hands-on activities for all the family Monday 22 July to Wednesday 24 July 11.00am – 4.00pm Centenary Square, Birmingham, UK 58

At a glance - Tuesday 23 July Keynotes

8.30 – 9.15

Ole H Petersen Takayuki Asahara Erin Schuman

Hall 1 (The ICC) Hall 4 (The ICC) Hall 8 (The ICC)

Morning symposia

9.30 – 11.30

Physiology of fasting and starvation Stem and progenitor cells in vascular remodelling and repair Dysfunctional chemoreceptors: Cause or consequence of the symptoms of cardiores… The Good, the Bad and the Ugly: New mechanisms of neuronal and glial signalling in… The role of toxic Ca signals in initiating pancreatitis and promoting pancreatic cancer Perivascular fat: Role in metabolic and cardiovascular disease From perceiving to acting: Neurophysiological mechanisms of conscious visual perception Historical perspectives on early physiology, 1870-1960 Transverse tubules in the heart: Normal physiology and involvement in disease Mammalian nutrient sensing Bicarbonate transport in normal and cancerous tissues An integrated approach to the physiology of organic cation transporters

Hall 1 (The ICC) Hall 4 (The ICC) Hall 5 (The ICC) Hall 6 (The ICC) Hall 7 (The ICC) Hall 8 (The ICC) Hall 9 (The ICC) Hall 10 (The ICC) Hall 11 (The ICC) Symphony Ballroom (Hyatt) Sonata Room (Hyatt) Kingston Theatre (Austin Court)

Plenary

11.45 – 12.45

Peter Carmeliet

Hall 1 (The ICC)

Lunchtime sessions

13.00 – 14.00

TR(i)P to Automated Patch Clamp Sponsored by Nanion Technologies Women in Science: Why mentoring and sponsorship works Effective presentation skills Statistics: The Emperor’s clothes

Hall 9 (The ICC)

Afternoon symposia

14.15 – 16.15

Local Ca2+ signals: Mechanism and function Potassium channel complexes: Dynamic aspects of the assembly and regulation… Understanding the brain mechanisms of chronic pain Multidisciplinary approaches to understanding synaptopathies New insights into the acid-base microclimate as an integral regulator of epithelial… Angiogenesis: Growth points Mother, placenta, fetus and life long health Using narratives and stories to enhance learning Leukocyte recruitment in inflammation The activation of skeletal muscles - implications for fatigue Ethical issues in physiology - synthetic biology: Scientific progress or ethical dilemma? Development and functional organisation of neural circuits controlling breathing

Hall 1 (The ICC) Hall 4 (The ICC) Hall 5 (The ICC) Hall 6 (The ICC) Hall 7 (The ICC) Hall 8 (The ICC) Hall 9 (The ICC) Hall 10 (The ICC) Hall 11 (The ICC) Symphony Ballroom (Hyatt) Sonata Room (Hyatt) Kingston Theatre (Austin Court)

Keynotes

16.30 – 17.15

Graham J Dockray Sumantra Chattarji Mark Hanson

Hall 1 (The ICC) Hall 4 (The ICC) Hall 5 (The ICC)

Formal Poster session B - Hall 3 (The ICC)

17.15 – 19.15

Congress Dinner

19.30

T U E S D A Y

Hall 10 (The ICC) Sonata Room (Hyatt) Hall 8 (The ICC)

The Mall (The ICC)

Research Symposia - Tuesday 23 July

09.30 – 11.30

Physiology of fasting and starvation

Stem and progenitor cells in vascular remodelling and repair (ESM and EVBO)

Perivascular fat: Role in metabolic and cardiovascular disease (ESM and EVBO)

Hall 1 (The ICC)

Hall 4 (The ICC)

Hall 8 (The ICC)

Organised by Marshall McCue St. Mary’s University, USA Teresa Valencak University of Veterinary Medicine

Organised by Neena Kalia University of Birmingham, UK Mark Majesky Seattle Children’s Research Institute, USA

Organised by Alfons Houben Cardiovascular Research Institute

Vienna, Austria

Maastricht – MUMC, The Netherlands

Etto Eringa VU University Medical Centre, The Netherlands

09.30

SA114

Muscle protein and strength retention by bears during winter fasting and starvation Henry Harlow University of Wyoming, USA

10.00

SA115

SA119

09.30

The adventitia: a dynamic interface containing resident progenitor cells Mark Majesky Seattle Children’s Research Institute,

Molecular actions of adipokines Maik Gollasch Charité University Medicine, Germany

10.00

USA

SA120

SA123

Direct measurements of substrate oxidation using 13CO2 breath testing reveals shifts in fuel mix during starvation Marshall McCue St. Mary’s University, USA

Enhancing stem cell recruitment within the microcirculation - chemokines, chemicals and caveats Dean Kavanagh University of Birmingham, UK

Perivascular adipose tissue as a determinant of organ perfusion Etto Eringa VU University Medical Centre, The

10.15

10.30

Differential mobilization and use of fatty acids during fasting Teresa Valencak University of Veterinary Medicine

Vascular differentiation of mesenchymal stem cells: regulation by PDGF receptors Cay Kielty University of Manchester, UK

Adipokine signaling and angiogenesis Anne Bouloumie INSERM, France

10.45

11.00

SA116

Vienna, Austria

SA117

SA121

Alternate day fasting: a novel dietary restriction regimen for weight loss in humans Krista Varady University of Illinois, USA

Identification of resident c-kit expressing vascular endothelial stem cells on the adult blood vessel wall Shentong Fang University of Helsinki, Finland

11.00

SA118

Netherlands

SA124

SA125

PVAT function in obesity: mechanisms and therapy Anthony Heagerty University of Manchester, UK

SA122

Thermoregulatory adaptations to starvation and cold in birds Esa Hohtola University of Oulu, Finland

Pericytes for cardiovascular repair: a roadmap towards first-in-man trial Paolo Madeddu Bristol Royal Infirmary, UK

Sponsored by:

Scandinavian Physiological Society

ESM & EVBO programme

ME 62

09.30

Transverse tubules in the heart: Normal physiology and involvement in disease

Dysfunctional chemoreceptors: Cause or consequence of the symptoms of cardiorespiratory disease?

From perceiving to acting: Neurophysiological mechanisms of conscious visual perception

Hall 11 (The ICC)

Hall 5 (The ICC)

Hall 9 (The ICC)

Organised by David Eisner University of Manchester, UK William Louch University of Oslo, Norway

Organised by Prem Kumar University of Birmingham, UK Luciane Gargaglioni Sao Paulo State University, Brazil

Organised by Erik Cook McGill University, Canada Kristine Krug University of Oxford, UK

09.30

SA126

Cardiac t-tubules as a specialised microdomain for trans-sarcolemmal Ca flux and its regulation in health and disease Clive Orchard University of Bristol, UK

SA131

SA136

Development of CO2 chemoceptive respiratory circuits in the mouse embryo: Insights into congenital central hypoventilation syndrome? Gilles Fortin CNRS, Institut de Neurobiologie Alfred

Perception and the expectation of reward Kristine Krug University of Oxford, UK

10.00

Fessard, France

10.00

SA127

SA132

SA137

Optical recording of action potential propagation in transverse-axial tubular system Leonardo Sacconi European Laboratory for Non-

Do the carotid bodies modulate heart rate variability and baroreflex control of blood pressure in humans? Erica Wehrwein Michigan State University, USA

Reconciling rapid neuronal and perceptual adaptation to motion Nicholas Price Monash University, Australia

10.15

Linear Spectroscopy/University of Florence, Italy

SA128

Plasticity of cardiomyocyte t-tubules Ole M Sejersted University of Oslo, Norway

10.45

SA129

SA133

Central chemoreceptors in developing heart failure Alexander Gourine University College London, UK

10.45

SA134

SA138

Perception and action in three-dimensional vision Peter Janssen Katholieke Universiteit Leuven,

Belgium

10.45

SA139

Functional significance of atrial t-tubules: effects of heart failure Katharine Dibb University of Manchester, UK

Significance of the carotid body in insulin resistance and hypertension Silvia Conde Universidade NOVA de Lisboa, Portugal

The neural mechanisms involved in finding objects and switching between targets Nicole Rust University of Pennsylvania, USA

11.00

SA130

SA135

SA140

Noradrenergic neurons and control of the central and peripheral chemoreflex Luciane Gargaglioni Sao Paulo State University,

Brazil

Progression of target-to-gaze command coding in superior colliculus and frontal eye fields during head unrestrained gaze shifts Douglas Crawford York University, Canada

Sponsored by:

Scandinavian Physiological Society

Brazilian Physiological Society

Canadian Physiological Society

Towards understanding the mechanism of T-tubule remodeling in cardiac disease Long-Sheng Song University of Iowa, USA

T U E S D A Y

N 63

Research Symposia - Tuesday 23 July Mammalian nutrient sensing

09.30 – 11.30

Historical perspectives on early physiology, 1870-1960

An integrated approach to the physiology of organic cation transporters

Hall 10 (The ICC)

Kingston Theatre (Austin Court)

Organised by Daniela Riccardi Cardiff University, UK Willis Samson Saint Louis University, USA

Organised by Jonathan Reinarz University of Birmingham, UK

Organised by Giuliano Ciarimboli University of Münster, Germany Sophie Gautron UMRS952/UMR7224, France

09.30

Symphony Ballroom (Hyatt Regency Hotel)

SA141

SA146

SA151

Nutrient sensing of Group C GPCRs Hans Bräuner-Osborne University of Copenhagen,

The growth of academic physiology in Britain, 1860-1930 Stephen Jacyna University College London, UK

OCTs: quintessential multidrug transporters Stephen Wright University of Arizona, USA

10.00

Denmark

SA142

SA147

Dietary programming of hypothalamic nutrient-sensing Nina Balthasar University of Bristol, UK

Unusual Patients: Sport and Exercise Medicine since c.1850 Vanessa Heggie University of Birmingham, UK

10.15

10.30

SA143

Brain lipid sensing and nervous control of energy balance Barry Levin VA Medical Center, USA

SA148

The prevention and the treatment of frostbite in the early twentieth century Lauren Howarth University of Brirmingham, UK

SA152

Cellular processing of organic cation transporters (OCT) Beatrice Hirsch University Hospital Münster,

Germany

10.15

SA153

An “Omics” view of Oats and Octs: the remote sensing and signaling hypothesis Sanjay Nigam University of California, San Diego, USA

10.45

SA144

10.45

SA149

10.45

Neural circuitry organizing behavioral responses to nutrient and electrolyte availability Gina Yosten Saint Louis University, USA

The Silver Hut Expedition: A seminal research expedition into high altitude medicine Roberta Rabbitts University of Birmingham, UK

Exploring OCT physiological functions in the bronchial epithelium Cynthia Bosquillon University of Nottingham, UK

11.00

SA145

Physiological biased signaling by the actions of Ca2+o or L-amino acids on the calcium-sensing receptor Arthur Conigrave University of Sydney, Australia

SA150

Historical aspects of the physiology of high altitude John West University of California, San Diego, USA

American Physiological Society

SA155

Organic cation transporter 2 controls response and vulnerability to stress Sophie Gautron UMRS952/UMR7224, France

Sponsored by:

SA154

The role of toxic Ca signals in initiating pancreatitis and promoting pancreatic cancer Hall 7 (The ICC)

The Good, the Bad and the Ugly: New mechanisms of neuronal and glial signalling in the injured spinal cord Hall 6 (The ICC)

Organised by Ole Petersen Cardiff University, UK Péter Hegyi University of Szeged, Hungary

Organised by Anne King University of Leeds, UK José Lopez-Garcia University of Alcala, Spain

Organised by Walter Boron

09.30

SA156

SA161

TRPC, Orai1 and STIM1 in physiological and pathological Ca2+ influx Shmuel Muallem National Institutes of Health (NIH),

Altered excitability of dorsal horn neurons José Lopez-Garcia University of Alcala, Spain

10.00

USA

SA157

SA162

Bicarbonate transport in normal and cancerous tissues Sonata Room (Hyatt Regency Hotel)

Case Western Reserve University, USA

SA166

Regulation and roles of the Na+HCO3cotransporter NBCn1 (SLC4A7) and the Na+/H+ exchanger NHE1 (SLC9A1) in breast cancer Stine Pedersen University of Copenhagen, Denmark

10.00

SA167

Protective role of calmodulin in pancreatic toxicity Julia Gerasimenko Cardiff University, UK

Mitochondrial dysfunction in chemotherapy-induced neuropathy Sarah Flatters King’s College London, UK

Physiological role of Na+-coupled HCO–3 transporters deduced from knockout studies Anne Sinning Jena University Hospital, Germany

10.15

SA158

SA163

Pancreatic Stellate Cells (PSCs): a starring role in pancreatitis and pancreatic cancer Minoti Apte University of New South Wales, Australia

Microglia causing neuropathic pain after nerve injury Kazuhide Inoue Kyushu University, Japan

Role of CAIX and CAXII in cancer Jacques Pouysséger CNRS – Nice, France

10.45

SA159

SA164

The effects of pancreatitis-inducing factors on calcium signaling in pancreatic ductal cells Péter Hegyi University of Szeged, Hungary

BDNF-induced plasticity before and after SCI Sandra Garraway Texas A&M University, USA

Structure-function relationships of Na+coupled HCO–3 transporters Mark Parker Case Western Reserve University, USA

11.00

SA160

Calcium signaling and pancreatic stellate cell function David Yule University of Rochester, USA

Altered inhibition in dorsal horn circuits and strategies for pharmacological restoration Hanns Ulrich Zeilhofer University of Zurich, Switzerland

SA165

T U E S D A Y

SA168

Role of exofacial carbonic anhydrase, NaHCO3 co-transport, and connexin channels in the spatial control of intracellular pH in multicellular tumour cell growths and myocardial tissue Richard Vaughan-Jones University of Oxford, UK

EM 65

Research Symposia - Tuesday 23 July

14.15 – 16.15

Local Ca2+ signals: Mechanism and function

Potassium channel complexes: Dynamic aspects of the assembly and regulation towards their physiological roles

Angiogenesis: Growth points (ESM and EVBO)

Hall 1 (The ICC)

Hall 4 (The ICC)

Hall 8 (The ICC)

Organised by Anant Parekh Oxford University, UK Barbara Niemeyer Saarland University, Germany

Organised by Yoshihiro Kubo National Institute for Physiological

Sciences, Japan

Organised by Stuart Egginton University of Leeds, UK Kari Alitalo University of Helsinki, Finland

14.15

SA169

Should I stay or should I go? – Regulating Orai function Barbara Niemeyer Saarland University, Germany

Bernard Attali Tel-Aviv University, Israel

SA173

Native neuronal Kv4-encoded channels function in macromolecular protein complexes Jeanne Nerbonne Washington University Medical

14.15

SA178

Therapeutic potential of endothelial growth factors and receptors Kari Alitalo University of Helsinki, Finland

School in St. Louis, USA

14.45

SA170

Physiological functions of store-operated calcium entry James Putney National Institute of Health and

Environmental Sciences, USA

14.45

SA174

SA171

Decoding calcium signalings for cancer progression Yih-Fung Chen National Cheng Kung University, Taiwan

Distinguishing neuropilin signalling in angiogenesis, arteriogenesis and vascular permeability Christiana Ruhrberg University College London, UK

15.00

SA175

SA172

STIM proteins, Ca2+ oscillations and gene expression Anant Parekh Oxford University, UK

Sponsored by:

Formation of microvascular networks: role of stromal interactions directing endothelial growth James Hoying University of Louisville, USA

15.30

SA176

The intermediate filament cytoskeleton plays a key role in endothelial sprout initiation Kayla Bayless Texas A&M Health Science Center, USA

15.45

SA177

Role of KCNQ4 K+ channels in sensory biology Thomas Jentsch Leibniz-Institut für Molekulare

Shear stress induced angiogenesis - origins and developments Roy Bicknell & Stuart Egginton University of

Pharmakologie im Forschungsverbund Berlin e.V. (FMP), Germany

Birmingham & University of Leeds, UK

Sponsored by:

ESM & EVBO programme

SA181

The regulation of KCNQ channels by phosphoinositides Stephen Harmer Queen Mary, University of London,

Physiological Society of Japan

SA180

Gated motions and assembly modalities of the IKS potassium channel complex Bernard Attali Tel Aviv University, Israel

15.45

SA179

Dynamic aspects of the subunit stoichiometry of the KCNQ/KCNE channel complex Koichi Nakajo National Institute for Physiological

Sciences, Japan

15.15

14.45

Leukocyte recruitment in inflammation (ESM and EVBO)

Understanding the brain mechanisms of chronic pain

Mother, placenta, fetus and life long health

Hall 11 (The ICC)

Hall 5 (The ICC)

Hall 9 (The ICC)

Organised by Markus Sperandio Ludwig-Maximilians Universität,

Organised by Jun Chen The Fourth Military Medical University (Xi’an),

Organised by Rohan Lewis University of Southampton, UK Susan Greenwood University of Manchester, UK

Germany

14.15

China

Irene Tracey University of Oxford, UK

Paul Kubes University of Calgary, Canada

SA182

14.15

Recruitment and role of platelets and leukocytes in models of infection and immunity Paul Kubes University of Calgary, Canada

Neuroimaging of pain in the human brain Irene Tracey University of Oxford, UK

Maternal environment, placental phenotype and fetal growth Abigail Fowden University of Cambridge, UK

14.45

SA183

SA186

SA190

14.45

SA191

Leukocyte recruitment during angiogenesis Mia Phillipson Uppsala University, Sweden

Molecular correlates of pain in the anterior cingulate cortex Long-Jun Wu Rutgers University, USA

An integrated approach to amino acid transfer and its regulation Jane Cleal University of Southampton, UK

15.00

SA184

SA187

SA192

Regulation of endothelial junctions in leukocyte extravasation Dietmar Vestweber Max Planck Institute for

Maladaptive brain plasticity in pain: amygdala and prefrontal cortex Volker Neugebauer University of Texas Medical

Maternal obesity and placental function Theresa Powell University of Texas Health Science

Molecular Biomedicine, Germany

Branch, USA

15.30

Leukocyte recruitment during inflammation is modulated by S100A9 Monika Prünster Ludwig-Maximilians Universität,

Central neuronal mechanisms underlying the central post stroke pain Bai Chuang Shyu Institute of Biomedical Sciences,

Targeted delivery of drugs to the placenta to improve treatment of pregnancy pathologies Lynda Harris University of Manchester, UK

15.45

Germany

SA185

Mode and dynamics of neutrophil transmigration in vivo Sussan Nourshargh Queen Mary, University of

London, UK

SA188

Taiwan

SA189

Functional changes in entorhinalhippocampal circuits may contribute to pain-associated object recognition memory impairment Jun Chen The Fourth Military Medical University,

T U E S D A Y

Center San Antonio, USA

SA193

SA194

Diabetes mellitus and the placenta: The key role of maternal and fetal insulin Gernot Desoye Medical University of Graz, Austri

China

Sponsored by:

ESM & EVBO programme

The Chinese Association of Physiological Sciences

ME 67

Research Symposia - Tuesday 23 July The activation of skeletal muscles - implications for fatigue

Using narratives and stories to enhance learning

Development and functional organisation of neural circuits controlling breathing

Symphony Ballroom (Hyatt Regency Hotel)

Hall 10 (The ICC)

Kingston Theatre (Austin Court)

Organised by Ole Bækgaard Nielsen Aarhus University, Denmark Janet Taylor University of New South Wales, Australia

Organised by Frank Mojiminiyi Usman Danfodio University, Nigeria Penelope Hansen Memorial University of Newfoundland,

Organised by Alexander Gourine University College London, UK Muriel Thoby-Brisson Université Bordeaux, France

14.15

SA195

Canada

SA198

SA203

Effects of muscle fatigue and exercise on the way in which the nervous system drives the muscles during voluntary contractions Janet Taylor University of New South Wales, Australia

Weaving laboratory data into true stories from patients and their families Tony Macknight ADInstruments, New Zealand

An inhibitory connectome controls the respiratory rhythm in vivo Diethelm Richter University of Göttingen, Germany

14.45

SA196

SA199

SA204

A model of motoneuron behavior and muscle-force generation for sustained isometric contractions Paola Contessa Boston University, USA

Anecdotes in the learning of physiology Adesina Arikawe University of Lagos, Nigeria

Purinergic modulation of preBötzinger complex inspiratory rhythm generating networks Jennifer Zwicker University of Alberta, Canada

15.15

15.00

Regulation of excitability of active muscles relation to muscle fatigue Thomas Holm Pedersen Aarhus University,

Enlivening physiology teaching with African folklore Frank Mojiminiyi Usman Danfodio University, Nigeria

Role of synaptic inhibition for respiratory rhythm and pattern formation Ana Abdala University of Bristol, UK

15.30

Denmark

15.45

SA197

What experiments with intact single muscle fibres tell us about the role of calcium in muscle fatigue in mammalian skeletal muscle Joseph Bruton Karolinska Institute, Sweden

HE 68

14.15 – 16.15

SA200

SA201

SA205

SA206

A narrative of the Facebook-PhysBook learning community Hwee Ming Cheng University of Malaya, Malaysia

Electrophysiological properties of the brainstem respiratory neurones in rats submitted to chronic intermittent hypoxia Davi Moraes University of São Paulo, Brazil

15.45

Using everyday situations to teach integrative physiology Penelope Hansen

SA202

Memorial University of Newfoundland, Canada

SA207

Emergence and maturation of the respiratory oscillator during embryonic development Muriel Thoby-Brisson Université Bordeaux, France

New insights into the acid-base microclimate as an integral regulator of epithelial function in health and disease

Multidisciplinary approaches to understanding synaptopathies

Hall 7 (The ICC)

Hall 6 (The ICC)

Organised by Michael Gray Newcastle University, UK Ursula Seidler Hannover Medical School, Germany

Organised by John Jefferys University of Birmingham, UK Sumantra Chattarji Tata Institute of Fundamental

Ethical issues in physiology synthetic biology: Scientific progress or ethical dilemma? Sonata Room (Hyatt Regency Hotel)

Research, India

Organised by Theophile Godfraind Université catholique de Louvain, Belgium

Penny Moody-Corbett Memorial University of Newfoundland, Canada

14.15

SA208

Using transgenic animal models to understand the role and regulation of the gastrointestinal surface pH microclimate Ursula Seidler Hannover Medical School, Germany

14.15

SA213

Homeostatic responses fail to correct defective amygdala inhibitory circuit maturation in Fragile X syndrome Molly-Maureen Huntsman University of

14.15

SA218

Selected scientific topics on synthetic biology François Képès Genopole®, CNRS, France

Colorado, USA

14.45

SA209

14.45

SA214

14.45

SLC26A8 and CFTR cooperation in the regulation of anions exchanges during sperm motility and activation Aminata Touré

Abnormal thalamocortical activation of somatosensory cortex in the young Fmr1KO mouse model of Fragile X Syndrome Aleksander Domanski University of Edinburgh, UK

Ethical aspects of the use of animals containing human material Thomas Baldwin University of York, UK

15.00

15.15

Institute Cochin, INSERM, France

SA210

SA215

SA219

Airways surface liquid pH: regulation of ion transport by novel acid-sensitive soluble mediators Robert Tarran University of North Carolina, Chapel

Altered vesicle dynamics and neuronal synchrony in a mouse model of mental retardation Andrew Powell University of Birmingham, UK

Legal knowledge gaps and constructs in synthetic biology – a comparative review of the state of the art Djims Milius McGill University, Canada

15.30

Hill, USA

SA211

SA216

SA220

Luminal pancreatic ductal acid-base microclimate and pancreatic disease Viktoria Venglovecz University of Szeged, Hungary

Troubled translation in Fragile X Emily Osterweil Massachusetts Institute of

Who owns living organisms issued from synthetic biology? Catherine Rhodes University of Manchester, UK

15.45

16.00

SA212

Unraveling secreted mucins by luminal HCO3- ions Paul Quinton University of California, San Diego, USA

Technology, USA

SA217

Synaptic alterations in animal models of Rett syndrome Tommaso Pizzorusso University of Florence, Italy

T U E S D A Y

SA221

Biotechnology and use of living: a public matter Dorothée Benoit Browaeys VivAgora, France

Sponsored by: The Federation of European Physiological Societies

GI 69

Poster Communications - Tuesday 23 July Inhibition of the ventricular function of rat by Bisphenol A Panchali Tarafder*, Kaushik Sarkar, Goutam Paul

Relationship between chronic kidney disease and left ventricular mass independent of haemodynamic factors in an African community sample

PCB001

Congenital Heart Diseases (CHD) PCB007 and role of NKx 2.5 in Pakistani population

Afsheen Arif*, Syeda Qamarunissa, Sitwat Zehra, Abid Azhar

PCB002

Fabian Maunganidze*, Norton Gavin, Angela Woodiwiss

Signal Transducer and Activator PCB003 of Transcription 3 (STAT3) and heart failure with age: A positionCR dependent gene knock out model in mice Aqeela Imamdin*, Joy McCarthy, Sandrine Lecour, Karen Sliwa-Hanle, Neil Davies

Rudo Mapanga*, Mohamed Essop

Effect of oral administration of PCB005 levonogestrel with or without ethinyl estradiol on glucose CR tolerance and plasma lipid parameters in female Wistar rats Olugbenga Michael*, Lawrence Olatunji

Comparative effect of PCB008 ciprofloxacin and levofloxacin on systolic, diastolic and mean CR arterial blood pressure values of dogs Olutayo Omobowale*, Olayinka Oridupa, Babatola Fabiyi, John Abiola, Temitayo Ajibade, Temitayo Adeyeoluwa

Improvement of the anabolic-to- PCB009 androgenic ratio of nandrolone decanoate by 5α-reductase CR inhibition worsen its cardiac effects

Benfotiamine: a novel therapeutic PCB006 agent for the treatment of hyperglycemia-mediated cardiac CR contractile dysfunction

Testosterone in anabolic PCB010 concentration induces apoptosis of cardiomyocytes in vitro CR with involvement of tumor necrosis factor alpha and renin angiotensin system Andrews Nascimento*, Ewelyne Lima, Dominik Lenz, Denise Endringer, Giovanna Boechat, Tadeu Andrade

Enrichment of metabolic substrates diminish nitric oxide synthase-mediated antiadrenergic effect of insulin in LV myocytes from normal and hypertensive rats

PCB011

PCB012

PCB014

Hayley Crumbie*, Glenn Rodrigo, Iain Squire

Acute pre- or –post, ischaemic treatment with elevated extracellular glucose imparts a cardioprotection to isolated cardiomyocytes

PCB015

Charlotte Poile*, Iain Squire, Richard Rainbow

Induced automaticity in PCB016 the ventricular myocytes of transgenic mouse overexpressing CR HCN2 Kensuke Oshita*, Sachiyo Igata, Yoshihiro Kuwabara, Koichiro Kuwahara, Kazuo Ushijima, Makoto Takano

PCB017

Ian Temple*, Gillian Quigley, Oliver Monfredi, Tomoko Yamanushi, Min Zi, Elizabeth Cartwright, Vaikom Mahadevan, Mark Boyett, George Hart

The effects of gastric afferent autonomic activity on cardiac efferent autonomic balance in healthy human volunteers

Rudo Mapanga*, Buin Adams, Mohamed Essop

Nazare Bissoli, Polyana Dalpiaz*, Suely Figueiredo, Aline Lamas, Izabela Caliman, Ana Raquel Medeiros, Tadeu Andrade, Márcio Alves, Adriana Carmona, Washington Gonçalves, Margareth Moysés

Diurnal variation in sympathetic control of excitation-contraction coupling: the role of β3 adrenoceptors and nitric oxide

Arrhythmogenic profile of the atrium and atrioventricular node in pulmonary arterial hypertension

Zai hao Zhao*, Chun Zi Jin, Sung Joon Kim, Yin Hua Zhang

Coronary perfuse pressure is associated with angiotensinconverting enzyme (ACE) in female and with ACE2 activity in male SHR.

PCB013

Toyib Olaniyan*, Lawrence Olatunji

Girlandia Brasil*, Elizângela Mata, Andrerws Nascimento, Ewelyne Lima, Ieda Kalil, Denise Endringer, Giovanna Boechat, Nazaré Bissoli, Tadeu Andrade

Novel interventions to ameliorate PCB004 hyperglycemia-induced cardiac dysfunction following ischemiaCR reperfusion

Elevated myocardial oxygen consumption during cutaneous cold stress in young adult overweight and obese Africans

Lubobo Kazadi*, Janine Fletcher, Paul Barrow

PCB018

Hall 3, ICC

*Denotes presenting author

The transmembrane proteoglycan PCB019 syndecan-4 regulates cardiac myofibroblast differentiation in CR response to pressure overload, affecting extracellular matrix composition and myocardial stiffness Kate Herum*, Ida Lunde, Biljana Skrbic, William Louch, Almira Hasic, Ivar Sjaastad, Andreas Unger, Wolfgang Linke, Maria Gomez, Geir Christensen

AmphiphysinII controls t-tubule formation in cardiac muscle Jessica Caldwell*, David Eisner, Katharine Dibb, Andrew Trafford

PCB020

Fat tissue remodelling in persistent atrial fibrillation – 3D quantitative analysis using highresolution magnetic resonance imaging

PCB025

PCB027

Tahreem Iqbal*, Alicia D’Souza, Frank Howarth, Ernest Adeghate, Keshore Bidasee, Jaipaul Singh

Does the crista terminalis possess PCB021 a key role in the elevated risk of arrhythmogenic episodes in the CR elderly population? Fiona Hatch, Matthew Lancaster, Sandra Jones*

Prevention of β-adrenergic PCB032 myocardial damage by α-linolenic acid enriched diet

Anna Folino*, Andrea Sprio, Giovanni Berta, Gianni Losano, Raffaella Rastaldo

Jiung Pang Huang*, Li-Man Hung

The β3 agonist BRL37344 mediates a negative inotropic effect in rat atrial cells

Ageing further increases the PCB022 diversification between the atria in the expression of cellular CR calcium regulators: a substrate for increased arrhythmia risk?

Differences in intracellular calcium handling in rabbit atrial and ventricular myocytes.

Fiona Hatch*, Jennifer Waby, Matthew Lancaster, Sandra Jones

Hanne Gadeberg*, Cherrie Kong, Mark Cannell, Andrew James

Characterization of smallPCB023 conductance Ca2+-activated K+ channels in patients with chronic CR atrial fibrillation

Alterations to secreted levels of extracellular matrix moderators in young and aged ovine cardiac fibroblasts

MiaoLing Li*, Tao Li, Huan Lan, Liang Mao, Xianhong Ou, Chang Li, Yan Yang, XiaoRong Zeng

Margaux Horn*, Andrew Trafford

Dario Melgari*, Aziza El Harchi, Christopher Dempsey, Jules Hancox

Cardiac remodeling in obese and PCB033 non-obese insulin resistant rat models CR PCB028

CR Unaltered mitochondrial organization and compartmentation in creatine deficient GAMT-/- mouse cardiomyocyte

Cynthia Sam*, Tom Bolton, Ian Piper, Munan Al-Jobarah, Nicholas Freestone

Investigation of the interaction PCB024 between flecainide and hERG potassium channels, through the CR use of flecainide analogues

PCB031

Shuri Marui*, Mayumi Matsuda, Kei Nagashima

Carlos Afonso*, Bart Maesen, Rebecca A. Burton, Stef Zeemering, Daniel Stuckey, Damian Tyler, Ulrich Schotten, Peter Kohl, Vicente Grau

Left ventricle structural remodelling and cardiomyocyte contractile function in the streptozotocin-induced type 1 diabetic rat

The influence of estrogen on circadian rhythms of body temperature and heart rates in female rats

PCB029

PCB030

T U E S D A Y

PCB034

Jelena Branovets*, Mervi Sepp, Svetlana Kotlyarova, Natalja Jepihhina, Niina Sokolova, Dunja Aksentijevic, Craig Lygate, Stefan Neubauer, Marko Vendelin, Rikke Birkedal

Ivabradine reverses the PCB035 extracellular matrix changes and affects fibroblast number and CR phenotype in heart failure Priyanthi Dias*, Manoraj Navaratnarajah, Padmini Sarathchandra, Samha Alayoubi, James Cartledge, Najma Latif, Magdi Yacoub, Cesare Terracciano

Electrophysiological remodelling PCB036 in response to chronic mechanical load variations: A CR multicellular study Samha AlAyoubi*, Michael Ibrahim, James Cartledge, Magdi Yacoub, Cesare Terracciano, Patrizia Camelliti

Poster Communications - Tuesday 23 July Sarcoplasmic reticulum content is reduced by the RyR2 R4496C mutation at a range of frequencies in mouse cardiac myocytes

PCB037

Pak1 deficiency in cardiomyocytes increases in susceptibility to ventricular arrhythmogenesis in mice

PCB043

Regulation of the cardiac sodium/ PCB038 calcium exchanger by protein palmitoylation

Remodelling of the caveolar PCB044 domain in right ventricular failure in rats

Louise Reilly*, Michael Ashford, William Fuller

Ruth Norman*, Matthew Hardy, Ewan Fowler, Ed White, Sarah Calaghan

Pacemaker phenotype is the basis PCB039 of tachyarrhythmias originating in the atrioventricular rings and the CR right ventricular outflow tract

Lidocaine and tetrodotoxin are decreased upstroke velocity of the action potentials in cells of mouse sinoauricular node with slowest dV/dtmax

Sunil Jit Logantha*, Heiko Schneider, Andrew Atkinson, Guoliang Hao, Mark Boyett, Halina Dobrzynski

Increased sarcoplasmic reticulum PCB040 diastolic calcium leak can produce biphasic decay of the CR cardiac systolic calcium transient Rajiv Sankaranarayanan*, Yatong Li, David Greensmith, Andrew Trafford, David Eisner, Luigi Venetucci

The modulation of mitochondrial PCB041 Ca2+-uptake by inorganic phosphate, pH, adenosine CR phosphates and Mg2+ in single permeabilized ventricular myocytes of rat

PCB045

Regional action potential PCB050 heterogeneity in the sheep left ventricle- changes in heart failure CR and isolated dyssynchrony Graeme Kirkwood*, Mark Richards, Andrew Trafford

Freshly isolated adult fibroblasts PCB051 from normal and overloaded hearts affect viability, cell volume CR and calcium cycling of cardiac myocytes in co-culture by paracrine TGF-Î˛ signalling. James Cartledge*, Priyanthi Dias, Michael Ibrahim, Samha Alayoubi, Magdi Yacoub, Patrizia Camelliti, Cesare Terracciano

Elena Lebedeva*, Vladimir Golovko

Regional differences in PCB046 inflammation and fibrosis in rightand left-sided heart failure

Gillian Quigley*, Ian Temple, Min Zi, Elizabeth Cartwright, Tomoko Yamanushi, Xue Cai, Joseph Yanni, Halina Dobrzynski, George Hart, Mark Boyett

A chromanol-sensitive outward PCB052 potassium current contributes to the repolarization of action potential in mouse sino-auricular CR node cells. Mikhail Gonotkov*, Vladimir Golovko

Ultrastructural evidence of PCB047 cardiomyocyte apoptosis in acute myocardial infarction and chronic CR aneurism wall Yulian Kyyak, Olga Barnett*, Hryhoriy Kyyak, Oleg Leshchuk

Jeong-Hoon Lee*, Jeong-Mi Ha, Jae-Boum Youm, Chae Hun Leem

PCB049

Sander Land*, Steven Niederer, Daniel Stuckey, Markus Sikkel, Sian Harding, Nicolas Smith

Hoyee Tsui, Yanwen Wang*, Wei Liu, Ying Shi, Rui Wang, Yanmin Zhang, R. John Solaro, Yunbo Ke, Henggui Zhang, Derek Terrar, Elizabeth Cartwright, Xin Wang, Ming Lei

Carmine Circelli*, Luigi Venetucci, Andrew Trafford, David Eisner

Computational modelling of stress (Takotsubo) cardiomyopathy

NecroX-5 prevents hypoxia/ PCB042 reoxygenation injury by inhibiting the mitochondrial calcium CR uniporter

Rate-dependency of effective PCB048 electrical size in healthy and border-zone remodelled CR myocardium in small mammalian and human ventricular models: implications for modelling scarrelated arrhythmias

Thu Vu*, Hyoung-Kyu Kim, Thanh Long Le, Sung-Ryul Lee, Nari Kim, Jin Han

Yolanda Hill*, Asha Pavithran, Gernot Plank, Nicolas Smith, Martin Bishop

Can we automatically identify parameters from experiments? Modeling calcium dynamics in the rat cardiac myocytes

PCB053

Sara Gattoni*, Steven Niederer, Nicolas Smith

The direct anti-fibrillatory action PCB054 of vagus nerve stimulation is mediated by nitric oxide release CR from neuronal nitric oxide synthase James Winter*, Shui Chin, Kieran Brack, G. Andre Ng

Hall 3, ICC

*Denotes presenting author

Independent roles for PCB055 isoforms 1 and 4 of the plasma membrane calcium ATPase in the CR development of left ventricular hypertrophy and failure Nicholas Stafford*, Min Zi, Mohamed Shaheen, Sam Cook, Tamer Mohamed, Ludwig Neyses, Elizabeth Cartwright

Prolonged arsenic trioxide PCB056 treatment increased action potential duration and increased CR sensitivity to HERG channel blockade in induced pluripotent stem cells cardiomyocytes Maria Hortigon-Vinagre*, Iffath Ghouri, Francis Burton, Blake Anson, Robert Wallis, Margaret-Ann Craig, Godfrey Smith

Reduced expression of creatine PCB057 kinase and diastolic dysfunction in failing rat ventricular myocytes CR

Spontaneously contracting 3D in vitro heart model established from fish for the use in pharmacology

PCB061

PCB067

Bianka Grunow*, Lisa Mohamet, Holly Shiels

Soyeon Goo*, June-Chiew Han, Andrew Taberner, Poul Nielsen, Ian LeGrice, Denis Loiselle

The absence of interference PCB062 sounds present the phase shifting and signal missing on the heart CR sound spectral

Sensitivity of optical action PCB068 potentials recorded in cardiomyocytes derived from CR human induced pluripotent stem cells to a range of drugs

Nurida Finahari, Setyawan Sakti, Retty Ratnawaty*, M Rasjad Indra

Bupranolol blocks the cardiostimulatory effect of CGP12177 in rat atrial myocytes mediated via the low affinity β1-adrenoceptor

Iffath Ghouri*, Maria Hortigon-Vinagre, Robert Wallis, Francis Burton, Jon Cooper, Margaret-Ann Craig, Blake Anson, Godfrey Smith

PCB063

Cynthia Sam*, Tom Bolton, Ian Piper, Nicholas Freestone

Long non-coding RNAs are differentially expressed in heart failure

PCB069

Emma Robinson*, Syed Haider, Hilary Hei, Gregory Formovsky, Llewelyn Roderick, Roger S-Y Foo

Ewan Fowler*, Rachel Stones, Derek Steele, Ed White

Differential regulation of the PCB058 slow and rapid delayed rectifier potassium currents by cGMP CR dependent nitric oxide signalling pathways in isolated adult guinea pig ventricular myocytes

Dietary fat does not alter mechanical efficiency of the rat heart: an isolated working heart study

Isoprenaline induced changes of PCB064 action potential configuration, the role of Ca2+ and K+ currents of CR canine ventricular cells Kornél Kistamás*, Norbert Szentandrássy, László Bárándi, Bence Hegyi, Ferenc Ruzsnavszky, Krisztina Váczi, Tamás Bányász, János Magyar, Péter Nánási

T U E S D A Y

Exposure to rosiglitazone in late PCB070 gestation reduces cardiomyocyte size and cardiac metabolism in CR the sheep fetus S. Lie, M. Hui, I. McMillen*, B. Muhlhausler, G. Posterino, S. Dunn, K. Wang, K. Botting, J. Morrison

Rachel Caves*, Kieran Brack, Andre Ng, John Mitcheson

Regulation of Kv1.5 presence at the sarcolemma in atrial haemodynamic overload

PCB059

Camille Barbier*, Catherine Eichel, Nathalie Mougenot, Adeline Jacquet, Catherine Rucker-Martin, Florent Louault, Alain Coulombe, Stéphane Hatem, Elise Balse

The effect of stimulation PCB060 frequency on post-rest potentiation and calcium handling in sheep atrial myocytes CR Daniel Wrigley*, Andrew Trafford, Katharine Dibb

PDE5 inhibition reduces ICa-L and PCB065 systolic calcium transient in the failing sheep ventricle

Michael Lawless*, David Eisner, Andrew Trafford

Chamber-specific expression of sarcoplasmic reticulum Ca2+ATPase in healthy and diseased rat hearts Cynthia Sam*, Tom Bolton, Aarne Feldheiser, Ian Piper, Nicholas Freestone

PCB066

Systemic maternal inflammation PCB071 and neonatal oxidative stress affect postnatal cardiac function

Markus Velten*, Matthew Gorr, Dane Youtz, Christina Velten, Lynette Rogers, Loren Wold

L-arginine and asymmetric dimethyl arginine (ADMA) levels in human pericardial fluid in patients with open cardiac surgery

PCB072

Zoltan Nemeth*, Attila Cziraki, Sandor Keki, Bernadett Biri, Sandor Szabados, Ivan Horvath, Andrea Parniczky, Istvan Seffer, Attila Miseta, Akos Koller

Poster Communications - Tuesday 23 July Cardioprotection from insulin is dependent on ROS signalling at reperfusion and is abrogated when combined with ischemic postconditioning

PCB073

PCB079

Catherine Eichel*, Florent Louault, Gilles Dilanian, Maria Essers, Hugues Abriel, Alain Coulombe, Stéphane Hatem, Elise Balse

Erik Helgeland*, Lars Breivik, Anne Jonassen

Estrogen reduced the occurrence PCB074 of Takotsubo cardiomyopathy via balancing Gs /Gi protein signal CR pathway

Osmotic activation of Na+H+exchanger and Na+HCO3cotransporter in isolated rat ventricular myocytes

PCB075

Histones induce rat ventricular myocyte arrhythmia and cell necrosis

PCB080

Oxidation of DHA is responsible PCB076 for its anti-arrhythmic effects on mouse ventricular myocytes

Jérôme Roy*, Olivia Touzet-Mercier, Julien Roussel, Camille Oger, Jean-marie Galano, Edith Pinot, Thierry Durand, Jean-Yves Leguennec

PCB085

5-HT2 receptor activation maintains phrenic motor output following chronic cervical spinal cord injury

PCB086

Kun-Ze Lee*, Brendan Dougherty, Milap Sandhu, David Fuller

PCB081

Adam Bleakley*, Charlotte Evers, Adrian Duke, Zhaokang Yang, Derek Steele, Simon Harrison

Chokanan Thaitirarot*, Hayley Crumbie, Glenn Rodrigo

Smooth Muscle in Turtle Atrial Myocardium: Functional and Histological Evidence Sophie Saxton*, Jonathan Stecyk, Bren Gannon, Tony Farrell, Holly Shiels

Lukas Sottmann*, Pawel Swietach, Richard Vaughan-Jones

Di Sun, Chunle Zhou, Lin Zhang, Xiancun Cao, Lu Fu*, Lili Sang, Jingmin Chong, Shoulei Kang, Ying Liu, Hong Sun

The role of nitric oxide and Ca2+regulation in cardioprotection from remote ischaemic preconditioning

Regulation of a specific population of Nav1.5 channels by CASK

Phosphodiesterase type 4 PCB082 inhibition increases delayed afterdepolarizations upon CR β-adrenergic stimulation in cardiac myocytes: Role of protein kinase A and Ca2+/calmodulin kinase II.

Fractal correlation property of PCB087 heart rate variability in response to the active orthostatic test in CR healthy women José Cisternas*, Luiz Carlos de Abreu, Adriano Roque, Bianca de Castro, Lucas Ferreira, Heraldo Guida, Luiz Carlos Vanderlei, Vitor Valenti

Heart rate variability in healthy adolescents at rest Franciele Vanderlei*, Renata Rossi, Naiara de Souza, Denise de Sá, Tatiana Gonçalves, Carlos Pastre, Luiz Carlos de Abreu, Vitor Valenti, Luiz Carlos Vanderlei

PCB088

Pierre Bobin*, Rodolphe Fischmeister, Grégoire Vandecasteele, Jérôme Leroy

Regulation of calcium homeostasis by palmitoylcarnitine in ventricular cardiomyocyte: Role of mitochondria Julien Roussel*, Jérome Thireau, Valérie Scheuermann, Catherine Brenner, Alain Lacampagne, Jean-yves Le-Guennec, Jérémy Fauconnier

PCB077

CR Contribution of active and passive PCB083 stiffness to diastolic dysfunction in rats following aortic banding

PCB089

Rajesh Goit*, Rita Khadka, Lekhjung Thapa, Bishnu Paudel

Åsmund Røe*, Jan Magnus Aronsen, Michael Frisk, Ole Sejersted, Ivar Sjaastad, William Louch

Impact of cigarette smoking on blood pressure and heart rate variability Dmitry Dimitriev, Elena Saperova*

Effect of moderate aerobic exercise on cardiovascular autonomic function in type 2 diabetes mellitus

PCB084

Comparison of the functional regenerative activity of Human Umbilical Cord Blood MNCs and CD34+ cells in acute myocardial infarction rat model Noha Abogresha, Magda Mohamed*, Mona Tawfik, Mohamed Refaat Habba, Yasser El-Wazir

PCB090

Hall 3, ICC

*Denotes presenting author

Ghrelin - Is it cardioprotective in type 2 diabetics? Sherine Abd El-Fattah, Gamela Nasr, Dalia Abd-Elhalim, Yasser El-Wazir*

PCB091

The role of orexin in morphine tolerance and its effect on neural activity of Lateral Paragigantocellularis nucleus

PCB098

Masoumeh Ghaemi Jandabi, Yadollah Ranjbar-Slamloo, Hossein Azizi, Saeed Semnanian*

Assessment of autonomic nerve PCB092 function in patients with irritable bowel syndrome

Mohammed Nayem, Noorzahan Begum, Sultana Ferdousi*

Opotogenetic investigation in astrocyte-neurone signalling in locus coeruleus Feige Tang*, Sam Lane, Melina Figueiredo, Anja Teschemacher, Sergey Kasparov

Orchidectomy attenuates PCB093 cardiopulmonary reflex-mediated bradycardia and hypotension in CR conscious rats Tadeu Andrade*, Andrews Nascimento, Otávio Heringer, Karla Cassaro, Pothira Cunha, Ieda Kalil, Nazaré Bissoli

Acute responses of heart rate variability to oscillatory pole exercise

PCB094

Combined assessment of capillary PCB095 microcirculation and arterial stiffness to identify cardiovascular CR risk in human hypertension M. Dinkel*, M. Saedon, J. Lismore, P. Ray, C. Imray, Donald Singer

PCB096

Sue Robinson, Marie Nugent, David Dinsdale, Joern Steinert*

PCB099

PCB100

Synaptic vesicles expressing adaptor protein 3 contribute primarily to asynchronous release and regulate the fidelity of neurotransmission at hippocampal mossy fibre terminals

PCB097

Non-genomic effects of estradiol PCB105 on the excitability of Locus Coeruleus neurons in neonatal N rats Adriano Silva, Christopher Kushmerick*

Increased speed of information PCB106 processing by the brain in alcohol users in certain circumstances N might be related to its effect in neural differentiation: a hypothetical consideration Menizibeya Welcome*, Vladimir Pereverzev

PCB101

Pharmacological investigation of triheteromeric NMDA receptors in rat substantia nigra dopaminergic neurones.

T U E S D A Y

PCB107

Rachida Ammari*, Suzanne Scott, Susan Jones, Alasdair Gibb

Alesya Evstratova, Victor Faundez, Katalin Toth*

Contribution of endogenous VIP VPAC1 receptor activation during hypoxia and interictallike activity induced in vitro by 0-Mg2+ to subsequent changes in LTP expression in the rat hippocampus.

PCB102

Diana Cunha-Reis*

Ivan Rivera-Arconada, José Lopez-Garcia*

Prion protein mediates synaptic vesicle formation

Emanuele Schiavon*, Helen Parker, Ian Forsythe

Eder Moraes, Christopher Kushmerick, Ligia Naves*

Cristiane Ogata*, Marcelo Navega, Vitor Valenti

Characterisation of rebound depolarisation in mice deep dorsal horn neurons in vitro

Characteristics of dorsal root ganglia neurons sensitive to substance P.

Deafness related to PCB104 hyperbilirubinaemia is associated with transmission failure at N central auditory synapses.

The maturation of AMPA receptors in human pluripotent stem cell-derived cortical excitatory neurones

PCB103

Cilostazol does not inhibits KCl PCB108 and capcaicin induced increase in intracellular calcium signaling in N rat sensory neurons Selim Kutlu*, Emine Kacar, Oktay Burma, Ayhan Uysal

Detecting purines, catecholamines and glutamate with a mutant α-haemolysin pore one molecule at a time: a synthetic mutant sniffer patch

PCB109

Keith Brain*, Arnold Boersma, Peter Sidaway, Hagan Bayley

Matthew Livesey*, Bilada Bilican, Ghazal Haghi, Giles Hardingham, Siddharthan Chandran, David Wyllie

Poster Communications - Tuesday 23 July Study on restrain stress-induced PCB110 changes in serum lipid profile and haemoconcentration and effects N of sympathetic blocker on it in rats Jesmine Akhtar*

Infraslow brain potential PCB117 oscillations are implicated in multisensory mechanisms of N information processing: evidence from intracortical field potential recordings

Patterning neurons and informing neurite geometry on photolithographically defined parylene-C coated SiO2.

PCB123

Mark Hughes*, Andrew Bunting, Katherine Cameron, Alan Murray, Mike Shipston

Konstantin Pugachev*, Igor Filippov, Artem Krebs

TR(i)P to automation Ilka Rinke, Claudia Haarmann, Nadine Becker*, Alison Obergrussberger, Sonja StĂślzle, Andrea BrĂźggemann, Michael George, Niels Fertig

PCB111

Infraslow brain potentials (<0.5 PCB118 Hz) in primary sensory cortical areas of the rat brain: effects of N brain neurotransmission centers electrical stimulation

Orexin-A differentially modulates PCB124 AMPA responses of ganglion cells and amacrine cells in rat retina

Chao Zheng*, Meng-Ya Wang, Xiong-Li Yang, Yong-Mei Zhong

Artem Krebs*, Igor Filippov, Konstantin Pugachev

Neuroprotective potential of PCB112 N-nitro-L-arginine-methylester in transient cerebral ischemia and N reperfusion in rats Hiba Awooda*, Gihan Sharara

Endocannabinoid modulates developmental plasticity of central vestibular synapses and the expression of vestibular behaviors in rats

PCB113

HCN channels regulate spontaneous firing rate of olfactory receptor neurons for glomerular formation

PCB119

Noriyuki Nakashima*, Takahiro Ishii, Harunori Ohmori

N Expression of purinergic P2Y12 receptors in rat trigeminal ganglion neurons

Wei Shi*, Huijing Hu, Daisy Kwok-Yan Shum, Ying-shing Chan

PCB120

Aya Kawaguchi*, Yoshiyuki Shibukawa, Hidetaka Kuroda, Manabu Soya, Masaki Satou, Masakazu Tazaki, Tatsuya Ichinohe

Glutamine transport by System N and System A in astrocytes adjacent to the calyx of Held glutamatergic synapse

Tourandokht Baluchnejadmojarad, Mehrdad Roghani, Mitra Kamran*

N Ischemic preconditioning as PCB121 induction of ischemic tolerance after transient cerebral ischemia N and reperfusion in rats PCB116

Hiba Awooda*

Ryo Egawa*, Shoko Hososhima, Hidetaka Katow, Toru Ishizuka, Hiromu Yawo

Electrophysiological PCB126 characterisation of neuronal excitability of l-LNv neurons and N their role in controlling circadian rhythm. Marie Nugent*, Ezio Rosato, Joern Steinert, Ian Forsythe

Differential effects of an enhancer PCB127 stimulus into the putamen nucleus

P. Montes-Lourido*, A. Vicente, M. Bermudez, M. Romero, R. Perez, F. Gonzalez

N Bio-inspired peptide modulators PCB122 of calcium dependent inactivation revealed the role N of CaV1.3 channels in neuronal development Min Liu*, Xiaodong Liu

PCB125

PCB115

Mari-Carmen Marx*, Brian Billups

The effect of alpha-lipoic acid on learning and memory deficit in a rat model of temporal lobe epilepsy

Optogenetically-evoked Ca2+ release from intracellular store in the calyx-type presynaptic terminal of the embryonic chick ciliary ganglion

Short term synaptic plasticity defines neuronal groups firing together in cultures of cortical cells Violeta Lopez-Huerta*, Luis CarrilloReid, Marianela Garcia-Munoz, Gordon Arbuthnott

PCB128

Hall 3, ICC

*Denotes presenting author

Mechanism of nitric oxide dependent LTP revealed by kinetic analysis of AMPAR trafficking in rat cerebellar Purkinje cell

PCB129

Investigating neuronal morphology and physiology in the rat lateral reticular nucleus

PCB136

Rebecca Jordan*, Steve Edgley, Susan Jones

Ionotropic purine receptors P2X in frog and turtle retina: an immunocytochemical study

PCB143

Liliya Vitanova*, Petia Kupenova

Kazuhiko Yamaguchi*

Expression and function of Kir7.1 PCB130 in neurons and glia of the mouse CNS

Investigating synaptic regulation of neurones in the rat lateral reticular nucleus

PCB137

Julia Heckenast*, Steve Edgley, Susan Jones

Neuroprotective effects and the underlying mechanisms of Paeoniflorin

PCB144

Linyin Feng*

Maria Papanikolaou*, James Hallett, Anthony Lewis, Arthur Butt

Decreased excitability of neurons PCB132 in the ventral nucleus of the trapezoid body may contribute N to medial olivocochlear system dysfunction in the C57BL/6 James Sinclair*, Margaret Barnes-Davies, Ian Forsythe

The oxygen sensitivity of sympathetic premotor neurons does not involve Heme Oxygenase 2 (HO-2)

PCB138

Lama Bou Farah, S. McMullan*

Imaging the motility of inositol PCB145 trisphosphate receptors in intact mammalian cells using single N particle tracking photoactivated localization microscopy (sptPALM) Ian Smith*, Divya Swaminathan, Ian Parker

Reproduction of transducin PCB139 timecourse of rod and cone cells under various light intensities

Yukari Hosoki*, Chieko Koike, Yukari Takeda, Akira Amano

Regulation of excitatory synaptic PCB134 function by estrogen: implications for health and disease

T U E S D A Y

The in vitro anti-cancer effects of PCB146 emodin in human cancer cells Xie Mingjie*, Wang Limeng

Abdulla Ibrahim*, Jenni Harvey

Cocaine preferentially potentiates PCB135 fast releasable vesicle pool in mouse dopaminergic striatum N in vivo Panli Zuo, Li Zhou, Xinjiang Kang, Huadong Xu, Bo Zhang, Haiqiang Dou, Feipeng Zhu, Lina Liu, Shu Guo, Changhe Wang*, Qing Li, Shirong Wang, Wei Yao, Howard Gu, Zhuan Zhou

Mitochondrial modulators and persistent orofacial pain in mice Andrei Dondas*, Andrei Luca, Teodora Alexa, Dana Negru, Catalina Roxana Bohotin

PCB140

Opiorphin inhibits calcium signaling response in capsaicin sensitive rat sensory neurons

PCB147

Mete Ozcan*, Ahmet Ayar, Emine Kacar, Haluk Kelestimur

Methylphenidate enhances PCB141 NMDA-receptor response in the rat medial prefrontal cortex N via sigma-1 receptor: a novel mechanism for methylphenidate action Chunlei Zhang, Zejun Feng, Yue Liu, Xiaohua Ji, Jiyun Peng, Xuehan Zhang, Xuechu Zhen, Baoming Li*

Natriuretic peptides decrease calcium transients and neurotransmission in cardiac sympathetic nerves

TRPA1 and TRPV4 activation in human odontoblast-like cells stimulates ATP release

PCB148

Obi Egbuniwe, Sibani Grover, Mehdi Yazdi, Tara Renton, Lucy Di Silvio, Andrew Grant*

PCB142

Dan Li*, Hannah Wright, Elisa Vergari, Chieh-Ju Lu, Neil Herring, David Paterson

Poster Communications - Tuesday 23 July Effect of materials based on gold and silver nanoparticles and natural compounds on carrageenan-induced rat paw edema

PCB149

Danielle Oliveira-Tavares, Celia Da-Silva, Fernando Padovan-Neto, Elaine Del Bel*

Adriana Filip*, Doina Daicoviciu, Pompei Bolfa, Simona Clichici, Adriana Muresan, Luminita David, Liliana Olenic

Adaptive sampling of visual information by photoreceptor ultrastructure and stochastic reactions

PCB150

Zhuoyi Song*, Marten Postma, Stephen A. Billings, Daniel Coca, Roger Hardie, Mikko Juusola

ATP signals in supporting cells PCB151 of the organ of Corti in the adult mouse

Piotr Sirko*, Jonathan Gale, Jonathan Ashmore

Neuronal damage and tau pathology in a murine model of cerebral ischemia Sabah Khan*, Nadira Yuldasheva, Trevor Batten, Sikha Saha

PCB152

Liu Yang, Guan Xin, Fang Chen, Liang Feng, Han Nv, Han Chao, Huang Liang, Zhang Qi, Liu Jing, Zou Wei*

Mukesh Jha*

Abdul Ansari*, Suman Jain, Rashmi Mathur, Mansi Bhattacharjee

PCB157

Takayoshi Hosono*, Megumi Yamamoto, Cihiro Igi, Keisuke Akasaka, Mayu Arakawa, Miki Nakamoto, Kenji Minato

Transcutaneous auricular vagus nerve stimulation for the treatment of pediatric epilepsy

Altered nerve structure and electrophysiological responses to mechanical stress in the Trembler-J mouse model of Charcot-Marie-Tooth disease

PCB158

Wei He*, Xianghong Jing, Xiaoyu Wang, Hong Shi, Hongyan Shang, Peijing Rong, Liang Li, Bing Zhu

Glucocorticoid negative feedback PCB164 alters electrical excitability of murine anterior pituitary N corticotroph cells

Production of Tumor Necrosis PCB159 Factor- alpha by Microglia in Rat Brain After Traumatic Brain Injury

Che-Chuan Wang*, Chung-Zhing Yang, Ching-Ping Chang, Ming-Wen Chang, BorChih Cheng, Bi-Ying Chio, Jung-Sheng Yu

PCB154

Maria Conti*, Antonela Terrizzi, Ching Lee, Patricia Mandalunis, Clarisa Bozzini, Maria Martinez

Protective effect of melanin PCB160 derived from White Silky Fowl on rat model of Parkinson’s disease N induced by 6-Hydroxydopa

Perioperative buprenorphine infusion influences recovery following experimental stroke Dale Corbett*, Kristopher Langdon, Matthew Jeffers, Shauna Smith, Shirley Granter-Button

Chronic exposure to intermittent PCB165 hypoxia in lead intoxicated growing rats impairs bone biology EM

Impact of lead intoxication under PCB166 intermittent hypoxia on oral health of growing rats EM Maria Martinez*, Antonela Terrizzi, Ching Lee, Javier Fernandez Solari, Juan Elverdin, Maria Conti

PCB161

Interstitial calcium modulates cholinergic-induced eccrine sweating

PCB167

Kristen Metzler-Wilson, Thad Wilson*

Modulation of branchial cystic PCB168 fibrosis transmembrane regulator (CFTR) expression in sea bream EM encountering abrupt salinity changes Norman Woo*

PCB163

Bridget Power*, Mark Pickering, James Jones

Yi He*, Fei Long Zhang, Xiao Min Wang

Effect of transcutaneous auricular PCB155 vagus nerve stimulation on refractory epilepsy Peijing Rong*, Hui Ben, Liang Li, Xia Li, Bing Zhu

Effects of duration of hyperthermic hypoxia on neonatal rats assessed after growth by behavior

Effect of slow frequency repeated PCB162 transcranial magnetic stimulation on pain modulation status of N female fibromyalgia patients: An electrophysiological study

Peter Duncan*, Michael Shipston

ER-α36, a novel variant of ER-α, PCB153 involved in the neuroprotective effects of E2 against apoptosis in N nervous system

Visual evoked potentials in primary open angle glaucoma

Cyclooxygenase-2 mediates PCB156 striatum activation in the mouse 6-Hydroxydopamine model of N Parkinson’s disease

Hall 3, ICC

*Denotes presenting author

Effects of non-lethal cold stress PCB169 on the mitochondrion-rich cells in gills of the euryhaline milkfish EM (Chanos chanos) acclimated to seawater and fresh water

Lubiprostone activates CFTR in human bronchial epithelial cells via a prostanoid receptor dependent process.

PCB175

Ayodele Soladoye*, Olabisi Ayoola, Lawrence Olatunji

Chao-Kai Kang*, Yi-Chi Chen, Tsung-Han Lee

Justyna Przeworek*, Hasmik Samvelyan, Antonina Hassouni, Christopher Taylor, Louise Robson

L-arginine-nitric oxide pathway in neutrophils from chronic renal failure patients under haemodialysis

Carbonic anhydrase II enhances PCB176 activity of endogenous Na-H exchangers and not the Na/HCO3 EM cotransporter, NBCe1, when expressed in Xenopus oocytes

PCB170

Daniele Abrantes, Tatiana Brunini, Monique Oliveira, Natalia Pinto, Carolina Correa, Cicera MAchado, Sergio Santos, Antonio Claudio Mendes-Ribeiro*

Erythrocyte Na+-K+ ATPase activity PCB181 in normotensive underweight, overweight and obese women EM

Mathematical modeling of bicarbonate versus carbonate transport by the electrogenic Na+/HCO3- cotransporter

PCB182

Rossana Occhipinti*, Seong-Ki Lee, Walter Boron

Fraser Moss*, Walter Boron

Identification of ARAP3 function PCB171 as a novel modulator of lymphatic vessel morphogenesis

Joelle Kartopawiro, Emmanuelle Frampton, Tara Karnezis, Kaska Koltowska, Neil Bower, Stephan Schulte-Mercker, Marc Achen, Jane Kazenwadel, Natasha Harvey, Benjamin Hogan, Mathias Francois*

Interleukin-1β-induced decrease PCB172 of NHE3 interacting protein PDZK1, as well as sh-RNAEM mediated PDZK1 knockdown, is associated with NHE3 dysfunction in the colonic epithelial cell line Caco-2bbe.

Confocal microscope observation PCB177 on paracellular fluid transport in the vascularly perfused EM submandibular gland Masataka Murakami*, Fei Wei, Takanori Narita, Miwako Fukushima, Sadamitsu Hashimoto, Yoshiyuki Shibukawa, Masaki Sato

Organic cation transporter subtypes of isolated mouse proximal tubules are differently regulated by protein kinases

PCB178

Adenosine regulates Cl- channels PCB179 in human adenocarcinoma cell monolayer

Maggie Y Hao*, Alison WM Chow, Wallace CY Yip, Winnie TF Wan, Woody WY Chan, Christopher HK Cheng, Wing Hung Ko

Albert Rosell*, Meritxell Costa-Torres, Elena Álvarez-Marimon, Antonio Zorzano, Dimitrios Fotiadis, Manuel Palacín

Crystallization and functional characterization of a new bacterial homologue of heteromeric amino acid transporters

PCB184

Carbonic anhydrase II PCB185 enhances transport activity of monocarboxylate transporters via EM direct interaction

Mikio Hayashi*, Akihiro Inagaki, Hiroko Matsuda

Holger Becker*, Hella Heidtmann, Sina Ibne Noor, Steffen Dietz, Malin Stridh, Michael Klier, Christopher Boone, Robert McKenna, Joachim Deitmer

Changes in Na+ metabolism PCB180 and their effects on nutrient absorption in claudin 15 knockout EM mice

y+ LAT1 conditional KO mice as the first animal model for LPI

Hisayoshi Hayashi*, Yukino Komatsu, Miki Watanabe, Yuichi Suzuki

Ekaitz Errasti Murugarren*, Paola Bartoccioni, Manuel Palacín

Eberhard Schlatter*, Svenja Holle, Denise Guckel, Philipp Klassen, Vivian Massmann, Giuliano Ciarimboli

Giripraksh Chodisetti, Min Luo, Anja Klöpper, Brigitte Riederer, Peijian He, Chris Yun, Sunil Yeruva*, Ursula Seidler

Activation of the novel G protein- PCB173 coupled receptor 30 (GPR30) inhibits P2Y receptor-mediated EM Ca2+ signalling in human bronchial epithelia

Expression of human heteromeric PCB183 amino acid transporters in the yeast Pichia pastoris

T U E S D A Y

Susanna Bodoy*, Meritxell Espino, Rafael Artuch, Manuel Palacín

PCB186

Lubiprostone activates CFTR PCB174 in human bronchial epithelial cells via a protein kinase A EM independent dependent process Justyna Przeworek, Hasmik Samvelyan, Antonina Hassouni, Richmond Muimo, Christopher Taylor, Louise Robson*

Poster Communications - Tuesday 23 July Cesium inhibited HeLa cells proliferation Daisuke Kobayashi*, Kei Kakinouchi, Kanan Matsumura, Akihiro Hazama

PCB187

Extracellular cysteine residues form a disulphide bridge in the amino acid transporter PAT2 (slc36a2)

PCB194

Noel Edwards*, David Thwaites

Deficiency of claudins -2 and -15 PCB201 causes defects in paracellular Na+ flow and nutrient transport in EM small intestine and leads to death from malnutrition in mice Atsushi Tamura*, Masami Wada, Nobuyuki Takahashi, Sachiko Tsukita

Human pancreatic duct cells express functional gastric and non-gastric H+/K+ ATPases and are sensitive to proton pump inhibitors

PCB188

Ivana Novak*, Jing Wang

Chimeric constructs endow human CFTR with the subconductance state of murine CFTR

Plasmonic gold nanoparticles as a possible potassium channel opener in vascular smooth muscle cells

PCB195

Anatoly Soloviev*, Irina Ivanova, Tartiana Novokhatska, Sergei Zelensky, Alaxandra Raevska, Alexander Stroyuk, Vladimir Ephanov, Igor Parneta

Zhiwei Cai*, Isabelle Callebaut, David LeaSmith, Barbara Stevenson, Ann Doherty, Heather Davidson, David Porteous, JeanPaul Mornon, Pierre Lehn, A. Christopher Boyd, David Sheppard

PCB196

Julia Horilova*, Dusan Chorvat, Anton Mateasik, Alzbeta Chorvatova

Impact of urate on prostate cancer development

PCB190

Ely Rodrigues, Andrew Bahn*

Hepatoprotective role of PCB197 ashwagandha (withania somnifera) root extract against gentamicin induced liver damage EM in rats Nayma Sultana*

Investigation of UT-B urea transporter isoforms in the human Ileum Caragh Walpole*, Sinead Edwards, Desmond Winter, Alan Baird, Gavin Stewart

The roles of hepcidin and ferroportin in autocrine regulation of iron levels Samira Lakhal-Littleton*, Daniel Biggs, R. Diaz, A. Santos, C. Peerce, B. Davies, Peter Robbins

F508del and A561E: cystic fibrosis PCB192 mutations that disrupt the trafficking, thermostability and EM gating of CFTR have differential sensitivity to small-molecule CFTR modulators Yiting Wang, Jia Liu, Camilla Gorard, James Povey, David Sheppard, Hongyu Li*

Nicholas Delamere*, Elena de Turco, Mohammad Shahidullah

PCB203

Xuemei Liu*, Taolang Li, Brigitte Riederer, Anurag Singh, Weiliang Xia, Qin Yu, Penghong Song, Biguang Tuo, De-an Tian, Manoocher Soleimani, Ursula Seidler

Slc26a6 (PAT-1) mediates PCB204 dipeptide and CO2/HCO3- induced stimulation of jejunal fluid and EM HCO3- absorption in murine small intestine

The development of an in-vitro PCB205 mouse proximal tubule cell model as a platform for drug transporter and drug-drug interaction studies EM Sarah Billington*, Git Chung, Colin Brown

Endothelial protection of a PCB199 polysaccharide fraction from Laminaria japonica from the South China Sea in psychological EM stress rats induced by irregular water supply/empty bottle stressor

Estrogen increases Na+ absorption and ENaC channel expression in kidney collecting duct cells Manuel Yusef Robles*, Warren Thomas, Brian Harvey

Anti-tumor effect of salidroside PCB200 in human gastric carcinoma cells SGC-7901

Shurong Mo*, Lilan Wei

Expression and function of Slc26a9 member of the Slc26 anion transporter family in the gastrointestinal tract

PCB198

Lu Xie*, Jing Li, Xiao-Mei Yang, Bing Liang, Meng-Hua Chen

Na,K-ATPase studies in Mel-290 PCB193 uveal melanoma cells that display unusual sodium and potassium EM concentrations.

Qin Yu*, Weiliang Xia, Anurag Kumar Singh, Brigitte Riederer, Regina Engelhardt, Penghong Song, De-An Tian, Manoocher Soleimani, Ursula Seidler

PCB191

PCB202

Mary Pipedi-Tshekiso*, Padmaja Chaturvedi, Arnold Kefentse Tumedi

PCB189 Time-resolved spectroscopy and imaging of mitochondrial metabolic state in living cells

The antioxidant effect of water melon on paracetamol induced liver toxicity

PCB206

Hall 3, ICC

*Denotes presenting author

Hypercapnia reduces cAMPPCB208 dependent HCO3- transport across human airway epithelial cells

Relationship between PCB214 temperature and substrate affinity in GAT1, KAAT1 and PepT1

Analysis of the human cationic PCB220 amino acid transporter hCAT-1 in human T lymphocytes EM

Mark Turner*, Martin Cann, Michael Gray

Alessandra Vollero*, Antonio Peres, Eleonora Margheritis, Elena Bossi

Anke Werner*, Vanessa Schnitzius, Alice Habermeier, Jean-Paul Boissel, Claudia Luckner-Minden, Markus Munder, Ellen Closs

Bile acid modulation of Clsecretion in Calu-3 airway epithelial cells

PCB209

Siobhan Hendrick*, Catherine Greene, Stephen Keely, Brian Harvey

Development and characterisation of rat primary proximal tubule cells

PCB211

PCB212

Sho Kobayashi*, Takayuki Kasakoshi, Takumi Tsutsui, Soichiro Azumi, Tomomi Okada, Tomoyoshi Soga, Kiharu Igarashi, Shiro Bannai, Hideyo Sato

The single-channel behaviour of F508del-CFTR rescued by the CFTR corrector VX-809

Modulation of the intestinal PCB221 epithelial tight junction barrier in response to infection

Hidekazu Fukuda*, Katsumasa Kawahara, Min-Hwang Chang, Michael Romero, Shigehisa Hirose

Emily Blakesley*, Simon Carding, Alastair Watson, Alex Jones

Regulation of the basolateral PCB216 Cl- HCO3- anion exchanger by cAMP and the actin cytoskeleton EM in human airway epithelial cells

Reducing noradrenergic PCB222 stimulation of the epithelial sodium channel (ENaC) may EM contribute to the blood pressure lowering effect of renal sympathetic denervation

Salam Ibrahim*, Alicia Haigh, Chris Comer, Mark Turner, Michael Gray

Morag Mansley*, Marko Bertog, Christoph Korbmacher

T U E S D A Y

Emma Lofthouse*, Suzanne Brooks, Jane Cleal, Mark Hanson, Kirsten Poore, Ita O’Kelly, Rohan Lewis

Cystathionine is a physiological substrate of cystine/glutamate transporter, System x c -

A novel variant of the PCB215 Na+/HCO3- cotransporter 4 (NBC4) may regulate the cerebrospinal EM fluid production via the cAMP signaling axis

PCB210

Git Chung*, Sarah Billington, Naeem Soomro, Colin Brown

N-acetylcysteine stimulates glutamate efflux in Xenopus oocytes expressing xCT/4F2hc

The putative gating residues Y163 PCB217 and F272 are critical for PAT2 (slc36a2) mediated amino acid EM transport

Donal O’Donoghue*, Vivek Dua, Guy Moss, Paola Vergani

Nichola Conlon*, Noel Edwards, Timothy Cheek, Catriona Anderson, David Thwaites

Roles of NHE1 activity and pHi regulation in ATM mediated DNA-damage response

Increased apical Na+ permeability PCB223 in cystic fibrosis is supported by a quantitative model of epithelial EM ion transport

PCB218

Gitte Lauritzen*, Bradley Webb, Sandra Christensen, Diane Barber, Stine Pedersen

PCB213

Molecular cloning and kinetic PCB224 characterization of fish amino acid transporter B0 AT1 (SLC6A19) EM Eleonora Margheritis*, Raffaella Cinquetti, Genciana Terova, Andrea Cardillo, Antonio Peres, Elena Bossi

Yiting Wang*, Zhiwei Cai, David.N Sheppard

Cooperation of basolateral PCB219 epithelial amino acid transporters TAT1 and LAT2 investigated in a double knock out mouse model EM Emilia Boiadjieva*, Clara Vilches, Susanna Bodoy, Adriano Guetg, François Verrey, Manuel Palacin

Interaction of murine and human PCB225 organic cation transporters with tyrosine kinase inhibitors and EM platin derivatives Dorothea Zeeh*, Saliha Harrach, Meike Fischer, Eberhard Schlatter, Jessica Bertrand, Giuliano Ciarimboli

Poster Communications - Tuesday 23 July Exploring with the anticancer gold-based compound-Auphen the mechanism(s) by which Aquaporin-3 participates in cell proliferation

PCB226

MicroRNA miR-222 is elevated in PCB232 human placenta from teenagers with low maternal folate status

B. Baker*, K. Forbes, S. Lean, F. Mackie, C. Taylor, A. Garrod, S. Greenwood, R. Jones

Ana Galán-Cobo*, Ana Serna, Ismael Sánchez-Gomar, Juan José Toledo-Aral, Angela Casini, Graça Soveral, Miriam Echevarría

Aaron Phillips*, Andrei Krassioukov, Philip Ainslie, Darren Warburton

Butyrate: a potential antiangiogenic therapy for breast cancer? Bile acids regulate proinflammatory cytokine secretion from human airway epithelial cells

PCB227

Joanne Longster, Hannah Lemar, Aliki-Eleni Farmaki, Bernard Corfe, Carolyn Staton*

Corticospinal excitability map in less than 2 minutes

Different expression patterns of PCB228 FXYD11 and Na+/K+-ATPase in gills of the brackish medaka (Oryzias EM dancena) when acclimated to hypo- or hyper-osmotic environments Chia-Hao Chang*, Wen-Kai Yang, TsungHan Lee

Justyna Kowal*, Kristian Haanes, Nynne Christensen, Ivana Novak

Autonomic nervous response and PCB235 subjective evaluation about sleep quality for sleep in menstrual HE cycle

Renal vasoconstriction occurs during isometric calf exercise in humans: role of the muscle mechanoreflex

PCB236

Monica Patti*, Chiara Ghezzi, Ian Forster

Tadashi Saitoh*, Hotaka Kobayashi, Jun Yanai, Ryo Nomura, Hiroshi Tsutsui, Hiroaki Takana, Kyuichi Niizeki

Gemma Roest*, Katrine Mark, Stine Pedersen

PCB241

Heather Ballard, Lin Lu*, Weisong Cai

PCB242

Hilal Akseki, Selma Vardar*, Muzaffer Demir, Orkide Palabiyik, Aziz Karaca, Zuhal Guksu, Arif Ortanca, Necdet Sut

Bathing with artificial high PCB243 concentration CO2- water affected quiet standing posture control

Effect of a controlled respiratory PCB237 rate on oxygen uptake kinetics during cycling exercise

Rachel Drew*, Matthew Muller, Ruda Cui, Cheryl Blaha, Jessica Mast, Michael Herr, Lawrence Sinoway

PCB231

Involvement of connexin hemichannels in acidosis- and exercise-induced ATP release from skeletal muscle

Amino-terminal propeptide of C-type natriuretic peptide (NT-ProCNP) levels are altered following anaerobic exercise in physically active young men

A critical internal cation release PCB230 step is revealed by conferring electrogenicity to the renal EM electroneutral phosphate cotransporter NaPi-IIc (SLC34A3)

Roles of ezrin, radixin, merlin, and the Na+/H+ exchanger NHE1 in regulation of growth and motility of human breast cancer cells

PCB240

PCB234

Michiko Tanaka*, Mou Nagasaka, Chiyomi Egami, Miyuki Kondo, Yoshikazu Sakakibara

PCB229

Acidosis-induced ATP release from skeletal muscle involves activation of CFTR through the cAMP/PKA pathway Jie Tu*, Lin Lu, Heather Ballard

Mark van de Ruit*, Michael Grey

PCB233

Arundhuti Ghatak*, Joseph Ward, Stephen Keely, Emma Caraher

Physiological and pathophysiological effects of various agents on ATP release in pancreatic ducts.

The effect of blood pressure on PCB239 regional cerebral blood flow velocity and neurovascular coupling in individuals with spinal HE cord injury

Noriyuki Yamamoto*, Masaaki Hashimoto

A metabolomic approach to investigate metabolic changes induced by acute sprint running before and after long sprint training Carina Enea, Francois Seguin, Olivier Bernard, Delphine Bon, Christine Hanon, Benoit Dugue*

Are motor units with different activation thresholds spatially distributed in human gastrocnemius medialis PCB238

Emma Hodson-Tole*, Ian Loram, Marco Minetto, Alberto Botter, Taian Vieira

PCB244

Hall 3, ICC

*Denotes presenting author

24 hours chronomics of blood pressure/heart rate in rotating night shift workers and its relation with 6- sulfatoxy melatonin

PCB245

PCB246

David Bishop*, Cesare Granata, Elise Brentnall, Kathrin Renner, Rodrigo da Silva Fermino de Oliveira

Erythropoiesis as an antioxidant response to the oxidative stress of hypoxia; focus on the inhibition of hydroxyl radical formation in-vivo

PCB258

Dominique Gagnon*, Heikki Kyröläinen, Sheila Gagnon, Karl-Heinz Herzig, Hannu Rintamäki

Effect of go/no-go signal on pulse PCB252 volume amplitude during motor task performance

The use of antioxidant vitamin-E PCB259 supplement: a study of female athletes. Pratima Chatterjee*

The influence of voluntary hyperventilation on a standing balance of athletes

Effects of acute ingestion of PCB260 cashew apple juice on oxidative stress and white blood cells count PCB253

Naruemon Leelayuwat*, Piyapong Prasertsri, Terdthai Thong-un, Supaporn Muchimapura, Jintanaporn Wattanathorn

Maxim Malakhov*, Elena Makarenkova, Andrey Mel’nikov

PCB248

Gender-based EEG before and after acute exercise Nirmala Limbu*, Ramanjan Sihna, Meenakshi Sihna, Bishnu Hari Paudel

Damian Bailey*, Carsten Lundby, Peter Rasmussen, Sarah Taudorf, Ronan Berg, Bente Pedersen, Mariusz Gutowski, Jerome Sullivan, Jane McEneny, Ian Young, Max Gassmann, Erik Swenson, Hidayat Rahmouni, Kirsten Moller, Marcel Culcasi, Sylvia Pietri

PCB254

PCB261

The impact of Pilates on power, PCB262 speed and endurance parameters of teenage swimmers Fadil Ozyener*, Funda Coskun, Senay Koparan, Aysegul Dogan, Dane Ediger

Wilaiwan Khrisanapant*, Orapin Pasurivong, Tunda Suthitum, Jureeporn Namarmarth

HE Exercise training protects against PCB256 neuronal damage via HSP72 overexpression in rat spinal cord HE injury model

Gareth Davison*, Giuseppe De Vito, Ciara Hughes, George Burke, Jane McEneny, Conor McClean, Mark Fogarty

T U E S D A Y

Impact of exercise training on PCB255 cardiopulmonary fitness in obese Thai women

PCB249

Relationships between resting metabolism and maximum muscle force Junichiro Yamauchi*

Intracellular DNA damage following isolated muscle contractions: a preliminary investigation into P53 gene expression

Whole-body cooling modulates skeletal muscle oxygenation during aerobic exercise

K. Deepak*, Chhaya Kharya, Mithilesh Pal, Gaurav Jain, Ashok Jaryal, Hari Singh, Sneh Anand

The influence of physical exercise PCB247 duration to nitric oxide (pure experimental research on rats) Afriwardi Wahab*

PCB251

Daniel Lima*, Antonio Claudio MendesRibeiro, Carolina Maria Chamma, Daniele Abrantes, Marcela Martins, Luiz Claudio Cameron, Tatiana Marlowe Brunini, Cristiane Matsuura

Narsingh Verma*, B. Anjum, Sandeep Tewari, Ranjana Singh, Abbas Mahdi

Mitochondrial adaptations to intense exercise training and detraining

Red blood cell oxidative stress during prolonged and strenuous exercise

Does preceding human posture predict the priority of force minimisation over position control?

PCB263

Ian Loram*

Ching-Ping Chang, Ling-Yu Tang*, CheChuan Wang, Bor-Chih Cheng, Cheng-Kuei Chang, Bi-Ying Chio, Jung-Sheng Yu

The effect of exertional heat stress induced hypohydration on human physiology and biochemistry Medha Kapoor*, Laxmi Singh

Effect of acute hypoxia on C2C12 myoblast proliferation

PCB250

HE Development of a four-day rapid PCB257 acclimation schedule for military personnel Laxmi Singh*, Medha Kapoor

Carla Gallagher*, Jack Sharkey, Neil Martin, Darren Player, Stephen Myers, Mark Lewis

PCB264

Poster Communications - Tuesday 23 July Appetite hormone response and body composition changes after 8 weeks exercise training with low and high intensities in overweight/obese females

PCB265

Correlation between maximal inspiratory pressure and spirometric indices in young rowers

PCB271

Rat supraoptic nucleus neurons respond to glucose increase through closure of ATP dependent potassium channels

Jana Kivastik*, Mati Arend, Jarek Mäestu

Zhilin Song*, Wanida Stevens, Celia Sladek

Heterogeneity of blood flow and PCB272 VO2 in exercising normal human muscle assessed by near infrared HE spectroscopy

Anti-diabetic and antioxidant effects of virgin coconut oil in alloxan-induced diabetic male Sprague Dawley rats

Peter Wagner*, Helmut Habazettl, Ioannis Vogiatzis, Zafeiris Louvaris, Harrieth Wagner, Spyros Zakynthinos

Bolanle Iranloye*, Gabriel Oludare, Olubiyi Makinde

PCB277

Hans-Peter Kubis*, Matthew Jackson, Fardin Fatahi, David King, Alice Turner

Magnetic Resonance Elastography measurement of human skeletal muscle stiffness shows a decline in older adults compared with young.

PCB266

PCB278

Paul Kennedy, Scott Semple, Calum Gray, Eric Barnhill, Edwin van Beek, Neil Roberts, Carolyn Greig*

The contributions of PCB267 cyclooxygenase (COX) and NO synthase (NOS) pathways HE to endothelium-dependent dilatation in the finger of women.

Pulmonary function and respiratory muscle strength in pregnancy Salma Ibrahim*, Omer Musa

PCB273

The effect of cyclic monoterpene PCB279 menthol on blood glucose, water and electrolyte excretion in rats Chinedu Onwuchekwa*, Kasimu Ghandi, Nnaemeka Ndodo

Kirsten Lafferty*, Clare Ray, Janice Marshall

Chaperone protein binding in human muscle fibres during recovery from unaccustomed exercise

PCB268

A single night of fragmented sleep reduces cerebral vascular reactivity and central chemoreceptor CO2 sensitivity

PCB274

Keith Pugh*, Shahrad Taheri, George Balanos

Gamma amino butyric acid (GABA)-induced vasorelaxation mediated by nitric oxide and GABAA receptor in non diabetic and streptozotocin induced diabetic rat vessels

PCB280

Nepton Soltani*, Mansoor Keshavarz

Rudolf Billeter*, Katie Miller, David Thomas, Zara Kwan, Kanagaraj Marimuthu, Paul Greenhaff, Hans Hoppeler

Mechanical hyperventilation enhances static cerebral autoregulation in critically ill patients with severe sepsis

Serum lipids: profile during pregnancy in women in Benin City, Nigeria PCB269

Poor agreement between PCB270 transcranial doppler and nearinfrared spectroscopy-based estimates of cerebral blood flow HE in patients with sepsis

Marie Petersen*, Linea Toksvang, Claus Christiansen, Kirsten Møller, Ronni Plovsing, Ronan M. Berg

Linea Toksvang*, Marie Petersen, Ronni Plovsing, Kirsten Møller, Ronan Berg

Maureen Ebomoyi*, Clement Ekhator

PCB275

RFamide related peptide-1 PCB276 attenuates gonadotropinreleasing hormone release in immortalized GT1-7 cells without ME changing intracellular calcium concentration Haluk Kelestimur*, Emine Kacar, Mete Ozcan, Selim Kutlu

Effect of the administration PCB281 of Soanum nigrum on blood glucose, lipid profiles and ME sensitivity of the vascular mesenteric bed to Phenylephrine in streptozotocin-induced diabetic rats Nepton Soltani*, Shahla Sohrabipour, Fatemah Kharazmi

Effect of the administration of PCB282 magnesium sulfate on GLU4 gen expression in streptozotocinME induced diabetic rats Nepton Soltani*, Kyanoosh Malkzadeh, Haneyah Solymani

Hall 3, ICC

*Denotes presenting author

Regulation of 1,25-Dihydroxyvitamin D3induced intestinal calcium transport by Fibroblast Growth Factor (FGF)-23 as a part of the bone-kidney-intestinal axis

PCB283

PCB289

Raj Yadav*, Ritesh Netam, Rajesh Khadgawat, Kumar Sarvottam, Rashmi Yadav, Dipti Magan

Narattaphol Charoenphandhu*, Jarinthorn Teerapornpuntakit, Pissared Khuituan, Kannikar Wongdee, Nateetip Krishnamra

Lipopolysaccharide inhibits the expression of resistin in adipocytes

Diabetes risk factors, interleukin-6 and vitamin d are modified by a short-term yogabased lifestyle intervention in overweight/obese subjects

PCB284

The effects of Moringa oleifera Lam. seed oil in ovariectomized rats Piyathida Kusolrat*, Sajeera Kupittayanant

PCB290

Yin Li*, Xinxin Xiang, Wenjiao An, Changtao Jiang, Xian Wang, Weizhen Zhang

Intestinal glucose uptake PCB285 responses to infusion of glucose, fructose and galactose in dogs Akinola Alada*, Toyin Salman, David Oyebola

Estrogen activities of winged bean seed oil in ovariectomized rats Pakanit Kupittayanant*, Piyathida Kusolrat, Angsumalin Munpanich, Atcharaporn Thaeomor, Sajeera Kupittayanant

Muhammad Aslam*

Serum transforming growth factor β concentrations and primary antibodies immunostaining effects on Leydig and Sertoli Cells in streptozotocin-induced and insulin resistant diabetic adult male rat

PCB286

Daniel Giterman, Ernest Adeghate*, Steve Harvey

PCB287

PCB296

Jarinthorn Teerapornpuntakit*, Kannikar Wongdee, Nateetip Krishnamra, Nitsara Karoonuthaisiri, Narattaphol Charoenphandhu

PCB292

Katalin Könczöl, Dóra Zelena, Ottó Pintér, János Varga, Miklós Palkovits, Zsuzsanna Tóth*

PCB297

ME Neuronal and glial cell changes in a trasngenic mouse model of retinal neovascularisation Lisa Tee*, Anne Nguyen, Ireni Ali Rahman, Chooi Lai

PCB298

Seo-Yoon Chang*, Yang-Hyeok Jo, MyungJun Kim

Differential modulatory activity of leukotrienes on vasopressin secretion in a hypovolemia vs. sepsis condition

PCB288

Expression mechanism of PCB293 lipocalin-2 by co-stimulation with interleukin-1β and interferon-γ in ME RINm5F beta-cells

Luis Henrique Costa, Paulo Basso, Maria José Rocha*

Yi-Hua Qiu*, Yan Liu, Jian-Lei Tang, Hui-Wei Huang, Yu-Ping Peng

Transcriptome responses of the intestinal epithelial cells for the upregulation of gene-related to calcium and nutrient absorption in lactating rats and pituitarygrafted hyperprolactinemic rats

Targeting BACE1 to improve leptin sensitivity and reverse obesity

Adesina Arikawe*, Kayode Dada, Abimbola Ogunsola, Daniel Osiagwu, Bolanle Iranloye

CD4+ T cell-derived catecholamines induce a shift of Th1/Th2 balance toward Th2 profile

William Cawthorn*, Erica Scheller, Brian Learman, David Broome, Sandra Soliman, Jenifer DelProposto, Carey Lumeng, Katherine Gallagher, Joshua Miller, Venkatesh Krishnan, Pouneh Fazeli, Anne Klibanski, Mark Horowitz, Clifford Rosen, Ormond MacDougald

The satiety molecule nesfatin-1 increases body temperature of rat Exocrine growth hormone?

Effects of stress hormones on testicular steroidogenesis and role of antioxidants in vitro

PCB291

Bone marrow adipose tissue as a PCB295 source of serum adiponectin: The ‘adiponectin paradox’ explained?

PCB294

Paul Meakin*, Susan Jalicy, Gemma Montagut, Stuart Irvine, Michael Ashford

PCB299

ME beta-arrestin1 mediates cholecystokinin functions in pancreatic beta cells Shanglei Ning, Nan Liang, Jing Su, Chunhua Liu, Junhong Dong, Hui Li, Jin-Peng Sun, Xiao Yu*

PCB300

Poster Communications - Tuesday 23 July Effects of early life leptin intervention on reward-related receptor levels and behaviour Timothy South*, Sung Eun Bae, Jennifer Roberts, Amandine Mullier, Lucilla Poston, Paul Taylor, Clive Coen

PCB301

Protein kinase Cα downregulation PCB307 and increased cAMP generation both enhance calcium-sensing ME receptor-mediated intracellular calcium mobilisation in HEK-293 cells. Mohd Ezuan Bin Khayat*, Katherine Campion, Arthur Conigrave, Donald Ward

Effects of Curcuma comosai PCB302 Roxb. on human osteoblast proliferation and differentiation. Duangrat Tantikanlayaporn*, Lisa Robinson, Apichart Suksamrarn, Pawinee Piyachaturawat, Harry Blair

Litter size manipulation alters PCB308 hormones plasma concentration and vascular reactivity

Andre Mecawi*, Paula Marangon, Natalia Gonzaga, Patricia Passaglia, Carlos Tirapelli, Lucila Elias, José Antunes-Rodrigues

17β-estradiol replacement to ovariectomized rats ameliorates depression-like behavior: antiinflammation and inhibition of IDO activation

Resistance training ameliorates PCB313 resistance insulin, adiposity and bone structure in ovariectomized ME rats. Aluana Santana, Aline Santos, Sanderson Alves, Carlos Alberto Costa, Richard Leite, Patricia Lisboa, Celly Cristina NascimentoSaba*

Duodenal I-cells contain CB1 PCB314 receptor mRNA transcript that is upregulated by energy restriction. Alexandros Sykaras*, Claire Demenis, R.Maynard Case, John McLaughlin, Craig Smith

PCB303

Jianqiang Lu*, Yongjun Xu, Hui Sheng, Yu Liu, Zhiping Tang, Xin Ni

Effects of leptin, TNF alpha, PCB309 IL-1 and insulin on intracellular calcium concentration and pH in ME human articular chondrocytes from healthy and osteoarthritic cartilage

Effects of ofloxacin residues on health biomarkers in chicken

PCB315

Muhammad Arshad*, Salman Butt, Zia Rahman, Farheen Asad

Julio Sánchez*, Diego López-Zapata

Coupling between electrical and PCB304 calcium oscillatory activity in beta cell networks in mouse pancreas ME slices Jurij Dolensek*, Masa Skelin Klemen, Andraz Stozer, Evan Miller, Roger Tsien, Marjan Slak Rupnik

Fayez Almabhouh, Harbindarjeet Singh*, Khairul Osman, Siti Fatimah

PCB310

Zia Rahman*, Farheen Asad, Salman Butt

ME Deteriorative effects of PCB317 norfloxacin residues on quality of broiler meat

Microarray Analysis of the retina PCB311 in growth hormone transgenic mice Steve Harvey*, Brent Martin, Edward List, John Kopchick, Yves Sauve

Salman Butt*, Zia Rahman, Farheen Asad

Correlated responses to a multidirectional artificial selection in the bank vole: Changes in organ size

Glucagon-like peptide-1 enhances PCB306 glucokinase activity in pancreatic β-cells

Ethanol as endo-and exogenous factor in the regulation of functions Menizibeya Welcome*, Vladimir Pereverzev

Adverse effects of leptin on PCB305 sperm count and morphology in Sprague-Dawley rats are reversed ME between six to eight weeks of recovery

Dae-Kyu Song*, Jae-Hyung Park, Jae-Hoon Bae, Seung-Soon Im

Effect of ciprofloxacin residues on PCB316 the quality of meat and eggs in layer chicks

Pawel Koteja*, Katarzyna Baliga-Klimczyk, Katarzyna Chrzascik, Geoffrey Dheyongera, Mateusz Konczal, Uttaran Maiti, Patrycja Orlowska, Agata Rudolf, Clare Stawski, Edyta Sadowska

PCB318

Hall 3, ICC

*Denotes presenting author

The behavioral satiety sequence in pigeons (Columba livia): description and calibration of a test protocol

PCB319

William Spudeit, Natalia Sulzbach, Myla Bittencourt, Ana Andrade, Anita Duarte, Margel Cantarelli, Gabryella Hunning, Tiago dos Santos, Cilene Lino-de-Oliveira, José Marino-Neto*

Hydration and biomechanical PCB325 biomarkers are useful to identify the impact of overweight in skin’s ME physiology Liliana Tavares, Lidia Palma, Osvaldo Santos, Maria Roberto, Maria Bujan, Luis Rodrigues*

Continuous and intermittent PCB320 training protocols improve expression of proteins involved in ME muscle metabolism of inducedobese rats

Susumu Ohya*, Yuka Fukuyo, Miki Matsui, Hisao Yamamura, Rina Shibaoka, Hiroki Niguma, Masanori Fujii, Yuji Imaizumi

Central effects of exenatide, a PCB326 glucagon-like peptide-1 receptor agonist, on human brain ME activation Shane McKie*, Lucy Wasse, Tessa Coulson, Charlotte Bryant, John McLaughlin

Patricia Seraphim*, Bruna Brandao, Lidiane Souza, Beatriz Trombetta, Marcos Fernando Teixeira, Camilo Santos, Silvana Bordin

Are FNDC5 gene expression and irisin release regulated by exercise? Satu Pekkala, Petri Wiklund, Juha Hulmi, Juha Ahtiainen, Mia Horttanainen, Eija Pöllänen, Kari Mäkelä, Heikki Kainulainen, Keijo Häkkinen, Kai Nyman, Markku Alen, Karl-Heinz Herzig*, Sulin Cheng

Effect of sequential oral and PCB327 gastrointestinal stimulation on brain BOLD responses to glucose

Charlotte Bryant*, Lucy Wasse, Shane McKie, John McLaughlin

Attenuation of unloadinginduced rat soleus atrophy with the heat shock protein inducer 17-(Allylamino)-17Demethoxygeldanamycin

PCB322

Differential effects of intragastric PCB328 glucose and fructose on human brain activation, a physiological ME functional magnetic resonance imaging study Lucy Wasse*, Charlotte Bryant, Shane McKie, John McLaughlin

Transplantation safety testing of human adipose tissuederived stem cells labeled with amine-surface modified superparamagnetic iron oxide nanoparticles in rats

Tatiana Nemirovskaya*, Yulia Lomonosova

An explanation of motility PCB334 dysfunction of gut due to arsenicosis via neurotransmitter pathway regulation and oxidative ME stress

PCB329

Xin Guan, Yang Liu, Jing Liu, Nan Wang, Chao Han, Jingyuan Zhao, Yue Dong, Bo Sun, Yue Du, Wei Zou*

Molecular mechanisms involved in the suppression of atrophyrelated genes induced by β2-adrenergic stimulation in denervated mouse skeletal muscles

PCB335

Danilo Lustrino*, Wilian Silveira, Dawit Gonçalves, Neusa Zanon, Isis Kettelhut, Luiz Carlos Navegantes

Hemanth Kandikattu*

Liliana Tavares, Osvaldo Santos, Lidia Palma, Maria Roberto, Maria Bujan, Luis Rodrigues*

PCB333

Mouri Ghosh*, Goutam Paul

Celastrus paninculatus enhances PCB323 endurance activity by improving angiogenesis, mitochondrial ME biogenesis, glucose and lactate transport and protect muscle cells against t-BHP induced oxidative and apoptotic damage

Body mass index impact on in vivo skin’s physiology

Acute effect of dietary and skin PCB332 TRPM8 ion channel stimulation on human thermoregulation and ME metabolism Angelica Valente*, Athanasios Jamurtas, Yiannis Koutedakis, Andreas Flouris

Inflammatory responses to high- PCB321 intensity intermittent training in diet-induced obese rats Patricia Seraphim*, Rafael Moreira, Ana Carolina Panveloski-Costa, Marcos Fernando Teixeira

Role of the intermediatePCB331 conductance Ca2+-activated K+ channel, KCa 3.1 in CD4+ ME T-lymphocytes of mesenteric lymph node of mice inflammatory bowel disease model

PCB324

Intermittent hypoglycaemia affects memory in a mouse model of type 1 diabetes Alison McNeilly*, John Sharkey, Rory McCrimmon

PCB330

Poster Communications - Tuesday 23 July Effects of lipopolysaccharide on mitochondrial functions of skeletal muscle in rats Elif Ozkok, Hatice Yorulmaz, Gulten Ates, Piraye Oflazer, Ayse Sule Tamer*

PCB337

M. Kate Curtis*, Lowri Cochlin, Mark Cole, David O’Neill, Michael Dodd, Damian Tyler, Kieran Clarke, Peter Robbins

Reproductive parameters and PCB350 oxidative status of male Sprague Dawley rats treated with low and ME high salt diet Bolanle Iranloye*, Gabriel Oludare, Naomi Esume, Lucy Ekeh

Hypoxia, placental phenotype and fetal growth in mice

PCB345

Josephine Higgins*, Owen Vaughan, Abigail Fowden, Amanda Sferruzzi-Perri

Gene polymorhisms of water and PCB351 glycerol channels aquaporin 7 and 9 in obese and/or diabetic ME patients Orkide Palabiyik*, Levent Ozturk, Tammam Sipahi, Sibel Guldiken

Muscle recovery after hindlimb PCB339 immobilization is improved by chronic dietary supplementation with alpha-hydroxyisocaproic acid ME (alpha-HICA), but not leucine Hugues Magne*, Charles Lang, Anne Pruznak, M. Navaratnarajah, Kristina Rankine, G. Deiter, Elizabeth Offord, Denis Breuillé

The role of peroxisome proliferator-activated receptor gamma co-activator 1-alpha in pregnancy

PCB346

Aoife Delany*, Fergus McCarthy, Sarah Walsh, Louise Kenny

The effects of Syzygium aromaticum-derived maslinic acid on blood glucose, blood pressure and kidney function of streptozotcin-induced diabetic rats

PCB351a

B.N. Mkhwanazi, C.T. Musabayane*, F.R. Van Heerden

Obesogenic diet alters fetoplacental phenotype

PCB340

Amanda Sferruzzi-Perri*, Owen Vaughan, Maria Haro, Babara Musial, Miguel Constancia, Abigail Fowden

Bin Guo*, Xue-Chao Tian, Dang-Dang Li, LiBing Wei, Ju-Xiong Liu, Zhan-Peng Yue

PCB344

Owen Vaughan*, Hannah Fisher, Amanda Sferruzzi-Perri, Abigail Fowden

Using 31P NMR spectroscopy to PCB338 investigate the effects of iron deficiency on murine skeletal muscle metabolism and function ME during exercise.

Expression and hormonal regulation of CryAB in mouse uterus during early pregnancy

Exogenous corticosterone administration increases materno-fetal glucose transport in the mouse in late pregnancy

PCB341

High fat/high cholesterol diet induces TLRs-associated pulmonary inflammation in C57BL/6J mice

PCB347

Shuang Wang, Tingting Zhu, Ting Chen, Lian Zhang, Xuemei Lian*

Investigating cholesterol PCB348 homeostasis with a twocompartment mathematical model: Towards tailored ME prevention and treatment of high cholesterol

Rab35 regulates pseudopodia PCB352 extension of breast cancer cells in response to extracellular matrix Yichao Zhu*

Role of a jumonji histone demethylase in osteoclast differentiation Seon-Young Kim*, Hye-Jin Kim, Jong-Wan Park, Yang-Sook Chun

PCB353

Olga Hrydziuszko*, Krystian Kubica, Artur Wrona, Joanna Balbus

Signalling from fetus to mother; PCB342 role of the Delta-like homologue 1 Marika Charalambous*, Mary Cleaton, Anne Ferguson-Smith

Periconceptional alcohol exposure impacts on placental structure and gene expression Emelie Gardebjer*, James Cuffe, Karen Moritz

PCB343

Calcium waves in coupled cells of PCB354 the arterial wall: a macro-scale phenomenon Pharmacological enhancement PCB349 of postprandial macro and microvascular blood flow does ME not enhance the anabolic responses to nutrition in skeletal muscle of young men Bethan Phillips*, Philip Atherton, Krishna Varadhan, Marie Limb, Michael Rennie, Kenneth Smith, John Williams

Tim David*, Mohsin Shaikh

Coronary vasodilator effect of flavonoid quercetin Anna Monori-Kiss*, Emil Monos, György Nádasy

PCB355

Hall 3, ICC

*Denotes presenting author

Measurement of endothelial permeability under chronic applied shear stress in a bioreactor

PCB356

Stephen Gray*, Peter Weinberg, Darryl Overby, Anna Randi

Blood temperature influences erythrocyte ATP release and muscle blood flow in human limbs

Platelets activate hepatic endothelium and provide P-Selectin as a bridge for leukocyte recruitment.

PCB363

Patricia Lalor*, John Herbert, Roy Bicknell, David Adams

PCB357

Kameljit Kalsi*, Scott Chiesa, Steven Trangmar, José González-Alonso

PCB370

Javier Blanco-Rivero*, Laura Caracuel, Esther Sastre, Isabel Prieto, Carlos Nieto, M. Angeles Aller, Jaime Arias, Gloria Balfagón

Local perfusion conditions PCB364 influence the epidermal “barrier” function in the lower limb Henrique Silva, Hugo Ferreira, Liliana Tavares, Julia Bujan, Luis Rodrigues*

Microsurgical extrahepatic cholestasis decreases vasoconstrictor response to phenylephrine in rat mesenteric resistance arteries.

Calcium activated chloride PCB371 channels have critical functional effects on intracellular calcium and spontaneous contractions in VS human and rat myometrium Karen Noble*, Susan Wray

The NLRP3 inflammasome: link to PCB358 interleukin-1β production in the human placenta Ebtehaj Maneta, Daniel Hay, Raheela Khan*

miRNA-223 regulates platelet PCB359 function by targeting β1 integrin and factor XIII-A Amro Elgheznawy*, Voahanginirina Randriamboavonjy, Ingrid Fleming

Vasoactive agonists causes changes in vascular smooth muscle cell stiffness and induces stiffness oscillations and remodeling of cytoskeletal architecture

PCB360

Correlation of altered lipid profile PCB361 to chronology of derangement of vascular biomarkers

Inhibitory effects of menthol and its derivative on intestinal contraction of mice Tomoo Homma*, Minami Katagiri, Kazuya Suzuki, Mai Itoh, Naoko Yoneda, Hiroki Tsuyama, Masafumi Fujimoto, Yuichi Suzuki

PCB365

VS Overactive bladder mediated by accelerated Ca2+ influx mode of Na+/Ca2+ exchanger in smooth muscle

Yun Liu*

Tocolytic Effects of Talinum Paniculatum Leaf Extract in Female Virgin Rats Catthareeya Thanamool*, Sajeera Kupittayanant

PCB366

Modulation of urinary PCB367 bladder muscle contractility and mucosal ATP release by inhibition of intracellular protein VS phosphatases.

PCB362

Observation and analysis of an PCB368 ultrafast calcium wave in cultured vascular smooth muscle cells Jairo Quijano*, Jean-Louis Bény, JeanJacques Meister

PCB372

Hisao Yamamura*, William Cole, Satomi Kita, Shingo Hotta, Hidemichi Murata, Yoshiaki Suzuki, Susumu Ohya, Takahiro Iwamoto, Yuji Imaizumi

Jamie Clayton, Darryl Kitney, Theresa Hague, Angilika Talstaya, Christopher Fry, Rita Jabr*

Zhongkui Hong, Zhe Sun, Zhaohui Li, Jerome Trzeciakowski, Gerald Meininger*

Manish Bajpai*, Preeti Kanaujia

Spectral CT imaging for the assessment of non-calcified plaque compositions in carotid atherosclerosis

α1 modulation of spontaneous activity in prostate tissue from men with benign prostatic hyperplasia (BPH) or prostate enlargement

PCB373

Basu Chakrabarty, Mark Frydenberg, Nathan Lawrentschuk, Gail Risbridger, Betty Exintaris*

Enhanced Ca2+-sensing receptor PCB374 function in idiopathic pulmonary arterial hypertension Aya Yamamura*, Qiang Guo, Hisao Yamamura, Adriana Zimnicka, Nicole Pohl, Kimberly Smith, Ruby Fernandez, Amy Zeifman, Ayako Makino, Hui Dong, Jason Yuan

Lysosome-sarcoplasmic reticulum PCB369 junctions: A trigger zone for calcium waves in vascular smooth VS muscle Nicola Fameli*, Cornelis van Breemen, A. Mark Evans

Poster Communications - Tuesday 23 July TMEM16A currents in urethra smooth muscle Eamonn Bradley, Timothy Webb, Mark Hollywood, Keith Thornbury, Noel McHale, Gerard Sergeant*

Oxytocin reduces the tocolytic effect of magnesium sulphate in human myometrium Sarah Arrowsmith*, Harriett Wood, James Neilson, Susan Wray

PCB375

Retention of caveolae PCB382 morphology during physiological mechanosensitisation of VS resistance arteries

Alterations to spontaneous PCB388 activity during mild, moderate and severe heating of isolated pig VS bladder preparations

Michele Sweeney*, Christopher Nicholson, Michael Taggart

Darryl Kitney*, Rita Jabr, Christopher Fry

PCB376

Interrelation between pyeloureteral and peribladder zones pacemaker activity

PCB383

Luiza Simonyan*, Knarik Kazaryan

Role of BDNF-TrkB signaling in neuromuscular junction remodeling Gary Sieck*, Leonid Ermilov, Dylan Sieck, Wen-Zhi Zhan, Carlos Mantilla

PCB377

Hydrogen sufide modulated duodenal motility in rat via activating TRPV1 and KATP channels

PCB384

Characterisation of spontaneous PCB385 activity in the human prostate gland Basu Chakrabarty*, Mark Frydenberg, Nathan Lawrentschuk, Gail Risbridger, Betty Exintaris

Prolonged elevation of cAMP enhances spontaneous contractility in human myometrium from pregnant women at term

PCB391

Pei Lai*, Rachel Tribe, Mark Johnson

VS Enhancement of BK channel activity in vascular smooth muscle (VSM) cells by cGMPdependent protein kinaseinduced phosphorylation of identified serine residues PCB380

PCB386

Barry Kyle*, Soleil Hurst, Pardeep Dhaliwal, Andrew Braun

Intestine of dystrophic mice presents stretch resistance, muscle atrophy and impaired calcium-dependent contractility

PCB392

Gabriel Alves*, Luisa Silva, Rafael Ribeiro, Eloi Rosa, Jeannine Aboulafia, Edna Freymüller, Caden Souccar, Viviane Nouailhetas

Ahmet Ayar*, Oznur Gedikli, Aysegul Kurt, Ramazan Sahan, Mete Ozcan

The role of Protein Kinase A (PKA) PCB390 in calcium wave propagation in isolated Interstitial cells of Cajal VS (ICC) from the rabbit urethra

PCB379

Oluseye Ogunbayo*, Hao-Yu Yang, Mark Evans

Investigation of role of “funny” (If) current in spontaneous and agonist-stimulated contractions in isolated rat myometrium

Sadaf Mumtaz*, Seham AlSaif, Susan Wray, Karen Noble

PCB378

Conor McCloskey, Gerard Sergeant, Mark Hollywood, Noel McHale, Keith Thornbury*

Angiotensin 1- 7 inhibits angiotensin II –induced calcium signal in pulmonary arterial smooth muscle cells.

PCB389

Bernard Drumm*, Gerard Sergeant, Mark Hollywood, Keith Thornbury, Brian Harvey, Noel McHale

Chuanyong Liu*, Wen Lu, Jing Li, Yanfang Ye, Togntong Che, Yan Luo, Jingxin Li, Renzhi Zhan, Wei Yao, Kejing Liu, Shuang Cui

Effects of 8-Br-cAMP and forskolin on spontaneous activity in isolated rabbit corpus cavernosusm myocytes.

Inhibitory effect of visfatin and leptin on human and rat myometrial contractility

Enhanced contractility in the rat PCB381 diabetic bladder: correlation with cellular remodelling

Abnormal phosphorylation of PCB387 myosin light chain phosphatase and myosin downstream of RhoVS associated kinase contributes to the dysfunctional cerebral myogenic response of GotoKakizaki rats

Louise Johnston, Kevin Monaghan, Bronagh McDonnell, Karen McCloskey*

Khaled Abd-Elrahman*, Emma Walsh, Michael Walsh, Cole William

Contrasting effects of gap PCB393 junction blockers on contractility of rat urinary bladder strips Dominika Bijos*, Marcus Drake

Hall 3, ICC

*Denotes presenting author

Time-dependent structural and functional changes in the spinal cord injured rat bladder Susannah Gray*, Niamh McKerr, Barbara Frias, Celia Cruz, Francisco Cruz, Gordon McMurray, Karen McCloskey

PCB394

Differential effects of environmental toxicants, PCB 126 and PCB 77, on cardiac electrophysiology

PCB407

Mi-Hyeong Park*, Su-Hyun Jo

Youn Kyoung Son*, Da Hye Hong, Won Sun Park

In vivo irradiation negatively PCB395 impacts neurogenic and agonistevoked contractions in the mouse VS bladder Bronagh McDonnell*, Karl Butterworth, Kevin Prise, Karen McCloskey

Simvastatin inhibits human myometrial contractility by mechanisms independent of cholesterol depletion and HMGCoA reductase inhibition

Expression of smooth musclePCB401 specific ion channels in TGF-β1induced differentiation of human adipose-derived mesenchymal VS stem cells

The effect of PI3 kinase inhibitor PCB402 LY294002 on voltage-dependent K+ channels in rabbit coronary VS arterial smooth muscle cells Da Hye Hong*, Sung Hun Na, Youn Kyoung Son, Won Sun Park

PCB396

Vincent Pang*

Decreased expression of ATP-sensitive K+ channel in aortic smooth muscle during isoproterenol-induced left ventricular hypertrophy

PCB403

Novel approach to inhibition of neointimal hyperplasia in arteriovenous fistulae Richard Corbett*, Nicolò Demicheli, Lorenza Grechy, Francesco Iori, Jeremy Crane, Neill Duncan, Peter Vincent, Colin Caro

PCB408

Perivascular adipose tissue PCB409 inhibits thoracic aorta endothelial function through Cav-1VS dependent inhibition of nitric oxide production Shiu-Jen Chen*, Hui-Hsin Lee, Cheng-Ming Tsao, Chin-Chen Wu

Youn Kyoung Son*, Da Hye Hong, Won Sun Park

Rapid dilatation induced by release of muscle compression Marco Turturici*, Silvestro Roatta

The role of TRPM8 channels in normal rat bladder function Matthew King*, Orla Murray, Susannah Gray, Louise Johnston, Karen McKloskey, Chris Johnson

PCB397

PCB398

William Murphy, Susan Browne*, Ricardo Segurado, Brigid Gallagher, Ciaran Murphy, Emma Tong

Sarah Withers*, Laura Simpson, Matthias Werner, Anthony Heagerty

Effects of chronic administration PCB399 of virgin coconut oil on the cardiovascular profile in middle aged male rats VS Nattaya Thongsepee*, Chaweewan Jansakul

Inhibitory mechanism of T-type PCB400 Ca2+ channel inhibitor, mibefradil on voltage-dependent K+ channels in coronary arterial VS smooth muscle cells Sung Hun Na*, Da Hye Hong, Won Sun Park

Physiological dynamics in the PCB404 reversal of the Fåhraeus effect in the venous microcirculation of VS the human finger pulp

PKG signalling mediates PCB410 perivascular adipose tissue function of up- and downstream VS of secreted adipokines via regulation of the expression and signalling of adiponectin

Lercanidipine and PCB405 labedipinedilol-A play antiinflammatory role through inhibition of lipopolysaccharide/ VS interferon-γ-induced HMGB1 release and MMP-2, 9 activities in vascular smooth muscle cells Shu-Fen Liou*, Mei-Fen Shih, Chiu-Lan Chen

Effect of azelastine on cardiac action potential duration and hERG K+ channel current Mi-Hyeong Park*, Hyun Jo Su

PCB406

Local cleavage of endothelial cell PCB411 junctional adhesion molecule (JAM)-C by neutrophil elastase governs development of systemic VS inflammation Bartomeu Colom*, Jennifer Bodkin, Mathieu Voisin, David Leinster, Michel Aurrand-Lions, Triantafyllos Chavakis, Beat Imhof, Sussan Nourshargh

Impact of gap junctionmediated information transfer on vessel tone and structure of microvascular networks

PCB412

Bianca Nitzsche, Bettina Reglin, Timothy Secomb, Axel Radlach Pries, Michael Hoepfner, Martin Maibier*

Poster Communications - Tuesday 23 July Potentiated vasoconstrictor PCB413 responses in mesenteric arterioles in elevated extracellular glucose may be due VS in part to a reduction in receptor desensitisation

Effect of perivascular adipose tissue and AMPK activation on vascular myocyte BKCa currents Yiwen Dong*, Gillian Edwards, Anthony Heagerty

PCB418

Robert Jackson, Noel Davies, Richard Rainbow*

Ilaria Floris*, Giuseppe Mangialardi, Anna Maria Posadino, Giampiero Capobianco, Pintus Gianfranco, Costanza Emanueli

Ouabain induces nitric oxide PCB414 release by PI3K/AKT-dependent pathway in isolated aortic of rats with heart failure VS Fabiana Siman*, Edna Silveira, Aurélia Fernandes, Eduardo Meira, Ivanita Stefanon, Dalton Vassallo, Alessandra Padilha

Outgrowth endothelial cell responses to hypoxia: role for BMP/SMAD signalling? Imran Ali*, Michelle Hookham, Tina Schmidt, Nathan Cantley, Melanie Wilson, Andrea Mullins, Reinhold Medina, Alan Stitt, Derek Brazil

Novel inhibitors of serinerich protein kinase -1 prevent choroidal neovascularization in rodent models - a role for potential topical therapeutics in macular degeneration Melissa Gammons*, Andrew Dick, Steven Harper, David Bates

Normotension with enhanced PCB419 body weight and fat deposition in mice deficient for CYP17A1 Zouhair Aherrahrou, Kjestine Schmidt*, Redouane Aherrahrou, Heribert Schunkert, Jeanette Erdmann, Cor de Wit

Preferential Involvement of PPARβ/δ Versus IP in Mediating PAR-Stimulated Angiogenesis PCB415

Charlotte Farrar*, Giles Kalindjian, Justin Mason, Jane Mitchell, Caroline WheelerJones

PCB420

Patterns of arterial wall PCB421 permeability to plasma macromolecules change with age –a high-throughput confocal VS microscopy study PCB416

Modeling of drug kinetics and PCB424 blood flow response dynamics during transdermal iontophoresis of metacholine and acetylcholine VS Fredrik Iredahl*, Johannes Hackethal, Veeranjaneyulu Sadda, Liam Ward, Erik Tesselaar, Simon Farnebo, Folke Sjöberg

Emma Bailey*, Eleni Bazigou, Piotr Sowinski, Peter Weinberg

VS IR emissions from human hands: PCB422 changes and recovery profiles following a reliable, quantifiable VS provocation challenge Danny Clegg*, Peter McCarthy

Phenotypic characterisation and PCB423 molecular changes induced by gestational diabetes mellitus VS on human umbilical endothelial cells: focus on the KDM2B/miR101/ EZH2 pathway

Novel mapping of intercellular stresses in endothelial monolayers during contractile responses to hyperpermeability Erik Valent*, Charles Hardin, Ramaswamy Krishnan, Victor van Hinsbergh, Geerten van Nieuw Amerongen

PCB425

Other Activities Tuesday 23 July 9.30 – 11.30

Faraday Room (Austin Court)

Joint Management Board, Physiological Reports

12.00 – 17.00

Faraday Room (Austin Court)

International Neuroendocrine Federation Council

13.00 – 14.00

Hall 10 (The ICC)

Women in Science: Why mentoring and sponsorship works

13.00 – 14.00

Hall 9 (The ICC)

TR(i)P to Automated Patch Clamp sponsored by Nanion Technologies

13.00 – 14.00

Hall 7 (The ICC)

Annual General Meeting, British Microcirculation Society

13.00 – 14.00

Lodges Room (Austin Court)

Departmental Representatives Meeting, The Physiological Society

13.00 – 14.00

Sonata Room (Hyatt Regency Hotel)

Effective presentation skills

13.00 – 14.00

Hall 8 (The ICC)

Statistics: the Emperor’s clothes

17.30 – 19.00

Executive Room 8 (The ICC)

Executive Committee, Federation of European Physiological Societies

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At a glance - Wednesday 24 July Keynotes

8.30 – 9.15

Heping (Peace) Cheng Hee-Sup Shin Patrik Rorsman

Hall 1 (The ICC) Hall 4 (The ICC) Hall 8 (The ICC)

Morning symposia

9.30 – 11.30

Mechanical stress and vascular remodelling Role of TRP channels in the cardiovascular system Insight into the physiological roles of membrane transporters from drug transport studies Peptide modulation of hedonic food intake Neurons, synapses and circuits in the auditory system: Physiology, pathophysiology and… Generation of respiratory and sympathetic activities in health and diseases Molecular basis of cardiac conduction system in disease The glutamatergic synapse: A neurodegenerative and psychiatric disease target Voltage-gated calcium channels: Novel roles New advances in the physiome and systems biology Network oscillations: Binding brain areas to functional structures

Hall 1 (The ICC) Hall 4 (The ICC) Hall 5 (The ICC) Hall 6 (The ICC) Hall 7 (The ICC) Hall 8 (The ICC) Hall 9 (The ICC) Hall 10 (The ICC) Hall 11 (The ICC) Symphony Ballroom (Hyatt) Kingston Theatre (Austin Court)

Plenary

11.45 – 12.45

Thomas M Jessell

Hall 1 (The ICC)

Lunchtime sessions

13.00 – 14.00

Interdisciplinary Research, Funding and Publication

Hall 8 (The ICC)

Supported by WIREs Membrane Transport and Signaling

Women in Science: Juggling Balls – family and physiology

Hall 6 (The ICC)

Afternoon symposia

14.15 – 16.15

Three decades of Ca2+ sparks and Ca2+ waves in cardiac muscle Vascular calcification Collateral vessels: Adaptive growth mechanisms and functional characteristics Physiology of protein palmitoylation The role of intrinsic electrical activity in the maturation and refinement of the auditory… Molecular mechanisms of transmitter release Mechanistic insights into genotype-to-phenotype relationships Gastrointestinal flexibility: Ecology, evolution and microbial symbiosis Atomic structures and molecular mechanisms of voltage-gated and ligand-gated ion… The role of membrane transport in tumor cell growth and metabolism Auxiliary AMPA receptor subunits: Their role in central synaptic transmission

Keynotes

16.30 – 17.15

William A Catterall Sandra Davidge Peter Hunter

Hall 1 (The ICC) Hall 4 (The ICC) Hall 8 (The ICC)

Formal Poster session C - Hall 3 (The ICC)

17.15 – 19.15

W E D N E S D A Y

Research Symposia - Wednesday 24 July

09.30 – 11.30

Mechanical stress and vascular remodeling (ESM and EVBO)

Role of TRP channels in the cardiovascular system (ESM and EVBO)

Generation of respiratory and sympathetic activities in health and diseases

Hall 1 (The ICC)

Hall 4 (The ICC)

Hall 8 (The ICC)

Organised by Qingbo Xu King’s College London, UK Nanping Wang Xi’an Jiaotong University, China

Organised by Susan Brain King’s College London, UK Scott Earley Colorado State University, USA

Organised by Benedito Machado Universidade de São Paulo, Brazil

Ann Goodchild Macquarie University, Australia

09.30

SA222

09.30

SA227

SA232

Role of microRNAs in vascular inflammation and proliferation in response to mechanical stress Shu Chien University of California, San Diego, USA

TRP channels in cerebral arteries Scott Earley Colorado State University, USA

Functions of the C1 neurons: a synthetic overview Patrice Guyenet University of Virginia, USA

10.00

SA223

SA228

SA233

The role of nuclear matrix on proliferation and apoptosis of vascular cells modulated by mechanical strain Ying-Xin Qi Shanghai Jiao Tong University, China

Pressure-sensing by TRPC5-containing channels in aortic baroreceptor Ching-On Wong The Chinese University of Hong

Kong, China

Respiratory modulation of sympathetic nerve activity: insights from human studies James Fisher University of Birmingham, UK

10.15

SA224

SA229

Atheroprotective effects of shear stress through the regulation of the reninangiotensin system Stephanie Lehoux McGill University, Canada

Lipid-sensing TRPC channels in cardiovascular health and disease David Beech University of Leeds, UK

10.45

SA225

SA234

Inhibitory regulation of sympathetic outflows Ann Goodchild Macquarie University, Australia

SA230

10.45

SA235

Regulation of proinflammatory signalling pathways by shear stress in vascular endothelial cells Mustafa Zakkar St George’s, University of London,

TRPA1 channels and cutaneous blood flow Aisah Aubdool King’s College London, UK

Central respiratory-sympathetic coupling and sympathetic overactivity after chronic intermittent hypoxia Daniel Zoccal São Paulo State University, Brazil

11.00

SA226

SA231

SA236

Athero-susceptibility of the stressed endothelium Peter Davies University of Pennsylvania, USA

TRP channels as regulators of blood pressure and cardiac hypertrophy Marc Freichel Heidelberg University, Germany

Oxygen sensing and hypertension Julian Paton University of Bristol, UK

Sponsored by:

ESM & EVBO programme

Brazilian Physiological Society

VS 98

09.30

Voltage-gated calcium channels: Novel roles

Insight into the physiological roles of membrane transporters from drug transport studies

Molecular basis of cardiac conduction system in disease

Hall 11 (The ICC)

Hall 5 (The ICC)

Hall 9 (The ICC)

Organised by Annette Dolphin University College London, UK Roberto Chiesa Mario Negri Institute of Pharmacological

Organised by Catriona Andersonm Newcastle University, UK Ikumi Tamai Kanazawa University, Japan

Organised by Halina Dobrzynski University of Manchester, UK Dario DiFrancesco University of Milan, Italy

09.30

Research, Italy

SA237

SA242

SA247

Neuronal voltage-gated calcium channels: the role of auxiliary α2δ subunits in channel trafficking and in neuropathic pain Annette Dolphin University College London, UK

Pharmacological relevance of intestinal drug transporters Ikumi Tamai Kanazawa University, Japan

Development of the cardiac conduction system Vincent Christoffels Academic Medical Center, The

10.00

SA238

Quality control of P/Q-type channels: implication in channelopathies Alexandre Mezghrani Institut de Génomique

Fonctionnelle, France

SA243

Netherlands

SA248

Polyspecific transporters as powerful pharmacological targets: the case of PEPTs (SLC15) and OCTs (SLC22) Monica Sala-Rabanal Washington University in St.

Optical mapping of the sinus and atrioventricular nodes Vadim Fedorov The Ohio State University, USA

10.15

Louis, USA

10.15

SA239

Neuronal dysfunction in genetic prion diseases: mutant prion protein impairs delivery of voltage-gated calcium channels to the presynaptic membrane Roberto Chiesa Mario Negri Institute of

SA244

SA249

The role of folate transporters in folate homeostasis and the targeted delivery of pharmacological agents to cancer cells I. David Goldman Albert Einstein College of

HCN channelopathies and sinus node arrhythmias Dario DiFrancesco University of Milan, Italy

10.45

Medicine, USA

Pharmacological Research, Italy

10.45

SA240

CRMPs curb calcium channels for cessation of chronic pain: an old target engages a new partner Rajesh Khanna Indiana University School of Medicine, USA

SA245

Regulated trafficking of concentrative nucleoside transporters (CNTs) to the plasma membrane: a key event in nucleoside-derived drugs action Paula Fernández Calotti University of Barcelona,

SA250

W E D N E S D A Y

Modulation of atrioventricular node cell activity: endothelin-1 and acetyl-choline Stephanie Choisy University of Bristol, UK

Spain

11.00

SA241

Ca2+ channel subunits α2δ2 and α2δ3 are essential for normal hearing in mice Jutta Engel Saarland University, Germany

11.00

SA246

Physiological and pharmacological insights from OATP uptake transporter knockout mice Alfred Schinkel The Netherlands Cancer Institute,

11.00

SA251

Purkinje fibers and arrhythmias Penny Boyden Columbia University, USA

The Netherlands

Sponsored by:

CR 99

Research Symposia - Wednesday 24 July New advances in the physiome and systems biology

Symphony Ballroom (Hyatt Regency Hotel) Organised by Andrew McCulloch University of California, San Diego,

USA

Chae Hun Leem University of Ulsan College of Medicine,

09.30 – 11.30

The glutamatergic synapse: A neurodegenerative and psychiatric disease target

Network oscillations: Binding brain areas to functional structures

Hall 10 (The ICC)

Kingston Theatre (Austin Court)

Organised by David Wyllie University of Edinburgh, UK Lynn Raymond University of British Columbia, Canada

Organised by Attila Sik University of Birmingham, UK Anton Sirota University of Tübingen, Germany

09.30

Glutamatergic synaptic dysfunction in Huntington disease Lynn Raymond University of British Columbia,

Computations performed by theta LFP oscillations in the hippocampal formation John O’Keefe University College London, UK

10.00

South Korea

09.30

SA252

The future of medicine: putting the individual where she should be Hans Westerhoff University of Manchester, UK

10.00

SA253

Microvascular systems biology Shayn Peirce University of Virginia, USA

10.15

SA254

Multi-scale modeling of cardiac excitationcontraction coupling Nicolas Smith King’s College London, UK

Canada

SA257

SA261

SA262

Regulators of spine density as targets for the treatment of psychiatric disease Amy Ramsey University of Toronto, Canada

Network dynamics in entorhinohippocampal circuits during exploratory behaviour Anton Sirota University of Tübingen, Germany

10.15

SA258

Synaptic signaling scaffolds and autism spectrum disorder Eunjoon Kim Korea Advanced Institute of Science and

SA263

Cell-type specific regulation of hippocampal microcircuits Ivan Soltesz University of California, Irvine, USA

Technology, South Korea

10.45

SA255

10.45

SA259

10.45

SA264

Modeling the pulmonary physiome: integration of clinical data with multi-scale analysis Merryn Tawhai University of Auckland, New Zealand

Glutamate receptor surface dynamics: regulation in brain pathophysiology Laurent Groc University of Bordeaux, France

Optogenetic dissection of oscillatory circuits Iris Oren University of Edinburgh, UK

11.00

SA256

Stochastic multiscale modelling of the neuro-musculoskeletal system Marco Viceconti University of Sheffield, UK

SA260

Effect of disease causing mutations on NMDA receptor function Stephen Traynelis Emory University School of

Medicine, USA

SA265

Cortical properties of human slow wave sleep Istvan Ulbert Hungarian Academy of Sciences, Hungary

Supported by: Generous donations from Unisense, Tucker-Davis Technologies, Triangle Biosystems International and Lafayette-Campden Instruments

CR ET 100

Neurons, synapses and circuits in the auditory system: Physiology, pathophysiology and potential therapeutics for hearing disorders

Peptide modulation of hedonic food intake

Hall 7 (The ICC)

Hall 6 (The ICC)

Organised by Ricardo Leão University of São Paulo, Brazil Ana Belén Elgoyhen INGEBI-CONICET, Argentina

Organised by Gareth Leng University of Edinburgh, UK Zsolt Liposits Hungarian Academy of Sciences, Hungary

09.30

SA266

SA271

The efferent olivocochlear system and protection from acoustic trauma Ana Belén Elgoyhen INGEBI-CONICET, Argentina

Ghrelin: an orexigenic gut - brain reward signal Suzanne Dickson The Sahlgrenska Academy at the

10.00

SA267

University of Gothenburg, Sweden

SA272

Effect of myelin loss on synaptic function in the auditory brainstem Jun Hee Kim University of Texas at San Antonio, USA

Reciprocal interactions between the stress response and hedonic food reward after prenatal stress John Menzies University of Edinburgh, UK

10.15

SA268

Cellular mechanism of sound localization Gerard Borst Erasmus Medical College, The

Netherlands

SA273

In vivo neural responses to changes in energy balance, leptin and ghrelin Roger Adan University Medical Center Utrecht, The Netherlands

10.45

SA269

10.45

SA274

What does a cochlear implant do to your brain? Plastic changes in the primary auditory cortex with long-term deafness and cochlear implant use James Fallon Bionics Institute, Australia

Dissecting the neural and behavioral processes linking leptin and reward Stephanie Fulton University of Montreal, Canada

11.00

SA270

Optimizing VNS-directed neural plasticity for the treatment of chronic tinnitus Michael Kilgard University of Texas Health Science

W E D N E S D A Y

SA275

Opioid orchestration of feeding behavior Carlos Dieguez University of Santiago de

Compostela, Spain

Center, USA

Sponsored by: Brazilian Physiological Society

N 101

Research Symposia - Wednesday 24 July

14.15 – 16.15

Three decades of Ca2+ sparks and Ca2+ waves in cardiac muscle

Vascular calcification (ESM and EVBO)

Molecular mechanisms of transmitter release

Hall 1 (The ICC)

Hall 4 (The ICC)

Hall 8 (The ICC)

Organised by Godfrey Smith University of Glasgow, UK John Bridge University of Utah, USA

Organised by Yvonne Alexander University of Manchester, UK Cecilia Giachelli University of Washington, USA

Organised by Jens Rettig Saarland University, Germany Tao Xu Chinese Academy of Sciences, China

14.15

SA276

The “ins and outs” of Ca2+ sparks Mark Cannell University of Bristol, UK

14.45

SA277

Subcellular alterations in RyR activation in a sheep model of atrial fibrillation Niall MacQuaide KU Leuven, Belgium

15.00

SA278

SA281

Mechanisms of vascular ageing and calcification Catherine Shanahan King’s College London, UK

Towards a better understanding of neuropeptide exocytosis using C. elegans model Tao Xu Chinese Academy of Sciences, China

14.45

SA282

miRNA-125b and their targets in cardiovascular calcification Claudia Goettsch Center for Interdisciplinary

Deciphering dead-end docking of large dense core vesicles in chromaffin cells Ute Becherer Saarland University, Germany

15.00

Cardiovascular Sciences Brigham and Women’s Hospital, Harvard Medical School, USA

SA283

SA287

Termination of Ca sparks: role of cytosolic and intra-luminal Ca Aleksey Zima Loyola University Chicago, USA

Arterial calcification in chronic kidney disease (CKD): role of phosphate and phosphate transporters Cecilia Giachelli University of Washington, USA

DOC2B and Munc13-1 differentially regulate neuronal network activity Uri Ashery Tel Aviv University, Israel

15.30

SA279

SA284

Slow Ca2+ sparks de-synchronize Ca2+ release in failing cardiomyocytes William Louch University of Oslo, Norway

Calcium phosphate crystals and cell death Diane Proudfoot Babraham Institute, UK

Myosin V function in organelle trafficking Claire Desnos Université Paris Descartes, France

15.45

SA280

A modified local control model for Ca transients in cardiomyocytes John Bridge University of Utah, USA

SA285

Pro-inflammatory aspects of cardiovascular calcification: insights from molecular imaging Elena Aikawa Harvard Medical School, USA

ESM & EVBO programme

SA288

Activity-mediate expansion of the secretory fusion pore is regulated by a calcineurindependent dynamin-syndapin signaling pathway in neuroendocrine mouse adrenal chromaffin cells Corey Smith Case Western Reserve University, USA

Sponsored by:

102

SA286

Atomic structures and molecular mechanisms of voltage-gated and ligandgated ion channels

Collateral vessels: Adaptive growth mechanisms and functional characteristics (ESM and EVBO)

Mechanistic insights into genotype-to-phenotype relationships

Hall 11 (The ICC)

Hall 5 (The ICC)

Hall 9 (The ICC)

Organised by Raimund Dutzler University of Zurich, Switzerland João Morais Cabral IBMC, Portugal

Organised by Ulrich Pohl Ludwig-Maximilians University, Germany

Organised by Daniel Beard Medical College of Wisconsin, USA Elena Marchiori Radboud University, The Netherlands

14.15

SA289

SA294

SA297

Studies of a cyclic nucleotide regulated potassium channel João Morais Cabral IBMC, Portugal

Biomechanical control of the SMC phenotype during arteriogenesis Thomas Korff Heidelberg University, Germany

Constraint-based analysis of energy metabolism in mitochondrial diseases Elena Marchiori Radboud University, The

14.45

SA290

Structure and regulation of the CorA magnesium channel Jian Payandeh Genentech, Inc., USA

SA295

Netherlands

Inhibition of individual 14q32 microRNAs drastically increases neovascularization and blood flow recovery after ischemia Yaël Nossent Leiden University Medical Center, The

Empowering the laboratory rat through advances in genetic engineering Aron Geurts Medical College of Wisconsin, USA

15.00

Netherlands

15.00

SA291

SA296

SA298

Activation and inhibition of prokaryotic pentameric ligand-gated ion channels Raimund Dutzler University of Zurich, Switzerland

Vasomotor properties of collateral arteries: effects of exercise training Maurice Laughlin University of Missouri, USA

Detecting gene-gene interactions in genome-wide association studies of complex diseases Heather Cordell Newcastle University, UK

15.30

Modulation of arteriogenesis by signals from downstream tissue Rabea Hinkel Ludwig-Maximilians-University,

Germany

Molecular programming of cell and vessel phenotypes during neurovascular formation Amina Qutub Rice University, USA

15.45

Connexins: multifunctional regulators of arterial vessel growth, remodeling and function Janis Burt University of Arizona, USA

Causally cohesive genotype - phenotype modelling Jon Olav Vik Norwegian University of Life Sciences,

SA292

Comparison of the structure of a potassium channel in both 2D and 3D crystals Catharine Vénien-Bryan University of Oxford, UK

15.45

SA293

Structure of sodium channel pore implications for ion permeation and gating Daniel Minor University of California, San Francisco,

USA

SA299

W E D N E S D A Y

Norway

Sponsored by:

Scandinavian Physiological Society

American Physiological Society

ESM & EVBO programme

SA337

Vasoprotective axis of the RAS- a novel target against diabetic retinopathy Qiuhong Li University of Florida, USA

134

09.30

Membrane potential investigated with voltage sensitive dyes

Microvascular networks: Causes and consequences (ESM and EVBO)

Intracellular signalling microdomains in heart

Hall 11 (The ICC)

Hall 5 (The ICC)

Hall 9 (The ICC)

Organised by Marco Canepari INSERM U836, France Carl Petersen EPFL, Switzerland

Organised by Axel Pries CharitĂŠ, Berlin, Germany Ed van Bavel AMC, Amsterdam, The Netherlands

Organised by Richard Vaughan-Jones University of Oxford, UK Yin Hua Zhang Seoul National University, South Korea

09.30

Simultaneous optical recording of membrane potential and calcium signals Marco Canepari INSERM U836, France

How does it start: branching morphogenesis Anne Eichmann Yale University, USA

Local Ca2+ signalling microdomains, and their integration within the cell Tullio Pozzan University of Padua, Italy

10.00

09.30

SA338

SA339

Voltage imaging from axons and dendritic spines Marko Popovic Yale University School of Medicine,

USA

SA343

Coronary microvascular network adaptation in a rabbit model of developing heart failure: insights from 3D cryomicrotome imaging Jeroen van den Wijngaard AMC, University of

10.00

SA347

Compartmentation of nitric oxide synthase regulates Ca2+ signalling in heart Yin Hua Zhang Seoul National University, South

Korea

Amsterdam, The Netherlands

10.15

SA340

10.15

SA344

10.15

SA348

Membrane potential investigated with voltage sensitive dyes Carl Petersen EPFL, Switzerland

Generation of microvascular networks: a biological patterning problem TW Secomb University of Arizona, USA

Spatial coupling between pH and Ca2+ in the ventricular myocyte Pawel Swietach University of Oxford, UK

10.45

SA341

Teasing apart biophysical unpinnings of CNS axon spike kinectics Amanda Foust UniversitĂŠ Paris Descartes, France

11.00

SA342

SA345

SA349

A microvascular origin of the systemic arterial pressure level Jens Christian Jacobsen University of

Orchestration of signaling microdomains in heart by cytoskeleton and protein scaffolds Jeffrey Saucerman University of Virginia, USA

11.00

Copenhagen, Denmark

SA346

SA350

Membrane potential imaging during functional development of neuronal circuits in vertebrate embryos Yoko Momose-Sato Kanto Gakuin University, Japan

Microvascular network assessment in the clinic Daniel De Backer Erasme University Hospital,

Belgium

Caveolae contribute to spatial control of cAMP within the cardiac cell Sarah Calaghan University of Leeds, UK

Sponsored by:

The Federation of European Physiological Societies

Scandinavian Physiological Society

T H U R S D A Y

CR 135

Research Symposia - Thursday 25 July

09.30 – 11.30

Interplay between neurones, astrocytes and blood vessels

Brain imaging – an ethical time bomb?

Symphony Ballroom (Hyatt Regency Hotel)

High resolution microscopy (nanoscopy) and correlative light and electron microscopy (CLEM)

Hall 10 (The ICC)

Kingston Theatre (Austin Court)

Organised by Sergey Kasparov University of Bristol, UK Maiken Nedergaard University of Rochester, USA

Organised by Joanna Wardlaw University of Edinburgh, UK Hank Greely Stanford University, USA

Organised by Katharina Gaus University of New South Wales,

09.30

New insights into the functions of cortical astrocytes from multiphoton imaging in awake mice Maiken Nedergaard University of Rochester, USA

Brain and mind reading Geraint Rees University College London, UK

10.00

In vivo evidence for neuron-glia metabolic coupling Benjamin Boury-Jamot University of Lausanne,

The Brain Imaging Dialogue: navigating the politics of science and technology Oliver Escobar University of Edinburgh, UK

Nano-resolution fluorescence electron microscopy Shigeki Watanabe University of Utah, USA

10.15

Switzerland

SA351

Imaging brain activity from capillaries Serge Charpak Paris Descartes University, France

SA354

SA352

Molecular insights into the regulation of T cell signalling Katharina Gaus University of New South Wales,

SA355

SA356

10.00

SA360

SA361

The business of brain imaging – a commercial perspective Gemma Calvert Nanyang Technological University,

Seeing the forest, tree by tree - Single molecule superresolution microscopy of multiprotein complexes Helge Ewers UZH | ETH Zurich, Switzerland

10.45

SA357

Astroglial hemichannels modulate UP and DOWN states in the olfactory bulb Lisa Roux NYU Langone Medical Center, USA

The promises and perils of brain imaging technology: an ethical perspective Laura Cabrera University of Basel, Switzerland

Nanoscale imaging of synapses in living brain slices using STED microscopy Valentin Nägerl CNRS Bordeaux, France

11.00

SA353

Astrocytes control release of noradrenaline in the locus coeruleus via a novel signalling mechanism Anja Teschemacher University of Bristol, UK

SA358

Society meets neuroimaging – likely tensions Hank Greely Stanford University, USA

CR ET

SA362

High-speed hyperspectral nanoscopy for studying dynamic protein interactions below the diffraction limit Keith Lidke University of New Mexico, USA

Sponsored by:

136

SA359

Australia

Singapore

10.45

Australia

Jens Rettig Saarland University, Germany

Solute and ion cotransporters and exchangers at atomic resolution

Myometrial physiology - time to translate?

Hall 7 (The ICC)

Hall 6 (The ICC)

Organised by David Thwaites Newcastle University, UK Olga Boudker Weill Cornell Medical College, USA

Organised by Susan Wray University of Liverpool, UK Jorge Cavajal Pontificia Universidad Católica de Chile,

09.30

SA363

Chile

09.30

SA368

Conformational changes during the CLC transport cycle Alessio Accardi Weill Cornell Medical College, USA

Time to translate? Overview of myometrial contractility Susan Wray University of Liverpool, UK

10.00

SA364

The mechanics of Na+/H+ antiport David Drew Imperial College London, UK

10.15

SA369

From genome-wide screens to computational modelling: finding novel targets to manipulate uterine function Andrew Blanks University of Warwick, UK

SA365

10.15

SA370

Dance lessons for proteins: conformational dynamics of a glutamate transporter homologue Olga Boudker Weill Cornell Medical College, USA

The importance of the smooth muscle cytoskeleton for pre-term labour Kathleen Morgan Boston University, USA

10.45

SA366

SA371

Structural physiology of PepT1, the mammalian proton coupled peptide transporter Simon Newstead University of Oxford, UK

Finding new agent and mechanisms in medicinal plants Sajeera Kupittayanant Suranaree University of

11.00

SA367

From crystallographic snapshots towards a mechanism for secondary transport Christine Ziegler Max-Planck-Institut für Biophysik,

Germany

Technology, Thailand

SA372

A tale of two channels-Kv7 and ERG in myometrial regulation Iain Greenwood St George’s University of London, UK

T H U R S D A Y

VS 137

Research Symposia - Thursday 25 July

14.15 – 16.15

Cardiovascular regulation by miRNAs (ESM and EVBO)

Understanding the etiology of hypertension

Cardiovascular developments that changed the world

Hall 1 (The ICC)

Hall 4 (The ICC)

Hall 8 (The ICC)

Organised by Giovanni Mann King’s College London, UK

Organised by Andrew Allen University of Melbourne, Australia Hidefumi Waki Wakayama Medical University School

Organised by Holly Shiels University of Manchester, UK Jonathan Stecyk University of Alaska Anchorage, USA

14.15

of Medicine, Japan

14.15

SA373

SA377

SA382

The role of miRNAs in cardiovascular ageing Reinier Boon Goethe University, Germany

Type 1 angiotensin receptors in the kidney and the control of blood pressure Susan Gurley Duke University Medical Center, USA

Advent of the coronary circulation: comings and goings among most of the world’s vertebrates Tony Farrell University of British Columbia, Canada

14.45

SA374

SA378

SA383

The role of miRNA in vascular remodeling Andrew Baker University of Glasgow, UK

Sympathetic vasomotor control by oxidative stress in renovascular hypertension Ruy Campos Federal University of São Paulo, Brazil

Cardiovascular function in fish: consequences from life in a chronically heated environment Erik Sandblom University of Gothenburg, Sweden

15.15

15.00

SA375

SA379

SA384

microRNAs, transforming growth factor beta-1 and tissue fibrosis Robert Jenkins Cardiff University, UK

Mice with selective angiotensin type 1A receptor deletion from catecholaminergic neurons show altered angiotensin IIdependent hypertension Andrew Allen University of Melbourne, Australia

Control of pacemaker HCN channel function by cAMP and voltage Eric Accili University of British Columbia, Canada

15.45

15.30

SA376

Role of miRNAs in mitochondria and genetic disease Alexandra Henrion-Caude INSERM U781, France

SA380

SA385

Contributions of vascular inflammation in the brainstem for neurogenic hypertension Hidefumi Waki Wakayama Medical University School

Take a deep breath: cellular adaptations for life without oxygen Gina Galli University of Manchester, UK

15.45

Adaptive immunity, inflammation and hypertension Tomasz Guzik University of Glasgow, UK

Gaining control, the role of the contractile element in the evolution of muscle function Todd Gillis University of Guelph, Canada

of Medicine, Japan

138

Sponsored by:

ESM & EVBO programme

American Physiological Society

VWR International Ltd

SA386

The physiology of rapid responses to estrogen

Physiological roles of non-coding RNAs

Imaging mouse visual cortex function and plasticity

Hall 11 (The ICC)

Hall 5 (The ICC)

Hall 9 (The ICC)

Organised by Brian Harvey Royal College of Surgeons in Ireland,

Organised by Andreas Werner Newcastle University, UK Noora Kotaja University of Turku, Finland

Organised by Mark Hübener Max Planck Institute of Neurobiology,

Germany

14.15

Plasma membrane estrogen receptors and the biology of estrogen action Ellis Levin University of California, Irvine, USA

RNA at the epicentre of human evolution, development and cognition John Mattick Garvan Institute of Medical Research, Australia

Spontaneous activity patterns in the developing mouse visual cortex Christian Lohmann Netherlands Institute for

Neuroscience, The Netherlands

14.45

Membrane initiated estrogen actions on the cytoskeleton Marilena Kampa University of Crete, Greece

Non coding RNAs and drug resistance in melanoma Laura Poliseno Istituto Toscano, Italy

Structural correlates of visual cortex plasticity Tara Keck King’s College London, UK

15.00

Ireland

Ellis Levin University of California, Irvine, USA

14.15

SA387

SA388

SA389

The G-protein-coupled estrogen receptor GPER in health and disease Matthias Barton University of Zurich, Switzerland

SA392

Long non-coding RNA & cancer Sven Diederichs German Cancer Research Center DKFZ, Germany

Frank Sengpiel Cardiff University, UK

SA395

SA396

SA397

In vivo imaging of coordinated excitatory and inhibitory synaptic dynamics on pyramidal cell dendrites Elly Nedivi Massachusetts Institute of Technology,

USA

15.30

SA390

15.30

SA393

15.30

SA398

Estrogen regulation of KCNQ1: KCNE3 channels in intestinal secretion Raphael Rapetti-Mauss Royal College of Surgeons

Human nuclear dicer restricts accumulation of endogenous double strand RNA Monika Gullerova University of Oxford, UK

The emergence of functional microcircuits in visual cortex Sonja Hofer University College London, UK

15.45

in Ireland, Ireland

SA391

Oestrogen receptor beta: a new target for type 2 diabetes treatment Angel Nadal Universidad Miguel Hernández de Elche,

RNA regulation in male germline Noora Kotaja University of Turku, Finland

Spain

SA394

How sensory deprivation and learning change neuronal responses in mouse visual cortex Mark Hübener Max Planck Institute of Neurobiology,

Germany

Sponsored by:

The Federation of European Physiological Societies

Integrated DNA Technologies

SA399

T H U R S D A Y

EM N 139

Research Symposia - Thursday 25 July Nanojunctions and calcium signalling in smooth muscle cells: From contraction and relaxation to gene expression (ESM and EVBO) Symphony Ballroom (Hyatt Regency Hotel) Organised by A Mark Evans University of Edinburgh, UK Maria Gomez Lund University, Sweden

14.15

SA400

14.15 – 16.15

The case for comparative and evolutionary physiology in clinical research

Pathophysiology of atrial fibrillation

Hall 10 (The ICC)

Kingston Theatre (Austin Court)

Organised by Michael Joyner Mayo Clinic, USA Sandy Martin University of Colorado School of Medicine,

Organised by Ulrich Schotten University Maastricht, The Netherlands

14.15

USA

SA405

Calcium dynamics in nano-junctions between the sarcoplasmic reticulum (SR), plasma-membrane and other organelles in vascular smooth muscle Casey van Breemen University of British Columbia,

Has the continuing relevance of comparative physiology “gone missing” in biomedical research? Michael Joyner Mayo Clinic, USA

Cellular and molecular mechanisms of ion channel trafficking in atrial fibrillation Elise Balse INSERM, Paris, France

14.45

Canada

SA401

SA406

Acidosis dilates brain parenchymal arterioles by reshaping spontaneous calcium signals to activate BKCa channels Fabrice Dabertrand University of Vermont, USA

Sex, nerves and blood pressure: a comparative analysis of the role that sex plays in blood pressure modulation Emma Hart University of Bristol, UK

Role of micRNAs in the development of the substrate for atrial fibrillation Reza Wakili University of Munich, Germany

15.00

SA402

SA407

SA410

From contraction to gene expression: function-specific calcium signals are delivered by the strategic positioning of calcium pumps and release channels within membrane-membrane nanojunctions of the sarcoplasmic reticulum A Mark Evans University of Edinburgh, UK

Maintaining homeostasis despite deadly physiological extremes: lessons from a natural expert Sandy Martin University of Colorado School of

Role of myocardial ROS signalling in postoperative and non-surgical atrial fibrillation Barbara Casadei University of Oxford, UK

15.30

SA403

Targeted STIM deletion impairs calcium homeostasis, NFAT activation, and growth of smooth muscle cells Salvatore Mancarella Temple University School of

Medicine, USA

SA408

SA411

Comparative physiology in regenerative medicine Henrik Lauridsen Aarhus University, Denmark

Changes in spatio-temporal pattern of Ca2+ release in tachycardia-induced atrial remodelling Maura Greiser University of Maryland, USA

15.45

Medicine, USA

15.45

SA404

NFAT-dependent excitation-transcription coupling in smooth muscle Maria Gomez Lund University, Sweden

SA409

Comparative physiology of temperature regulation: of brains and different sized bodies Shane Maloney The University of Western Australia,

Australia

Sponsored by:

ESM & EVBO programme

The Federation of European Physiological Societies

VS 140

PITX IIc and atrial fibrillation – how left atrial development determines AF susceptibility Paulus Kirchhof University of Birmingham, UK

An update on inherited renal tubular disorders

Orchestrating signals towards early therapeutically relevant clinical measures of neurodegeneration

Hall 7 (The ICC)

Hall 6 (The ICC)

Organised by René Bindels Radboud University, The Netherlands Fiona Karet University of Cambridge, UK

Organised by Graham Collingridge University of Bristol, UK Paul Wren Neurodegeneration DPU, GlaxoSmithKline,

14.15

SA412

Chasing tails: clinics and C-termini Fiona Karet University of Cambridge, UK

14.45

China

14.15

SA417

Translational spectral electroencephalographic markers in the European PharmaCog project: a new resource for drug discovery for Alzheimer’s disease Claudio Babiloni University of Foggia, Italy

SA413

14.45

SA418

The role of Tmem27 and ACE2 on renal neutral amino acid transport Simone Camargo University of Zürich, Switzerland

Cortical gamma oscillations and mitochondrial dysfunction: food for thought in neurodegeneration? Mark Cunningham Newcastle University, UK

15.00

SA414

Disorders of neutral amino acid transport Stefan Broer The Australian National University,

Australia

SA419

Neuron-glia crosstalk under pathological condition of Alzheimer’s disease Inhee Mook-Jung Seoul National University College

of Medicine, South Korea

15.30

SA415

15.30

SA420

Tubular defects leading to renal stones John Sayer Newcastle University, UK

Understanding physiological roles of microtuble binding protein tau Daniel Whitcomb University of Bristol, UK

15.45

SA416

Uromodulin-associated kidney diseases Olivier Devuyst University of Zürich, Switzerland

Elevation of brain magnesium as the new paradigm for the treatment of aging dependent memory decline and Alzheimer disease Guosong Liu Tsinghua University, China

T H U R S D A Y

N 141

Poster Communications - Thursday 25 July Importance of Caveolin-1 in PCD002 ouabain-induced Na+K+-ATPase signaling and cardiac hypertrophy CR but not in inotropic effect in mouse hearts

Targeting ventricular arrhythmias: PCD007 MKK7 a remarkable player? Sanjoy Chowdhury*, Min Zi, Wei Liu, Hoyee Tsui, Yanwen Wang, Holly Shiels, Elizabeth Cartwright, Ming Lei, Xin Wang

Yan Bai, Jian Wu, Daxiang Li, Lijun Liu*

Identification a pool of cardiac phospholemman that does not interact with the sodium pump Krzysztof Wypijewski*, Jacqueline Howie, Louise Reilly, Karen Aughton, Michael Shattock, Sarah Calaghan, William Fuller

Proteome-wide characterisation of lipid raft proteins in adult rat ventricular myocytes Krzysztof Wypijewski*, Michele Tinti, Sarah Calaghan, William Fuller

Glucagon-like peptide-1 eluting PCD013 mesenchymal stem cells reduce apoptosis and improve viability of ischemic human cardiomyocytes CR in vitro Elizabeth Wright*, Christine Wallrapp, Andrew Lewis, Moustapha Kassem, Nadim Malik, Cathy Holt

PCD003

PCD004

Metabolic stress alters the PCD005 balance between palmitoylation and glutathionylation of the CR Na pump regulatory protein phospholemman Jacqueline Howie*, Jill Swarbrick, Michael Shattock, William Fuller

Kolaviron, a biflavonoid of PCD006 Garcinia kola seed offered cardioprotection against ischaemic/reperfusion injury by CR up-regulation of pro-survival and down-regulation of apoptotic signaling pathways

Cardioprotective adaptation of rats to chronic hypoxia is accompanied by changes in myocardial adenylyl cyclase signaling

PCD008

Klara Hahnova*, Barbora Volfova, Lucie Hejnova, Jan Neckar, Frantisek Kolar, Jiri Novotny

Chronic morphine treatment alters the adenylyl cyclase signaling system of the rat heart Jitka Skrabalova*, Barbora Volfova, Jiri Novotny, Lucie Hejnova, Jan Neckar, Frantisek Kolar

Lawrence Olatunji, Isaiah Owolabi*, Bello Olohuntoyin, Toyib Olaniyan

PCD009

Na+/K+-ATPase activities in normotensive human subjects with and without family history of hypentension in south Western Nigeria

Investigating the role of epicardial fat as an imaging biomarker in type-2 diabetes Deirdre Cassidy*, Stephen Gandy, Suzanne Duce, Faisel Khan, Patrica Martin, Richard Nicholas, John Houston

Effects of exercise training on PCD010 cardiac myocytes and fibroblasts intercellular coupling Marcia Alves*, Parvinder Kaur, Jose Moreira, Karin Solvang-Garten, Hoydal Morten, Ragnhild Rosbjorgen, Gustavo Silva, Ulrik Wisloff

Glucose tolerance: an important PCD014 indicator for the early onset of diabetes in young sickle-cell trait CR carriers

PCD015

Effect of cigarette smoke and PCD016 cook smoke on nasal mucociliary clearance Priscilla Johnson*, Prathibha Muthu, Preetha Paul, Sitalakshmi Ramadoss, Manu Kurian Baby, Padmavathi Ramasamy, Kalpana Balakrishnan

PCD011

Correlates of cigarette use in High Schools in Chatsworth, Durban, South Africa

Olubunmi Oyekunle*, Ayodele Soladoye

Premjith Gathiram*, Tonya Esterhuizen, Soornarain Naidoo

The soluble guanylate cyclase PCD012 activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling CR organ systems

Cardiac systolic and diastolic functions in spinal cord injured patients during lower body heating

PCD017

Ademola Oyagbemi*, Ebenezer Farombi, Jacobs Bester, Adriaan Esterhuyse

Benjamin Vandendriessche*, Elke Rogge, Vera Goossens, Peter Vandenabeele, Johannes-Peter Stasch, Peter Brouckaert, Anje Cauwels

142

Manabu Shibasaki*, Yasunori Umemoto, Tokio Kinoshita, Ken Kouda, Tomoyuki Ito, Takeshi Nakamura, Craig Crandall, Fumihiro Tajima

PCD018

Hall 3, ICC

*Denotes presenting author

Localizing the intracellular ADP diffusion restrictions in trout cardiomyocytes Niina Sokolova*, Mervi Sepp, Marko Vendelin, Rikke Birkedal

PCD019

The influenses of hand work PCD020 and stand up on the function of autonomic nervous system during menstrual cycle in healthy female CR college students Yuko Itoi*, MIyuki Onozaki, Tomomi Shimizu, Takao Okada

The beginning of the calcium transient and contraction in rat embryonic heart. Takeshi Kobayashi*, Sachiko Maeda, Nobutoshi Ichise, Tatsuya Sato, Tsuyoshi Miyakawa, Yoichi Yamada, Noritsugu Tohse

Effect of postnatal Leptin on cardiac structure and function Anne-Maj Samuelsson*, James Clark, Michael Shattock, Olena Rudyk, Joaquim Pombo, Sung Eun Bae, Timothy South, Clive Coen, Lucilla Poston, Paul Taylor

Maternal high fat diet during pregnancy and lactation alters mitochondrial electron transport chain activity and gene expression in adult mouse offspring heart

PCD025

PCD026

Angiotensin II serum levels after different exercise intensities in human Sander van Ginkel*, Martin Flueck, Arnold de Haan, Jos de Koning

PCD021 Estrogen protects myocardium against ischemia/reperfusion insult by up-regulation of CRH receptor type 2

PCD031

Luisa de Meirelles, Angelo Salgado, Cristiane Matsuura, Natalia Pereira, Pedro Cascarelli, Antonio Claudio MendesRibeiro, Tatiana Brunini*

Mehrdad Bordbar Amirian*, Kerry Hyde, Kimberley Bruce, Hugh Thomas, Christopher Byrne, Mark Hanson, Felino Cagampang

Effects of exercise on the L-arginine nitric oxide pathway and redox state in chronic heart failure patients

PCD027

PCD032

Block-face imaging of waxPCD033 embedded tissue as a modality to aid three-dimensional histological CR reconstruction of the heart Urszula Siedlecka*, Ramon Casero Canas, Rebecca Burton, Carlos Afonso, Christian Bollensdorff, Vicente Grau, Peter Kohl

Xin Ni*, Binhai Cong, Xiaoyan Zhu, Buqing Cao

Postnatal change of heart rate and sinoatrial node pacemaker activity in mice Takeshi Adachi*, Shigehiro Shibata, Yosuke Okamoto, Shinichi Sato, Susumu Fujisawa, Takayoshi Ohba, Kyoichi Ono

PCD023

Distribution of the pacemaker PCD028 cardiomyocytes in the vertebrate heart Valentina Prosheva*

The role of extracellular Ca2+o and voltage-gated calcium channels in vasculogenesis in the fetal lung Sarah Brennan*, Brenda Finney, Denise Al Alam, Russell Townsend, Maria Lazarou, Dirk Adriaensen, Edwin Jesudason, David Warburton, Paul Kemp, Daniela Riccardi

PCD024

The features of regulation of PCD029 the heart rate and external respiration observed in Aborigines and Europeans of the CR Russiaâ&#x20AC;&#x2122;s northeast Arkady Maximov*

A new noninvasive method to estimate mixed venous oxygen content with a pulse oximeter Katsuo Uchida*

PCD030

3D reconstruction of the human PCD034 cardiac conduction system based on micro-CT and histology Andrew Atkinson*, Theodora Nikolaidou, Mark Boyett, Halina Dobrzynski

The inter-relationship between the junctional SR and the sarcolemma; a big hug that makes your heart beat

PCD035

Christian Pinali*, Hayley Bennett, Bernard Davenport, Andrew Trafford, Ashraf Kitmitto

The comparison of the kinetics of of rapid and slow delayed rectifier currents in undiseased human, dog, rabbit and guinea pig ventricular myocytes

T H U R S D A Y

PCD036

Claudia Corici, Zsofia Kohajda, Andras Horvath, Miklos Bitay, Gabor Bogats, Julius Papp, Laszlo Virag, Andras Varro, Dr. Norbert Jost*

143

Poster Communications - Thursday 25 July An integrated method to PCD037 quantify calcium fluxes in cardiac excitation-contraction coupling Martin Laasmaa*, Marko Vendelin, Rikke Birkedal

Altered Ca2+-handling features in TRIC-A channel-deficient and overexpressing vascular smooth muscle cells

PCD043

Daiju Yamazaki, Nishi Miyuki, Jianjie Ma, Hiroshi Takeshima*

A novel steady-state K+ current PCD038 inhibited by noradrenaline via a pertussis toxin-sensitive β2 adrenoceptor-mediated pathway CR in rat atrial myocytes Richard Bond*, Stephanie Choisy, Simon Bryant, Jules Hancox, Andrew James

Use of chimeras to investigate PCD039 the molecular basis of differences in agonist and antagonist action between human P2X1 and P2X2 CR receptors for ATP

Rebecca Allsopp*, Louise Farmer, Alistair Fryatt, Richard Evans

Decreased expression of smallconductance Ca2+-activated K+ channels SK1, SK2, and SK3 in patients with persistent atrial fibrillation

PCD040

The basis of antagonist binding at cardiovascular P2X receptors for ATP Louise Farmer*, Richard Evans

Effects of muscarinic agonists PCD050 and RGS4 on voltage-dependent responses of cardiac G proteingated potassium currents CR I-Shan Chen*, Kazuharu Furutani, Atsushi Inanobe, Yoshihisa Kurachi

Functional targeting of the Kir2.1 PCD045 3’ UTR by multiple microRNAs Janet Yarham*, Lyndsey Ferguson, Mary McGahon, David Simpson, Anthony Collins

PCD049

Fiona O’Brien*, Elena Galfré, Elisa Venturi, Antoni Matyjaszkiewicz, Daiju Yamazaki, Miyuki Nishi, Hiroshi Takeshima, Rebecca Sitsapesan

Class 3 inhibition of hERG K+ PCD044 channel by caffeic acid phenethyl ester (CAPE) and curcumin Seong Woo Choi*, Dong Hoon Shin, Kyung Su Kim, Hae Young Yoo, Han Choe, Woo Kyung Kim, Yin Hua Zhang, Sung Joon Kim

pH regulates the single-channel gating behaviour of TRIC-B channels derived from TRIC-A knockout tissue

PCD046

Remodeling of the diaphragm in mice during the development of heart failure Todd Gillis*, Mathew Plat, Alicia Arkell, Andrew Foster, Jeremy Simpson

Effects of Melatonin on oxygen free radical and apoptosis of myocardium in renal ischemia reperfusion rats

PCD051

PCD052

Xiaohong Xia*, Hao Rong, Yanxia Tian, Jiao Jin, Zhihui Miao

Lan Huan, Xu Qiang, Li Miaoling, Chen Tangting, Zeng Xiaorong*

PDZ domain-binding motif of the PCD041 cardiac sodium channel Nav1.5 regulates compartment-specific channel expression and cardiac CR conduction in cardiomyocytes Diana Shy*, Ludovic Gillet, Jakob Ogrodnik, Maxime Albesa, Arie Verkerk, Maria Essers, Rianne Wolswinkel, Ninda Syam, Roos Marsman, Anneke van Mil, Samuel Rotman, Connie Bezzina, Carol Ann Remme, Hugues Abriel

Regulation of hERG channel function and pharmacology by a KCNE1 variant Chunyun Du*, Aziza El Harchi, Niall Kerr, Jules Hancox

Increased glomerular water permeability in streptozotocininduced diabetes: roles of hyaluronan and chondroitin sulphate

PCD053

Amy Russell*, Andrew Salmon

Voltage-dependent stochastic PCD048 gating of TRIC-B channels derived from TRIC-A knockout mouse skeletal muscle CR Antoni Matyjaszkiewicz*, Elisa Venturi, Daiju Yamazaki, Miyuki Nishi, Krasimira Tsaneva-Atanasova, Hiroshi Takeshima, Rebecca Sitsapesan

144

PCD047

Respiratory health status of rural PCD054 Indian women. Does Domestic Cooking fuel really matter? Mrunal Phatak*, Neelam Sukhsohole

Hall 3, ICC

*Denotes presenting author

Characterization of a new mouse PCD055 model of COPD via conditional over-expression of RAGE by alveolar epithelium CR Paul Reynolds*

Fasudil, but not N–Acetylcystein PCD061 or Hyperoxia accelerates recovery from pulmonary hypertension induced by exposure to chronic CR hypoxia

Effect of active sensitisation to acarian allergen on rat airway function and morphology Boutchi Mounkaila, Etienne Roux*

PCD067

Olga Vajnerova*, Katerina Plocova, Hana Maxova, Martin Vizek, Jan Herget

Assessment of respiratory function in poultry workers in Niger Delta Region, Nigeria M. Odoya*, Chikuememeka Aloamaka

Characterization of respiration in mice with Rett syndrome mutations T158A and R168X John Bissonnette*, Sharon Knopp, Laura Shaevitz, Zhaolan Zhou

Apoptotic cell instillation promotes antifibrotic feedback loop between COX-2/PGE2 signaling and HGF in the bleomycin-stimulated lung

Effect of TGF-β on the TREM-1/ PCD068 TREM-2 ratio in mice macrophage

PCD056

PCD057

Onset to hypoxia produces increased matrix metalloproteinase activity in peripheral pulmonary arteries and generation of collagen fragments

PCD062

CR Simulating bronchoconstriction PCD069 in a patient specific model of the major airways

Jana Novotna*, Jan Herget

PCD058

Li Peng, Yong Zhou, Hui Xie, Guo-Ying Sun, Wen-Zhuo Ran, Yong-Ping Liu, Wen-Xiu Mei, Cha-xiang Guan*

Rafel Bordas*, Bindi Brook, David Kay, Kelly Burrowes

Switching of lower jaw PCD063 movements between the inspiratory and expiratory phases generated by chemoreceptor CR inputs Kiyomi Nakayama*, Mitsuru Yokomatsu, Ayako Mochizuki, Tomio Inoue, Itaru Yazawa

Simulation of pulmonary function test using a one dimensional airway ventilation model

PCD070

Minsuok Kim*, David Kay, Kelly Burrowes

Young-So Yoon*, Youn-Hee Choi, Jihee Kang

Effects of TPPU on lipopolysaccharide-induced acute lung injury in mice Effects of asthma, TGF-β treatment and allergen sensitization on expression of p115-RhoGEF and other RhoAassociated proteins in human airway smooth muscle cells and mouse lung

PCD059

Yong Zhou, Guo-Ying Sun, Hui Xie, Peng Li, Cha-xiang Guan*

PCD064

Vivian Biancardi*, Luis Gustavo Patrone, Kênia Bícego, Luciane Gargaglioni

Yasin Shaifta, Katie O’Brien, David Wright, Nneka Irechukwu, Jeremy Ward, Greg Knock*

Effect of CGRP on macrophage alternative activation Hui Xie, Yong Zhou, Wen-Zhuo Ran, Yong-Ping Liu, Cha-xiang Guan*

Respiratory pattern of newborn PCD071 male rats (P6) exposed to fluoxetine during prenatal period

PCD065

The orexin receptor 1 (OX1R) in the Locus Coeruleus contributes to the hypercapnic chemoreflex in unanesthetized rats

PCD072

Mirela Dias*, Mariane Vicente, Luciane Gargaglioni

Nitro-oxidative stress markers PCD060 with diagnostic and prognostic value in occupational exposure to isocyanates CR

The importance of the PCD066 diaphragmatic ligament in maintaining contractile function in the preterm sheep diaphragm

Parvu Alina Elena*, Catoi Florinela, Perseca Ovidiu, Taulescu Marian Aurel, Orasan Remus

Gavin Pinniger*, Kanakeswary Karisnan, Clare Berry, Peter Noble, Jane Pillow, Anthony Bakker

Theoretical estimates of pulmonary diffusing capacity Tuhin Roy*, Timothy Secomb

T H U R S D A Y

PCD073

145

Poster Communications - Thursday 25 July Coal dust in the working environment- Effects on Forced Expiratory Flow 25 â&#x20AC;&#x201C; 75 % amongst Sri Lankans

PCD074

Effects of gremlin PCD080 haploinsufficiency on the pulmonary vascular endothelium CR in the hypoxic murine lung Simon Rowan*, Edwina Cahill, Paul McLoughlin

Savithri Wimalasekera*, Lagath Wanigabadu, Anthony Senevirathne, Sarath Paranevitane, Vajira Palipane

Biomechanical effect of PCD075 advancing pregnany on forced vital capacity in pregnant primigravida and grandmultipara CR

Pulmonary function and respiratory muscle power in patients with type 2 diabetes mellitus

PCD086

Pavol Mikolka*, Daniela Mokra, Jana Kopincova, Lucia Tomcikova, Jozef Hatok, Andrea Calkovska

PCD081

Salma Ibrahim, Omer Musa*

Vincent Iyawe*, Arthur Omorogiuwa

Respiratory parameters and molecular profile of antiinflammatory therapy in experimental meconium aspiration syndrome

Pulmonary function patterns in the three trimesters of pregnancy and early peuperium of primigravida, nullipara and primipara

PCD087

Arthur Omorogiuwa*, Vincent Iyawe

Ethnic variations in Sudanese lung function Amir Bashir*, Omer Musa

PCD076

Heparanase upregulation in the PCD077 inflammatory airway facilitates syndecan shedding and sustained CR inflammation Lap Kei Kenneth Wu*, Stanley CH Chan, Mary SM Ip, Daisy KY Shum

The transcription factor CREB1 is required to maintain normal pulmonary vascular resistance Lili Li*, Katherine Howell, Michelle Sands, Mark Banahan, Stephen Frohlich, Simon Rowan, Donal Ryan, Paul McLoughlin

PCD082

Aamir Magzoub*, Omer Musa, Amir Bashir, Selma Ibrahim

146

Lung microvascular endothelial cells exposed to hypoxia reveals novel microRNAs that may contribute to the pathophysiology of chronic lung disease

PCD083

Neonatal conditioning of rat upper airway dilator muscle by chronic intermittent hypoxia Fiona McDonald*, Ken Oâ&#x20AC;&#x2122;Halloran

PCD090

PCD078

Federico Formenti*, Rongsheng Chen, Hanne McPeak, Andrew Farmery, Clive E. Hahn

Gender variation in lung function; could it be explained by difference in respiratory muscle power?

PCD089

Muhammad Kanpurwala*, Zeenat Ayoob, Masood Qureshi, Zaman Shaikh

Noor Ali*, Nancy Mah, Paul McLoughlin, Christine Costello

A fast fibre optic sensor with potential to detect rapid arterial PO2 oscillations in Acute Respiratory Distress Syndrome (ARDS)

A statistical model to predict expected pulmonary function Indices in type 2 diabetes individuals

Normal Sudanese spirometeric values for police men Omer Musa, Barakat Bakhit*, Mohanad Malla

PCD079

In utero inflammation impaired preterm lamb diaphragm function Kanakeswary Karisnan*, Gavin Pinniger, Anthony Bakker, Song Yong, Clare Berry, Peter Noble, Jane Pillow

PCD084

PCD085

Effect of petrol vapours on the petrol pump workers lung function indices Muhammad Kanpurwala*

PCD091

Hall 3, ICC

*Denotes presenting author

Temporal assessment of PCD093 respiratory mechanics in rats with sepsis Luiz Santos*, Erika Garcia, Layla Cabral, Alexandre Vieira, Henrique Moryia, Roseli Soncini

Bronchial hyperresponsiveness in mechanical ventilation in two elastase-induced emphysema models

Monika Okuliarova*, Lubos Molcan, Anna Vesela, Michal Zeman

PCD094

Luiz Santos*, Daniela Cervilha, Layla Cabral, Erika Garcia, Jose Brito, Henrique Moryia, Roseli Soncini

Evgeny Bondarenko*, Deborah Hodgson, Eugene Nalivaiko

Blanaid Hicks, Alex Zholos, Chris Johnson*

PCD100

Simulation of developmental PCD101 change in structure of transverse tubules and intracellular Ca2+ dynamics using cardiac CR ventricular cell models

PCD096

Perlecan heparan sulfate in hypoxia-induced pulmonary vascular remodeling Ya-Ting Chang*, Philip Tannenberg, Chi-Nan Tseng, Phan-Kiet Tran, Ulf Hedin, Karin Tran-Lundmark

PCD097

Comparison of the agonist activities of treprostinil and naxaprostene in systemic blood vessels

PCD102

PCD103

Nawazish-i- Syed*, Robert Jones

Rotating phase advanced shifts of PCD098 lighting regimen disturb circadian rhythms of heart rate, blood pressure clock genes expression CR and plasma hormones in rats Michal Zeman*, Lubos Molcan, Monika Okuliarova, Anna Vesela, Iveta Herichova

Hypertension, oedema and PCD105 shock - diseases of capillary fluid imbalance? Frank Prior*, Gareth Clegg, Sarah Richardson

Factors released from the PCD106 placenta cause changes to glutamate and GABA receptors in cortical neurones N Thomas Phillips*, Patrick Case, Veronica Leinster, Elek Molnar

Glutamate release from placenta PCD107 can be blocked to protect foetal neurones from injury Aman Sood*, Patrick Case

Riko Aoki*, Hitomi Sano, Chikako Okubo, Yasuhiro Naito, Masaru Tomita

Lisa Rancan*, Celia Muñoz, Cruz Garcìa, Eduardo Vidaurre, Ignacio Garutti, Carlos Simon, Elena Vara

The role of TRPM8 channels in normal rat trachea function

Simulation of developmental changes in energy metabolism between fetal and adult ventricular cells Tamami Toki*, Hitomi Sano, Chikako Okubo, Yasuhiro Naito, Masaru Tomita

Amygdala and prefrontal cortex PCD095 mediate respiratory activation in response to brief and prolonged stressors CR

Lidocaine prevents lung proinflammatory response secondary to ischemia reperfusion

Chronodisruption alters PCD099 cardiovascular and behavioural responses to emotional stressors CR in rats

Particles, pore size, pulse and PCD104 pressure - the physico chemistry of osmosis Frank Prior*, Gareth Clegg

Effect of increased corticospinal PCD108 excitability by quadripulse transcranial magnetic stimulation N to the primary motor cortex on the spinal inhibitory circuit Naoki Matsuda*, Fuminari Kaneko, Eriko Shibata, Takehide Kimura

Prenatal hypoxia-ischemic affects PCD109 neurons distribution in ventral tegmental area and nucleus accumbens, modifying memory N in rats Ive Sab*, Marcia Ferraz, Claudia Sequeira, Marcos Ferraz, Tatiana Brunini, Antônio Claudio Mendes Ribeiro

Altered brain morphology in a mouse model of mental retardation Kalbinder Gill*, Prashan Kangesu, John Jefferys, Andrew Powell

T H U R S D A Y

PCD110

147

Poster Communications - Thursday 25 July NADPH oxidase 4-derived PCD111 reactive oxygen species mediate the activation of adaptive N antioxidant pathways in early diabetic retinas of db/db mice

Prenatal exposure to valproic acid PCD117 weakens the maternal behavior in rats Ksenia Tanaeva*, Anton Malyshev, Vyacheslav Dubynin

Gareth Morris*, Premysl Jiruska, Wei-Chih Chang, Andrew Powell, John Jefferys

PCD112

Functional connections between PCD113 the ventrolateral periaqueductal grey and cerebellum – a role in N fear behaviour? Jonathan Crook*, Stella Koutsikou, Emma Earl, J. Lianne Leith, Richard Apps, Bridget Lumb

Chronic neuropathic pain is alleviated by the highly specific iNOS inhibitor, 1400W Caroline Staunton*, Laiche Djouhri, Richard Barrett-Jolley, Swamy Thippeswamy

Characterization of recurrent laryngeal nerve function in rats Isaac Naggar, Niv Mor, Ko Nakase*, Paul Zolkind, Joshua Silverman, Krishnamurthi Sundaram, Mark Stewart, Richard Kollmar

Repeated exposure to novel PCD118 spatial arrangement of objects: impact on hippocampaldependent learning and synaptic N plasticity Ângela Amaro-Leal*, António Carmo, Isabel Rocha, Diana Cunha-Reis

Auxiliary KChIP4a suppresses voltage-gated A-type K+ current through ER retention and promoting closed-state inactivation of Kv4 channels

A novel compound targeting Kv7.2/3 channels relieves inflammatory and neuropathic pain

PCD119

Andrei Sokolov*, Vladimir Fokin, Efimtcev Aleksandr, Sergei Vorobyev

PCD120

Trafficking of AMPA receptors in dorsal horn neurons during persistent pain: the changes in synaptic and extrasynaptic receptor pools

PCD125

D-series resolvins suppressed PCD126 sensory TRP activities resulting in multiple anti-nociception Sungjae Yoo*, Sangsu Bang, Tae-Jin Yang, Ji Yeon Lim, Sun Wook Hwang

Asher Peretz*, Eti Patrich, Polina Kornilov, Nataly Menaker, Bernard Attali

PCD115

Cyclin-dependent kinase 5 (Cdk5) regulates TRPV1 membrane trafficking through phosphorylating KIF13B

PCD121

Identifying ligand induced conformational changes of human P2X1 with voltage clamp fluorometry

PCD127

Alistair Fryatt*, Richard Evans

PCD116

Insulin modulates GABAA channels-mediated inhibition in rat hippocampal and amygdala neurons Zhe Jin*, Yang Jin, Sergiy Korol, Bryndis Birnir

148

Facilitation of hyperpolarization- PCD124 activated cyclic nucleotide-gated channel by Prostaglandin E1 in trigeminal ganglia neurons in N mice

Olga Kopach*, Andrey Sotnik, Pavel Belan, Nana Voitenko

Ying Zhang*, Bao-Ming Xing, Yan-Rui Yang, Jun-Xia Du, Yun Wang

Localization of cortical areas activated by visual memory task using functional magnetic resonance imaging

Sung Jun Jung*

Yiquan Tang, Jingheng Zhou, Yanxin Lu, Ping Liang, Lei Lei, Xiling Bian, Kewei Wang*

PCD114

PCD123

Koji Shibasaki*, Katsuya Yamada, Hideki Miwa, Makoto Tominaga, Yasuki Ishizaki

Meihua He*, Hong Pan, Chunxia Xiao, Mingliang Pu

Investigating the role of interneurons in epileptic high frequency activity

Brain temperature is a critical determinant of neuronal excitability through TRPV4 activation

PCD122

A DMD-based multicolor irradiation system for the optogenetic analysis of neural circuits Seiichiro Sakai, Takaaki Mishima*, Toru Ishizuka, Hiromu Yawo

PCD128

Hall 3, ICC

*Denotes presenting author

Selective changes of AMPA, NMDA and Kainate receptor subunit mRNAs in the hippocampus and orbitofrontal cortex but not in prefrontal cortex of human alcoholics

PCD129

Stuart Hanmer*, William Wilkinson, Paul Kemp, Wynand van der Goes van Naters

Regulation of TREK1 two pore domain potassium channels by amitriptyline Ehab Al-Moubarak*, Emma Veale, Alistair Mathie

Muneaki Mizote*

PCD135

Electrophysiological study of PCD141 voltage-gated ion channels in photoreceptors and bipolar cells in the human retina N Eiichi Miyachi*, Fusao Kawai, Mahito Ohkuma, Masayuki Horiguchi

Amol Bhandage*, Zhe Jin, Igor Bazov, Olga Kononenko, Esa Korpi, Georgy Bakalkin, Bryndis Birnir

A P2X receptor from the model cnidarian Hydra: expression in a unique cell type

Relation between Ia and motoneuron responses induced by vibratory stretches in a cat

Indian red scorpion venom depresses spinal synaptic transmission involving 5-hydroxytryptaminergic system PCD130

PCD136

Amar Maurya*, Shripad Deshpande

Joao Zugaib, Ricardo Leao*

Maternal choices: Opioid receptors mediation – caring for young or hunting? PCD131

Salicylate enhances PCD142 depolarization suppression of excitation in cartwheel neurons from the dorsal cochlear nucleus N of the rat

Marianne Klein*, Aline Cruz, Newton Canteras, Luciano Felicio

PCD137

Comparative study on the dopaminergic D1 and D2 receptor modulation of the electroretinographic responses in the dark-adapted frog retina

PCD143

Elka Popova, Petia Kupenova*

Renal denervation decreases PCD138 alpha 1 adrenergic receptor protein in the renal cortex of rabbits with chronic heart failure N TRPV4 and KCa: The model couple? Claire Feetham*, Nicolas Nunn, Rebecca Lewis, Richard Barrett-Jolley

Recombinant α9α10 nicotinic cholinergic receptors depend on extracellular Ca2+ to reach maximum activation

PCD132

Alicia Schiller*, Karla Haack, Pamela Curry, Irving Zucker

Comparison of rectangular pulse PCD144 and triangular pulse on evoking retinal ganglion cell responses in retinal degenerated (rd1) mice N

PCD133

Analgesic and anti-inflammatory PCD139 effects of honey is modulated by alpha-1 adrenergic antagonist Bamidele Owoyele*, Kayode Ajomole

Juan Boffi*, Paola Plazas, Marcela Lipovsek, Eleonora Katz, Belen Elgoyhen, Belen Elgoyhen

Yongsook Goo*, Kun No Ahn, Wang Woo Lee, Joo Yun Kim

Localization of the chemokine PCD145 receptor XCR1 in rat spinal and nucleus caudalis (Vc) trigeminal dorsal horn: a novel regulator of N nociception? Ilona Obara*, Calum McDonald Wood, Mukti Singh, Fiona Boissonade, Anne King

GABA-A channel subunit expression in cell lines derived from human glioblastoma Omar Babateen*, Zhe Jin, Amol Bhandage, Bengt Westermark, Karin Forsberg-Nilsson, Lene Uhrbom, Anja Smits, Bryndis Birnir

T H U R S D A Y

PCD134

The cooperation of sustained and phasic inhibitions regulates the sensitivity to interaural time difference cue in the nucleus laminaris of birds

PCD146

Rei Yamada*, Hiroko Okuda, Hiroshi Kuba, Eri Nishino, Takahiro Ishii, Harunori Ohmori

149

Poster Communications - Thursday 25 July VEGF165b attenuates hyperglycaemia-induced sensitisation of neuronal TRPA1 activation: implications for diabetic neuropathy

PCD147

Richard Hulse*, Hamza Riaz, Priyanka Singhal, David Bates, Lucy Donaldson

Electrophysiological characteristics of GABAergic neurons and localization of calcitonin receptor-like receptor in the mouse trigeminal subnucleus caudalis

PCD148

Shun-ichi Kuwana*, Yuki Hosokawa, Takeo Sugita, Nobuo Umezawa, Akiko Matsumoto, Hirofumi Arisaka, Kazu-ichi Yoshida, Sigeki Sakuraba

Antinociceptive and antiPCD153 inflammatory effects of essential oil of Nepeta pogonosperma N Jamzad et Assadi in Wister rats

A comparison of medial PCD159 prefrontal cortical activity during micturition in the awake and N anaesthetised rat

Taskina Ali*, Mohammad Javan, Ali Sonboli, Saeed Semnanian

Rob Mason, Georgina Fenton, Clare Spicer, Yvonne Mbaki*

Effect of vitamin B12 on pain and PCD154 inflammation in Long Evans rats

ERK/MAPK in the spinal cord is involved in pain hypersensitivity in a mouse model of type 2 diabetes

Masud Imtiaz, Noorzahan Begum*, Taskina Ali

Simon Gandevia*, Lee Walsh, Annie Butler, Martin HĂŠroux

Kinesthetic perception based on PCD155 integration of motor imagery and afferent inputs from antagonistic muscles with tendon vibration N

PCD149

Spatial- and motion selectivity of PCD150 population responses in primate area MT Spencer Chen*, John Morley, Samuel Solomon

Visual evoked potential in primary open angle glaucoma patients Bishnu Hari Paudel*, Mukesh Kumar Jha, Badri P Badhu, Nirmala Limbu, Dilip Thakur

Coupling between apical inner hair cells of the adult mouse cochlea Antonio Garcia de Diego*, Piotr Sirko, Jonathan Ashmore

150

PCD152

Increased A-nociceptor-evoked Fos expression in a functionally distinct subdivision of midbrain periaqueductal grey in a rat model of inflammatory pain

PCD161

Joyce Mendes Gomes*, Meng-Tzu Hsieh, Lucy Donaldson, Bridget Lumb

Interplay between mast cells, 5-HT and TRPA1 in sensory signalling from the GI tract: Influence of ageing

PCD156

Yang Yu*, Linda Nocchi, Aleks Rust, Christopher Keating, Wen Jiang, David Grundy

PCD151

Hong Cao*, Xiang Xu, Hui Chen, Lan Xu

Eriko Shibata*, Fuminari Kaneko

An illusion of grasping your own finger

PCD160

Intracranial recording of the primary motor and somatosensory activity during kinesthetic perception

PCD162

Fuminari Kaneko*, Yuichi Kubota

Study of the effect of excitability PCD157 change in the primary motor cortex on the sensitivity of N kinesthetic perception Megumi Okawada*, Fuminari Kaneko, Eriko Shibata, Nobuhiro Aoki, Naoki Matsuda

Movement deficits of patients presenting with cerebellar degeneration during precise auxometric finger movements

PCD163

Dieter Kutz*, Dagmar Timmann, Florian Kolb

Ontogenetic plasticity of the PCD158 metabolic apparatus and electrical properties of Calliphora N vicina photoreceptors Jerneja Rudolf*, Andrej Megli?, Gregor Zupan?i?, Gregor Belu?i?

Impact of birth order on child development in a rural community, India Syed Sadat Ali*, Shivaprasad Goudar, Dhaded Sm

PCD164

Hall 3, ICC

*Denotes presenting author

Mechanisms of calcium PCD165 independent but voltage dependent secretion (ciVDS) and calcium dependent secrtion (CDS) N in somata of primary sensory neurons Changhe Wang*, Xiaoyu Zhang, Xi Wu, Zuyin Chai, Panpan Hou, Haowen Liu, Yongfeng Liu, Tao Liu, Yeshi Wang, Bin Liu, Chen Zhang, Wei Guo, Shirong Wang, Xi Zhang, Jiuping Ding, Zhuan Zhou

Modelling mechanotransduction PCD166 in primary sensory endings T. Suslak*, G. Bewick, J. Armstrong, A. Jarman

EP3 receptor activation in the PCD171 ventrolateral periaqueductal grey facilitates nociceptive N spinal reflexes in the normal and arthritic rat Robert Drake*, Lianne Leith, Bridget Lumb, Donaldson Lucy

Mechanically elicited evoked potentials: a physiological approach to assessment of anorectal sensory pathways

Water and sodium intake by hyperosmotic rats treated with moxonidine into the lateral parabrachial nucleus depends on the activation of central cholinergic mechanisms

PCD178

Camila Roncari, Richard David, Patrícia De Paula, Débora Colombari, Laurival De Luca Jr., Eduardo Colombari, José Menani*

PCD172

Emma Carrington*, Judith Evers, Marc Scott, Charles Knowles, Ronan O’Connell, James Jones

The combined administration of natriuretic peptides (ANP and CNP) in the lateral ventricle modulates the fluid intake in response to sodium depletion and water deprivation

PCD179

Lisandra Margatho*, Bruna Fortes de Morais, Lucila Elias, Jose AntunesRodrigues

Role of the cerebellum in descending control of nociception Nirosha Weerasinghe*, Bridget Lumb, Richard Apps, Joanna Murrell

PCD167

The descending noradrenergic system spatially restricts and temporally delays the onset of A-fibre mediated heat hypersensitivity in a model of neuropathic pain

PCD173

Sam Hughes*, Tony Pickering, Bridget Lumb

Adrenomedullin-induced modulation of calcium channels in osteoblasts Takayuki Endoh*, Hiroshi Kobayashi, Masakazu Tazaki, Kenji Sueishi

Development of fluorescent and biotinylated agonists for a novel glutamate receptor in mechanosensory terminals

PCD180

PCD168

Sonia Watson*, Chiara Zanato, Sergio Dall’Angello, Robert Banks, Iain Greig, Matteo Zanda, Guy Bewick

Whisker photostimulation evokes PCD174 barrel cortical response of ChR2 transgenic rat Tatsuya Honjoh*, Akira Sumiyoshi, Yukinobu Yokoyama, Zhi-Gang Ji, Toru Ishizuka, Ryuta Kawashima, Hiromu Yawo

Apical KCNN4c channel regulated PCD181 by Epac1 signaling affect epithelial Cl- secretion in diarrhea Irshad Sheikh, Ritam Sinah, Dhrubajyoti Nag, Hemanta Koley, Manoj Chakraborty, Mirajul Kazi*

Spinal mu and delta opiate PCD169 receptors differentially modulate a-nociceptor processing in primary and secondary N inflammatory hyperalgesia in rats Meng-Tzu Hsieh*, Lucy Donaldson, Bridget Lumb

Sacral neuromodulation PCD170 facilitates anal canal evoked potentials but not median nerve evoked potentials in the primary N somatosensory cortex in a rat model

Effect of tetrahydrobiopterin PCD175 deficiency on hyperoxia-induced vascular damage in the retina Kevin Edgar*, Nuria Matesanz, Tom Gardiner, Zvonimir Katusic, Denise McDonald

Hypothalamic Gαi2 proteins: a central molecular mechanism that counters the development of salt-sensitive hypertension

PCD177

Interleukin-1β reduces K+ channel activity through phosphorylation processes mediated by protein kinase C in human kidney proximal tubule cells

PCD182

T H U R S D A Y

Kazuyoshi Nakamura*, You Komagiri, Manabu Kubokawa

Richard Wainford*, Jill Kuwabara

Judith Evers*, Ronan O’Connell, James Jones

151

Poster Communications - Thursday 25 July Determination of the oligomeric PCD183 assembly and intramolecular distances in the TRPV1 ion channel via FRET measurements EM

Membrane-dependent activation PCD189 of the bile acid-sensitive ion channel (BASIC), a DEG/ENaC EM channel expressed in the liver

Leon Islas*, Victor De la Rosa, Gisela Rangel

Dominik Wiemuth*, Axel Schmidt, Stefan Gründer

Expression of exogenously PCD184 transfected ROMK K+ channel activity favors the polarized apical membrane of cultured M1 EM collecting duct cells

A gate-coupled expansion of the PCD190 cytoplasmic pore of mammalian inward rectifier potassium channels EM

Manabu Kubokawa*, Kazuyoshi Nakamura, Taira Mayanagi, Kenji Sobue

Atsushi Inanobe*, Atsushi Nakagawa, Yoshihisa Kurachi

Mathematical modelling of unique subconductnace level states in heteromeric Kir4.1/ Kir5.1 channels from Xenopus tropicalis

Contribution of Orai-STIM to histamine-induced store operated Ca2+ entry and functional coupling with Ca2+-activated K+ channels in Chondrocytes

PCD185

Lijun Shang*

TRPC1/C6 and STIM/Orai channels may regulate cell cycle progression of bone marrow stromal cells

Hana Inoue*, Takashi Murayama, Masato Konishi

Serotonin-specific reuptake inhibitor (SSRI) enhances anoctamin 6 (ANO6) calcium activated Cl- channel activity Hyunjong Kim, Yungkyu Kim, Mingoo Lee, Joohyun Nam*

Voltage-gated Na+ channels contribute to depolarised membrane potential in the MDA-MB-231 human breast cancer cell line

PCD196

Ming Yang*, William Brackenbury

PCD191

Extracellular ATP arrests the PCD197 adaptive reaction in mouse eggs subjected to hypotonic stress Maria Pogorelova*, Valentina Pogorelova

STIM and Orai proteins regulate store-operated calcium entry and NADPH oxidase activity in primary human monocytes

PCD186

Effects of local anaesthetics on ion channels of canine articular chondrocytes Michaela Wegg*, Rebecca Lewis, Ali Mobasheri, Richard Barrett-Jolley

PCD187

Expression of TRP channels in isolated single Merkel cells from hamster oral mucosa Manabu Soya*, Hidetaka Kuroda, Aya Kawaguchi, Masaki Sato, Ubaidus Sobhan, Masakazu Tazaki, Tatsuya Ichinohe, Yoshiyuki Shibukawa

PCD192

Role of membrane cholesterol and lipid rafts in cellular mechanotransduction and actin remodeling

PCD198

Stephanie Saul*, Bastian Pasieka, David Conrad, Gertrud Schwär, Reinhard Kappl, Barbara Niemeyer, Ivan Bogeski

PCD193

Synergistic activation of the human bile acid-sensitive ion channel (hBASIC) by chenodeoxycholic and deoxycholic acid

PCD194

PCD199

Cathérine Lefèvre*, Stefan Gründer, Dominik Wiemuth

Lipid rafts as regulators of P2X7 receptor and pannexin-1 signalling

PCD188

Vladislav Chubinskiy-Nadezhdin*, Yuri Negulyaev, Sofia Khaitlina, Tatiana Efremova, Elena Morachevskaya

152

Sarah Williams*, Andrew Bateman, Ita O’Kelly

PCD195

Munenori Inayama, Yoshiaki Suzuki, Hisao Yamamura, Susumu Ohya, Yuji Imaizumi*

Jun Ichikawa*, Ryuji Inoue

Inhibition of TRPM7 by oxidative stress is dependent on intracellular magnesium

Altered expression of two-pore domain potassium (K2P channels in cancer

Lucy Robinson*, Ruth Murrell-Lagnado

PCD200

Hall 3, ICC

*Denotes presenting author

Evaluation of the role of pH in cancer cell proliferation Ujjal Bose*, Cinzia Allegrucci, Cyril Rauch, Cristina Tufarelli, Raheela Khan

PCD201

Real-time electrochemical detection of endogenous substance release in freshly isolated perfused kidney

PCD207

Oleg Palygin, Vladislav Levchenko, Daria Ilatovskaya, Tengis Pavlov, Robert Ryan, Allen Cowley, Alexander Staruschenko*

The role of P2X7 receptor C-terminal in trafficking and targeting to the plasma membrane Marie Brunet*, Lucy Robinson, Mitesh Shridar, Ruth Murrell-Lagnado

Acute effects of angiotensin II on PCD208 TRPC6 channels in the podocytes of the freshly isolated glomeruli Daria Ilatovskaya*, Vladislav ChubinskiyNadezhdin, Yuri A. Negulyaev, Alexander Staruschenko

Role of TRPV6 calcium channels in proliferation of human T lymphocytes Viktor Tomilin*, Yuri Negulyaev, Svetlana Semenova

Dose-dependent effects of Angiotensin-(1–7) on the NHE3 exchanger and the [Ca2+]i in in vivo proximal tubule

The mouse calcium sensing PCD209 receptor of the intercalated cell type B in the collecting duct may contribute to alkali secretion via EM stimulation of pendrin during dietary calcium loading

Ryo Hatano, Eiko Fujii, Hiroko Segawa, Kenichi Mukaisho, Mitsunobu Matsubara, Ken-ichi Miyamoto, Takanori Hattori, Hiroyuki Sugihara, Shinji Asano*

PCD205

Identification and PCD210 characterization of a new promoter regulating expression of Slc4a10 in rat kidney, and EM localization of Slc4a10 proteins in renal tubules

Remi Peyronnet*, Eric Honoré, Fabrice Duprat

Upregulation of NOX4 mediates PCD216 TGFβ-induced apoptosis in mouse podocyte Ranjan Das, Shanhua Xu, Xianglan Quan, Seung-Kuy Cha, In Deok Kong, Kyu-Sang Park*

Deng-Ke Wang, Ying Liu, Yi-Min Guo, De-Zhi Jiang, Zhang-Dong Xie, Li-Ming Chen*

Sinaling pathways involved in the rapid biphasic effect of aldosterone on Na+/H+ exchanger in IRPTC cells Histological analysis of quercetin PCD211 effects on cisplatin-induced acute renal failure in rats

PCD206

Mechanoprotection by PCD215 polycystins against apoptosis is mediated through the opening of stretch-activated K2P channels EM

Yukiko Yasuoka*, Yuichi Sato, Hiroshi Nonoguchi, Katsumasa Kawahara

Regiane Castelo-Branco*, Deise LeiteDellova, Margarida Mello-Aires

Regulation of glomerular filtration rate by canonical transient receptor potential 6 in glomerular mesangial cells

The membrane cytoskeletal PCD214 crosslinker ezrin is essential for the regulation of phosphate and EM calcium homeostasis

PCD203

Propylamine activates and blocks PCD204 ELIC channels Alessandro Marabelli*, Remigijus Lape, Lucia Sivilotti

Guangping Chen*, Xuechen Li, Jeff Sands

PCD202

Sialylation of N-glycan stimulated PCD213 by protein kinase C (PKC) increases urea transporter UT-A1 EM activity

Siriphun Hiranyachattada*, Paradorn Muangnil, Piyakorn Boonyoung, Pornpimol Kirirat

PCD217

Deise Leite-Dellova*, Giovana Fonseca, Maria Oliveira-Souza, Margarida MelloAires

T H U R S D A Y

An antatomically-unbiased PCD218 approach for analysis of renal BOLD magnetic resonance images

Rong Ma*, Yanfeng Ding, Crystal Smedley, Bing Zhu, Yanxia Wang, Min Ding, Sarika Chaudhari

The citrus flavonoid naringenin PCD212 inhibits the growth of Dictyostelium and MDCK-derived cysts in a polycystin-2-dependent EM manner

Robert Menzies, Andrew Zammit-Mangion, Maurits Jansen, David Webb, John Mullins, James Dear, Guido Sanguinetti, Matthew Bailey*

Abdul Waheed, Marthe Ludtmann, Nicole Pakes, Steve Robery, Adam Kuspa, Christopher Dinh, Deborah Baines, Robin Williams, Mark Carew*

153

Poster Communications - Thursday 25 July The effects of Angiotensin 1-7 on PCD219 renal haemodynamics Wafaa Osman*, Edward Johns, Ahmad Ahmeda

Cell signaling responses in rabbit PCD220 renal proximal tubules exposed to acute acid-base disturbances Lara Skelton*, Walter Boron

Extracellular nucleotides increase PCD225 albumin permeability of isolated intact wistar rat glomeruli Malgorzata Kasztan*, Agnieszka Piwkowska, Ewelina Kreft, Robert Kowalski, Miroslawa Szczepanska-Konkel, Maciej Jankowski

PCD222

Nicolas Markadieu*, Paul Welling, Eric Delpire

Glucocorticoid receptor haploinsufficiency causes saltsensitivity and dysregulation of the thiazide-sensitive Na-Cl cotransporter

PCD223

Meng Xiang*, Ning Li, Peng Lu, Lili Le, Jing Quan, Dan Meng, Xinhong Wang, Rui Wang, Alex F Chen, Sifeng Chen

PCD227

Keith Siew*, Paola de los Heros, Dario Alessi, Kevin Oâ&#x20AC;&#x2122;Shaughnessy

Iodinated contrast media PCD228 induced oxidative stress and tubular necrosis in isolated thick ascending limb of rat EM

PCD224

Zhi Zhao Liu*, Kristin Schmerbach, Pontus B. Persson, Erdmann Seeliger, Cantow Kathleen, Andreas Patzak, Mauricio Sendeski

Dual roles for syndecan-4 in angiogenesis

PCD232

James Whiteford*

T-cell trafficking during PCD233 inflammation is regulated by a novel PEPtide Inhibitor of TransEndothelial Migration, a pathway EM defective in chronic disease Myriam Chimen*, Helen McGettrick, Clara Yates, Ashley Martin, Francesca Barone, Lucy Walker, Christopher Buckley, Gerard Nash, George Rainger

Comparison between automated PCD234 inflation and manual inflation for forearm blood flow measurements made with venous HE occlusion plethysmography in humans Rehan Junejo*, Francesca Pavliv, Clare Ray, Janice Marshall

EM Inflammatory cytokines provokes PCD229 a macrophage phenotype switch by modulation of Ivns 1abp Chrysoula Mastora*, Anna Sola, Marina Ventayol, Silvia Buenestado, Teresa Carbonell, Georgina Hotter

Comparing the effects of minocycline and 5-aminoisoquinolinone on paraquat-induced renal toxicity Dev Katarey*

154

Jessica Ivy*, Louise Evans, Rachel Richardson, Peter Flatman, Karen Chapman, Christopher Kenyon, Matthew Bailey

Systemic iPSs decrease kidney injury dependent on ROSfacilitated engraftment

MO25Î˛ has no physiological role in electrolyte homeostasis or systemic blood pressure maintenance

PCD231

Dev Katarey*

Expression of the extracellular PCD226 calcium-sensing receptor, CaSR, in rat, human and mouse kidney Joao Graca*, Martin Schepelmann, Daniela Riccardi, Sally Price

Cleavage of SPAK kinase by kidney-enriched protease(s)

A comparison of the effects of minocycline and 5-aminoisoquinolinone on gentamicin-induced oxidant injury in renal epithelial cells

The effect of longer cold water immersion time in the contrast bath on the skin temperature and parasympathetic activity

PCD235

Katsuya Inoue*, Jun Udagawa, Naruhiko Wakasugi, Katsuaki Endo

PCD230

Pre-cooling for endurance exercise performance in the heat: a systematic review Paul Jones*, Christian Barton, Dylan Morrissey, Nicola Maffulli, Stephanie Hemmings

PCD236

Hall 3, ICC

*Denotes presenting author

Using perceived exertion to self- PCD237 regulate exercise on a wheelchair ergometer in able-bodied novice HE participants Bryn Savill*, Vicky Tolfrey, Tom Paulson

Intrauterine growth restriction induces hyperreactivity to Angiotensin II in adult offspring: the role of aerobic training and AT2 receptors

PCD243

Is the replacement of skeletal PCD249 alpha-actin by cardiac alpha-actin in skeletal muscles beneficial? Julien Ochala*, Hiroyuki Iwamoto, Gianina Ravenscroft, Kristen Nowak

Vanessa Oliveira*, Eliana Akamine, Lisete Michelini, Maria Helena Carvalho, Zuleica Fortes, Tatiana Cunha, Maria do Carmo Franco

The role of prostaglandin and PCD238 antioxidant availability on recovery from forearm ischemiareperfusion injury in humans HE Sophie Carter*, Mark Rakobowchuk

Viscoelastic analysis of myosin adsorbed to gold Sex difference of the human brain PCD244 functional connectivity related to the second to fourth digit ratio Tomohiro Donishi*, Masaki Terada, Yoshiki Kaneoke

Effects of acute strenuous exercise on vascular endothelial cell activation Kihachiro Fukada*, Hidehiko Kushi, Kazuma Oki, Ryo Koshizawa, Akio Mori

Oxidative stress is not involved PCD241 in the morphofunctional impairments of non-pregnant murine uterus caused by intense HE and exhaustive exercise Alessandra Costa*, Manoel Sim천es, Joelmir Silva, Viviane Nouailhetas

Do the vascular responses to cool water immersion in young Asian males give them greater susceptibility to Non-Freezing Cold-induced Injury (NFCI) than white Caucasians? William Blevins*, Clare Ray, Michael Tipton, Janice Marshall

Monoclonal antibodies to myosin PCD251 head retard formation of rigor actin-myosin linkages in skinned rabbit psoas muscle fibers HE Preliminary methods for automated detection of fasciculations associated with motor neuron disease

PCD245

Toshiko Yamazawa*, Hideto Oyamada, Takashi Murayama, Nagomi Kurebayashi, Katsuji Oguchi, Takashi Sakurai, Masamitsu Iino, Shigeru Takemori

Physiological finger tremor size mirrors speed of finger movement due to muscle thixotropy

Lin Lu*, Jie Tu, Weisong Cai, Heather Ballard

Carlijn Vernooij*, Raymond Reynolds, Martin Lakie

Mdx mice skeletal muscle differentiation and recovery of neuromuscular junctions after bone marrow stem cells transplantation PCD247

PCD253

Anastasiia Sokolova*, Violetta Kravtsova, Natalia Timonina, Igor Krivoi, Vyacheslav Mikhailov

Alterations in calcium handling PCD248 in isolated fast fibres from speed gene knockout mice Stewart Head*, Stephen Chan, Peter Houweling, Robin Murphy, Kate Quinlan, Kathryn North

PCD252

HE ATP release from rat skeletal muscle may involve chloride channels

Takakazu Kobayashi*, Takahiro Abe, Kazushige Kimura, Haruo Sugi

Peter Harding*, Ian Loram, Nicholas Costen, Nicholas Combes, Emma HodsonTole

Exploration of functional PCD246 mutations of ryanodine receptor in malignant hyperthermia

PCD242

HE EM

PCD239

Tetsuo Ohno*, Michiru Wagatsuma, Motoko Ichihashi, Atsushi Itoh

PCD250

T H U R S D A Y

Involvement of the lateral PCD254 reticular nucleus in the suppression induced by stimulation of the red nucleus on HE the jaw-opening reflex Yoshihide Satoh*, Eriko Yajima, Kenichi Ishizuka, Yasuhiro Nagamine, Shin-ichi Iwasaki

155

Poster Communications - Thursday 25 July The contractile properties of slow PCD255 and fast skeletal muscles from Protease Activated Receptor-1 null mice HE

Effect of ascorbic acid on force PCD261 frequency relationship of skeletal muscle fibers in long term cold HE exposed Sprague Dawley rats

Anthony Bakker*, Sitparan Paran, Pagel Charles, Mackie Eleanor, Gavin Pinniger

Aneeqa Shahid*, Umar Ali Khan

The impact of resveratrol and PCD256 hydrogen peroxide on C2C12 myoblast regenerative cascade is dose-dependent HE

Contributions of lower muscle PCD262 mass and specific force to muscle weakness in old mice Sam Ballak*, Hans Degens, Arnold de Haan, Richard Jaspers

Alessandra Bosutti*, Michele Salamova, Jörn Rittweger, Hans Degens

Acute effects of curcumin on skeletal muscle contractile function Jenny Lam*, Gavin Pinniger, Anthony Bakker

Mei Li*, Monika Andersson-Lendahl, Thomas Sejersen, Anders Arner

PCD267

High cholesterol level and statin PCD268 treatment affect the calcium homestasis of rat skeletal muscle cells HE Janos Vincze*, Marta Fuzi, Agnes Jenes, Beatrix Dienes, Peter Szentesi, Pal Kertai, Gyorgy Paragh, Laszlo Csernoch

Alessandra Bosutti*, Hans Degens

The adaptive response of PCD257 capillarisation to disuse is musclespecific

Skeletal muscle myopathy in zebrafish larvae following knockdown of desmin

PCD263

Impact of Kv7 voltage-gated potassium channel modulators on contractile activity of myometrium from pregnant women at term

PCD269

Yosef Mansour*, Laura McCallum, Iain Greenwood, Rachel Tribe

Temperature and ‘fatigue’ effects PCD259 on ATP induced actomyosin dissociation kinetics Christina Karatzaferi*, Michael Geeves

Ca2+-calmodulin/calcineurin PCD264 mediated signaling pathways are essential for upregulation of MHC I mRNA level in C2C12 cells HE Yoshiaki Mori*, Maki Yamamoto, Reiko Hiroshima, Tadashi Nakano, Masahito Watanabe

Flow mediated dilation is associated with endothelial cell oxidative stress in humans Alvaro Gurovich*, Joseph Avery, Randy Braith

Endogenous and maximal SR calcium content in human vastus lateralis muscle fibres is decreased with ageing Cedric Lamboley*, Robyn Murphy, Michael McKenna, Graham Lamb

PCD270

PCD260

Mutation of the valosincontaining protein (VCP) decreases the fatigue tolerance of fast-twitch skeletal muscle fibres

PCD265

Louise Cully*, Giles Watts, Gabriel Mutungi

Cerebrovascular reactivity PCD271 and systemic haemodynamic parameters in response to acute hyperoxia in stroke patients and HE healthy volunteers Ivana Hegedus*, Anita Cosic, Ines Drenjancevic

Intrinsic ankle stiffness is reduced PCD266 by increasing ankle sway in standing individuals Tania Sakanaka*, Raymond Reynolds, Martin Lakie

Comparison of endothelial PCD272 function using three non-invasive methods: flow-mediated dilation, changes in distension and HE changes in pulsewave velocity Ashton Faulkner*, Sophie Carter, Mark Rakobowchuk

156

Hall 3, ICC

*Denotes presenting author

Muscular arterial stiffness is not altered by ischemia-reperfusion injury and not influenced by cyclooxygenase inhibition by Ibuprofen

PCD273

Arthur Reed*, Sophie Carter, Mark Rakobowchuk

Effect of hypoxia during incubation on the metabolic rate and thermal preference of 8–10-day-old chicks

Effects of high-fat feeding during PCD279 pregnancy and lactation on the morphofunctional development ME of the hippocampus in rat offspring Gabrielle Gonzalez, Aline Santos, Aluana Santana, Rejane Gaspar-Reis, Celly Cristina Nascimento-Saba*, Penha Barradas

PCD274

Kenia Bicego*, Paula Velasquez, Marcia Fernandes, Carolina Scarpellini, Marcos Macari, Luciane Gargaglione

Enhanced spermiogram in Cinnamon verum treated male Alloxan-induced diabetic Wistar albino rats

Exposure to maternal obesity or to maternal weight loss around the time of conception in the sheep has long term impact on hepatic fatty acid metabolism in the offspring at four months of age

PCD285

Lisa Nicholas*, Leewen Rattanatray, Severence MacLaughlin, Dave Kleemann, Simon Walker, Janna Morrison, Song Zhang, Isabella McMillen

PCD280

Olushola Adeleye*, Olukayode Akinlabi, Abiodun Adetomiwa, Adenike Adeleye

Cortisol exposure and advancing PCD286 gestational age results altered DNA methylation of the phosphoenolpyruvate ME carboxykinase (PEPCK) gene promoter in the sheep fetus Lisa Nicholas*, Jacob Ross, Lisa Edwards, Janna Morrison, Isabella McMillen

Amelioratory effect of proanthocyanidine on paraquat - induced oxidative stress, biochemical and histopathological changes in rat kidney

PCD275

The developmental transition of epicardial, pericardial and omental adipose tissue during early life in the sheep

PCD281

ME Central role for melanocortin system in energy balance and blood pressure regulation in offspring of obese dams

Graeme Davies*, Mark Birtwistle, Mark Pope, Viv Perry, Harold Sacks, Helen Budge, Michael Symonds

Ali Jebur*, Fatma El-Demerdash, Ahmed Attia

PCD287

Anne-Maj Samuelsson*, Amandine Mullier, Anna Stepien, Keval Patel, Joaquim Pombo, Clive Coen, Lucilla Poston, Paul Taylor

Oxidative Stress, biochemical PCD276 perturbations and environmental safety in Petrochemical Industry Mohamed ElMasry*, Elsayed Salem, Fatma El-Demerdash, Hassan Hassan

Heterothermy in free-living vervet monkeys as an index of environmental stress Andrea Fuller*, Alwyn Lubbe, Richard McFarland, Duncan Mitchell, Louise Barrett, Peter Henzi, Robyn Hetem

PCD277

Cheetah do not abandon hunts because they overheat

PCD278

Robyn Hetem, Brenda de Witt, Andrea Fuller, Linda Fick, Leith Meyer, Shane Maloney, Duncan Mitchell*

Maternal obesity results in lower PCD282 energy expenditure in adult offspring when exposed to an ME obesogenic diet in adulthood Identification of human adipose tissue native progenitor cell subsets in distinct adipogenic states

Xanthi Maragkoudaki*, Lucilla Poston, Paul Taylor

Identification and PCD283 characterisation of human foetal adrenocortical progenitor cells Jessica Sampson*, David Wilson, Ita O’Kelly

PCD288

David Esteve*, Nathalie Boulet, Alexia Zakaroff-Girard, Severine Ledoux, Pauline Decaunes, Jason Iacovoni, Christophe Heymes, Anne Bouloumié, Jean Galitzky

Impact of increased carbohydrate PCD284 and fat intake during postnatal and juvenile life on gene expression in the sternal fat of ME sheep

Effects of Bone Morphogenetic Proteins (BMPs) on human adipose conversion and adipose tissue (AT) development

PCD289

T H U R S D A Y

Nathalie Boulet*, David Esteve, Pauline Decaunes, Anne Bouloumié, Jean Galitzky

Mark Birtwistle*, Prabhat Khanal, Anna Hauntoft Kongsted, Mette Olaf Nielsen, Helen Budge, Michael Symonds

157

Poster Communications - Thursday 25 July The effects of gravidity, digestion, PCD290 and exhaustive activity on oxygen consumption in the viviparous ME checkered garter snake

Intensity-response effects of electro-acupuncture on gastric motility and its underlying peripheral neural mechanism

Alexander Jackson*, Neil Ford, James Hicks

Yangshuai Su, Hong Shi, Xiaoyu Wang, Hongyan Shang, Juanjuan Xin, Zhaokun Yang, Wei He, Xianghong Jing*, Bing Zhu

Comparative effects of the long- PCD291 term black or green tea decoction consumption on lipid digestibility and adipose abdominal tissue ME mass in rat fed high-fat diet

Luqman Olayaki*, Elizabeth Mbukanma, Abdulraheem Abdulraheem

Chahira Snoussi, Karima Dhaouadi, Houda Abaidi, Sami Fattouch, Mohamed Hamdaoui*

A new mouse model for obesity and steatosis

PCD292

Huachun Weng*, Yukiko Naito, Kosuke Endo, Naoharu Iwai

Hydroxysteroid sulfotransferase SULT2B1b promotes hepatocellular carcinoma cells proliferation in vitro and in vivo

Attenuation of acetaminopheninduced hepatotoxicity by short day photoperiod in Wistar rats

PCD293

Xiaoming Yang, Ping Zhou, Yanxia Ning, Xiuling Zhi, Xiaobo Li, Lianhua Yin*

PCD296

Treating overweight/obesity using alginate enriched bread

PCD302

David Houghton*, Matthew Wilcox, Iain Brownlee, Chris Seal, Jeffrey Pearson

PCD297

Intestinal handling of glucose in PCD303 rats treated with Kolaviron (A biflavonoid of Garcinia Kola seed) Samuel Olaleye, Olugbenga Odukanmi*

Protective effects of cumin PCD298 essential oil and a probiotic bacterial strain against cadmium ME hepatotoxicity in rats

Effects of different sweeteners PCD304 on gastric emptying, incretins release and glucose homeostasis in healthy humans ME Ricardo Pereira*, Marie Secaf, Ricardo de Oliveira

Lobna El Hosseiny*, Fatma El-Demerdash, Hoda Baghdadi, Mostafa El-Shenawy

Metabolic response of growing PCD305 rats fed fructose from two dietary supplements Antioxidative and hepatoprotective effect of beta carotene on acetaminophen induced liver damage in rats

PCD299

Abdulwahid Ajibola*, Joseph Chamunorwa, Kennedy Erlwanger

Oluwakemi Oyelowo*, Ayodele Morakinyo, Bolanle Iranloye, Jennifer Nnaji

PCD294

Kennedy Erlwanger*, Zinhle Gasa, Siyanda Makaula

Dietary supplementation PCD295 with coriander (Coriandrum sativum L) seed: Effect on growth performance, circulating ME metabolic substrates, and lipid profile of the liver and adipose tissue in healthy female Sprague Dawley rats Trevor Nyakudya*, Siyanda Makaula, Nompilo Mkumla, Kennedy Erlwanger

158

ME Novel insights in the cross-talk of PparÎą and PparÎł with the Hedgehog-Signaling Pathway

Effects of a crude Aloe vera leaf aqueous extract and fenofibrate on diet induced metabolic dysfunction in growing rats

Assessment of coal tar creosote toxicity in rat liver: role of rosemary Ehab Abbady*, Fatma El-Demerdash, Hoda Baghdadi

PCD300

The role of the anti-inflammatory PCD301 cholinergic pathway in the pathogenesis of a rat model of acute colitis ME Meltem Kolgazi*, Unal Uslu, Meral Yuksel, Ayliz Velioglu-Ogunc, Feriha Ercan, Inci Alican

Katrin Arnold*, Madlen Matz-Soja, Eugenia Marbach, Wolfgang Schmidt-Heck, Reinhard Guthke, Rolf Gebhardt

PCD306

HEDGEHOG AROUND THE CLOCK: PCD307 Mutual interaction between circadian rhythms of hepatic ME lipid metabolism and hedgehog morphogen pathway Eugenia Marbach*, Madlen Matz-Soja, Katrin Arnold, Wolfgang Schmidt-Heck, Rheinhold Guthke, Rolf Gebhardt

Hall 3, ICC

*Denotes presenting author

Microcirculatory blood flow during liver regeneration after partial hepatectomy in LPSsensitive and –insensitive mice: an IVFM study

PCD308

Vasorelaxant mechanism of 3, 5, PCD313 7, 3’, 4’-pentamethoxyflavone on isolated thoracic aorta of female VS rats

Tight junction in hyaloid vessels could be induced by interaction between pericytes and endothelial cells

Chaweewan Jansakul*

Jin Hyoung Kim*, Dong Hyun Jo, ChungHyun Cho, Jeong Hun Kim

Marlini Muhamad*, Ayako Mabuchi, Beth Mallard, Hairulhisyam Ngatiman, Antony Wheatley

Impairment of cerebrovascular reactivity is proportional to degree of insulin resistance in patients with type 2 diabetes

PCD309

Ashok Kumar Jaryal*, Kiran Prakash, Dinu Chandran, Rajesh Khadgawat, Kishore Kumar Deepak

Rice bran proteins inhibit effects PCD310 of angiotensin and oxidative stress in murine macrophage cells Veerapol Kukongviriyapan*, Kampeeporn Boonloh, Patchareewan Pannangpetch, Bunkerd Kongyingyoes, Upa Kukongviriyapan, Supawan Thawornchinsombut

Mineral imbalance and loss of contractile phenotype induce vascular smooth muscle cell calcification by promoting exosome secretion

PCD314

Prevention of macrophagePCD315 induced adhesion molecules production and endothelial permeability in SEVC endothelial VS cells by Sporopollenin

Blood-retinal barrier breakdown PCD320 of diabetic retinopathy could be attenuated by blockade of protein VS kinase C ζ signaling pathway

Inhibitory effect of the antidepressant paroxetine on human ether-a-go-go-related gene (hERG) K+ current

PCD321

Hee-Kyung Hong, Su-Hyun Jo, Mi-Hyeong Park*

Mei-Fen Shih*, Shu Fen Liou, Lei-Yi Chen, Su-Jong Chen, Shu-Ching Luo, I-Chin Chen, Lih-Chi Chen

Semaphorin 4D recruits PCD316 pericytes and regulates vascular permeability through endothelial production of PDGF-B and VS ANGPTL4

Retty Ratnawati*, Mohamad Widodo, Nur Permatasari

Hua Zhou, John Basile*

Harumi Hotta*, Kazuto Masamoto, Sae Uchida, Yuta Sekiguchi, Hiroyuki Takuwa, Hiroshi Kawaguchi, Kazuhiro Shigemoto, Ryo Sudo, Kazuo Tanishita, Hiroshi Ito, Iwao Kanno

Jeong Hun Kim*, Hyoung Oh Jun, Jin Hyoung Kim

Alexander Kapustin*, Ignat Drozdov, Daniel Soong, Malgorzata Furmanik, Daniel Alvarez-Hernandez, Pilar Sanchis, Roshni Molls, Rukshana Shroff, Xiaoke Yin, Jeremy Skepper, Manuel Mayr, Catherine Shanahan

Non-genomic effect of 17 β PCD311 estradiol in the endothelial domination role via nitric oxide in the aorta of guinea pig: study ME in HUVECs culture and bioassay.

Layer-specific dilation of cortical arteries during stimulation of the nucleus basalis of Meynert in mice

PCD319

PCD312

Exposure to low level of arsenic and lead in drinking water alter cardiovascular parameters and reduces vasomotion in rat aorta

PCD317

Javier Palacios*, Jose Luis Vega, Fredi Cifuentes

GTP cyclohydrolase I rescues microRNA-34a impairment of endothelial progenitor cell angiogenesis in aging Dandan Chen, Hong Yuan, Keith Channon, Alex Chen*

PCD318

Direct inhibition of hERG K+ channel by classic histamine H1 receptor antagonist hydroxyzine Byung Hoon Lee, Su-Hyun Jo, Mi-Hyeong Park*

PCD322

Prelamin A accelerates vascular PCD323 calcification via activation of the DNA damage response and senescence associated secretory VS phenotype in vascular smooth muscle cells Yiwen Liu*, Ignat Drozdov, Rukshana Shroff, Leilani Beltran, Catherine Shanahan

T H U R S D A Y

Blockade of the renin-angiotensin PCD324 system improves cerebral microcirculatory perfusion in VS diabetic hypertensive rats Vanessa Estato*, Nathalie Obadia, Felipe Freitas, Marcos Adriano Lessa, Patrícia Reis, Hugo Castro-Faria-Neto, Juliana CarvalhoTavares, Eduardo Tibiriçá

159

Poster Communications - Thursday 25 July Vascular reactivity and membrane potential in survivor and non-survivor rats with peritonitis-induced septic shock

PCD325

Shiu-Jen Chen, Chih-Chin Shih, Cheng-Ming Tsao, Chin-Chen Wu*

The AMP-activated protein kinase PCD331 (AMPK) decreases endothelial angiotensin converting VS enzyme (ACE) expression by phosphorylation of p53 and posttransscriptional upregulation of microRNA (miR)-143/145 Karin Kohlstedt*, Caroline Trouvain, Thomas Boettger, Beate Fisslthaler, Lei Shi, Ingrid Fleming

Molecular profile of fibrosis and elastogenesis in the vein wall of human leg varicose veins. An immunohistochemical and morphometrical study.

PCD326

VS Tetrahydrocurcumin ameliorates PCD332 vascular dysfunction and aortic remodeling in nitric oxideVS deficient rats

Javier Regadera*, Juan Velasco-Martin, Maria Rubio, Gabriel España-Caparros, Parichat Prachaney, Pilar RodriguezRodriguez, Luis Reparaz, Silvia Arribas

Upa Kukongviriyapan*, Orachorn Boonla, Saowanee Nakmareong, Poungrat Pakdeechote, Veerapol Kukongviriyapan, Patchareewan Pannangpetch, Praphassorn Surawattanawan, Stephen Greenwald

Large-scale analysis and characterisation of the cardiac microvascular endothelial proteome Hans Strijdom*, Amanda Genis, Sam Van Rensburg, Salome Smit

Nitric Oxide-cGMP signalling PCD333 induces β-Catenin nuclear translocation and transcriptional VS activity Christina Warboys*, Nan Chen, Qiuping Zhang, Yasin Shaifta, Jeremy Ward, Albert Ferro

Cilostazol inhibits leukocyteendothelial cell interaction in murine microvessels after transient bilateral common carotid artery occlusion

Low Akt activity, decreased VEGFR-2 expression and bcl-2 suppression are associated with regressing vascular tumors in mice

PCD329

cAMP signalling in endothelial cells: Differential effects on angiogenesis via PKA and Epac signalling Muhammad Aslam*, Susanne Rohrbach, Rainer Schulz, Christian Hamm, Dursun Guenduez

160

Hyun-Joo Park, Su-Ryun Kim, Mi-Kyoung Kim, Soo-Kyung Bae, Moon-Kyoung Bae*

Alaaeldin Saleh, Ali Eid*

Hyperglycaemia downregulates TRPV4 channels in retinal endothelial cells Kevin Monaghan*, Jennifer McNaughten, Dan Kyle, Caitriona Kelly, Mary McGahon, Ross Hamilton, Norman Scholfield, Graham McGeown, Tim Curtis

Sanela Unfirer, John Falck, Ines Drenjancevic*

Neuromedin B induces endothelial angiogenesis via activation of ERK and Akt

PCD330

Pernille Hansen*, Per Svenningsen, Anne Thuesen, Kenneth Andersen, He Shin, Boye Jensen, Ole Skott

PCD334

Peace Mabeta*, Michael Pepper

Endothelial T-type channels PCD338 (Cav3.1) are co-localized with eNOS and promote NO-formation and vasodilatation during VS depolarization in mesenteric resistance arteries

Lynn McKeown*, David Beech

VS Cytochrome P450-epoxygenase metabolites play role in vasodilation of middle cerebral arteries in response to reduced pO2 in healthy and diabetic rats that underwent hyperbaric oxygenation

Properties and roles of tunneling PCD340 nanotubes in vascular endothelial cells

PCD328

Takuya Fukuoka*, Takeshi Hayashi, Hajime Maruyama, Hiroyasu Sano, Makiko Hirayama, Norio Tanahashi

Ya-nan Shu, Mei Han*

Cortisol increases the expression PCD339 of alpha 2C adrenoceptor in human arteriolar smooth muscle VS cells: Role of Epac

PCD327

SM22α modulates NF-kB signaling PCD336 via three different pathways in vascular smooth muscle cells

PCD335

PCD341

Hall 3, ICC

*Denotes presenting author

Elevated expression levels PCD342 of microRNA-143/145 drive aberrant smooth muscle cell phenotype and function in Type 2 VS diabetes – evidence of metabolic memory Kirsten Riches*, Neil Turner, David O’Regan, Ian Wood, Karen Porter

Investigating a role for CGRP in the ageing cardiovascular system PCD343 Ross King*, Sarah Smillie, Susan Brain

Endocannabinoid-mediated CB1 receptor activation attenuates the vasoconstrictor effect of angiotensin II and other Ca2+mobilizing GPCR agonists in skeletal muscle resistance vasculature

PCD344

Tamy Banin*, Laena Pernomian, Roberto da Silva, Lusiane Bendhack

Characterisation of cannabinoid- PCD354 induced vasorelaxation in human mesenteric arteries

Microparticles in diabetesassociated microvascular dysfunction Pingnian He*, Christian Stork, Dong Yuan, Sulei Xu

Giα-coupled β2-adrenoceptor signaling mediates oxidative stress and the endothelial dysfunction induced by isoproterenol

PCD355

PCD350

FAM3A promotes proliferation PCD357 and migration of vascular smooth muscle cells via activation of Akt and ERK1/2 pathways through VS P2Y receptor Shi Jia, Zhenzhen Chen, Youfei Guan, Jichun Yang*

PCD351

VS Inhibition of phospholipase c and protein kinase c activity from human umbilical veins endothelial cells by aqueous extract of Bixa orellana leaves Yoke Keong Yong*, Zuraini Ahmad, Jun Jie Tan, Daud Ahmad Israf Ali

PCD346 Valve defects in Foxc2+ mice predispose lymphatic vessels to pump failure

Ana Paula Davel, Patricia Brum, Luciana Rossoni*

Richard Sweat*, Walter Murfee

Christopher Stanley*, Saoirse O’Sullivan

Cristina Valenzuela, Pia Ávila, Susana Rojas, Roberto Villalobos, Carlos Palma, Victoria Gallardo, Luis Sobrevia, Marcelo González*

Michael Davis*, Amelie Sabine, Tatiana Petrova, Naoyuki Miura, Joshua Scallan

The new NO-donor does not induce in vitro tolerance in rat aorta.

PCD349

Piia Keskivali*, Nick Curzen, Geraldine Clough, Christopher Torrens

Elizabeth Fernandes*, Claire Sand, Robin Salamon, Jennifer Bodkin, Aisah Aubdool, Susan Brain

Anna O’Connor*, Jasenka Guduric-Fuchs, David Simpson, Tim Curtis

Effects of acute and long-term incubation with high D-glucose on mechanisms that induces nitric oxide and reactive oxygen species in human fetal endothelium.

Withdrawal of early age acute statin treatment alters RhoA pathway gene expression long term in rat mesenteric arteries

TRPA1 mediates the cold-induced PCD345 hemodynamic changes observed in the arthritic knee following VS exposure to low temperature

Vascular endothelial growth PCD353 factor-C induces angiogenesis and lymphangiogenesis in the rat VS mesentery culture model

Michele Paulo, Marcella Grando, Juliana Vercesi, Roberto da Silva, Lusiane Bendhack*

Maria Szekeres*, György Nádasy, Gábor Turu, Eszter Soltész-Katona, Eszter Szabó, Zsuzsanna Tóth, Zoltán Takáts, László Hunyady

MicroRNA-26a regulates Ca2+ signalling via the IP3 pathway in retinal endothelial cells

The new nitric oxide donor PCD348 (RuBPY) induces tolerance only after 60 minutes exposure and it does not induce cross-tolerance VS with acetylcholine.

PCD352

PCD358

T H U R S D A Y

PCD347

161

Poster Communications - Thursday 25 July Functional restoration of tissue perfusion by strategic recruitment of proangiogenic leukocytes to the ischemic hindlimb

PCD359

Evelina Vågesjö*, Gustaf Christoffersson, Olle Korsgren, Magnus Essand, Mia Phillipson

Tylophorine, a phenanthraindolizidine alkaloid isolated from Tylophora indica exerts antiangiogenic and antitumor activity by targeting Vascular Endothelial Growth Factor Receptor 2–Mediated Angiogenesis

PCD365

Differences in the signalling mechanisms underlying UTPevoked vasoconstriction of pulmonary and systemic-like arteries

PCD370

Nawazish-i- Syed*, Asrin Tengah, Siti Tajidah Abdul Talip, Siti Nur Basirah Bujang, Charles Kennedy

Sarita Saraswati*

Vascular smooth muscle cellderived exosomes isolated from human blood are enriched with fetuin-A, and may be involved in the mechanisms of vascular calcification

PCD360

Sundeep Kalra*, Alexander Kapustin, Abeera Abbas, Alberto Smith, Matthew Waltham, Catherine Shanahan

Effect of Nigella sativa (Blackseed) oil on inflammation and nitric oxide productionin wistar rats

Chi-Nan Tseng*, Ya-Ting Chang, Malin Kronqvist, Mariette Lengquist, Ulf Hedin, Einar Eriksson

Synthetic or contractile, that is the question: comparing in vitro methods to modulate VSMC phenotype

PCD371

Jessal Patel*, Mark Fowler, Richard Siow

EunYeong Seo*, Hae Jin Kim, Chun Zi Jin, Yin Hua Zhang, Sung Joon Kim

PCD361

Abdulbasit Amin*, Victor Owoyele

Blocking selectin reduced late intimal hyperplasia in vein graft in mice

Decreased K current in arterial PCD366 myocytes of angiotensin IIinduced hypertensive rats and its recovery by exercise training VS +

Does oxidative stress has effect on microvascular reactivity in young healthy individuals? Macrophage heterogeneity in developing vulnerable atherosclerotic plaques modulated by shear stress

PCD367

Anita Cosic*, Ana Cavka, Lidija Rasic, Ines Drenjancevic

PCD372

Anusha Seneviratne*, Jennifer Cole, Michael Goddard, Rob Krams, Claudia Monaco

Cutaneous microvascular PCD373 regulatory response to ischaemia and association with mean oxygen saturation VS

PCD362

Endothelin-1-mediated vasoconstriction: is there therapeutic potential for intracellular sarcoplasmic reticulum calcium blockade?

PCD368

Damilola Adingupu*, Clare Thorn, Francesco Casanova, Salim Elyas, Phillip Gates, Angela Shore, W. Strain

Yann Chan*, Benjamin A Reddi, John Beltrame, Grigori Rychkov, David Wilson

Selective Estrogen Receptor Modulators benefits endothelial function by enhancing the nitric oxide via and reducing oxidative stress in ovariectomized rats

PCD363

Contradictory role of apelin in vascular calcification

Xu Teng*, Yongfen Qi, Zhengfei Lu, Yebo Zhou, Yan Cai, Chaoshu Tang

Juan Velasco-Martin*, Lucia Recio, Javier Regadera, Maria Ojeda, Francisco Leyva, Luisa Botella

Omary Chillo*, Judith Pagel, Anika Mauer, Teresa Trenkwalder, Christoph Reichel, Elisabeth Deindl

162

Endothelial endoglin expression PCD369 and phatobiology mechanism regulation of angiogenesis in wound healing and skin angiomas VS

Aline Lamas*, Izabela Caliman, Polyana Dalpiaz, Phablo Oliveira, Antônio Melo Júnior, Suely Figueiredo, Margareth Moysés, Nazaré Bissoli

The functional role of mast cells in arteriogenesis

PCD374

PCD364

Influence of hyperbaric oxygenation on gene expression in diabetic and healthy female Sprague-Dawley rats Sanja Novak*, Dragan Manojlovic, Zrinka Mihaljevi?, Ines Drenjancevic

PCD375

Hall 3, ICC

*Denotes presenting author

Transient receptor potential PCD376 vanilloid 1 in the vascular system, at baseline and in inflammation Claire Sand*, Andrew Grant, Manasi Nandi

Dynamics of neutrophilendothelial interactions governs dissemination of local inflammation

PCD381

Jennifer Bodkin*, Martina Beyrau, Abigail Woodfin, Bartomeu Colom, Natalie McCloskey, Marco Bianchi, Sussan Nourshargh

Effects of dietary zinc and PCD377 selenium on vascular responses to acetylcholine and reduced pO2 in aortic rings of male SpragueVS Dawley rats Ana Cavka*, Ivana Grizelj, Anita Cosic, Sanja Novak, Zdenko Loncaric, Brigita Popovic, Ines Drenjancevic

Signalling responses in cardiac endothelial cells, following treatment with high concentrations of TNF-α, with or without co-treatment with Oleanolic Acid.

PCD382

Targeting vulnerable loci in the endothelium Joana Amado-Azevedo*, Jan van Bezu, Erik Valent, Victor van Hinsbergh, Geerten van Nieuw Amerongen

PCD386

Endothelial-dependent relaxation PCD387 in the murine thoracic aorta is transiently increased after high fat feeding. VS Christopher Cobb*, Rachel Walker, Kelly Farrell, David Eisner, Clare Austin, Cathy Holt

Amanda Genis*, Corli Westcott, Mashudu Mudau, Hans Strijdom

Deficiency in endothelial cell PCD378 tetrahydrobipterin reveals hydrogen peroxide mediated changes in vascular function and VS blood pressure in vivo Surawee Chuaiphichai*, Eileen McNeill, Jennifer Bendall, Gillian Douglas, Mark Crabtree, Ashley Hale, Nicholas Alp, Keith Channon

Simvastatin and lovastatin PCD379 reverse functional microvascular rarefaction in the brain and skeletal muscle of spontaneously VS hypertensive rats Felipe Freitas*, Vanessa Estato, Marcos Adriano Lessa, Eduardo Tibiriçá

Rho kinase mediates impaired PCD380 vasoconstriction of femoral artery induced by hindlimb unweighting in rats VS ZhongChao Wang*, Huan Liu, YunGang Bai, JinWen Yu, HaiJun Zhang, YaoPing Cheng, JunXiang Bao, Jin Ma

Chronic hypoxia-enforced PCD388 inhibition of vascularization; Involvement of HIF1α and HIF2α Regulation of lymphatic endothelial cell migration by platelets Stacey Langan*, Leyre Navarro-Núñez, Steve Watson, Gerard Nash

PCD383

Tessa Nauta*, Ester Weijer, Sue Gibbs, Rik Scheper, Victor van Hinsberg, Pieter Koolwijk

Targeted deletion of the PCD384 extracellular calcium-sensing receptor (CaSR) from vascular smooth muscle cells reveals roles VS for the receptor in blood pressure regulation and protection against vascular calcification Martin Schepelmann*, Thomas Davies, Polina Yarova, Sarah Brennan, Joao Graca, Wenhan Chang, Daniel Bikle, Peter Edwards, Martin Krssak, Donald Ward, Ann Canfield, David Edwards, Sally Price, Paul Kemp, Daniela Riccardi

Investigating the role of perivascular adipose tissue on vasoconstriction in mouse mesenteric arteries

PCD389

Pratish Thakore*, Aisah Aubdool, Susan Brain, Ian McFadzean

Microcirculation disorders and PCD390 inflammatory markers in patients with coronary artery decease and VS chronic heart failure Anastasia Shchendrygina*, Elena Privalova, Yuri Belenkov

Characterization of endothelial progenitor cell migration in vivo Joachim Pircher*, Kristin Pogoda, Ulrich Pohl

T H U R S D A Y

PCD385

Responses of aortic and cardiac microvascular endothelial cells to TNF-α: Does endothelial heterogeneity matter?

PCD391

Mashudu Mudau*, Amanda Genis, Corli Westcott, Hans Strijdom

163

Poster Communications - Thursday 25 July Exchange protein activated by cAMP (Epac) inhibits human vascular smooth muscle cell migration

PCD392

Jenny McKean*, Derryck Shewan, George Gibson, Graeme Nixon

Concordant low frequency oscillations in tissue blood flux and oxygenation in human skin Katarzyna Kuliga*, Andrew Chipperfield, Rodney Gush, Geraldine Clough

Comparative morphological, temporal and pharmacological profiles of two 96-well in vitro kinetic angiogenesis co-culture assays

PCD398

Hyperoxic-induced contraction in PCD404 porcine pulmonary veins Amy Arnold*, Caiomhe Hannon, Ciprian Dospinescu, Hélène Widmer, Iain Rowe, Stuart Cruickshank

Clare Szybut*, Dyke McEwan, Kalpana Patel, Kevin Allard, Belinda O’Clair, Eric Endsley, Tim Dale, Vince Groppi, Derek Trezise

PCD394

The adhesion of platelets to monocyte subsets in stirred whole blood in response to different platelet agonists

PCD399

Induction of classically activated macrophages results in the loss of anti-contractile effect of perivascular adipose tissue

PCD405

Lucy Murfitt*, Sarah Withers, Charlotte Bussey, Anthony Heagerty

Clare Box*, Clara Yates, Myriam Chimen, Matthew Harrison, Gerard Nash, Steve Watson, Ed Rainger

Scavenger receptors mediate PCD395 uptake of modified low-density lipoprotein by circulating blood monocyte subsets: consequences VS for atherosclerosis Willliam Jackson*, Ramzi Khamis, Dorian Haskard, Kevin Woollard

Investigating the effects PCD396 of L-phenylalanine on the endogenous tetrahydrobiopterin regulatory system in VS spontaneously hypertensive rats. Lamia Heikal*, Anna Starr, Dania Hussein, Jesus Prieto-Lloret, Phil Aaronson, Lea Ann Dailey, Manasi Nandi

Evaluation of the mechanisms PCD400 involved in the reduced vascular contraction in aortas of diabetic VS female rats: role of iNOS and insulin Simone Sartoretto*, Rosangela Dos Santos, Graziela Ceravolo, Rita Tostes, Maria Helena Carvalho, Zuleica Fortes, Eliana Akamine

Olga Barnett*, Yulian Kyyak, Hryhoriy Kyyak, Oleg Leshchuk

Investigating tetrahydrobiopterin PCD407 biosynthesis

Vitronectin stabilizes neutrophil- PCD401 endothelial cell interactions in the inflamed microvasculature

PCD397

Endothelial cell-mediated lipid handling in human adipose tissue. Fanny Volat*, Pauline Decaunes, Alexia Zakaroff-Girard, Jean Galitzky, Anne Bouloumié

TMEM16A: Do we have suitable pharmacological tools? Rebecca Brookfield*, Alison Gurney, Paolo Tammaro

Redox-dependent angiogenesis by nucleoside derivatives of deoxyribose-1-phosphate Dina Vara*, Caroline Wheeler-Jones, Harry Mellor, Giordano Pula

164

Charlotte Bussey*, Sarah Withers, Gillian Edwards, Anthony Heagerty

Dania Hussein*, Anna Starr, Lamia Heilkal, Manasi Nandi

Gabriele Zuchtriegel*, Kirsten Lauber, Fritz Krombach, Christoph Reichel

Endothelial cell and cardiomyocite remodelling and hibernation in hypertension as risk factor for heart failure

β-adrenergic signalling PCD406 contributes to the anticontractile action of perivascular adipose tissue through nitric oxide VS release.

PCD408

PCD402

PCD403

Divergent vascular effects of PCD409 hydrogen-peroxide in isolated systemic and coronary arterioles Viktória Csató*, Attila Tóth, Ákos Koller, István Édes, Zoltán Papp

Hall 3, ICC

*Denotes presenting author

Spironolactone but not losartan PCD410 prevents enhanced contractility and oxidative stress mediated by nitric oxide synthase uncoupling VS in aortas from isoproterenoltreated rats Jamaira Victorio, Luciana Rossoni, Ana Davel*

Inhibitory influence of physiological levels of arterial shear stress on local proteolysis and podosome formation of endothelial cells

PCD411

MicroRNA-143 and microRNA-145 knockout mice show reduced neointimal formation in model of in-stent stenosis

PCD415

Anne Thuesen*, Lotte Rasmussen, Anja Toft, Niels Marcussen, Steen Walther, Boye Jensen, Lars Rasmussen, Pernille Hansen

Hollie Robinson*, Gillian Douglas, Robert McDonald, Keith Channon, Andrew Baker

The effects of endocannabinoids PCD416 on permeability in a cell culture model of the blood-brain barrier William Hind*, Timothy England, Saoirse O’Sullivan

Embryological origin of human smooth muscle cells influences their ability to support vasculogenesis.

PCD412

Kimberly Jett*, Jason Cui, Harleen Chohan, Darian Arman, Arash Tehrani, Jan Friedman, Casey Van Breemen, Mitra Esfandiarei

Magnetic resonance imaging (MRI) of microvascular blood volume recruitment capacity in the rat heart.

PCD422

Judith van Haare*, Hans Vink, Eline Kooi, Jos Slenter, Gustav Strijkers, Hanneke Cobelens, Jurgen van Teeffelen

Theres Fey*, Ulrich Pohl, Andreas Dendorfer

Impairment of aortic structure and function in a mouse model of neurofibromatosis type 1

Non-L-type calcium channels play PCD421 a role in regulating contractile responses in human mammary VS arteries

PCD417

Zebrafish caudal fin regeneration PCD423 – a novel quantitative angiogenic assay in vivo Daniel Brönnimann*

Lucinda Low*, Christine Cheung, Martin Bennett, Sanjay Sinha

The role of microRNA-30c-2* as an anti-angiogenic mediator C-type natriuretic peptide PCD413 reduces phenylephrine-induced vasoconstriction in intact endothelium aorta isolated from VS rats submitted by septic shock

Saran Shantikumar*, Andrea Caporali, Marco Meloni, Micol Marchetti, Lynsey Howard, Fabio Martelli, Costanza Emanueli

PCD418

Uric acid prevents middle PCD424 cerebral artery structural and mechanical alterations induced by focal cerebral ischemia in rats VS Yara Onetti*, Francesc Jiménez, Belén Pérez, Elisabet Vila

Laena Pernomian*, Lusiane Bendhack

Cannabidiol ameliorates the increased permeability of the blood-brain barrier following oxygen-glucose deprivation, an in vitro study

PCD414

Diltiazem prevents aortic PCD425 aneurysm formation via inhibition of Interleukin-6-induced AP-1 promoter activity in macrophages VS Anja Mieth*, Marc Revermann, Andreas Weigert, Bernhard Brüne, Ralf Brandes

T H U R S D A Y

William Hind*, Timothy England, Saoirse O’Sullivan

165

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166

Other Activities Thursday 25 July 13.00 – 14.00

Hall 10 (The ICC)

Women in Science: What glass ceiling?

13.00 – 14.00

Hall 7 (The ICC)

Annual General Meeting, European Society for Microcirculation

16.00 – 18.00

Faraday Room (Austin Court)

International Liaison Committee for Microcirculation

18.00 – 20.00

Executive Room 8 (The ICC)

Board Meeting, Scandinavian Physiological Society

T H U R S D A Y

167

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At a glance - Friday 26 July Keynotes

8.30 – 9.15

Mala Shah Göran Nilsson

Hall 4 (The ICC) Hall 5 (The ICC)

Morning symposia

9.30 – 11.30

Ageing, exercise training, gender, inactivity and nutrition: Implications to skeletal muscle Cardiac ß-adrenergic signalling in health and disease Dendritic ion channel function and plasticity Understanding microcirculatory blood flow using quantitative approaches Shedding light in the neurophysiological black box Intercellular communications in the vasculature: From physiology to pathophysiology Publishing for beginners Developmental programming of cardiovascular and renal disease in adulthood Neurotransmitter transporters: Impact on nerve cell excitability and function Current advances in structure and regulation of epithelial tight junctions Hypometabolism, hypothermia and hibernation

Plenary

11.45 – 12.45

Karl Deisseroth

Hall 4 (The ICC)

Closing Ceremony - Hall 4 (The ICC)

13.00 – 14.00

Essential Guide to Reading Biomedical Papers by Philip D. Langton ISBN: 978-1-119-95997-7 Paperback | 350 pages | November 2012

This concise, easy-to-follow text gives an insight into core techniques and practices in biomedical research and how, when and why a technique should be used and presented in the literature.

F R I D A Y

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169

Research Symposia - Friday 26 July

09.30 – 11.30

Ageing, exercise training, gender, inactivity and nutrition: Implications to skeletal muscle mass and metabolic function in humans

Cardiac ß-adrenergic signalling in health and disease

Intercellular communications in the vasculature: From physiology to pathophysiology (ESM and EVBO)

Hall 1 (The ICC)

Hall 4 (The ICC)

Hall 8 (The ICC)

Organised by Paul Greenhaff University of Nottingham, UK Bettina Mittendorfer Washington University School

Organised by Andrew Trafford University of Manchester, UK Patrick Most University of Heidelberg, Germany

Organised by Christelle Guibert Bordeaux Segalen University /

09.30

of Medicine, USA

SA421

SA426

INSERM, France

Cor De Wit University of Lübeck, Germany

SA431

Gender specific differences in muscle protein metabolism Bettina Mittendorfer Washington University

β-adrenergic signalling in Takotsubo cardiomyopathy Sian Harding Imperial College London, UK

Interaction of endothelial connexins: Can they mutually replace each other at the functional level? Cor De Wit University of Lübeck, Germany

10.00

School of Medicine, USA

SA422

Metabolic and molecular regulation of skeletal muscle in older age Philip Atherton University of Nottingham, UK

SA427

SA432

Spatio-temporal dynamics of cAMPdependent protein kinase in cardiac myocytes Gregoire Vandecasteele University of Paris Sud,

Role of Pannexin 1 in the regulation of blood pressure Marie Billaud University of Virginia, USA

10.15

France

10.15

SA423

Muscle insulin resistance, immobilisation and remobilisation Flemming Dela University of Copenhagen, Denmark

SA428

Targeting β-AR signalling in heart disease through G-protein receptor kinases Patrick Most University of Heidelberg, Germany

SA433

Cellular mechanisms mediated by connexin channels involved in the control of blood pressure Jacques-Antoine Haefliger Centre hospitalier universitaire vaudois (CHUV), Switzerland

10.45

SA424

Ageing, inactivity and rehabilitation Charlotte Suetta University of Copenhagen,

Denmark

10.45

SA429

10.45

SA434

Compartmentalized beta-adrenergic receptor signalling to cAMP in healthy and failing cardiomyocytes Viacheslav Nikolaev Heart Research Center

Connexins in ischemia-reperfusion injury Sandrine Morel University of Geneva, Switzerland

11.00

Göttingen (HRCG), Germany

11.00

SA425

Maximising muscle protein synthesis: influence of nutrition and training modalities Stuart Phillips

Cyclic nucleotides, physiology and function in heart disease Manuela Zaccolo University of Oxford, UK

McMaster University, Canada

HE 170

SA430

Gap junctions in the pulmonary artery: from physiology to pulmonary hypertension Christelle Guibert Bordeaux Segalen University / INSERM, France

Sponsored by:

The British Heart Foundation

ESM & EVBO programme

SA435

Neurotransmitter transporters: impact on nerve cell excitability and function

Dendritic ion channel function and plasticity

Understanding microcirculatory blood flow using quantitative approaches

Hall 11 (The ICC)

Hall 5 (The ICC)

Hall 6 (The ICC)

Organised by Francisco Suárez European University of Madrid, Spain Susan Amara National Institutes of Health, USA

Organised by Mala Shah University College London, UK Michael Häusser University College London, UK

Organised by Jefferson Frisbee West Virginia University, USA Sylvie Lorthois Institut de Mécanique des Fluides de

09.30

SA436

SA441

Toulouse, France

SA445

A new take on uptake: neurotransmitter transporters & the celular mechanisms of amphetamine action Susan Amara National Institutes of Health, USA

Dorsal-ventral differences in HCN channel function and expression in hippocampus Daniel Johnston University of Texas at Austin, USA

Altered spatial and temporal microvascular perfusion heterogeneity in metabolic syndrome Jefferson Frisbee West Virginia University, USA

10.00

SA437

SA442

SA446

Dendritic inhibition by DAT-mediated dopamine-release Björn Falkenburger RWTH Aachen University,

The cellular basis of sensory hyperexcitability in the Fmr1 knockout mouse model of Fragile X Syndrome Andreas Frick INSERM, France

The role of pericytes in microvascular network pattern formation Walter Murfee Tulane University, USA

10.15

Germany

SA438

SA443

SA4487

Molecular physiology and pathophysiology of glutamate transporter-associated anion channels Christoph Fahlke FZ Jülich, Germany

Dendritic computation in vivo Michael Häusser University College London, UK

10.45

GABA transporters, GABA release and opioid dependence Elena Bagley University of Sydney, Australia

Dendritic activity underlying sensory perception Matthew Larkum Charité Universitätsmedizin

The spatio-temporal dynamics of vascular plexus regeneration are related to vessel function Maria Machado University of Bristol, UK

11.00

SA439

SA440

Bath salts interactions with the human dopamine transporter Louis De Felice Virginia Commonwealth University, USA

Insights from numerical simulations of brain blood flow regulation in large anatomical networks Sylvie Lorthois Institut de Mécanique des Fluides de Toulouse, France

Berlin, Germany

SA444

Sensory-evoked calcium signaling in dendrites and spines of cortical neurons in vivo Arthur Konnerth Technische Universität München, Germany

SA448

SA449

Insights from structure based imaging, analysis and computational modelling of coronary microcirculation Nicolas Smith King’s College London, UK

F R I D A Y

VS 171

Research Symposia - Friday 26 July

09.30 – 11.30

Current advances in structure and regulation of epithelial tight junctions

Developmental programming of cardiovascular and renal disease in adulthood

Hypometabolism, hypothermia and hibernation

Symphony Ballroom (Hyatt Regency Hotel)

Hall 10 (The ICC)

Kingston Theatre (Austin Court)

Organised by Jennifer Pollock Georgia Regents University, USA Abigail Fowden University of Cambridge, UK

Organised by Shi-Qiang Wang Peking University College of Life

09.30

Organised by Radhakrishna Rao University of Tennessee Health

Science Center, USA

Sachiko Tsukita Osaka University, Japan

09.30

SA450

SA455

Sciences, China

Esa Hohtola University of Oulu, Finland

Role of tight junction claudins in biological systems – more than a simple paracellular barrier in inflammation and metabolism Sachiko Tsukita Osaka University, Japan

Maternal obesity and the developmental programming of hypertension; a role for Leptin Paul Taylor King’s College London, UK

Heterothermy in Afrotropical birds: phylogenetic and ecological patterns Andrew McKechnie University of Pretoria, South

10.00

SA451

SA456

Africa

SA461

Elucidating the molecular organization of tight junction strands and design of claudin-modulators Joerg Piontek Leibniz-Institut für Molekulare

Epigenetic mechanisms in the developmental programming of cardiovascular and metabolic disease Torsten Plosch University Medical Center Groningen,

Mechanisms of mitochondrial metabolic suppression in hibernation James Staples University of Western Ontario,

10.15

Pharmakologie, Germany

SA452

Canada

The Netherlands

SA457

SA462

Identifying proteins and protein networks of the tight junction James Anderson National Institutes of Health, USA

Early life stress-induced mechanisms of cardiovascular disease Jennifer Pollock Georgia Regents University, USA

Translating drug-induced hibernation to therapeutic hypothermia Kelly Drew University of Alaska Fairbanks, USA

10.45

SA453

Patch clamp recordings reveal paracellular claudin-2 channels Christopher Weber The University of Chicago, USA

11.00

SA454

Towards understanding tight junction functions and signalling Maria Balda University College London, UK

SA458

The roles of 11β-hydroxysteroid dehydrogenase type 2 in placenta and fetus in developmental programming Elizabeth Cottrell University of Manchester, UK

11.00

SA459

Sex differences and programming of hypertension Barbara Alexander University of Mississippi Medical Center, USA

Negev, Israel

11.00

The Chinese Association of Physiological Sciences

CR ET

SA464

Remodeling of cardiac excitationcontraction coupling in hibernation: comparison with heart failure Shi-Qiang Wang Peking University College of Life

Sponsored by:

SA463

Waking to drink: rates of evaporative water loss determine arousal frequency in hibernating bats Miriam Ben-Hamo Ben-Gurion University of the

Sciences, China

172

SA460

Shedding light in the neurophysiological black box

Publishing for Beginners

Hall 7 (The ICC)

Hall 9 (The ICC)

Organised by Hiromu Yawo Tohoku University, Japan Georg Nagel University of Wuerzburg, Germany

Organised by Kim E. Barrett Professor of Medicine and

09.30

SA465

Dean of Graduate Studies, University of California, San Diego, USA

09.30

Characterization and engineering of natural photoreceptors for optogenetic applications Georg Nagel University of Wuerzburg, Germany

Telling a compelling story David Paterson Editor-in-Chief, Journal

10.00

SA466

Towards the Dynamictome Alipasha Vaziri University of Vienna, Austria

of Physiology

Nuts and bolts of the review process – how to give the editors what they want Ian Forsythe Senior Editor and Reviews Editor, Journal of Physiology

10.15

SA467

The use of optogenetics to probe the role of spontaneous rhythmic activity and cyclic AMP transients during in-vivo spinal motor circuit development Lynn Landmesser Case Western Reserve University,

10.30 Avoiding common mistakes and ethical issues in your submission Kim Barrett Deputy Editor-in-Chief for the Americas, Journal of Physiology

USA

10.45

SA468

Optogenetical approach to reveal the regulatory mechanism of instinctive behaviors by the hypothalamic neurons Akihiro Yamanaka Nagoya University, Japan

11.00

SA469

Optogenetic delivery of touch sense into peripheral and central nervous systems Hiromu Yawo Tohoku University, Japan

Sponsored by: Physiological Society of Japan

11.00 Panel discussion (30 minutes): Drs. Paterson, Forsythe, Barrett, Julian Paton (Deputy Editor-in-Chief for Europe, Journal of Physiology) and Yoshihiro Kubo (Deputy Editor-in-Chief for Asia, Journal of Physiology) At the beginning of a career in physiology, scientific publishing can seem a mysterious enterprise. The goal of this session is to introduce postgraduate students, postdoctoral fellows, and early career investigators to some of the unwritten “dos and don’ts” of publishing. Armed with this information, you should be equipped to increase their chances of securing publication of your work in the journal of your choice while avoiding ethical minefields along the way.

F R I D A Y

N 173

Late Breaking Posters - Friday 26 July Scortial circumference and semen characteristics of west african dwarf bucks fed with soyabean meal and concentrate supplementati

LB1

Obesity modifies nitric oxide and prostaglandins pathways in coronary arteries

LB9

Spatiotemporal pattern of Ca2+ in osteoclasts orchestrates calpaindependent migration

LB18

Ana Maria Gamez Mendez

Benjamin Wheal

Serum biochemical profile and LB2 microbial flora of edible freshwter crabs from Southwest Nigeria

MicroRNA-503 is regulated by LB10 p75NTR receptor and inhibits intercellular communication between vascular cells in diabetes

High Agreement between Recovery LB19 Times in the Estimation of Critical Velocity

Adenike Ogunshe

Andrea Caporali

Bettina Karsten

Histological Evidence of Intersex in LB3 Tilapias from Ogun River, Nigeria

Block of NMDA receptor mediated LB11 EPSCs in substantia nigra dopamine neurones by memantine and MK801 in response to different fre

Resting electroencephalogram predicts IQ and IQ predicts academic performance in medical students

Angela R. Wild

Bishnu Hari Paudel

Oyeyemi Matthew Olugbenga

Adeogun Aina Olubukola

The effect of Moringa oleifera on LB4 lead induced cardiotoxicity in male wistar rats Adeyeoluwa Temitayo Esther

A novel Cep290 collecting duct tubule cell line of the ciliopathy Joubert syndrome

LB12

Ann Marie Hynes

Effect of maternal and postnatal LB5 high fat diet on mammalian target of rapamycin (mTOR) signalling in adult mouse offspring liver Aditi Jalali

Measuring prestin-mediated chloride transport with a genetically encoded YFP-based sensor.

Activation of protease-activated receptor 2 suppresses the activity of TRPM8 channel

LB20

LB21

Bo Zeng

LB13

Trichostatin histone deacetylase LB22 inhibitor induced the extracellular release of APE1/Ref-1 Byeong Hwa Jeon

Anna Krasnow

Mechanism the generate and LB6 pattern glutamatergic retinal waves Alejandro Akrouh

Electrophysiological remodelling of key pacemaker mechanisms underlies endurance traininginduced resting bradycardia

Inhibition of Individual 14q32 LB14 MicroRNAs Drastically Increases Neovascularization and Blood Flow Recovery after Ischemia LB7

Alicia Dâ&#x20AC;&#x2122;Souza

Almudena Albillos MartĂ&#x152;nez

Nigella Sativa improves LB15 osteoporosis in ovariectomized rats

LB8

Anti fertility Activity of Ingestion LB16 of Nigerian Bonny Light Crude Oil Contaminated feed in Male Albino Wistar Rats: A Possibl Arthur Nwafor

174

Carolina da Silveira Scarpellini

Anne Yael Nossent

Ansam Aly Seif

Biophysical and functional properties of native human Cav1 channels and their blockade by dihydropyridines

Effects of salt loading on the LB23 thermoregulatory behaviour of the lizard, Pogona vitticeps

Characterization of Cardiac LB24 Autonomic Neuropathy in Diabetic Mouse Models Catherine L. Stables

Oxidised chylomicron remnants induce microparticle production from human monocytes, in vitro

LB25

Charlotte Lawson

Notch-1 Mediated Cardiac LB33 Protection Following Pluripotent Stem Cell Transplantation in Doxorubicin-induced Heart Failure

An in vitro model for investigating pancreatic innervation

LB42

Elisa Vergari

Dinender Singla

Repeated squat-stand cycles as a LB26 tool for demonstrating integrative cardiovascular and cerebrovascular physiology in humans

Morphogenetic investigation of cerebrospinal fluid contacting neurons expressing PKD2L1

Christina MacKay

Djenoune Lydia

Cardiomyoctes influence fibroblast LB27 proliferation and ?-smooth muscle actin expression via the secretion of paracrine mediators Christopher Kane

Elisabetta Marongiu

LB36

On pathophysiological-therapeutic LB44 motor/electrical reactions of human/g.-pig urogenital tract after drugs (Ca-/antagonists,etc.) Eva Neu

Nasreen Akhtar

Decosahexaenoic acid improves LB28 vascular function via up-regulation of SIRT1 expression in endothelial cells Cuk Seong Kim

The Influence of Whole Body Vibration on the Central and Peripheral Cardiovascular System

Cognitive functions and electrophysiological profile in patients of vitamin B12 deficiency and the effect of treatment

LB34

Combined effect of acute venous LB43 and arteriolar vasodilatation on hemodynamic response during postexercise-induced metaboreflex a

Effects of Ramadan Intermittent LB37 Fasting on Fitness Profile in Young Male Sedentary Muslims of Kolkata, India.

The expression of TRP channels in baroreceptor

LB45

Eva Onchai Lau

Amit Bandyopadhyay

LB29

Dan Robbins

Effect of Thyroidectomy and LB46 Thyroxine on Glucose Transport in The Isolated Small Intestine of Rat Correlation of serum estradiol, IL-6 and IGF-1 with bone density in menopausal women with and without regular exercise

LB38

Fabiyi Temitope Deborah

Vita Muniarti Tarawan

b2-adrenergic agonist induces ERK1/2 and Akt/Foxo1 phosphorylation and atrogenes downregulation in an insulinindependent manner

Long term use of Oxytocin on the Health Biomarkers of Buffaloes LB30

Nutritional status of MBBS students LB39 of a selected government medical college of Bangladesh Uzire Azam Khan

LB31

Dimitar Tasev

Detection of differential alternative LB40 splicing events in human breast cancer using RNA-Seq data analysis

Fultang Livingstone Kimbi Fatele

Edwin Widodo

Demet Akin

Enhancement of tissue engineering-related features of endothelial colony-forming cells using hypoxia preconditioning

Farheen Asad

Stress induced regulation of the LB48 Glycine transporter 1a (GlyT1a) by activating transcription factor 4 (ATF4) in human intestinal

Dawit Albieiro Pinheiro GonĂ alves

Investigation of calcium channel subunits expression in genetic absence epilepsy rats from strausburg

LB47

LB32

Aldosterone alters expression of genes for antimicrobial proteins, cell cycle and immune function in fetal sheep lung

LB41

SCAM and concatenated receptors: LB49 a tool to investigate the agonist sites selectivity in pentameric ligand gated ion channel Gasparri Federica

F R I D A Y

Elaine M Richards

175

Late Breaking Posters - Friday 26 July Can altered crossbridge kinetics contribute to the development of residual force enhancement in mammalian skeletal muscle?

LB50

Involvement of caspases in the synaptogenesis of chick ciliary ganglion.

LB58

Hidetaka Katow

Gavin Jon Pinniger

Determination of the LB67 responsiveness of the rats to electroacupucture analgesia by the expression levels of hypothalamic AMPK Hyojeong Bae

Novel role for ROCK2 in the LB51 regulation of vascular permeability Geerten P. van Nieuw Amerongen

The MstnCmpt-dl1Abc mice. A mouse model to study in vivo muscle weakness and SOCE.

LB52

Geyer Nikolett

Expression and pro-vasculogenic activity of protease-activated receptor (PAR) 1 and 2 in human endothelial colony-forming cells

Effects of central administration of adrenomedullin 5 on oxytocinsecreting neurons and the cardiovascular system in rat

LB60 Sinoatrial compensation in the electrocardiogram

Hirofumi Hashimoto

James A J Heathers

Connection principles underlying LB61 the spatiotemporal receptive field structure of cat retiogeniculate system

Maternal and postnatal high fat diet alters circadian expression of genes regulating locomotor and feeding behaviour in mice

Hiromichi Sato

Jasmin Shearer

LB68

LB69

LB53

Giordano Pula

Contribution of quantitative changes in individual ionic current systems to the embryonic development of ventricular myocytes

LB62

The function of TMC proteins in mechanotransduction in sensory hair cells of the inner ear

LB70

Jeffrey R. Holt, Ph.D.

Hitomi I. Sano

Effect of estradiol in ingestive LB54 behavior induced by angiotensin II: MAPK p44/42 signaling pathway Gislaine de Almeida Pereira

Intermedin Modulates Hypoxic LB55 Pulmonary Vascular Remodeling by Apoptosis-dependent Mechanisms Gong Yongsheng

Regulation of human mesenchymal LB63 stem cell differentiation by extracellular ATP

Revascularization in hindlimb ischemia: Is it first angiogenesis or arteriogenesis in blood flow reestablishment?

Hongsen Peng

Jesus Israel Campos Villalobos

The role of Caveolin-1 in HaLB64 RasV12-induced cell softening and transformation Hsiu-Kuan Lin

The corneal permeabilityLB56 enhancing drug borneol stimulates lacrimation by activating TRPM8 channel Gui-Lan Chen

Perivascular adipose tissue inhibits LB65 aorta endothelium function through caveolin-1-dependent inhibition of NO production

Expression of Wnts and their receptors in pulmonary microvascular endothelial cells

LB71

LB72

Joanna Cornwell

Association between stress levels and academic performance in pregraduate students of cell physiology.

LB73

Julio C. S路nchez

Hui-Hsin Lee

Effect of Simvastatin on Erythrocyte LB57 Membrane Proteins in Endotoxemic Rats Hatice Yorulmaz

An interaction between Bcl-XL and LB66 VDAC facilitates mitochondrial Ca2+ uptake and bioenergetics Huiya Huang

176

Regulation mechanisms of bioLB74 active lipid metabolites on stem cells mobilization and self-renewal maintenance Jung-Min Ryu

Spontaneous, pro-arrhythmic LB75 calcium signals disrupt electrical pacing in pulmonary vein myocytes studied in mouse lung slices Katja Rietdorf

On pathophysiological and therapeutic vesical motor and electrical reactions after fl-sympathomimetics and anaesthetics

LB83

Water transport in seminiferous LB91 tubule: Aquaporins identification in Sertoli cells Marco Gouveia Alves

Lothar-Yorck Zebuhr

Changes in salivary stress markers under experimental xerostomia in the rat

LB76

Kenji Uchihashi

Effects of Fibrinogen in Mice Leukocyte Recruitment Planning the development of physiology laboratory of medical school based on the student perception of the current laboratory

LB84

LB77

Kieran E. Brack

Effects of Artemether and Artesunate on Pain

Deregulation of the key circadian LB85 rhythm component CLOCK in rat placenta during intermittent fasting LB78

Koofreh G. Davies

Expression of opioids and ghrelin mRNAs in the brain of diabetic piglets

LB79

LB86

LB80

Effect of chronic obestatin administration on serum testosterone level in male obese rats

LB87 Protective actions of sulforaphane LB96 against oxidative stress in fetal endothelial cells from gestational diabetic pregnancies

Magdi Ali Eldamarawi

Miss Bijal Patel

Respiratory sinus arrhythmia stabilises mean arterial blood pressure

Body Mass Index as a LB81 determinant of supraclavicular skin temperature in young healthy children.

Maja Elstad

Lindsay Elvidge

LB88 Influence of Melatonin on Altered Hemostatic Function in Hyperlipidemic Rats

LB97

Mona A. Ahmed

Cerebral microcirculation immediately after subarachnoid hemorrhage

LB89 The MstnCmpt-dl1Abc mice. A mouse model to study in vivo muscle weakness and SOCE.

Mami Ishikawa

Liping Han

LB95

Michael A. Hill

Kunichika Tsumoto

Spermine reduced no-reflow size induced by ischemia-reperfusion through regulating autophagy

LB94

Matthew Caldwell

Postnatal Development of Elastin Networks in Resistance Arteries

Lu-Yuan Lee

Krystyna Pierzchala-Koziec

Ischemia-induced Intracellular Remodeling of Sodium Channels as a Mechanism of Ventricular Proarrhythmia by Class-I Antiarrhythm

Mark R. Frey

An approximate maximum a posteriori approach to separating distinct populations of postsynaptic events

Luke Sansby

Hypersensitivity of pulmonary C-fibers induced by hemorrhagic hypotension in anesthetized rats

Maria Carlota Saldanha Lopes

ErbB4 activation blocks Paneth LB93 cell dropout and histological damage in experimental necrotizing enterocolitis.

Lubna Alasoom

The intrinsic cardiac nervous system of the rabbit

LB92

LB82

LB98

MĂ&#x203A;nika Sztretye

Circadian Rhythm of Peak Expiratory Flow Rate in healthy young adults Manoj Panta

LB90 The pattern of Amyloid-beta deposition in leptomeningeal arterial walls in Cerebral Amyloid Angiopathy in Alzheimers Disease

F R I D A Y

LB99

Nimeshi Jayakody

177

Late Breaking Posters - Friday 26 July Ivabradine alters alpha-smooth muscle actin expression and proliferation of left ventricular sheep fibroblasts in culture

LB100

Effects of haemorrhage on the LB108 haematological parameters of adult nigerian ducks

Cardiac Responses to IschemiaLB116 Reperfusion Injury in Experimental Androgen Deprivation

Olawuwo Stephen Olasunkanmi

Faten Mahmoud Diab

Protection against sodium arsenite- LB109 induced toxicity in wistar rats by ethanolic extract of spondias mombin l (anacardiaceae)

The vestibular sense of the gravito- LB118 inertial force field affects body image

Nirmitha Jayaratne

Keratinocytes flanking taste bud pores respond to norepinephrine

LB101

Nirupa Chaudhari

Richard C. Fitzpatrick

Olufunke Eunice Ola-Davies

Yoga-based lifestyle intervention for LB102 distal symmetric polyneuropathy associated with type 2 diabetes mellitus Nishanth Sampath

Blood pressure and heart rate,ECG LB110 and cardiovascular reflexes in hypertension and hypertensive heart failure

Carotid body sensory long term LB119 facilitation: post synaptic plasticity dependent on TRPV1 Richard J.A. Wilson

Olumide Odunayo Moyosola

A role for Src in agonist-induced LB103 activation of Rho-kinase in cultured human airway smooth muscle cells Nneka Irechukwu

The effects of baicalin on rhabdomyolysis induced acute renal injury in rats

LB111

Ozlem Yalcinkaya Yavuz

Comparative Study On The LB104 Protective Role Of Vitamin C And L-arginine In Experimental Renal Ischemia Reperfusion In Adult Rats Noha Nooh Lasheen

Desacyl ghrelin prevents doxorubicin-induced myocardial fibrosis and apoptosis via GHSRindependent pathway

LB120

Sabina Yeasmin

LB112

Parco Siu

Dynamic Effects of Spinal Cord Injury on Splanchnic Vascular Functions and Roles of Regenerative Medicine.

Motor Neuropathy in Hypothyroidism:Clinical and Electrophysiological findings

Involvement of the small LB121 conductance calcium-activated SK3 channel in the dopaminergic system: Molecular and behavioural studies Sabine Martin

LB105 Regulation by estrogens of LB113 bicarbonate secretion mechanisms in Sertoli cells

Noriko Iida, Ph.D

Pedro Fontes Oliveira

A possible role of uninjured adjacent L4 nerve in the development of peripheral neuropathic pain after L5 spinal nerve ligation

LB122

Safa Shehab

Fluorescent protein based sensors LB106 for ratiometric quantification of presynaptic calcium Okorocha, Albert Egwu

Fasting Induced Cytoplasmic Fto LB114 expression in Some Neurons of Rat Hypothalamus Predrag Vujovic

Influence of magnetic stimulation on pain modulation status of complete spinal cord injured rats Sajeev Ambalayam

Blood Group Distribution Pattern Among Adult Who Attended Federal Medical Centre, Lokoja, Kogi State, Nigeria. Olaniyan, Olugbemi Tope

178

LB107

Optical mapping of regional cardiac LB115 electrical effects from sympathetic nerve stimulation in the rabbit ventricle G. AndrĂ&#x2C6; Ng

LB123

Breadth of the placental surface and fetal growth

LB124

Saleh Alwasel

Neural representations of LB125 perceptual and semantic identities in the monkey anterior ventral inferior temporal cortex. Satoshi Eifuku

Physiological and gene expressional LB132 alternation in obesity animal model for ADME/PK characterization

Fatigue in Kidney Transplant Recipients: Is It Psychology or Physiology?

SUNG-HOON AHN, Ph.D.

Winnie Chan

Actions of omega-conotoxins CVID, LB133 CVIE and CVIF and their analogues are differentially affected by peripheral nerve injury

Mechanisms of Electroacupuncture-induced Analgesia on Neuropathic Pain

LB141

LB142

Woojin Kim Swetha Srinivasa Murali

Klotho regulates TRPC6 channel via LB126 PI3K/AKT-dependent mechanism Seung-Kuy Cha

Anti-Ulcer Effect of Moringa LB127 Oleifera On Indomethacin Induced Ulcer and Neutrophil-Lymphocyte Ratio In Adult Wistar Rats.

Heat dissipation limitation: LB134 manipulating thermal environment of the female independently from the pups

Electrophysiological effects of endogenous GABAA receptors in the globus pallidus of MPTP parkinsonian mice

Teresa G. Valencak

Xin-Yi Chen, Lei Chen

An Integrated Antiport Model of Outer Hair Cell Volume Changes

LB135

Timothy West

corelation between interleukin LB128 1 alpha,6 andechocardiographic results in patients with heart failure

Application of matrix-assisted laser LB136 desorption/ionization (MALDI) mass spectrometry in imaging of peptides in the rat brain Tymoteusz Zera

Shahlaa KH Chabuk

Dynamic Characteristics and Learning Ability of the Mouse Optokinetic and Vestibulo-ocular Reflexes

LB145

Yong Gyu Kim

LB129

Shui Hao Chin

Investigation of npy and leptin gen LB130 expression in kainic acid induced temporal lob epilepsy Sule Ozdas

LB144

Yasuyuki Sawada

Shafe Mercy Omoye

The Effect of Sympathetic and Vagus Nerve Interaction on Ventricular Fibrillation Inducibility

Mechanosensor and Gate Is Tightly Coupled in the Bacterial Mechanosensitive Channel MscL

LB143

On radiogenic vesical and LB137 vasomotor reactions (Gamma- and X-irradiation): Influence of drugs (AspirinR, etc.) and hyperthermia Ursula Welscher

Modulation of swimming endurance by Ocimum species at different temperatures

PIP2 alters pharmacological selectivity for epilepsy-causing KCNQ channels

LB146

Zhaobing Gao

LB138 Maternal fasting reduces kidney weight and increases blood pressure of male rat offspring

Venu Prasad

LB147

Ibrahim Alhazza

Effect of extract from peanut shellt LB139 in kidney of in senile rats Bioelectronics R&D: Join GSKâ&#x20AC;&#x2122;s vision for specific, closed loop, intelligent neuromodulation interventions for disease

Wang Min

Mapping changes in TRP channel and enteroendocrine cell marker expression in aged human bowel

LB140

LB148

F R I D A Y

Arun Sridhar

Wen Jiang

179

Physiology 2014 30 June 2014 - 2 July 2014 The Queen Elizabeth II Conference Centre, London, UK

Registration Opens 1 January 2014 Abstract Submission 1 March - 31 March 2014 www.physoc.org/p14 180

Other Activities Friday 26 July 8.00 – 12.00

Lodges Room (Austin Court)

Board of Directors, Virtual Physiological Human Institute

13.30 – 15.00

Executive Room 8 (The ICC)

New Council, The International Union of Physiological Sciences

14.00 – 18.00

Hall 6 (The ICC)

General Assembly, VPH Institute

Pharmacology 2013

F R I D A Y

17—19 December 2013, London, UK

Three days of the highest quality scientific content and invaluable networking opportunities featuring a selection of topical symposia, plenary lectures, free oral communications and poster sessions covering the whole spectrum of pharmacology from basic to clinical science. We look forward to you joining us in London! For more information or to register your interest please contact: t: +44 (0)207 239 0176 e: meetings@bps.ac.uk w: www.bps.ac.uk/meetings

bit.ly/V8FLy1 181

General Information Someone from the IUPS team can always be found at the registration desk. They are easily recognisable in their dark blue t-shirts. We will be happy to help with any queries you may have but you might be able to find an answer to your question on this page.

Registration The registration desk will be open: 15.00 – 19.00 7.30 – 19.00 7.30 – 19.00 7.30 – 17.30 7.30 – 17.30 7.30 – 13.00

Sunday 21 July Monday 22 July Tuesday 23 July Wednesday 24 July Thursday 25 July Friday 26 July

This information was sent in an email together with your final ID number. Should you need any clarification, please visit the poster help desk (situated in the foyer near the registration desk). It is the presenting author’s responsibility to be aware of their scheduled poster session. We are unable to accommodate posters not presented at your scheduled time at any other time. Please note that abstracts NOT presented in person will not form part of the final online published proceedings.

Late breaking abstracts

Abstracts

All late breaking abstracts are scheduled for presentation from 08:00 to 11:30 on Friday 26 July. This is not a dedicated poster session.

Speaker and poster abstracts are available either online or the Congress USB (available at the Wiley stand in Hall 3).

Late breaking abstracts are accepted as title only and will be listed as part of a programme addendum and will NOT form part of the final online published proceedings.

Poster Sessions

Poster help desk

All posters will be displayed in HALL 3 of The ICC for the entire day they are scheduled. Posters may be affixed from 8.00 onwards. The formal presentation time (when posters must be accompanied by the presenting author) is from 17.15 - 19.00, however, the earlier they are up; the more time people will have to view them. All posters must be removed at the end of the day and taken with you. Posters left in the Hall after 19.00 will be removed and The Society takes no responsibility for any subsequent damage or loss of property left behind. There are four dedicated poster sessions and they are scheduled as follows:

This is in the foyer near the registration desk. You can find Velcro to affix your poster here. No other fixings may be used. You can also find out when you are scheduled to present.

Lanyards You may notice that there are different colour lanyards. The code is as follows: • Blue – invited speakers • Pink – participants • Green – exhibitors • White - exhibition access only

Luggage storage and cloakroom This is on the ground floor of The Mall (The ICC). It is £1 per item.

Internet access

Monday 22 July

17.15 – 19.00

POSTER SESSION A

PCA001 - PCA417

There is free Wi-Fi available for attendees at The ICC (Network name: The ICC).

Tuesday 23 July

17.15 – 19.00

Internet café

POSTER SESSION B

PCB001 - PCB425

The internet café can be found in Hall 3.

Wednesday 24 July

17.15 – 19.00

Prayer room

POSTER SESSION C

PCC001 – PCC423

This can be found on The Mall past the Oak Kitchen.

Thursday 25 July

17.15 – 19.00

Birmingham – Where to go? What to see.

POSTER SESSION D

PCD001 – PCD425

Please note that the THIRD letter A, B, C or D in your communication number will NOT appear on the poster board signs in the Hall. These letters simply tell you which day you have been scheduled as follows: A – you are presenting on MONDAY 22 JULY B – you are presenting on TUESDAY 23 JULY C – you are presenting on WEDNESDAY 24 JULY D – you are presenting on THURSDAY 25 JULY For example, If your final ID number is PCA013, then you will need to present your poster on Monday 22 July. 182

If your final ID number is PCC013, then you will need to present your poster on Wednesday 24 July.

Y.O. Blacola’s Eclectic A to Z of Birmingham - check out this brilliant guide to Birmingham which is available on the Congress USB (available at the Wiley stand in Hall 3) or via the website www.iups2013.org Meet Birmingham will be in the registration area at the following times during the Congress: Sunday 21 July

15.00 – 18.00

Monday 22 July

9.00 – 18.00

Tuesday 23 July

9.00 – 18.00

Wednesday 24 July

9.00 – 18.00

Thursday 25 July

9.00 – 13.00

They are the experts on Birmingham and can help you find a restaurant, a gym, a park or shops to buy souvenirs.

Accessibility information

Feedback

The ICC Birmingham is accessible to wheelchair users via ramps or lifts. Tactile signage is fitted in the majority of lifts.

We want you to enjoy this meeting but are always happy to hear how we can improve. You can speak to a member of the team, or fill in your comments anonymously in a feedback questionnaire that will be emailed to you after the meeting.

Austin Court provides accessibility with a ground-level entrance into the building and reception and ramp access to the majority of groundfloor rooms. The first floor is accessible via a lift outside the Kingston Theatre with further access to the majority of first floor rooms. Hyatt Regency Hotel provides accessibility with a ground-level entrance into the building, and there are lifts to all floors.

In case of emergency Someone from the IUPS team (registration area) will be your first point of contact in any emergency. They will help you or find the person who can. Alternatively contact staff from The ICC, Hyatt Regency Hotel or Austin Court.

Mobile phones Don’t forget to turn off your mobile during all sessions at the Congress.

Video or audio recording of presentations Attendees are reminded that the video and audio recording of any session or presentation (Plenary Lectures, Keynote Lectures, Symposia, General Interest Sessions and Poster Sessions) using mobile devices or any such recording equipment is strictly prohibited.

Arriving late to sessions We know it is not always possible to get to sessions on time but we do ask that if you are running late, to take your seat quietly.

Donations Supporters of IUPS 2013 We are very grateful to those who have contributed:

• • • • • • • • • • • • • • •

Ulrich Pohl (Munich, Germany) Nick Boross-Toby (London, UK) Prem Kumar (Birmingham, UK) Clive Orchard (Bristol, UK) Ismaeel Bin-Jaliah (Abha, Saudi Arabia) David Eisner (Manchester, UK) Caroline McMillen (Adelaide, Australia) Mike Spyer (London, UK) Benedito Machado (Ribeirão Preto, Brazil) Suhail Ahmad (Anantnag, India) Ann Silver (Cambridge, UK) Bridget Lumb (Bristol, UK) Denis Noble (Oxford, UK) Frank Sengpiel (Cardiff, UK) Judy Harris (Bristol, UK)

Learned Society supporters Belgian Society of Fundamental and Clinical Physiology and Pharmacology Brazilian Society of Physiology (SBFis)

Corporate supporters

Smoking

Digitimer

You can’t smoke inside in the UK. If you wish to smoke then you need to go outside.

Thank you very much for your support.

Food and drink

Otto Hutter Teaching Prize 2013

Refreshments are available to purchase from a number of catering points in Hall 3 and in The Mall (The ICC).

The Society’s Otto Hutter Teaching Prize recognises outstanding teachers of undergraduate physiology. The £1000 prize includes £500 for the winner and £500 for the host institution (the latter to support education and teaching in physiology). In addition, the recipient is invited to present a lecture at the main meeting.

Lunch will be available in the exhibition hall from the various catering points for those with lunch vouchers. Vouchers cannot be purchased at the Congress. If you do not have lunch vouchers, there are plenty of shops and cafes in and around The ICC to purchase food.

Certificate of attendance

Nominations are now open for the 2013 Prize. www.physoc.org/prizes

After the Congress, we will send you a link to request an electronic certificate. We will NOT be providing certificates at the Congress.

Changes to abstracts We cannot make changes to abstracts.

Twitter The official Twitter hashtag is #iups2013 Make sure you are following @ThePhySoc to keep up to date on what’s happening at the Congress. 183

Social Programme We are delighted to have put together a concise social programme that will give you time to catch up with friends, colleagues and collaborators, but also means you have enough free time to take advantage of all that Birmingham is able to offer.

Sunday 21 July Opening ceremony and lecture

17.00 – 18.30 Hall 1 (The ICC)

The official opening of the Congress launches five days of cutting edge physiology. Representatives from IUPS and also The Physiological Society will welcome you to the event and also introduce Denis Noble who is giving the opening lecture.

Sunday 21 July

18.30 – 20.30

Welcome reception

Hall 3 (The ICC)

Ticket holders only – if you have registered for this event, a blue symbol will appear on your delegate badge. Join your friends, new and old, colleagues and collaborators and raise a glass to physiology. This will officially open the exhibition hall of the Congress. Entertainment is provided by GI Distress and the Fabulous FASEBettes. This event ends at 20.30 giving you plenty of time to go for dinner in the local area. It is not possible to purchase tickets for this event onsite. There may be some returns, please enquire at the registration desk.

Tuesday 23 July

19.30 – 23.30

Congress dinner

The Mall (The ICC)

Ticket holders only – if you have registered for this event, a pink symbol will appear on your delegate badge. Help us celebrate the “Best of English, Scottish, Welsh and Irish cuisine and entertainment” Buffet style areas will allow you to move from area to area and sample and see all the best that the UK and Ireland have to offer. There are two hours of free drinks and then a paying Irish bar until 23.00. Entertainment is a Scottish piper, the Kidderminster Welsh Male Voice Choir and an Irish band (Beer for Breakfast). It is not possible to purchase tickets for this event onsite. There may be some returns, please enquire at the registration desk.

Friday 26 July

13.00 – 14.00

Closing ceremony

Hall 4 (The ICC)

Join us to officially close the 37th Congress of the International Union of Physiological Sciences. Representatives from IUPS and The Physiological Society will give short addresses, and then formally handover to Benedito Machado representing the Brazilian Society of Physiology who are hosting the 38th Congress, in Rio de Janeiro, ‘The Rhythms of Life’ from 1 – 5 August 2017.

184

Preserving The Society’s records Managing The Society’s historical collections Publicising the history of physiology

The Physiological Society’s

History & Archives

Committee 185

General Interest Sessions and Industry Sessions A number of practical workshops and sessions have been organised and will be held during lunchtime. Here you can hone and develop your skills, and also explore various challenges that you may face in your career.

Tuesday 23 July 13.00 – 14.00

Hall 8 (The ICC)

Statistics: the Emperor’s clothes

Sunday 21 July

Organised by Gordon Drummond University of Edinburgh, UK and Statistics

Lodges Room (Austin Court)

10.00 - 16.00

EUDAT Training: iRODS, Data Staging and PIDs EUDAT is providing a free training session for attendees and interested members of the VPH community. We will cover iRODS, Data Staging, and PIDs in a series of interactive sessions. Lunch will be provided. Pre-registered participants only.

Monday 22 & Tuesday 23 July 13.00 – 14.00

Sonata Room (Hyatt Regency Hotel)

Effective presentation skills The use of PowerPoint and other presentation aids can be very helpful for scientists to effectively communicate their methods and findings. However, the PowerPoint presentation itself, if not prepared and rehearsed properly will dilute the strength of the message the presenter intends to put across. The aims of these sessions will be to assist young (and more senior) scientists who have a special need to improve their presentation skills. It will initially be delivered as a short talk (30 min) discussing the basic tips for making an effective scientific presentation in PowerPoint. Vivid illustrations and examples of good and bad slides will be also be used. Scientists/students/presenters (with need) will then be paired with mentors/faculty who will then help them to improve their skills on a one-on-one basis. Students will bring their laptops loaded with their own presentations and their mentors will help them at a personal level and can continue doing so throughout the course of the Congress. Notes for future reference will also be provided to all participants at the end of the workshop. Overall the short exercise will highlight the following areas: • What constitutes a good PowerPoint presentation? – What should it and what should it not do? • The presentation slides – designs, choice of background, fonts, font sizes, font colour, importance of contrast, amount of text per slide, clarity of graphs, diagrams, tables, spellings (SpellCheck facilities), animations, sounds, transition… • Voice projection, presentation speed, presentation aids, body language. • Common mistakes, the importance of rehearsing, timing, backup and general preparation before the presentation. • Creating and effective poster presentation using PowerPoint. Pre-registered participants only.

186

Editor, The Journal of Physiology

For many trainee scientists, it must seem that the papers they read are dressed up in statistics. In fact many of the statistical practices that are used are misapplied, and act to conceal rather than reveal the original data. Advice on experimental design, data presentation, and statistics is widely available, but doesn’t seem to be well translated into practice. This short session cannot provide a cure, but seeks to stimulate a fresh resolve in people too afraid to criticise the Emperor. I shall touch on design and data presentation (get that right and you’re nearly there), the logic or otherwise of statistical “proof”, interpreting tests, absence of evidence, nothing goes wrong, and replicates, what are they? The approach is to avoid equations and symbols as much as possible, and use analogy and pictures to demonstrate the underlying ideas. This talk is not designed for statistical sophisticates.

Wednesday 24 July 13.00 – 14.00

Hall 8 (The ICC)

Interdisciplinary Research, Funding and Publication Chaired by Alexei Verkhratsky University of Manchester, UK and Maiken Nedergaard University of Rochester, USA

Including the following presentations A journey from pure physiology to interdisciplinary biomedical science Ole Petersen Cardiff University, UK Physical methods and physiological concepts: getting the best of both worlds Dmitri Rusakov University College London, UK

Friday 26 July 9.30 – 11.30

Industry Sessions Hall 9 (The ICC)

Publishing for beginners

IUPS 2013 is delighted to host a number of workshops and seminars supported by our Sponsors. These sessions will provide you with practical hands-on knowledge and the chance to learn more about unique research applications.

Organised by Kim Barrett University of California, San Diego, USA

Monday 22 July At the beginning of a career in physiology, scientific publishing can seem a mysterious enterprise. The goal of this session is to introduce postgraduate students, postdoctoral fellows, and early career investigators to some of the unwritten “dos and don’ts” of publishing. Armed with this information, you should be equipped to increase their chances of securing publication of your work in the journal of your choice while avoiding ethical minefields along the way.

13.00 – 14.00

Hall 9 (The ICC) Telemetry in Neuroscience Research: Exploring Experimental Models of Sleep and Epilepsy Sponsored by Data Sciences International

The symposium will include editors from the Journal of Physiology and ample time will be set aside for an interactive panel with questions from the audience.

Data Sciences International (DSI) are hosting a one-hour luncheon featuring the following scientific presentations:

Including the following presentations

Differential effects of day versus night-time dosing with diazepam on sleep-wake patterns in telemetered, freely moving rats

Telling a compelling story David Paterson Editor-in-Chief, The Journal of Physiology Nuts and bolts of the review process – how to give the editors what they want Ian Forsythe Senior Editor and Reviews Editor, The Journal of Physiology Avoiding common mistakes and ethical issues in your submission Kim Barrett Deputy Editor-in-Chief for the Americas, The Journal of Physiology Panel discussion (30 minutes): Drs. Paterson, Forsythe, Barrett, Julian Paton (Deputy Editor-in-Chief for Europe, The Journal of Physiology) and Yoshihiro Kubo (Deputy Editor-in-Chief for Asia, The Journal of Physiology)

Haifeng Wei1, Fei-Yue Zhao1, Ross Jeggo1 and David Spanswick1,2 1Neurosolutions Ltd, 2University of Warwick, Coventry, UK

Radiotelemetry in epilepsy models John Jefferys University of Birmingham, UK Please join us to learn more about the unique research applications being explored by each of these presenters. Lunch and refreshments will be served. For more information on Data Sciences International, please visit their website www.datasci.com

Tuesday 23 July

13.00 – 14.00

Hall 9 (The ICC) TR(i)P to Automated Patch Clamp Sponsored by Nanion Technologies

Patch clamp demonstration is given by Nadine Becker, Application Scientist, Nanion Technologies The Port-a-Patch represents the smallest patch clamp rig in the world, making patch clamp easy to learn within one hour instead of weeks. The device has extremely versatile add-ons allowing for fast external perfusion, internal perfusion and temperature control, supporting high quality recordings from a multitude of different voltage- and ligand gated ion channels, cell lines, primary cell, organelles and artificial bilayers. Come to our workshop and learn from live, hands-on experiments, how to make high quality recordings from cells and ultra-low noise bilayer recordings from reconstituted ion channels! For more information on Nanion Technologies GmbH, please visit their website www.nanion.de 187

Women in science - Sponsored by the Biochemical Society An international organising committee, led by Susan Wray, will host 3 sessions focusing on different stages of the academic career, where women may typically encounter difficulty in progressing.

Wednesday 24 July

The sessions will explore some of the reasons that women are consistently under-represented in the more senior positions in academic science and consider how to overcome these potential obstacles; they will also highlight some of the success stories.

Juggling balls – family and physiology

The sessions are intended to be quite informal and generate lively discussion. As they will take place over lunchtime, delegates are invited to bring their lunch with them.

13.00 – 14.00

The speakers will provide their perspective of developing a work life balance, especially how to manage working with having family responsibilities; they will also talk more widely about the situation in their country. This will be followed by a panel discussion with the audience to share challenges and experiences and Denis Noble, President of IUPS, will summarise the discussion. We will see what factors helped and what hindered, and if there are clear global differences. This will not be an in depth study, but should be engaging and provide an excellent opportunity to network.

Tuesday 23 July Hall 10 (The ICC)

Hall 6 (The ICC)

13.00 – 14.00

Why mentoring and sponsorship works This session examines the paradox of why more women than men receive mentoring, but are less likely to advance in their careers. The key factor may be that women are not actively sponsored in the same way as men. Speakers will share their experiences of mentoring and sponsorship - both giving and receiving - at different stages of a global research career. Through discussion of panel members’ experiences, this session will identify how the role of the sponsor goes beyond giving feedback and advice to advocating for their mentees and helping them gain visibility in their field. Organised and Chaired by Caroline McMillen The University of Newcastle,

Organised by Susan Wray University of Liverpool, UK Chaired by Susan Wray University of Liverpool, UK and Luciana Rossoni University of Sao Paolo, Brazil. Speakers Kathy Morgan Boston University, USA Rafidah Hanim Mokhtar Universiti Sains Islam Malaysia, Malaysia Tamara Rosenbaum Universidad Nacional Autónoma de México, Mexico Azeez Oyebisi University of Ilorin, Nigeria Yvonne Hodgson Monash University, Australia At the end of this session The Physiological Society will also be launching its new booklet, Women in Physiology, celebrating female physiologists

Australia

Thursday 25 July

Panel: Barbara Cannon The Wenner-Gren Institute, Sweden, Abigail Fowden University of Cambridge, UK and Lisa Nicholas University of South Australia, Australia

Hall 10 (The ICC)

13.00 – 14.00

What glass ceiling? Speakers will provide their perspective of any glass ceilings facing women working in physiology and opportunities to break through these. The speakers will share their experiences of working in different countries and at different stages of an academic career. Organised by Bridget Lumb University of Bristol, UK Chaired by Bridget Lumb University of Bristol, UK and Elaine Guimaraes University of Sao Paolo, Brazil Speakers Nancy Rothwell

University of Manchester, UK

Ole Petersen

Cardiff University, UK